Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype

International Journal of Epidemiology

Volumn 38, Issue 4, 2009, Pages 971-975

  Brennan, Paul ^a   McKay, James ^a   Moore, Lee ^b   Zaridze, David ^c   Mukeria, Anush ^c   Szeszenia Dabrowska, Neonilia ^d   Lissowska, Jolanta ^e   Rudnai, Peter ^f   Fabianova, Eleonora ^g   Mates, Dana ^h   Bencko, Vladimir ⁱ   Foretova, Lenka ^j   Janout, Vladimir ^k   Chow, Wong Ho ^b   Rothman, Nathaniel ^b   Chabrier, Amélie ^a   Gaborieau, Valérie ^a   Timpson, Nic ^l   Hung, Rayjean J ^a,m   Smith, George Davey ^l  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b NATIONAL CANCER INSTITUTE   (United States)

^c N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^d NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

^e INSTITUTE OF ONCOLOGY   (Poland)

^f NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH   (Hungary)

^g Specialized Institute of Hygiene and Epidemiology   (Slovakia)

^h NATIONAL INSTITUTE OF PUBLIC HEALTH   (Romania)

ⁱ CHARLES UNIVERSITY   (Czech Republic)

^j Mazaryk Memorial Cancer Institute   (Czech Republic)

^k PALACKÝ UNIVERSITY   (Czech Republic)

^l MRC Centre for Causal Analyses in Translational Epidemiology   (United Kingdom)

^m MOUNT SINAI HOSPITAL   (Canada)

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Author keywords

Cancer; Mendelian randomization; Obesity

Indexed keywords

ONCOPROTEIN; PROTEIN FTO; UNCLASSIFIED DRUG;

BIOMARKER; CANCER; EPIDEMIOLOGY; GENETIC VARIATION; GENOTYPE; OBESITY; RISK FACTOR; SAMPLING BIAS; TOBACCO; VARIANCE ANALYSIS;

ADULT; ALLELE; ARTICLE; BODY MASS; CANCER GENETICS; CANCER RISK; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEAD AND NECK CANCER; HUMAN; KIDNEY CANCER; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; OBESITY; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; BODY MASS INDEX; EUROPE; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HEAD AND NECK NEOPLASMS; HUMANS; KIDNEY NEOPLASMS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASMS; OBESITY; PROTEINS; RISK FACTORS;

NICOTIANA TABACUM;

EID: 68849083791     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyp162     Document Type: Article

References (6)

1. IARC Handbooks of Cancer Prevention: Weight Control and Physical Activity. Lyon: IARC Press, 2002.
2. Scélo G, Brennan P. The epidemiology of bladder and kidney cancer. Nat Clin Pract Urol 2007;4:205-17.
3. Davey Smith G, Ebrahim S. 'Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22.
4. Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:89-94.
5. Dina C, Meyre D, Gallina S et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724-26.
6. Brennan P, McKay J, Moore L et al. Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: Case-control study. Hum Mol Genet 2007;16:1-8.