Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line

Journal of Nutrigenetics and Nutrigenomics

Volumn 3, Issue 1, 2010, Pages 37-45

  Lappalainen, Tiina ^a   Kolehmainen, Marjukka ^a   Schwab, Ursula ^a,b   Pulkkinen, Leena ^a   De Mello, Vanessa D F ^a   Vaittinen, Maija ^a   Laaksonen, David E ^a,b   Poutanen, Kaisa ^a,c   Uusitupa, Matti ^a   Gylling, Helena ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

Author keywords

Fat mass and obesity associated gene (FTO); Gene expression; Metabolic syndrome; Obesity

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; HIGH MOBILITY GROUP B1 PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL SUBCUTANEOUS FAT; ADIPOCYTE; ADULT; ARTICLE; BIOCHEMISTRY; BODY MASS; BODY WEIGHT; CELL DEATH; CELL SIZE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE ACTIVITY; GENE EXPRESSION; GENETIC RISK; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

ADIPOCYTES; BLOOD GLUCOSE; BODY MASS INDEX; C-REACTIVE PROTEIN; FEMALE; GENE EXPRESSION REGULATION; GENOTYPE; HUMANS; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; OBESITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROTEINS; REFERENCE VALUES; RNA; SUBCUTANEOUS FAT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77958485625     PISSN: 16616499     EISSN: 16616758     Source Type: Journal    
DOI: 10.1159/000320732     Document Type: Article

References (38)

1. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI:, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI:, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI:, Morris AD, Smith GD, Hattersley AT, McCarthy MI:, Smith GD, Hattersley AT, McCarthy MI:, Hattersley AT, McCarthy MI:: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894.
2. Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P: Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724-726.
3. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J: Genomewide association scan shows genetic variants in the FTO gene are associated with obesityrelated traits. PLoS Genet 2007;3: e115.
4. Hubacek JA, Bohuslavova R, Kuthanova L, Kubinova R, Peasey A, Pikhart H: The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study. Obesity 2008;16:2764-2766.
5. Peeters A, Beckers S, Verrijken A, Roevens P, Peeters P, Van Gaal L: Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab 2008;93:481-484.
6. Lappalainen TJ, Tolppanen AM, Kolehmainen M, Schwab U, Lindström J, Tuomilehto J: The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight - the Finnish Diabetes Prevention Study. Obesity 2009;17:832-836.
7. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007;318:1469-1472.
8. Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, Plomin R: Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 2008;93:3640-3643.
9. Wardle J, Llewellyn C, Sanderson S, Plomin R: The FTO gene and measured food intake in children. Int J Obes 2009;33:42-45.
10. van der Hoeven F, Schimmang T, Volkmann A, Mattei MG, Kyewski B, Rüther U: Programmed cell death is affected in the novel mouse mutant Fused toes (Ft). Development 1994;120:2601-2607.
11. Peters T, Ausmeier K, Rüther U: Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome 1999;10:983-986.
12. Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC: Inactivation of the FTO gene protects from obesity. Nature 2009;458:894-898.
13. Wåhlén K, Sjölin E, Hoffstedt J: The common rs9939609 gene variant of the fat massand obesity-associated gene FTO is related to fat cell lipolysis. J Lipid Res 2008;49:607-611.
14. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN, Genetic Investigation of Anthropometric Traits Consortium: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34.
15. Sanchez-Pulido L, Andrade-Navarro MA: The FTO (fat mass and obesity associated) gene codes for a novel member of the nonheme dioxygenase superfamily. BMC Biochem 2007;8:23.
16. Zabena C, González-Sánchez JL, Martínez-Larrad MT, Torres-García A, Alvarez-Fernández-Represa J, Corbatón- Anchuelo A, Pérez-Barba M, Serrano-Ríos M: The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients. Obes Surg 2009;19:87-95.
17. Klöting N, Schleinitz D, Ruschke K, Berndt J, Fasshauer M, Tönjes A, Schön MR, Kovacs P, Stumvoll M, Blüher M: Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia 2008;51:641-647.
18. Villalobos-Comparán M, Teresa Flores-Dorantes M, Teresa Villarreal-Molina M, Rodríguez-Cruz M, García-Ulloa AC, Robles L, Huertas-Vázquez A, Saucedo-Villarreal N, López-Alarcón M, Sánchez-Muñoz F, Domínguez-López A, Gutiérrez-Aguilar R, Menjivar M, Coral-Vázquez R, Hernández-Stengele G, Vital-Reyes VS, Acuña-Alonzo V, Romero-Hidalgo S, Ruiz-Gómez DG, Riaño-Barros D, Herrera MF, Gómez-Pérez FJ, Froguel P, García-García E, Teresa Tusié-Luna M, Aguilar-Salinas CA, Canizales-Quinteros S: The FTO gene is associated with adulthood obesity in the Mexican population. Obesity 2008;16:2296-2301.
19. Samaras K, Botelho NK, Chisholm DJ, Lord RV: Subcutaneous and visceral adipose tissue FTO gene expression and adiposity, insulin action, glucose metabolism, and inflammatory adipokines in type 2 diabetes mellitus and in health. Obes Surg 2010;20:108-113.
20. Grunnet LG, Nilsson E, Ling C, Hansen T, Pedersen O, Groop L, Vaag A, Poulsen P: Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. Diabetes 2009;58:2402-2408.
21. Kolehmainen M, Salopuro T, Schwab US, Kekäläinen J, Kallio P, Laaksonen DE, Pulkkinen L, Lindi VI, Sivenius K, Mager U, Siitonen N, Niskanen L, Gylling H, Rauramaa R, Uusitupa M: Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN study. Int J Obes 2008;32:292-303.
22. Laaksonen DE, Toppinen LK, Juntunen KS, Autio K, Liukkonen KH, Poutanen KS, Niskanen L, Mykkänen HM: Dietary carbohydrate modification enhances insulin secretion in persons with the metabolic syndrome. Am J Clin Nutr 2005;82:1218-1227.
23. Kallio P, Kolehmainen M, Laaksonen DE, Kekäläinen J, Salopuro T, Sivenius K, Pulkkinen L, Mykkänen HM, Niskanen L, Uusitupa M, Poutanen KS: Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study. Am J Clin Nutr 2007;85:1417-1427.
24. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F: Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Curr Opin Cardiol 2006;21:1-6.
25. Ohisalo JJ, Kaartinen JM, Ranta S, Mustajoki P, Hreniuk SP, LaNoue KF, Martin LF: Weight loss normalizes the inhibitory effect of N6-(phenylisopropyl) adenosine on lipolysis in fat cells of massively obese human subjects. Clin Sci (London) 1992;83:589-592.
26. Rodbell M: Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem 1964;239:375-380.
27. Semenza GL: Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. J Clin Invest 2000;106:809-812.
28. Bianchi ME: DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 2007;81:1-5.
29. Lotze MT, Tracey KJ: High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005;5:331-342.
30. Trayhurn P, Wood IS: Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004;92:347-355.
31. Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M, Shimomura I: Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 2007;56:901-911.
32. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS, Obin MS: Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005;46:2347-2355.
33. Strissel KJ, Stancheva Z, Miyoshi H, Perfield JW 2nd, DeFuria J, Jick Z, Greenberg AS, Obin MS: Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 2007;56:2910-2918.
34. Greijer AE, van der Wall E: The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 2004;57:1009-1014.
35. Prins JB, Niesler CU, Winterford CM, Bright NA, Siddle K, O'Rahilly S, Walker NI, Cameron DP: Tumor necrosis factor-alpha induces apoptosis of human adipose cells. Diabetes 1997;46:1939-1944.
36. Fisher E, Schulze MB, Stefan N, Häring HU, Döring F, Joost HG, Al-Hasani H, Boeing H, Pischon T: Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levels. Obesity 2009;17:330-334.
37. Qi L, Kang K, Zhang C, van Dam RM, Kraft P, Hunter D: Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes 2008;57:3145-3151.
38. Jowett JB, Curran JE, Johnson MP, Carless MA, Göring HH, Dyer TD: Genetic variation at the FTO locus influences RBL2 gene expression. Diabetes 2010;59:726-732.