The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Gao, Xue ^a   Shin, Yong Hyun ^a   Li, Min ^a   Wang, Fei ^a   Tong, Qiang ^a   Zhang, Pumin ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIOXYGENASE; FAT MASS AND OBESITY ASSOCIATED PROTEIN; SOMATOMEDIN C; UNCLASSIFIED DRUG; FTO (FAT MASS AND OBESITY ASSOCIATED) PROTEIN, MOUSE; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; BRAIN FUNCTION; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GROWTH REGULATION; GROWTH RETARDATION; MALE; MOUSE; NERVOUS SYSTEM; NONHUMAN; POSTNATAL GROWTH; PROTEIN BLOOD LEVEL; TISSUE SPECIFICITY; ANIMAL; BRAIN; C57BL MOUSE; FAT INTAKE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; GROWTH DISORDER; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOUSE MUTANT; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS;

ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; BONE DENSITY; BRAIN; DIETARY FATS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC PREDISPOSITION TO DISEASE; GROWTH DISORDERS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 78649512744     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014005     Document Type: Article

References (51)

1. Peters T, Ausmeier K, Ruther U (1999) Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome 10: 983-986.
2. Dina C, Meyre D, Gallina S, Durand E, Korner A, et al. (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39: 724-726.
3. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
4. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, et al. (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3: e115.
5. Hinney A, Nguyen TT, Scherag A, Friedel S, Bronner G, et al. (2007) Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS ONE 2: e1361.
6. Ohashi J, Naka I, Kimura R, Natsuhara K, Yamauchi T, et al. (2007) FTO polymorphisms in oceanic populations. J Hum Genet 52: 1031-1035.
7. Cha SW, Choi SM, Kim KS, Park BL, Kim JR, et al. (2008) Replication of genetic effects of FTO polymorphisms on BMI in a Korean population. Obesity (Silver Spring) 16: 2187-2189.
8. Chang YC, Liu PH, Lee WJ, Chang TJ, Jiang YD, et al. (2008) Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. Diabetes 57: 2245-2252.
9. Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, et al. (2008) Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet 53: 546-553.
10. Hubacek JA, Bohuslavova R, Kuthanova L, Kubinova R, Peasey A, et al. (2008) The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study. Obesity (Silver Spring) 16: 2764-2766.
11. Peeters A, Beckers S, Verrijken A, Roevens P, Peeters P, et al. (2008) Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab 93: 481-484.
12. Villalobos-Comparan M, Teresa Flores-Dorantes M, Teresa Villarreal- Molina M, Rodriguez-Cruz M, Garcia-Ulloa AC, et al. (2008) The FTO gene is associated with adulthood obesity in the Mexican population. Obesity (Silver Spring) 16: 2296-2301.
13. Zhang F, Xu L, Jin L, Wang XF (2008) A common variant in the FTO gene is associated with obesity in the Uyghur population. J Endocrinol Invest 31: 1043.
14. Cornes BK, Lind PA, Medland SE, Montgomery GW, Nyholt DR, et al. (2009) Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction. Int J Obes (Lond) 33: 75-79.
15. Gonzalez-Sanchez JL, Zabena C, Martinez-Larrad MT, Martinez- Calatrava MJ, Perez-Barba M, et al. (2009) Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain. Clin Endocrinol (Oxf) 70: 390-393.
16. Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, et al. (2008) Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 93: 3640-3643.
17. Wardle J, Llewellyn C, Sanderson S, Plomin R (2009) The FTO gene and measured food intake in children. Int J Obes (Lond) 33: 42-45.
18. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN (2008) An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 359: 2558-2566.
19. Speakman JR, Rance KA, Johnstone AM (2008) Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 16: 1961-1965.
20. Haupt A, Thamer C, Staiger H, Tschritter O, Kirchhoff K, et al. (2009) Variation in the FTO gene influences food intake but not energy expenditure. Exp Clin Endocrinol Diabetes 117: 194-197.
21. Timpson NJ, Emmett PM, Frayling TM, Rogers I, Hattersley AT, et al. (2008) The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr 88: 971-978.
22. Berentzen T, Kring SI, Holst C, Zimmermann E, Jess T, et al. (2008) Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity. J Clin Endocrinol Metab 93: 2904-2908.
23. Jonsson A, Renstrom F, Lyssenko V, Brito EC, Isomaa B, et al. (2009) Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults. Diabetologia 52: 1334-1338.
24. Hakanen M, Raitakari OT, Lehtimaki T, Peltonen N, Pahkala K, et al. (2009) FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab 94: 1281-1287.
25. Han Z, Niu T, Chang J, Lei X, Zhao M, et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464: 1205-1209.
26. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, et al. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318: 1469-1472.
27. Sanchez-Pulido L, Andrade-Navarro MA (2007) The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochem 8: 23.
28. Ozer A, Bruick RK (2007) Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nat Chem Biol 3: 144-153.
29. Loenarz C, Schofield CJ (2008) Expanding chemical biology of 2-oxoglutarate oxygenases. Nat Chem Biol 4: 152-156.
30. Jia G, Yang CG, Yang S, Jian X, Yi C, et al. (2008) Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett 582: 3313-3319.
31. Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, et al. (2009) Inactivation of the Fto gene protects from obesity. Nature 458: 894-898.
32. Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, et al. (2009) A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 5: e1000599.
33. Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, et al. (2010) Hypothalamicspecific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS ONE 5: e8771.
34. Tallquist MD, Soriano P (2000) Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26: 113-115.
35. Farley FW, Soriano P, Steffen LS, Dymecki SM (2000) Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28: 106-110.
36. Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, et al. (2009) Inactivation of the Fto gene protects from obesity. Nature.
37. Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutierrez-Aguilar R, et al. (2010) Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes 59: 311-318.
38. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, et al. (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23: 99-103.
39. Speakman J (2010) FTO effect on energy demand versus food intake. Natuer 464: E1.
40. Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, et al. (2010) Fischer et al reply. Nature 464: E2.
41. Zabena C, Gonzalez-Sanchez JL, Martinez-Larrad MT, Torres-Garcia A, Alvarez-Fernandez-Represa J, et al. (2009) The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients. Obes Surg 19: 87-95.
42. Grunnet LG, Nilsson E, Ling C, Hansen T, Pedersen O, et al. (2009) Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. Diabetes 58: 2402-2408.
43. Kloting N, Schleinitz D, Ruschke K, Berndt J, Fasshauer M, et al. (2008) Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia 51: 641-647.
44. Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, et al. (2009) Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet 85: 106-111.
45. Mullis PE (2005) Genetic control of growth. Eur J Endocrinol 152: 11-31.
46. Bassett JH, Williams GR (2008) Critical role of the hypothalamic-pituitarythyroid axis in bone. Bone 43: 418-426.
47. Kreitschmann-Andermahr I, Suarez P, Jennings R, Evers N, Brabant G (2010) GH/IGF-I regulation in obesity-mechanisms and practical consequences in children and adults. Horm Res Paediatr 73: 153-160.
48. Meyer CW, Korthaus D, Jagla W, Cornali E, Grosse J, et al. (2004) A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity. Endocrinology 145: 2531-2541.
49. Mishina Y, Duguid EM, He C (2006) Direct reversal of DNA alkylation damage. Chem Rev 106: 215-232.
50. Zhang P, Li MZ, Elledge SJ (2002) Towards genetic genome projects: genomic library screening and gene-targeting vector construction in a single step. Nat Genet 30: 31-39.
51. Srivenugopal K, Singh SP, Yuan XH, Ehmann S, Snyder AK (1994) Differential removal of insulin-like growth factor binding proteins in rat serum by solvent extraction procedures. Experientia 50: 451-455.