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Volumn 154, Issue 9, 2013, Pages 3141-3151

FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes

Author keywords

[No Author keywords available]

Indexed keywords

UNCOUPLING PROTEIN 1;

EID: 84883169345     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1873     Document Type: Article
Times cited : (69)

References (44)
  • 1
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889-894.
    • (2007) Science , vol.316 , Issue.5826 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3
  • 3
    • 77957105975 scopus 로고    scopus 로고
    • Association ofFTOgene variants with adiposity in African-American adolescents
    • Bollepalli S, DolanLM,Deka R, Martin LJ. Association ofFTOgene variants with adiposity in African-American adolescents. Obesity (Silver Spring). 2010;18(10):1959-1963.
    • (2010) Obesity (Silver Spring) , vol.18 , Issue.10 , pp. 1959-1963
    • Bollepalli, S.1    Dolan, L.M.2    Deka, R.3    Martin, L.J.4
  • 4
    • 34249777814 scopus 로고    scopus 로고
    • Variation in FTO contributes to childhood obesity and severe adult obesity
    • Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet. 2007;39(6): 724-726.
    • (2007) Nat Genet , vol.39 , Issue.6 , pp. 724-726
    • Dina, C.1    Meyre, D.2    Gallina, S.3
  • 5
    • 46249094941 scopus 로고    scopus 로고
    • Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP
    • Grant SF, Li M, Bradfield JP, et al. Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS ONE. 2008;3(3):e1746.
    • (2008) PLoS ONE , vol.3 , Issue.3
    • Grant, S.F.1    Li, M.2    Bradfield, J.P.3
  • 6
    • 64049095449 scopus 로고    scopus 로고
    • FTO gene variation and measures of body mass in an African population
    • Hennig BJ, Fulford AJ, Sirugo G, et al. FTO gene variation and measures of body mass in an African population. BMC Med Genet. 2009;10(1):21.
    • (2009) BMC Med Genet. , vol.10 , Issue.1 , pp. 21
    • Hennig, B.J.1    Fulford, A.J.2    Sirugo, G.3
  • 7
    • 44349129013 scopus 로고    scopus 로고
    • Variations in the FTO gene are associated with severe obesity in the Japanese
    • Hotta K, Nakata Y, Matsuo T, et al. Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet. 2008; 53(6):546-553.
    • (2008) J Hum Genet , vol.53 , Issue.6 , pp. 546-553
    • Hotta, K.1    Nakata, Y.2    Matsuo, T.3
  • 8
    • 40749094439 scopus 로고    scopus 로고
    • Variants in the FTO gene are associated with common obesity in the Belgian population
    • Peeters A, Beckers S, Verrijken A, et al. Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab. 2008;93(4):481-484.
    • (2008) Mol Genet Metab , vol.93 , Issue.4 , pp. 481-484
    • Peeters, A.1    Beckers, S.2    Verrijken, A.3
  • 9
    • 64549158008 scopus 로고    scopus 로고
    • Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
    • Apr
    • Renström F, Payne F, Nordström A, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet. 2009 Apr;18(8):1489-1496.
    • (2009) Hum Mol Genet. , vol.18 , Issue.8 , pp. 1489-1496
    • Renström, F.1    Payne, F.2    Nordström, A.3
  • 10
    • 34547625955 scopus 로고    scopus 로고
    • Genome-wide association scan shows genetic variants in the FTO gene are associated with obesityrelated traits
    • Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesityrelated traits. PLoS Genet. 2007;3(7):e115.
    • (2007) PLoS Genet , vol.3 , Issue.7
    • Scuteri, A.1    Sanna, S.2    Chen, W.M.3
  • 11
    • 77649123249 scopus 로고    scopus 로고
    • FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: A meta-analysis
    • Xi B, Mi J. FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a meta-analysis. Biomed Environ Sci. 2009;22(6):449-457.
    • (2009) Biomed Environ Sci , vol.22 , Issue.6 , pp. 449-457
    • Xi, B.1    Mi, J.2
  • 12
    • 36749041363 scopus 로고    scopus 로고
    • The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    • Gerken T, Girard CA, Tung YC, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. 2007;318(5855):1469-1472.
    • (2007) Science , vol.318 , Issue.5855 , pp. 1469-1472
    • Gerken, T.1    Girard, C.A.2    Tung, Y.C.3
  • 13
    • 39049154918 scopus 로고    scopus 로고
    • The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily
    • Sanchez-Pulido L, Andrade-Navarro MA. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochem. 2007;8:23.
    • (2007) BMC Biochem , vol.8 , pp. 23
    • Sanchez-Pulido, L.1    Andrade-Navarro, M.A.2
  • 14
    • 54849381000 scopus 로고    scopus 로고
    • Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
    • Jia G, Yang CG, Yang S, et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 2008;582(23-24):3313-3319.
    • (2008) FEBS Lett , vol.582 , Issue.23-24 , pp. 3313-3319
    • Jia, G.1    Yang, C.G.2    Yang, S.3
  • 15
    • 81355146483 scopus 로고    scopus 로고
    • N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
    • Jia G, Fu Y, Zhao X, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 2011;7(12):885-887.
    • (2011) Nat Chem Biol , vol.7 , Issue.12 , pp. 885-887
    • Jia, G.1    Fu, Y.2    Zhao, X.3
  • 16
    • 77951623073 scopus 로고    scopus 로고
    • Crystal structure of the FTO protein reveals basis for its substrate specificity
    • Han Z, Niu T, Chang J, et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature. 2010;464(7292): 1205-1209.
    • (2010) Nature , vol.464 , Issue.7292 , pp. 1205-1209
    • Han, Z.1    Niu, T.2    Chang, J.3
  • 17
    • 41149087641 scopus 로고    scopus 로고
    • Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans
    • Kloting N, Schleinitz D, Ruschke K, et al. Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia. 2008;51(4):641-647.
    • (2008) Diabetologia , vol.51 , Issue.4 , pp. 641-647
    • Kloting, N.1    Schleinitz, D.2    Ruschke, K.3
  • 18
    • 42949102733 scopus 로고    scopus 로고
    • The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis
    • Wahlen K, Sjolin E, Hoffstedt J. The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. J Lipid Res. 2008;49(3):607-611.
    • (2008) J Lipid Res , vol.49 , Issue.3 , pp. 607-611
    • Wahlen, K.1    Sjolin, E.2    Hoffstedt, J.3
  • 19
    • 78650959240 scopus 로고    scopus 로고
    • Regulation of FTO and FTM expression during human preadipocyte differentiation
    • Tews D, Fischer-Posovszky P, Wabitsch M. Regulation of FTO and FTM expression during human preadipocyte differentiation. Horm Metab Res. 2011;43(1):17-21.
    • (2011) Horm Metab Res. , vol.43 , Issue.1 , pp. 17-21
    • Tews, D.1    Fischer-Posovszky, P.2    Wabitsch, M.3
  • 20
    • 67349211789 scopus 로고    scopus 로고
    • Inactivation of the Fto gene protects from obesity
    • Fischer J, Koch L, Emmerling C, et al. Inactivation of the Fto gene protects from obesity. Nature. 2009;458(7240):894-898.
    • (2009) Nature , vol.458 , Issue.7240 , pp. 894-898
    • Fischer, J.1    Koch, L.2    Emmerling, C.3
  • 21
    • 70149100469 scopus 로고    scopus 로고
    • A mouse model for the metabolic effects of thehumanfat mass and obesity associated FTOgene
    • Church C, Lee S, Bagg EA, et al. A mouse model for the metabolic effects of thehumanfat mass and obesity associatedFTOgene. PLoS Genet. 2009;5(8):e1000599.
    • (2009) PLoS Genet. , vol.5 , Issue.8
    • Church, C.1    Lee, S.2    Bagg, E.A.3
  • 22
    • 78649512744 scopus 로고    scopus 로고
    • The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice
    • Gao X, Shin Y-H, LiM,WangF, Tong Q, Zhang P. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS ONE. 2010;5(11):e14005.
    • (2010) PLoS ONE. , vol.5 , Issue.11
    • Gao, X.1    Shin, Y.-H.2    Li, M.3    Wang, F.4    Tong, Q.5    Zhang, P.6
  • 23
    • 77952623888 scopus 로고    scopus 로고
    • The emergence of coldinduced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
    • Barbatelli G, Murano I, Madsen L, et al. The emergence of coldinduced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am J Physiol Endocrinol Metab. 2010;298(6):E1244-E1253.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , Issue.6
    • Barbatelli, G.1    Murano, I.2    Madsen, L.3
  • 24
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu J, Boström P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012;150(2): 366-76.
    • (2012) Cell , vol.150 , Issue.2 , pp. 366-376
    • Wu, J.1    Boström, P.2    Sparks, L.M.3
  • 25
    • 33644825988 scopus 로고    scopus 로고
    • Role of CD95-mediated adipocyte loss in autoimmune lipodystrophy
    • Fischer-Posovszky P, Hebestreit H, Hofmann AK, et al. Role of CD95-mediated adipocyte loss in autoimmune lipodystrophy. J Clin Endocrinol Metab. 2006;91(3):1129-1135.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.3 , pp. 1129-1135
    • Fischer-Posovszky, P.1    Hebestreit, H.2    Hofmann, A.K.3
  • 26
  • 27
    • 0029833754 scopus 로고    scopus 로고
    • Mitogenic and antiadipogenic properties of human growth hormone in differentiating human adipocyte precursor cells in primary culture
    • Wabitsch M, Braun S, Hauner H, et al. Mitogenic and antiadipogenic properties of human growth hormone in differentiating human adipocyte precursor cells in primary culture. Pediatr Res. 1996; 40(3):450-456.
    • (1996) Pediatr Res. , vol.40 , Issue.3 , pp. 450-456
    • Wabitsch, M.1    Braun, S.2    Hauner, H.3
  • 28
    • 70350434580 scopus 로고    scopus 로고
    • Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes
    • Elabd C, Chiellini C, Carmona M, et al. Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes. Stem Cells. 2009;27(11):2753-2760.
    • (2009) Stem Cells , vol.27 , Issue.11 , pp. 2753-2760
    • Elabd, C.1    Chiellini, C.2    Carmona, M.3
  • 29
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes EK, Willer CJ, Berndt SI, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42(11):937-948.
    • (2010) Nat Genet , vol.42 , Issue.11 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3
  • 30
    • 48749132799 scopus 로고    scopus 로고
    • Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
    • Speakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring). 2008;16(8):1961-1965.
    • (2008) Obesity (Silver Spring) , vol.16 , Issue.8 , pp. 1961-1965
    • Speakman, J.R.1    Rance, K.A.2    Johnstone, A.M.3
  • 31
    • 72749115949 scopus 로고    scopus 로고
    • The FTO gene rs9939609 obesity-risk allele and loss of control over eating
    • Tanofsky-Kraff M, Han JC, Anandalingam K, et al. The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nutr. 2009;90(6):1483-1488.
    • (2009) Am J Clin Nutr , vol.90 , Issue.6 , pp. 1483-1488
    • Tanofsky-Kraff, M.1    Han, J.C.2    Anandalingam, K.3
  • 33
    • 84861536364 scopus 로고    scopus 로고
    • Obesity susceptibility loci and dietary intake in the Look AHEAD Trial
    • McCaffery JM, Papandonatos GD, Peter I, et al. Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. Am J Clin Nutr. 2012;95(6):1477-1486.
    • (2012) Am J Clin Nutr. , vol.95 , Issue.6 , pp. 1477-1486
    • McCaffery, J.M.1    Papandonatos, G.D.2    Peter, I.3
  • 34
    • 84873520661 scopus 로고    scopus 로고
    • Adult onset global loss of the fto gene alters body composition and metabolism in the mouse
    • McMurray F, Church CD, Larder R, et al. Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet. 2013;9(1):e1003166.
    • (2013) PLoS Genet , vol.9 , Issue.1
    • McMurray, F.1    Church, C.D.2    Larder, R.3
  • 35
    • 84868131670 scopus 로고    scopus 로고
    • Recruitment of brown adipose tissue as a therapy for obesity-associated diseases
    • Boss O, Farmer SR. Recruitment of brown adipose tissue as a therapy for obesity-associated diseases. Front Endocrinol (Lausanne). 2012;3:14.
    • (2012) Front Endocrinol (Lausanne) , vol.3 , pp. 14
    • Boss, O.1    Farmer, S.R.2
  • 36
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 2009;9(2):203-209.
    • (2009) Cell Metab , vol.9 , Issue.2 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 37
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans.NEngl J Med. 2009; 360(15):1509-1517.
    • (2009) N. Engl J Med. , vol.360 , Issue.15 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 39
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med. 2009;360(15):1518-1525.
    • (2009) N Engl J Med , vol.360 , Issue.15 , pp. 1518-1525
    • Virtanen, K.A.1    Lidell, M.E.2    Orava, J.3
  • 41
    • 84874113202 scopus 로고    scopus 로고
    • FTO levels affect RNA modification and the transcriptome
    • Berulava T, Ziehe M, Klein-Hitpass L, et al. FTO levels affect RNA modification and the transcriptome. Eur J Hum Genet. 2013;21(3): 317-323.
    • (2013) Eur J Hum Genet , vol.21 , Issue.3 , pp. 317-323
    • Berulava, T.1    Ziehe, M.2    Klein-Hitpass, L.3
  • 42
    • 77952060999 scopus 로고    scopus 로고
    • Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue
    • Shore A, Karamitri A, Kemp P, Speakman JR, Lomax MA. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue. Diabetologia. 2010;53(6):1164-1173.
    • (2010) Diabetologia , vol.53 , Issue.6 , pp. 1164-1173
    • Shore, A.1    Karamitri, A.2    Kemp, P.3    Speakman, J.R.4    Lomax, M.A.5
  • 43
    • 84876162099 scopus 로고    scopus 로고
    • Acomparative approach to understanding tissue-specific expression of uncoupling protein 1 expression in adipose tissue
    • Shore A, Emes RD, Wessely F, Kemp P, Cillo C, D'Armiento M, Hoggard N, LomaxMA.Acomparative approach to understanding tissue-specific expression of uncoupling protein 1 expression in adipose tissue. Front Genet. 2012;3:304.
    • (2012) Front Genet. , vol.3 , pp. 304
    • Shore, A.1    Emes, R.D.2    Wessely, F.3    Kemp, P.4    Cillo, C.5    D'Armiento, M.6    Hoggard, N.7    Lomax, M.A.8
  • 44
    • 77955981202 scopus 로고    scopus 로고
    • The obesity-associated SNPs in intron 1 of theFTOgene affect primary transcript levels
    • Berulava T, Horsthemke B. The obesity-associated SNPs in intron 1 of theFTOgene affect primary transcript levels. Eur JHumGenet. 2010;18(9):1054- 1056.
    • (2010) Eur JHumGenet , vol.18 , Issue.9 , pp. 1054-1056
    • Berulava, T.1    Horsthemke, B.2


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