-
1
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
11742409 10.1038/414782a 1:CAS:528:DC%2BD38Xhtlymtg%3D%3D
-
Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782-787
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.2
Shaw, J.3
-
2
-
-
0025359247
-
Body-mass indexes of British separated twins
-
2336081 1:STN:280:DyaK3c3ksFSnuw%3D%3D
-
MacDonald A, Stunkard A (1990) Body-mass indexes of British separated twins. N Engl J Med 322:1530
-
(1990)
N Engl J Med
, vol.322
, pp. 1530
-
-
Macdonald, A.1
Stunkard, A.2
-
3
-
-
0030843960
-
Genetic and environmental factors in relative body weight and human adiposity
-
9519560 10.1023/A:1025635913927 1:STN:280:DyaK1c7otVSruw%3D%3D
-
Maes HH, Neale MC, Eaves LJ (1997) Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 27:325-351
-
(1997)
Behav Genet
, vol.27
, pp. 325-351
-
-
Maes, H.H.1
Neale, M.C.2
Eaves, L.J.3
-
4
-
-
0022589555
-
A twin study of human obesity
-
3712713 10.1001/jama.1986.03380010055024 1:STN:280:DyaL283isl2lsg%3D%3D
-
Stunkard AJ, Foch TT, Hrubec Z (1986) A twin study of human obesity. JAMA 256:51-54
-
(1986)
JAMA
, vol.256
, pp. 51-54
-
-
Stunkard, A.J.1
Foch, T.T.2
Hrubec, Z.3
-
5
-
-
0022657870
-
An adoption study of human obesity
-
3941707 10.1056/NEJM198601233140401 1:STN:280:DyaL28%2Fpt1Whuw%3D%3D
-
Stunkard AJ, Sorensen TI, Hanis C et al (1986) An adoption study of human obesity. N Engl J Med 314:193-198
-
(1986)
N Engl J Med
, vol.314
, pp. 193-198
-
-
Stunkard, A.J.1
Sorensen, T.I.2
Hanis, C.3
-
6
-
-
84866666334
-
Unraveling the brain regulation of appetite: Lessons from genetics
-
23007189 10.1038/nn.3211 1:CAS:528:DC%2BC38XhsVSltrzK
-
Yeo GS, Heisler LK (2012) Unraveling the brain regulation of appetite: lessons from genetics. Nat Neurosci 15:1343-1349
-
(2012)
Nat Neurosci
, vol.15
, pp. 1343-1349
-
-
Yeo, G.S.1
Heisler, L.K.2
-
7
-
-
34249777814
-
Variation in FTO contributes to childhood obesity and severe adult obesity
-
17496892 10.1038/ng2048 1:CAS:528:DC%2BD2sXlvVSgtL0%3D
-
Dina C, Meyre D, Gallina S et al (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39:724-726
-
(2007)
Nat Genet
, vol.39
, pp. 724-726
-
-
Dina, C.1
Meyre, D.2
Gallina, S.3
-
8
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
17434869 10.1126/science.1141634 1:CAS:528:DC%2BD2sXltVentL0%3D
-
Frayling TM, Timpson NJ, Weedon MN et al (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889-894
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
Timpson, N.J.2
Weedon, M.N.3
-
9
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
17658951 10.1371/journal.pgen.0030115
-
Scuteri A, Sanna S, Chen WM et al (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3:e115
-
(2007)
PLoS Genet
, vol.3
, pp. 115
-
-
Scuteri, A.1
Sanna, S.2
Chen, W.M.3
-
10
-
-
84859575363
-
Genetic determinants of common obesity and their value in prediction
-
22498250 10.1016/j.beem.2011.11.003 1:CAS:528:DC%2BC38XlvFKlsrs%3D
-
Loos RJ (2012) Genetic determinants of common obesity and their value in prediction. Best Pract Res Clin Endocrinol Metab 26:211-226
-
(2012)
Best Pract Res Clin Endocrinol Metab
, vol.26
, pp. 211-226
-
-
Loos, R.J.1
-
11
-
-
84873735640
-
Role for the obesity-related FTO gene in the cellular sensing of amino acids
-
23359686 10.1073/pnas.1222796110 1:CAS:528:DC%2BC3sXjsVehtr4%3D
-
Gulati P, Cheung MK, Antrobus R et al (2013) Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A 110:2557-2562
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 2557-2562
-
-
Gulati, P.1
Cheung, M.K.2
Antrobus, R.3
-
12
-
-
77953292057
-
The genetics of obesity: FTO leads the way
-
20381893 10.1016/j.tig.2010.02.006 1:CAS:528:DC%2BC3cXmslSis7Y%3D
-
Fawcett KA, Barroso I (2010) The genetics of obesity: FTO leads the way. Trends Genet 26:266-274
-
(2010)
Trends Genet
, vol.26
, pp. 266-274
-
-
Fawcett, K.A.1
Barroso, I.2
-
13
-
-
82455175773
-
Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children
-
22069379 10.1371/journal.pmed.1001116
-
Kilpelainen TO, Qi L, Brage S et al (2011) Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med 8:e1001116
-
(2011)
PLoS Med
, vol.8
, pp. 1001116
-
-
Kilpelainen, T.O.1
Qi, L.2
Brage, S.3
-
14
-
-
84867330691
-
FTO genotype is associated with phenotypic variability of body mass index
-
22982992 10.1038/nature11401 1:CAS:528:DC%2BC38XhtlCqtbrO
-
Yang J, Loos RJ, Powell JE et al (2012) FTO genotype is associated with phenotypic variability of body mass index. Nature 490:267-272
-
(2012)
Nature
, vol.490
, pp. 267-272
-
-
Yang, J.1
Loos, R.J.2
Powell, J.E.3
-
15
-
-
57749121512
-
An obesity-associated FTO gene variant and increased energy intake in children
-
19073975 10.1056/NEJMoa0803839 1:CAS:528:DC%2BD1cXhsV2ktrrF
-
Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN (2008) An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 359:2558-2566
-
(2008)
N Engl J Med
, vol.359
, pp. 2558-2566
-
-
Cecil, J.E.1
Tavendale, R.2
Watt, P.3
Hetherington, M.M.4
Palmer, C.N.5
-
16
-
-
67649852402
-
Variation in the FTO gene influences food intake but not energy expenditure
-
19053021 10.1055/s-0028-1087176 1:CAS:528:DC%2BD1MXmtlGrur8%3D
-
Haupt A, Thamer C, Staiger H et al (2009) Variation in the FTO gene influences food intake but not energy expenditure. Exp Clin Endocrinol Diabetes 117:194-197
-
(2009)
Exp Clin Endocrinol Diabetes
, vol.117
, pp. 194-197
-
-
Haupt, A.1
Thamer, C.2
Staiger, H.3
-
17
-
-
64349124477
-
Obesity, FTO gene variant, and energy intake in children
-
19357416 10.1056/NEJMc090017 1:CAS:528:DC%2BD1MXltlSqs7g%3D author reply 1572
-
Jonsson A, Franks PW (2009) Obesity, FTO gene variant, and energy intake in children. N Engl J Med 360:1571-1572, author reply 1572
-
(2009)
N Engl J Med
, vol.360
, pp. 1571-1572
-
-
Jonsson, A.1
Franks, P.W.2
-
18
-
-
48749132799
-
Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
-
10.1038/oby.2008.318 1:CAS:528:DC%2BD1cXptFOrtbo%3D
-
Speakman JR, Rance KA, Johnstone AM (2008) Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 16:1961-1965
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 1961-1965
-
-
Speakman, J.R.1
Rance, K.A.2
Johnstone, A.M.3
-
19
-
-
53849088890
-
The fat mass- and obesity-associated locus and dietary intake in children
-
18842783 1:CAS:528:DC%2BD1cXht1Gks7jF
-
Timpson NJ, Emmett PM, Frayling TM et al (2008) The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr 88:971-978
-
(2008)
Am J Clin Nutr
, vol.88
, pp. 971-978
-
-
Timpson, N.J.1
Emmett, P.M.2
Frayling, T.M.3
-
20
-
-
58149508094
-
The FTO gene and measured food intake in children
-
10.1038/ijo.2008.174 1:CAS:528:DC%2BD1MXkslyrtA%3D%3D
-
Wardle J, Llewellyn C, Sanderson S, Plomin R (2009) The FTO gene and measured food intake in children. Int J Obes (Lond) 33:42-45
-
(2009)
Int J Obes (Lond)
, vol.33
, pp. 42-45
-
-
Wardle, J.1
Llewellyn, C.2
Sanderson, S.3
Plomin, R.4
-
21
-
-
70350647201
-
Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO
-
10.3945/ajcn.2009.28053
-
den Hoed M, Westerterp-Plantenga MS, Bouwman FG, Mariman EC, Westerterp KR (2009) Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO. Am J Clin Nutr 90:1426-1432
-
(2009)
Am J Clin Nutr
, vol.90
, pp. 1426-1432
-
-
Den Hoed, M.1
Westerterp-Plantenga, M.S.2
Bouwman, F.G.3
Mariman, E.C.4
Westerterp, K.R.5
-
22
-
-
51649128621
-
Obesity associated genetic variation in FTO is associated with diminished satiety
-
18583465 10.1210/jc.2008-0472 1:CAS:528:DC%2BD1cXhtFChurfE
-
Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, Plomin R (2008) Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 93:3640-3643
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 3640-3643
-
-
Wardle, J.1
Carnell, S.2
Haworth, C.M.3
Farooqi, I.S.4
O'Rahilly, S.5
Plomin, R.6
-
23
-
-
72749115949
-
The FTO gene rs9939609 obesity-risk allele and loss of control over eating
-
19828706 10.3945/ajcn.2009.28439 1:CAS:528:DC%2BD1MXhsV2lt7zP
-
Tanofsky-Kraff M, Han JC, Anandalingam K et al (2009) The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nutr 90:1483-1488
-
(2009)
Am J Clin Nutr
, vol.90
, pp. 1483-1488
-
-
Tanofsky-Kraff, M.1
Han, J.C.2
Anandalingam, K.3
-
24
-
-
47549107452
-
Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity
-
18445669 10.1210/jc.2008-0007 1:CAS:528:DC%2BD1cXoslyrsb4%3D
-
Berentzen T, Kring SI, Holst C et al (2008) Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity. J Clin Endocrinol Metab 93:2904-2908
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 2904-2908
-
-
Berentzen, T.1
Kring, S.I.2
Holst, C.3
-
25
-
-
42449153273
-
Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study
-
18316358 10.2337/db07-1267 1:CAS:528:DC%2BD1cXksVGrs74%3D
-
Do R, Bailey SD, Desbiens K et al (2008) Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes 57:1147-1150
-
(2008)
Diabetes
, vol.57
, pp. 1147-1150
-
-
Do, R.1
Bailey, S.D.2
Desbiens, K.3
-
26
-
-
67449141659
-
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: The NUGENOB study
-
10.1038/ijo.2009.59 1:CAS:528:DC%2BD1MXnt1elsb4%3D
-
Goossens GH, Petersen L, Blaak EE et al (2009) Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study. Int J Obes (Lond) 33:669-679
-
(2009)
Int J Obes (Lond)
, vol.33
, pp. 669-679
-
-
Goossens, G.H.1
Petersen, L.2
Blaak, E.E.3
-
27
-
-
65249108267
-
FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity
-
19158205 10.1210/jc.2008-1199 1:CAS:528:DC%2BD1MXksFaitb0%3D
-
Hakanen M, Raitakari OT, Lehtimaki T et al (2009) FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab 94:1281-1287
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 1281-1287
-
-
Hakanen, M.1
Raitakari, O.T.2
Lehtimaki, T.3
-
28
-
-
67349234146
-
Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults
-
19373445 10.1007/s00125-009-1355-2 1:STN:280:DC%2BD1MzosFCrsQ%3D%3D
-
Jonsson A, Renstrom F, Lyssenko V et al (2009) Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults. Diabetologia 52:1334-1338
-
(2009)
Diabetologia
, vol.52
, pp. 1334-1338
-
-
Jonsson, A.1
Renstrom, F.2
Lyssenko, V.3
-
29
-
-
77950663129
-
FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth
-
10.1186/1471-2350-11-57
-
Liu G, Zhu H, Lagou V et al (2010) FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med Gen 11:57
-
(2010)
BMC Med Gen
, vol.11
, pp. 57
-
-
Liu, G.1
Zhu, H.2
Lagou, V.3
-
30
-
-
73149103718
-
Prioritizing GWAS results: A review of statistical methods and recommendations for their application
-
20074509 10.1016/j.ajhg.2009.11.017 1:CAS:528:DC%2BC3cXkvFKgsbc%3D
-
Cantor RM, Lange K, Sinsheimer JS (2010) Prioritizing GWAS results: a review of statistical methods and recommendations for their application. Am J Hum Genet 86:6-22
-
(2010)
Am J Hum Genet
, vol.86
, pp. 6-22
-
-
Cantor, R.M.1
Lange, K.2
Sinsheimer, J.S.3
-
31
-
-
79954533855
-
Where next for GWAS?
-
10.1093/bfgp/elr011
-
Yeo GS (2011) Where next for GWAS? Brief Funct Genom 10:51
-
(2011)
Brief Funct Genom
, vol.10
, pp. 51
-
-
Yeo, G.S.1
-
33
-
-
36749041363
-
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
-
17991826 10.1126/science.1151710 1:CAS:528:DC%2BD2sXhtlGmtLbI
-
Gerken T, Girard CA, Tung YC et al (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318:1469-1472
-
(2007)
Science
, vol.318
, pp. 1469-1472
-
-
Gerken, T.1
Girard, C.A.2
Tung, Y.C.3
-
34
-
-
34347324031
-
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome
-
17558409 10.1038/ng2039 1:CAS:528:DC%2BD2sXmvFKls78%3D
-
Delous M, Baala L, Salomon R et al (2007) The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nat Genet 39:875-881
-
(2007)
Nat Genet
, vol.39
, pp. 875-881
-
-
Delous, M.1
Baala, L.2
Salomon, R.3
-
35
-
-
54849381000
-
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
-
18775698 10.1016/j.febslet.2008.08.019 1:CAS:528:DC%2BD1cXht1Snur3I
-
Jia G, Yang CG, Yang S et al (2008) Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett 582:3313-3319
-
(2008)
FEBS Lett
, vol.582
, pp. 3313-3319
-
-
Jia, G.1
Yang, C.G.2
Yang, S.3
-
36
-
-
81355146483
-
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
-
22002720 10.1038/nchembio.687 1:CAS:528:DC%2BC3MXhtlWlurnM
-
Jia G, Fu Y, Zhao X et al (2011) N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 7:885-887
-
(2011)
Nat Chem Biol
, vol.7
, pp. 885-887
-
-
Jia, G.1
Fu, Y.2
Zhao, X.3
-
37
-
-
0027423649
-
A novel method for the determination of post-transcriptional modification in RNA by mass spectrometry
-
8233793 10.1093/nar/21.19.4577 1:CAS:528:DyaK3sXmsVCqsb8%3D
-
Kowalak JA, Pomerantz SC, Crain PF, McCloskey JA (1993) A novel method for the determination of post-transcriptional modification in RNA by mass spectrometry. Nucleic Acids Res 21:4577-4585
-
(1993)
Nucleic Acids Res
, vol.21
, pp. 4577-4585
-
-
Kowalak, J.A.1
Pomerantz, S.C.2
Crain, P.F.3
McCloskey, J.A.4
-
38
-
-
0016285746
-
Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells
-
4372599 10.1073/pnas.71.10.3971 1:CAS:528:DyaE2MXislChsg%3D%3D
-
Desrosiers R, Friderici K, Rottman F (1974) Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci U S A 71:3971-3975
-
(1974)
Proc Natl Acad Sci U S A
, vol.71
, pp. 3971-3975
-
-
Desrosiers, R.1
Friderici, K.2
Rottman, F.3
-
39
-
-
77951623073
-
Crystal structure of the FTO protein reveals basis for its substrate specificity
-
20376003 10.1038/nature08921 1:CAS:528:DC%2BC3cXktlSgu7s%3D
-
Han Z, Niu T, Chang J et al (2010) Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464:1205-1209
-
(2010)
Nature
, vol.464
, pp. 1205-1209
-
-
Han, Z.1
Niu, T.2
Chang, J.3
-
40
-
-
44349166252
-
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
-
18454146 10.1038/ng.156 1:CAS:528:DC%2BD1cXmsVejtrw%3D
-
Chambers JC, Elliott P, Zabaneh D et al (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 40:716-718
-
(2008)
Nat Genet
, vol.40
, pp. 716-718
-
-
Chambers, J.C.1
Elliott, P.2
Zabaneh, D.3
-
41
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
18454148 10.1038/ng.140 1:CAS:528:DC%2BD1cXmsVejsLo%3D
-
Loos RJ, Lindgren CM, Li S et al (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40:768-775
-
(2008)
Nat Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
Lindgren, C.M.2
Li, S.3
-
42
-
-
0031662163
-
A frameshift mutation in human MC4R is associated with a dominant form of obesity
-
9771699 10.1038/2407 1:CAS:528:DyaK1cXms1amsLo%3D
-
Vaisse C, Clement K, Guy-Grand B, Froguel P (1998) A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 20:113-114
-
(1998)
Nat Genet
, vol.20
, pp. 113-114
-
-
Vaisse, C.1
Clement, K.2
Guy-Grand, B.3
Froguel, P.4
-
43
-
-
0031668219
-
A frameshift mutation in MC4R associated with dominantly inherited human obesity
-
9771698 10.1038/2404 1:CAS:528:DyaK1cXms1amsLw%3D
-
Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O'Rahilly S (1998) A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 20:111-112
-
(1998)
Nat Genet
, vol.20
, pp. 111-112
-
-
Yeo, G.S.1
Farooqi, I.S.2
Aminian, S.3
Halsall, D.J.4
Stanhope, R.G.5
O'Rahilly, S.6
-
44
-
-
0037101841
-
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism
-
12165561 10.1093/hmg/11.17.1997 1:CAS:528:DC%2BD38Xms1Gntbk%3D
-
Challis BG, Pritchard LE, Creemers JW et al (2002) A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum Mol Genet 11:1997-2004
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1997-2004
-
-
Challis, B.G.1
Pritchard, L.E.2
Creemers, J.W.3
-
45
-
-
0031838353
-
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
-
9620771 10.1038/509 1:CAS:528:DyaK1cXls1Crt7o%3D
-
Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19:155-157
-
(1998)
Nat Genet
, vol.19
, pp. 155-157
-
-
Krude, H.1
Biebermann, H.2
Luck, W.3
Horn, R.4
Brabant, G.5
Gruters, A.6
-
46
-
-
33845530762
-
Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene
-
17130481 10.2337/db06-0550 1:CAS:528:DC%2BD28XhtlSmsb7O
-
Gray J, Yeo GS, Cox JJ et al (2006) Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 55:3366-3371
-
(2006)
Diabetes
, vol.55
, pp. 3366-3371
-
-
Gray, J.1
Yeo, G.S.2
Cox, J.J.3
-
47
-
-
50449091665
-
Brain-derived neurotrophic factor and obesity in the WAGR syndrome
-
18753648 10.1056/NEJMoa0801119 1:CAS:528:DC%2BD1cXhtVGms77F
-
Han JC, Liu QR, Jones M et al (2008) Brain-derived neurotrophic factor and obesity in the WAGR syndrome. N Engl J Med 359:918-927
-
(2008)
N Engl J Med
, vol.359
, pp. 918-927
-
-
Han, J.C.1
Liu, Q.R.2
Jones, M.3
-
48
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
19079260 10.1038/ng.274 1:CAS:528:DC%2BD1cXhsV2hsrjO
-
Thorleifsson G, Walters GB, Gudbjartsson DF et al (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41:18-24
-
(2009)
Nat Genet
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
Walters, G.B.2
Gudbjartsson, D.F.3
-
49
-
-
48349113289
-
Common nonsynonymous variants in PCSK1 confer risk of obesity
-
18604207 10.1038/ng.177 1:CAS:528:DC%2BD1cXptVKku78%3D
-
Benzinou M, Creemers JW, Choquet H et al (2008) Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet 40:943-945
-
(2008)
Nat Genet
, vol.40
, pp. 943-945
-
-
Benzinou, M.1
Creemers, J.W.2
Choquet, H.3
-
50
-
-
0030949271
-
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
-
9207799 10.1038/ng0797-303 1:CAS:528:DyaK2sXktFGntLY%3D
-
Jackson RS, Creemers JW, Ohagi S et al (1997) Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 16:303-306
-
(1997)
Nat Genet
, vol.16
, pp. 303-306
-
-
Jackson, R.S.1
Creemers, J.W.2
Ohagi, S.3
-
51
-
-
0032886705
-
Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation
-
10.1007/s003359901144 1:CAS:528:DyaK1MXmtlCru7k%3D
-
Peters T, Ausmeier K, Ruther U (1999) Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome Off J Int Mamm Genome Soc 10:983-986
-
(1999)
Mamm Genome off J Int Mamm Genome Soc
, vol.10
, pp. 983-986
-
-
Peters, T.1
Ausmeier, K.2
Ruther, U.3
-
52
-
-
33947146101
-
Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes
-
17241623 10.1016/j.ydbio.2006.12.025 1:CAS:528:DC%2BD2sXjt1Sktro%3D
-
Anselme I, Laclef C, Lanaud M, Ruther U, Schneider-Maunoury S (2007) Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes. Dev Biol 304:208-220
-
(2007)
Dev Biol
, vol.304
, pp. 208-220
-
-
Anselme, I.1
Laclef, C.2
Lanaud, M.3
Ruther, U.4
Schneider-Maunoury, S.5
-
53
-
-
0028025622
-
Programmed cell death is affected in the novel mouse mutant Fused toes (Ft)
-
7956835
-
van der Hoeven F, Schimmang T, Volkmann A, Mattei MG, Kyewski B, Ruther U (1994) Programmed cell death is affected in the novel mouse mutant Fused toes (Ft). Development 120:2601-2607
-
(1994)
Development
, vol.120
, pp. 2601-2607
-
-
Van Der Hoeven, F.1
Schimmang, T.2
Volkmann, A.3
Mattei, M.G.4
Kyewski, B.5
Ruther, U.6
-
54
-
-
67349211789
-
Inactivation of the Fto gene protects from obesity
-
19234441 10.1038/nature07848 1:CAS:528:DC%2BD1MXitFKltb4%3D
-
Fischer J, Koch L, Emmerling C et al (2009) Inactivation of the Fto gene protects from obesity. Nature 458:894-898
-
(2009)
Nature
, vol.458
, pp. 894-898
-
-
Fischer, J.1
Koch, L.2
Emmerling, C.3
-
55
-
-
84873520661
-
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse
-
23300482 10.1371/journal.pgen.1003166 1:CAS:528:DC%2BC3sXivVehu7Y%3D
-
McMurray F, Church CD, Larder R et al (2013) Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet 9:e1003166
-
(2013)
PLoS Genet
, vol.9
, pp. 1003166
-
-
McMurray, F.1
Church, C.D.2
Larder, R.3
-
56
-
-
67649875640
-
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations
-
19559399 10.1016/j.ajhg.2009.06.002 1:CAS:528:DC%2BD1MXhtVeltL7P
-
Boissel S, Reish O, Proulx K et al (2009) Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet 85:106-111
-
(2009)
Am J Hum Genet
, vol.85
, pp. 106-111
-
-
Boissel, S.1
Reish, O.2
Proulx, K.3
-
57
-
-
78649459183
-
Overexpression of Fto leads to increased food intake and results in obesity
-
21076408 10.1038/ng.713 1:CAS:528:DC%2BC3cXhsVWmurvF
-
Church C, Moir L, McMurray F et al (2010) Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 42:1086-1092
-
(2010)
Nat Genet
, vol.42
, pp. 1086-1092
-
-
Church, C.1
Moir, L.2
McMurray, F.3
-
58
-
-
77649303960
-
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats
-
20098739 10.1371/journal.pone.0008771
-
Tung YC, Ayuso E, Shan X et al (2010) Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One 5:e8771
-
(2010)
PLoS One
, vol.5
, pp. 8771
-
-
Tung, Y.C.1
Ayuso, E.2
Shan, X.3
-
59
-
-
78649512744
-
The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice
-
21103374 10.1371/journal.pone.0014005
-
Gao X, Shin YH, Li M, Wang F, Tong Q, Zhang P (2010) The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 5:e14005
-
(2010)
PLoS One
, vol.5
, pp. 14005
-
-
Gao, X.1
Shin, Y.H.2
Li, M.3
Wang, F.4
Tong, Q.5
Zhang, P.6
-
60
-
-
84873415004
-
FTO, obesity and the adolescent brain
-
23201753 10.1093/hmg/dds504 1:CAS:528:DC%2BC3sXhvV2qu7w%3D
-
Melka MG, Gillis J, Bernard M et al (2013) FTO, obesity and the adolescent brain. Hum Mol Genet 22:1050-1058
-
(2013)
Hum Mol Genet
, vol.22
, pp. 1050-1058
-
-
Melka, M.G.1
Gillis, J.2
Bernard, M.3
-
61
-
-
77952340870
-
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
-
20404173 10.1073/pnas.0910878107 1:CAS:528:DC%2BC3cXmtVWrs70%3D
-
Ho AJ, Stein JL, Hua X et al (2010) A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A 107:8404-8409
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 8404-8409
-
-
Ho, A.J.1
Stein, J.L.2
Hua, X.3
-
63
-
-
84888286267
-
The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression
-
10.1038/mp.2012.160 23164817
-
Samaan Z, Anand S, Zhang X et al (2012) The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. Mol Psychiatry. doi: 10.1038/mp.2012.160
-
(2012)
Mol Psychiatry
-
-
Samaan, Z.1
Anand, S.2
Zhang, X.3
-
64
-
-
84885185001
-
Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence
-
10.1007/s12031-013-0044-2
-
Wang L, Liu X, Luo X, Zeng M, Zuo L, Wang KS (2013) Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence. J Mol Neurosci. doi: 10.1007/s12031-013-0044-2
-
(2013)
J Mol Neurosci
-
-
Wang, L.1
Liu, X.2
Luo, X.3
Zeng, M.4
Zuo, L.5
Wang, K.S.6
-
65
-
-
84871206725
-
Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease
-
Alzheimer's Disease Neuroimaging I. 23251365 10.1371/journal.pone.0050354 1:CAS:528:DC%2BC3sXhs1I%3D Group N.-L
-
Reitz C, Tosto G, Mayeux R, Luchsinger JA, Group N-LNFS, Alzheimer's Disease Neuroimaging I (2012) Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease. PLoS One 7:e50354
-
(2012)
PLoS One
, vol.7
, pp. 50354
-
-
Reitz, C.1
Tosto, G.2
Mayeux, R.3
Luchsinger, J.A.4
-
66
-
-
84860871770
-
Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate
-
22435707 10.1042/BJ20120065 1:CAS:528:DC%2BC38XmvVKjs7o%3D
-
Ma M, Harding HP, O'Rahilly S, Ron D, Yeo GS (2012) Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate. Biochem J 444:183-187
-
(2012)
Biochem J
, vol.444
, pp. 183-187
-
-
Ma, M.1
Harding, H.P.2
O'Rahilly, S.3
Ron, D.4
Yeo, G.S.5
-
67
-
-
84877577199
-
FTO expression is regulated by availability of essential amino acids
-
10.1038/ijo.2012.77
-
Cheung MK, Gulati P, O'Rahilly S, Yeo GS (2012) FTO expression is regulated by availability of essential amino acids. Int J Obes (Lond) 37:744-747
-
(2012)
Int J Obes (Lond)
, vol.37
, pp. 744-747
-
-
Cheung, M.K.1
Gulati, P.2
O'Rahilly, S.3
Yeo, G.S.4
-
68
-
-
0033534561
-
Macromolecular assemblage of aminoacyl-tRNA synthetases: Identification of protein-protein interactions and characterization of a core protein
-
9878398 10.1006/jmbi.1998.2316 1:CAS:528:DyaK1MXntFCrtw%3D%3D
-
Quevillon S, Robinson JC, Berthonneau E, Siatecka M, Mirande M (1999) Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. J Mol Biol 285:183-195
-
(1999)
J Mol Biol
, vol.285
, pp. 183-195
-
-
Quevillon, S.1
Robinson, J.C.2
Berthonneau, E.3
Siatecka, M.4
Mirande, M.5
-
69
-
-
25144489447
-
Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: New perspectives on housekeepers
-
16125937 10.1016/j.tibs.2005.08.004 1:CAS:528:DC%2BD2MXhtVKjsL%2FM
-
Park SG, Ewalt KL, Kim S (2005) Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers. Trends Biochem Sci 30:569-574
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 569-574
-
-
Park, S.G.1
Ewalt, K.L.2
Kim, S.3
-
70
-
-
84859704385
-
Leucyl-tRNA synthetase controls TORC1 via the EGO complex
-
22424774 10.1016/j.molcel.2012.02.009 1:CAS:528:DC%2BC38Xkt1Ghtr4%3D
-
Bonfils G, Jaquenoud M, Bontron S, Ostrowicz C, Ungermann C, De Virgilio C (2012) Leucyl-tRNA synthetase controls TORC1 via the EGO complex. Mol Cell 46:105-110
-
(2012)
Mol Cell
, vol.46
, pp. 105-110
-
-
Bonfils, G.1
Jaquenoud, M.2
Bontron, S.3
Ostrowicz, C.4
Ungermann, C.5
De Virgilio, C.6
-
71
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
22424946 10.1016/j.cell.2012.02.044 1:CAS:528:DC%2BC38Xkt1Gnsbw%3D
-
Han JM, Jeong SJ, Park MC et al (2012) Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149:410-424
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
-
72
-
-
84860779086
-
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
-
22575960 10.1038/nature11112 1:CAS:528:DC%2BC38XmvVequ7g%3D
-
Dominissini D, Moshitch-Moshkovitz S, Schwartz S et al (2012) Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485:201-206
-
(2012)
Nature
, vol.485
, pp. 201-206
-
-
Dominissini, D.1
Moshitch-Moshkovitz, S.2
Schwartz, S.3
-
73
-
-
84862649489
-
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons
-
22608085 10.1016/j.cell.2012.05.003 1:CAS:528:DC%2BC38Xntlyrs7s%3D
-
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR (2012) Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell 149:1635-1646
-
(2012)
Cell
, vol.149
, pp. 1635-1646
-
-
Meyer, K.D.1
Saletore, Y.2
Zumbo, P.3
Elemento, O.4
Mason, C.E.5
Jaffrey, S.R.6
-
74
-
-
0030712151
-
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
-
9409616 1:CAS:528:DyaK2sXnsVelsL0%3D
-
Bokar JA, Shambaugh ME, Polayes D, Matera AG, Rottman FM (1997) Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA 3:1233-1247
-
(1997)
RNA
, vol.3
, pp. 1233-1247
-
-
Bokar, J.A.1
Shambaugh, M.E.2
Polayes, D.3
Matera, A.G.4
Rottman, F.M.5
-
75
-
-
84872274463
-
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
-
23177736 1:CAS:528:DC%2BC38XhslajsrzK
-
Zheng G, Dahl JA, Niu Y et al (2013) ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell 49:18-29
-
(2013)
Mol Cell
, vol.49
, pp. 18-29
-
-
Zheng, G.1
Dahl, J.A.2
Niu, Y.3
-
76
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
16690869 10.1126/science.1124147 1:CAS:528:DC%2BD28Xktlyhs7Y%3D
-
Cota D, Proulx K, Smith KA et al (2006) Hypothalamic mTOR signaling regulates food intake. Science 312:927-930
-
(2006)
Science
, vol.312
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Smith, K.A.3
-
77
-
-
84875922294
-
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
-
23636237 10.3945/ajcn.112.052183 1:CAS:528:DC%2BC3sXoslyqtbw%3D
-
Tanaka T, Ngwa JS, van Rooij FJ et al (2013) Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr 97:1395-1402
-
(2013)
Am J Clin Nutr
, vol.97
, pp. 1395-1402
-
-
Tanaka, T.1
Ngwa, J.S.2
Van Rooij, F.J.3
|