Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: An analysis of PanScan-I data

Cancer Causes and Control

Volumn 22, Issue 6, 2011, Pages 877-883

  Pierce, Brandon L ^a   Austin, Melissa A ^b   Ahsan, Habibul ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Genome wide association study; Pancreatic cancer; Risk score; Type 2 diabetes

Indexed keywords

GLUCOSE;

ADULT; AGED; ALLELE; ARTICLE; BCL11A GENE; CANCER RISK; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; EUROPE; FEMALE; FTO GENE; GENE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HUMAN; MADD GENE; MAJOR CLINICAL STUDY; MALE; MTNR1B GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS CANCER; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; DATA INTERPRETATION, STATISTICAL; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 79956263021     PISSN: 09575243     EISSN: 15737225     Source Type: Journal    
DOI: 10.1007/s10552-011-9760-5     Document Type: Article

References (41)

1. R Huxley A Ansary-Moghaddam A Berrington de Gonzalez F Barzi M Woodward 2005 Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies Br J Cancer 92 2076 2083 15886696 10.1038/sj.bjc.6602619 1:STN:280: DC%2BD2M3ot1Kjug%3D%3D (Pubitemid 40897433)
2. RZ Stolzenberg-Solomon BI Graubard S Chari, et al. 2005 Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers JAMA 294 2872 2878 16352795 10.1001/jama.294.22.2872 1:CAS:528:DC%2BD2MXhtlWrtb7E (Pubitemid 41785868)
3. SH Jee H Ohrr JW Sull JE Yun M Ji JM Samet 2005 Fasting serum glucose level and cancer risk in Korean men and women Jama 293 194 202 15644546 10.1001/jama.293.2.194 1:CAS:528:DC%2BD2MXktVyqsg%3D%3D (Pubitemid 40095870)
4. P Pisani 2008 Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies Arch Physiol Biochem 114 63 70 18465360 10.1080/13813450801954451 1:CAS:528:DC%2BD1cXotlKls7c%3D (Pubitemid 351998745)
5. Q Ben Q Cai Z Li, et al. 2011 The relationship between new-onset diabetes mellitus and pancreatic cancer risk: a case-control study Eur J Cancer 47 248 254 20709528 10.1016/j.ejca.2010.07.010
6. S Gupta E Vittinghoff D Bertenthal, et al. 2006 New-onset diabetes and pancreatic cancer Clin Gastroenterol Hepatol 4 1366 1372 16945591 10.1016/j.cgh.2006.06.024 (quiz 1301) (Pubitemid 44781089)
7. MM Hassan ML Bondy RA Wolff, et al. 2007 Risk factors for pancreatic cancer: case-control study Am J Gastroenterol 102 2696 2707 17764494 10.1111/j.1572-0241.2007.01510.x (Pubitemid 350179330)
8. D Li H Tang MM Hassan EA Holly PM Bracci DT Silverman 2011 Diabetes and risk of pancreatic cancer: a pooled analysis of three large case-control studies Cancer Causes Control 22 189 197 21104117 10.1007/s10552-010-9686-3 1:CAS:528:DC%2BC3MXmslOlsg%3D%3D
9. MC Rousseau ME Parent MN Pollak J Siemiatycki 2006 Diabetes mellitus and cancer risk in a population-based case-control study among men from Montreal, Canada Int J Cancer 118 2105 2109 16284945 10.1002/ijc.21600 1:CAS:528:DC%2BD28Xjt1Kjsrw%3D
10. F Wang S Gupta EA Holly 2006 Diabetes mellitus and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California Cancer Epidemiol Biomarkers Prev 15 1458 1463 16896032 10.1158/1055-9965.EPI-06- 0188 (Pubitemid 44299315)
11. D Li JL Abbruzzese 2010 New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts Clin Cancer Res 16 4313 4318 20647474 10.1158/1078-0432.CCR-09-1942 1:CAS:528:DC%2BC3cXhtV2rt7rE
12. N Bouatia-Naji A Bonnefond C Cavalcanti-Proenca, et al. 2009 A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk Nat Genet 41 89 94 19060909 10.1038/ng.277 1:CAS:528: DC%2BD1cXhsVKlt7zP
13. V Lyssenko CL Nagorny MR Erdos, et al. 2009 Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion Nat Genet 41 82 88 19060908 10.1038/ng.288 1:CAS:528: DC%2BD1cXhsVKlt77J
14. J Rung S Cauchi A Albrechtsen, et al. 2009 Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia Nat Genet 41 1110 1115 19734900 10.1038/ng.443 1:CAS:528:DC%2BD1MXhtV2gsb%2FL
15. R Saxena BF Voight V Lyssenko, et al. 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331 1336 17463246 10.1126/science.1142358 1:CAS:528:DC%2BD2sXmtVyitrk%3D (Pubitemid 46871653)
16. LJ Scott KL Mohlke LL Bonnycastle, et al. 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 316 1341 1345 17463248 10.1126/science.1142382 1:CAS:528: DC%2BD2sXmtVyitrY%3D (Pubitemid 46871655)
17. R Sladek G Rocheleau J Rung, et al. 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 881 885 17293876 10.1038/nature05616 1:CAS:528:DC%2BD2sXhvFGiurw%3D
18. H Unoki A Takahashi T Kawaguchi, et al. 2008 SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations Nat Genet 40 1098 1102 18711366 10.1038/ng.208 1:CAS:528:DC%2BD1cXhtVGgt77E
19. K Yasuda K Miyake Y Horikawa, et al. 2008 Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus Nat Genet 40 1092 1097 18711367 10.1038/ng.207 1:CAS:528:DC%2BD1cXhtVGgt77M
20. E Zeggini LJ Scott R Saxena, et al. 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nat Genet 40 638 645 18372903 10.1038/ng.120 1:CAS:528:DC%2BD1cXltFylurY%3D (Pubitemid 351601209)
21. J Dupuis C Langenberg I Prokopenko, et al. 2010 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nat Genet 42 105 116 20081858 10.1038/ng.520 1:CAS:528: DC%2BC3cXntVCqsw%3D%3D
22. R Saxena MF Hivert C Langenberg, et al. 2010 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat Genet 42 142 148 20081857 10.1038/ng.521 1:CAS:528:DC%2BC3cXntVCksw%3D%3D
23. BF Voight LJ Scott V Steinthorsdottir, et al. 2010 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis Nat Genet 42 579 589 20581827 10.1038/ng.609 1:CAS:528:DC%2BC3cXnvFykt70%3D
24. I Prokopenko C Langenberg JC Florez, et al. 2009 Variants in MTNR1B influence fasting glucose levels Nat Genet 41 77 81 19060907 10.1038/ng.290 1:CAS:528:DC%2BD1cXhsVKlt7vM
25. L Amundadottir P Kraft RZ Stolzenberg-Solomon, et al. 2009 Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer Nat Genet 41 986 990 19648918 10.1038/ng.429 1:CAS:528:DC%2BD1MXpt1Ogt7s%3D
26. GM Petersen L Amundadottir CS Fuchs, et al. 2010 A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33 Nat Genet 42 224 228 20101243 10.1038/ng.522 1:CAS:528:DC%2BC3cXhtVWrtL4%3D
27. AL Price NJ Patterson RM Plenge ME Weinblatt NA Shadick D Reich 2006 Principal components analysis corrects for stratification in genome-wide association studies Nat Genet 38 904 909 16862161 10.1038/ng1847 1:CAS:528:DC%2BD28XnsVCgsrg%3D (Pubitemid 44141658)
28. R Lawrence AG Day-Williams R Mott J Broxholme LR Cardon E Zeggini 2009 GLIDERS-a web-based search engine for genome-wide linkage disequilibrium between HapMap SNPs BMC Bioinf 10 367 10.1186/1471-2105-10-367
29. BL Pierce H Ahsan 2010 Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk Hum Hered 69 193 201 20203524 10.1159/000289594
30. S Purcell B Neale K Todd-Brown, et al. 2007 PLINK: a tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 81 559 575 17701901 10.1086/519795 1:CAS:528:DC%2BD2sXhtVSqurrL (Pubitemid 47330214)
31. TM Frayling NJ Timpson MN Weedon, et al. 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 316 889 894 17434869 10.1126/science.1141634 1:CAS:528:DC%2BD2sXltVentL0%3D (Pubitemid 46764279)
32. AA Arslan KJ Helzlsouer C Kooperberg, et al. 2010 Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan) Arch Intern Med 170 791 802 20458087 10.1001/archinternmed.2010.63
33. MD Fesinmeyer JL Stanford TA Brentnall, et al. 2009 Association between the peroxisome proliferator-activated receptor gamma Pro12Ala variant and haplotype and pancreatic cancer in a high-risk cohort of smokers: a pilot study Pancreas 38 631 637 19436234 10.1097/MPA.0b013e3181a53ef9 1:CAS:528: DC%2BD1MXovFSjtbg%3D
34. PY Fong MD Fesinmeyer E White, et al. 2010 Association of diabetes susceptibility gene calpain-10 with pancreatic cancer among smokers J Gastrointest Cancer 41 203 208 20178008 10.1007/s12029-010-9130-7 1:CAS:528:DC%2BC3cXhtlykt73P
35. CC Cowie KF Rust ES Ford, et al. 2009 Full accounting of diabetes and pre-diabetes in the US population in 1988-1994 and 2005-2006 Diabetes Care 32 287 294 19017771 10.2337/dc08-1296
36. AD Skol LJ Scott GR Abecasis M Boehnke 2006 Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies Nat Genet 38 209 213 16415888 10.1038/ng1706 1:CAS:528: DC%2BD28XotlGlsg%3D%3D (Pubitemid 43177235)
37. JE Yun I Jo J Park, et al. 2006 Cigarette smoking, elevated fasting serum glucose, and risk of pancreatic cancer in Korean men Int J Cancer 119 208 212 16450398 10.1002/ijc.21816 1:CAS:528:DC%2BD28Xkslyju7w%3D
38. JB Douglas DT Silverman MN Pollak Y Tao AS Soliman RZ Stolzenberg-Solomon 2010 Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, Colorectal, and ovarian cancer screening trial Cancer Epidemiol Biomarkers Prev 19 2298 2306 20699371 10.1158/1055-9965.EPI-10-0400 1:CAS:528:DC%2BC3cXhtFart7zE
39. BM Wolpin DS Michaud EL Giovannucci, et al. 2007 Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts Br J Cancer 97 98 104 17533398 10.1038/sj.bjc.6603826 1:CAS:528:DC%2BD2sXmvV2ms70%3D (Pubitemid 47012086)
40. RZ Stolzenberg-Solomon P Limburg M Pollak PR Taylor J Virtamo D Albanes 2004 Insulin-like growth factor (IGF)-1, IGF-binding protein-3, and pancreatic cancer in male smokers Cancer Epidemiol Biomarkers Prev 13 438 444 15006921 1:CAS:528:DC%2BD2cXhvVygt7g%3D (Pubitemid 38737470)
41. A Kong V Steinthorsdottir G Masson, et al. 2009 Parental origin of sequence variants associated with complex diseases Nature 462 868 874 20016592 10.1038/nature08625 1:CAS:528:DC%2BD1MXhsFOhtbvJ