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Volumn 23, Issue 3, 2011, Pages 461-469

The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: A prospective cohort study

Author keywords

Alzheimer's disease; APOE; body mass index; cardiovascular disease; dementia; diabetes; FTO; physical activity

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E EPISILON4; UNCLASSIFIED DRUG;

EID: 79951867607     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-101068     Document Type: Article
Times cited : (157)

References (32)
  • 2
    • 34548032087 scopus 로고    scopus 로고
    • Genome-wide association studies provide new insights into type 2 diabetes aetiology
    • DOI 10.1038/nrg2178, PII NRG2178
    • Frayling TM (2007) Genome-wide association studies provide newinsights into type 2 diabetes aetiology. Nat Rev Genet 8, 657-662. (Pubitemid 47281993)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.9 , pp. 657-662
    • Frayling, T.M.1
  • 4
    • 42249083837 scopus 로고    scopus 로고
    • The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
    • DOI 10.1210/en.2007-1457
    • Fredriksson R, Hagglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM, Levine AS, Lindblom J, Schioth HB (2008) The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 149, 2062-2071. (Pubitemid 351574484)
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2062-2071
    • Fredriksson, R.1    Hagglund, M.2    Olszewski, P.K.3    Stephansson, O.4    Jacobsson, J.A.5    Olszewska, A.M.6    Levine, A.S.7    Lindblom, J.8    Schioth, H.B.9
  • 8
    • 77649303960 scopus 로고    scopus 로고
    • Hypothalamic-specific manipulation of FTO, the ortholog of the human obesity gene FTO, affects food intake in rats
    • Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP, Yeo GS (2010) Hypothalamic-Specific Manipulation of FTO, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats. PLoS ONE 5, e8771.
    • (2010) PLoS ONE , vol.5
    • Tung, Y.C.1    Ayuso, E.2    Shan, X.3    Bosch, F.4    O'Rahilly, S.5    Coll, A.P.6    Yeo, G.S.7
  • 9
    • 42449153273 scopus 로고    scopus 로고
    • Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the quebec family study
    • Do R, Bailey SD, Desbiens K, Belisle A, Montpetit A, Bouchard C, Perusse L, Vohl MC, Engert JC (2008) Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes 57, 1147-1150.
    • (2008) Diabetes , vol.57 , pp. 1147-1150
    • Do, R.1    Bailey, S.D.2    Desbiens, K.3    Belisle, A.4    Montpetit, A.5    Bouchard, C.6    Perusse, L.7    Vohl, M.C.8    Engert, J.C.9
  • 10
    • 77949331704 scopus 로고    scopus 로고
    • The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: A Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study
    • Doney AS, Dannfald J, Kimber CH, Donnelly LA, Pearson E, Morris AD, Palmer CN (2009) The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study. Circ Cardiovasc Genet 2, 255-259.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 255-259
    • Doney, A.S.1    Dannfald, J.2    Kimber, C.H.3    Donnelly, L.A.4    Pearson, E.5    Morris, A.D.6    Palmer, C.N.7
  • 13
    • 29044449855 scopus 로고    scopus 로고
    • Risk of dementia in diabetes mellitus: A systematic review
    • DOI 10.1016/S1474-4422(05)70284-2, PII S1474442205702842
    • Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P (2006) Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 5, 64-74. (Pubitemid 41790697)
    • (2006) Lancet Neurology , vol.5 , Issue.1 , pp. 64-74
    • Biessels, G.J.1    Staekenborg, S.2    Brunner, E.3    Brayne, C.4    Scheltens, P.5
  • 15
    • 0026701491 scopus 로고
    • Clinical diagnosis of Alzheimer's disease and other dementias in a population survey. Agreement and causes of disagreement in applying Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition, Criteria
    • Fratiglioni L, Grut M, Forsell Y, Viitanen M, Winblad B (1992) Clinical diagnosis of Alzheimer's disease and other dementias in a population survey. Agreement and causes of disagreement in applying Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition, Criteria. Arch Neurol 49, 927-932.
    • (1992) Arch Neurol , vol.49 , pp. 927-932
    • Fratiglioni, L.1    Grut, M.2    Forsell, Y.3    Viitanen, M.4    Winblad, B.5
  • 18
    • 0007601432 scopus 로고    scopus 로고
    • Epidemiology of Alzheimer's disease: The Kungsholmen Project
    • Fratiglioni L (1999) Epidemiology of Alzheimer's disease: The Kungsholmen Project. Neurol Rev Int 3, 12-15.
    • (1999) Neurol Rev Int , vol.3 , pp. 12-15
    • Fratiglioni, L.1
  • 19
    • 0031024278 scopus 로고    scopus 로고
    • Very old women at highest risk of dementia and Alzheimer's disease: Incidence data from the Kungsholmen Project, Stockholm
    • Fratiglioni L, Viitanen M, von Strauss E, Tontodonati V, Herlitz A,Winblad B (1997), Very old women at highest risk of dementia and Alzheimer's disease: incidence data from the Kungsholmen Project, Stockholm. Neurology 48, 132-138. (Pubitemid 27039531)
    • (1997) Neurology , vol.48 , Issue.1 , pp. 132-138
    • Fratiglioni, L.1    Viitanen, M.2    Von Strauss, E.3    Tontodonati, V.4    Herlitz, A.5    Winblad, B.6
  • 20
    • 5344237420 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of dementia in the Kungsholmen project: A 6-year follow-up study
    • Xu WL, Qiu CX, Wahlin A, Winblad B, Fratiglioni L (2004) Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Neurology 63, 1181-1186. (Pubitemid 39350014)
    • (2004) Neurology , vol.63 , Issue.7 , pp. 1181-1186
    • Xu, W.L.1    Qiu, C.X.2    Wahlin, A.3    Winblad, B.4    Fratiglioni, L.5
  • 21
    • 67349085203 scopus 로고    scopus 로고
    • Uncontrolled diabetes increases the risk of Alzheimer's disease: A population-based cohort study
    • Xu WL, von Strauss E, Qiu CX, Winblad B, Fratiglioni L (2009) Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study. Diabetologia 52, 1031-1039.
    • (2009) Diabetologia , vol.52 , pp. 1031-1039
    • Xu, W.L.1    Von Strauss, E.2    Qiu, C.X.3    Winblad, B.4    Fratiglioni, L.5
  • 26
    • 58149340093 scopus 로고    scopus 로고
    • Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: Longitudinal analyses in two cohort studies and functional test
    • Qi L, Kang K, Zhang C, van Dam RM, Kraft P, Hunter D, Lee CH, Hu FB (2008) Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes 57, 3145-3151.
    • (2008) Diabetes , vol.57 , pp. 3145-3151
    • Qi, L.1    Kang, K.2    Zhang, C.3    Van Dam, R.M.4    Kraft, P.5    Hunter, D.6    Lee, C.H.7    Hu, F.B.8
  • 28
    • 35848938196 scopus 로고    scopus 로고
    • Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans [2]
    • DOI 10.1007/s00125-007-0839-1
    • Tschritter O, Preissl H, Yokoyama Y, Machicao F, Haring HU, Fritsche A (2007) Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans. Diabetologia. 50, 2602-2603. (Pubitemid 350060655)
    • (2007) Diabetologia , vol.50 , Issue.12 , pp. 2602-2603
    • Tschritter, O.1    Preissl, H.2    Yokoyama, Y.3    Machicao, F.4    Haring, H.-U.5    Fritsche, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.