MicroRNAs as potential biomarkers in diseases and toxicology

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 764-765, Issue , 2014, Pages 46-57

  Siddeek, Bénazir ^a,b,f   Inoubli, Lilia ^a,b   Lakhdari, Nadjem ^a,b   Rachel, Paul Bellon ^a,b   Fussell, Karma Claire ^g   Schneider, Steffen ^g   Mauduit, Claire ^a,b,c,d   Benahmed, Mohamed ^a,b,e  

^a CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c UNIVERSITÉ LYON 1   (France)

^d CENTRE HOSPITALIER LYON SUD   (France)

^e UNIVERSITY HOSPITAL OF NICE   (France)

^f BASF Agro   (France)

^g BASF SE   (Germany)

Author keywords

Chemicals; Circulating biomarkers; MicroRNAs

Indexed keywords

BIOLOGICAL MARKER; MICRORNA;

ARTICLE; AUTOIMMUNE DISEASE; DISEASE MARKER; ENVIRONMENTAL EXPOSURE; HUMAN; INFLAMMATORY DISEASE; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; TOXICITY; TOXICOLOGY;

CHEMICALS; CIRCULATING BIOMARKERS; MICRORNAS;

ANIMALS; BIOLOGICAL MARKERS; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; GENE EXPRESSION; HUMANS; MICRORNAS; RISK ASSESSMENT; RNA, MESSENGER; XENOBIOTICS;

EID: 84898799049     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2014.01.010     Document Type: Article

References (185)

1. Kim V.N., Han J., Siomi M.C. Biogenesis of small RNAs in animals. Nat. Rev. Mol. Cell Biol. 2009, 10:126-139.
2. Ghildiyal M., Zamore P.D. Small silencing RNAs: an expanding universe. Nat. Rev. Genet. 2009, 10:94-108.
3. Malone C.D., Hannon G.J. Small RNAs as guardians of the genome. Cell 2009, 136:656-668.
4. Mathers J.C., Strathdee G., Relton C.L. Induction of epigenetic alterations by dietary and other environmental factors. Adv. Genet. 2010, 71:3-39.
5. Lewis B.P., Burge C.B., Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120:15-20.
6. Szyf M. The dynamic epigenome and its implications in toxicology. Toxicol. Sci. 2007, 100:7-23.
7. Saito Y., Jones P.A. Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle 2006, 5:2220-2222.
8. Meunier L., Siddeek B., Vega A., Lakhdari N., Inoubli L., Bellon R.P., Lemaire G., Mauduit C., Benahmed M. Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1. Endocrinology 2012, 153:1936-1947.
9. LeBaron M.J., Rasoulpour R.J., Klapacz J., Ellis-Hutchings R.G., Hollnagel H.M., Gollapudi B.B. Epigenetics and chemical safety assessment. Mutat. Res. 2010, 705:83-95.
10. Fabian M.R., Sonenberg N. The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat. Struct. Mol. Biol. 2012, 19:586-593.
11. Fiedler S.D., Carletti M.Z., Christenson L.K. Quantitative RT-PCR methods for mature microRNA expression analysis. Methods Mol. Biol. 2010, 630:49-64.
12. Varallyay E., Burgyan J., Havelda Z. MicroRNA detection by northern blotting using locked nucleic acid probes. Nat. Protoc. 2008, 3:190-196.
13. Ambs S., Prueitt R.L., Yi M., Hudson R.S., Howe T.M., Petrocca F., Wallace T.A., Liu C.G., Volinia S., Calin G.A., Yfantis H.G., Stephens R.M., Croce C.M. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res. 2008, 68:6162-6170.
14. Williams Z., Ben-Dov I.Z., Elias R., Mihailovic A., Brown M., Rosenwaks Z., Tuschl T. Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:4255-4260.
15. Monteys A.M., Spengler R.M., Wan J., Tecedor L., Lennox K.A., Xing Y., Davidson B.L. Structure and activity of putative intronic miRNA promoters. RNA 2013, 16:495-505.
16. Lee Y., Kim M., Han J., Yeom K.H., Lee S., Baek S.H., Kim V.N. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004, 23:4051-4060.
17. Borchert G.M., Lanier W., Davidson B.L. RNA polymerase III transcribes human microRNAs. Nat. Struct. Mol. Biol. 2006, 13:1097-1101.
18. Lee Y.S., Dutta A. MicroRNAs in cancer. Annu. Rev. Pathol. 2009, 4:199-227.
19. Ozsolak F., Poling L.L., Wang Z., Liu H., Liu X.S., Roeder R.G., Zhang X., Song J.S., Fisher D.E. Chromatin structure analyses identify miRNA promoters. Genes Dev. 2008, 22:3172-3183.
20. Libri V., Miesen P., van Rij R.P., Buck A.H. Regulation of microRNA biogenesis and turnover by animals and their viruses. Cell. Mol. Life Sci. 2013, 70:3525-3544.
21. Lee Y., Ahn C., Han J., Choi H., Kim J., Yim J., Lee J., Provost P., Radmark O., Kim S., Kim V.N. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003, 425:415-419.
22. Gregory R.I., Yan K.P., Amuthan G., Chendrimada T., Doratotaj B., Cooch N., Shiekhattar R. The Microprocessor complex mediates the genesis of microRNAs. Nature 2004, 432:235-240.
23. Triboulet R., Chang H.M., Lapierre R.J., Gregory R.I. Post-transcriptional control of DGCR8 expression by the microprocessor. RNA 2009, 15:1005-1011.
24. Kadener S., Rodriguez J., Abruzzi K.C., Khodor Y.L., Sugino K., Marr M.T., Nelson S., Rosbash M. Genome-wide identification of targets of the drosha-pasha/DGCR8 complex. RNA 2009, 15:537-545.
25. Bernstein E., Caudy A.A., Hammond S.M., Hannon G.J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 2001, 409:363-366.
26. Hutvagner G., McLachlan J., Pasquinelli A.E., Balint E., Tuschl T., Zamore P.D. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 2001, 293:834-838.
27. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
28. Wang J., Lu M., Qiu C., Cui Q. TransmiR: a transcription factor-microRNA regulation database. Nucleic Acids Res. 2010, 38:D119-D122.
29. Davis-Dusenbery B.N., Hata A. Smad-mediated miRNA processing: a critical role for a conserved RNA sequence. RNA Biol. 2011, 8:71-76.
30. Wang X., Zhao X., Gao P., Wu M. c-Myc modulates microRNA processing via the transcriptional regulation of Drosha. Sci. Rep. 2013, 3:1942.
31. Suzuki H.I., Yamagata K., Sugimoto K., Iwamoto T., Kato S., Miyazono K. Modulation of microRNA processing by p53. Nature 2009, 460:529-533.
32. Hong S., Noh H., Chen H., Padia R., Pan Z.K., Su S.B., Jing Q., Ding H.F., Huang S. Signaling by p38 MAPK stimulates nuclear localization of the microprocessor component p68 for processing of selected primary microRNAs. Sci. Signal. 2013, 6:ra16.
33. Kawai S., Amano A. BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex. J. Cell Biol. 2012, 197:201-208.
34. Yamagata K., Fujiyama S., Ito S., Ueda T., Murata T., Naitou M., Takeyama K., Minami Y., O'Malley B.W., Kato S. Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol. Cell 2009, 36:340-347.
35. Sakamoto S., Aoki K., Higuchi T., Todaka H., Morisawa K., Tamaki N., Hatano E., Fukushima A., Taniguchi T., Agata Y. The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway. Mol. Cell. Biol. 2009, 29:3754-3769.
36. Newman M.A., Thomson J.M., Hammond S.M. Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 2008, 14:1539-1549.
37. Piskounova E., Polytarchou C., Thornton J.E., LaPierre R.J., Pothoulakis C., Hagan J.P., Iliopoulos D., Gregory R.I. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell 2011, 147:1066-1079.
38. Michlewski G., Caceres J.F. Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Nat. Struct. Mol. Biol. 2010, 17:1011-1018.
39. Choudhury N.R., Michlewski G. Terminal loop-mediated control of microRNA biogenesis. Biochem. Soc. Trans. 2012, 40:789-793.
40. Bail S., Swerdel M., Liu H., Jiao X., Goff L.A., Hart R.P., Kiledjian M. Differential regulation of microRNA stability. RNA 2006, 16:1032-1039.
41. Gantier M.P., McCoy C.E., Rusinova I., Saulep D., Wang D., Xu D., Irving A.T., Behlke M.A., Hertzog P.J., Mackay F., Williams B.R. Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res. 2011, 39:5692-5703.
42. Westholm J.O., Ladewig E., Okamura K., Robine N., Lai E.C. Common and distinct patterns of terminal modifications to mirtrons and canonical microRNAs. RNA 2012, 18:177-192.
43. Yokoi T., Nakajima M. microRNAs as mediators of drug toxicity. Annu. Rev. Pharmacol. Toxicol. 2013, 53:377-400.
44. Rieger J.K., Klein K., Winter S., Zanger U.M. Expression variability of absorption, distribution, metabolism, excretion-related microRNAs in human liver: influence of nongenetic factors and association with gene expression. Drug Metab. Dispos. 2013, 41:1752-1762.
45. Takagi S., Nakajima M., Mohri T., Yokoi T. Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. J. Biol. Chem. 2008, 283:9674-9680.
46. Hu W., Zhao J., Pei G. Activation of aryl hydrocarbon receptor (AhR) by Tranilast, an anti-allergy drug, promotes miR-302 expression and cell reprogramming,. J. Biol. Chem. 2013, 288:22972-22984.
47. Shizu R., Benoki S., Numakura Y., Kodama S., Miyata M., Yamazoe Y., Yoshinari K. Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor alpha (PPARalpha) is enhanced by pregnane X receptor (PXR) activation in mice. PLoS One 2013, 8:e61802.
48. Kida K., Nakajima M., Mohri T., Oda Y., Takagi S., Fukami T., Yokoi T. PPARalpha is regulated by miR-21 and miR-27b in human liver. Pharm. Res. 2011, 28:2467-2476.
49. Zheng L., Lv G.C., Sheng J., Yang Y.D. Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD. J. Gastroenterol. Hepatol. 2010, 25:156-163.
50. Shah Y.M., Morimura K., Yang Q., Tanabe T., Takagi M., Gonzalez F.J. Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation. Mol. Cell. Biol. 2007, 27:4238-4247.
51. Nakahama T., Hanieh H., Nguyen N.T., Chinen I., Ripley B., Millrine D., Lee S., Nyati K.K., Dubey P.K., Chowdhury K., Kawahara Y., Kishimoto T. Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17-producing T-helper cell differentiation. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:11964-11969.
52. Adams B.D., Furneaux H., White B.A. The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol. Endocrinol. 2007, 21:1132-1147.
53. Zhao J.J., Lin J., Yang H., Kong W., He L., Ma X., Coppola D., Cheng J.Q. MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer. J. Biol. Chem. 2008, 283:31079-31086.
54. Xiong J., Yu D., Wei N., Fu H., Cai T., Huang Y., Wu C., Zheng X., Du Q., Lin D., Liang Z. An estrogen receptor alpha suppressor, microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples. FEBS J. 2010, 277:1684-1694.
55. Yang Z., Wang L. Regulation of microRNA expression and function by nuclear receptor signaling. Cell Biosci. 2011, 1:31.
56. Wu J., Bao J., Wang L., Hu Y., Xu C. MicroRNA-184 downregulates nuclear receptor corepressor 2 in mouse spermatogenesis. BMC Dev. Biol. 2011, 11:64.
57. Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A., Pfeffer S., Rice A., Kamphorst A.O., Landthaler M., Lin C., Socci N.D., Hermida L., Fulci V., Chiaretti S., Foa R., Schliwka J., Fuchs U., Novosel A., Muller R.U., Schermer B., Bissels U., Inman J., Phan Q., Chien M., Weir D.B., Choksi R., De Vita G., Frezzetti D., Trompeter H.I., Hornung V., Teng G., Hartmann G., Palkovits M., Di Lauro R., Wernet P., Macino G., Rogler C.E., Nagle J.W., Ju J., Papavasiliou F.N., Benzing T., Lichter P., Tam W., Brownstein M.J., Bosio A., Borkhardt A., Russo J.J., Sander C., Zavolan M., Tuschl T. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007, 129:1401-1414.
58. Wang Y., Weng T., Gou D., Chen Z., Chintagari N.R., Liu L. Identification of rat lung-specific microRNAs by micoRNA microarray: valuable discoveries for the facilitation of lung research. BMC Genomics 2007, 8:29.
59. Satoh M., Minami Y., Takahashi Y., Tabuchi T., Nakamura M. Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy. J. Card. Fail. 2010, 16:404-410.
60. Grueter C.E., van Rooij E., Johnson B.A., DeLeon S.M., Sutherland L.B., Qi X., Gautron L., Elmquist J.K., Bassel-Duby R., Olson E.N. A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell 2012, 149:671-683.
61. Shapiro M.D., Bagley J., Latz J., Godwin J.G., Ge X., Tullius S.G., Iacomini J. MicroRNA expression data reveals a signature of kidney damage following ischemia reperfusion injury. PLoS One 2011, 6:e23011.
62. Vacchi-Suzzi C., Bauer Y., Berridge B.R., Bongiovanni S., Gerrish K., Hamadeh H.K., Letzkus M., Lyon J., Moggs J., Paules R.S., Pognan F., Staedtler F., Vidgeon-Hart M.P., Grenet O., Couttet P. Perturbation of microRNAs in rat heart during chronic doxorubicin treatment. PLoS One 2012, 7:e40395.
63. Shah M.Y., Pan X., Fix L.N., Farwell M.A., Zhang B. 5-Fluorouracil drug alters the microRNA expression profiles in MCF-7 breast cancer cells. J. Cell. Physiol. 2011, 226:1868-1878.
64. Koufaris C., Wright J., Currie R.A., Gooderham N.J. Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens. Toxicol. Sci. 2012, 128:532-543.
65. Wu X., Song Y. Preferential regulation of miRNA targets by environmental chemicals in the human genome. BMC Genomics 2011, 12:244.
66. Meunier L., Siddeek B., Vega A., Lakhdari N., Inoubli L., Bellon R.P., Lemaire G., Mauduit C., Benahmed M. Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR -29 family in the down-regulation of DNA methyltransferases and Mcl-1. Endocrinology 2012, 153:1936-1947.
67. Zhang Y., Chao T., Li R., Liu W., Chen Y., Yan X., Gong Y., Yin B., Qiang B., Zhao J., Yuan J., Peng X. MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a. J. Mol. Med. (Berl.) 2009, 87:43-51.
68. Marczylo E.L., Amoako A.A., Konje J.C., Gant T.W., Marczylo T.H. Smoking induces differential miRNA expression in human spermatozoa: a potential transgenerational epigenetic concern?. Epigenetics 2012, 7:432-439.
69. Mendell J.T., Olson E.N. MicroRNAs in stress signaling and human disease. Cell 2012, 148:1172-1187.
70. Lawrie C.H., Gal S., Dunlop H.M., Pushkaran B., Liggins A.P., Pulford K., Banham A.H., Pezzella F., Boultwood J., Wainscoat J.S., Hatton C.S., Harris A.L. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br. J. Haematol. 2008, 141:672-675.
71. Vickers K.C., Palmisano B.T., Shoucri B.M., Shamburek R.D., Remaley A.T. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat. Cell. Biol. 2011, 13:423-433.
72. Thery C., Zitvogel L., Amigorena S. Exosomes: composition, biogenesis and function. Nat. Rev. Immunol. 2002, 2:569-579.
73. Stoorvogel W., Kleijmeer M.J., Geuze H.J., Raposo G. The biogenesis and functions of exosomes. Traffic 2002, 3:321-330.
74. Boon R.A., Vickers K.C. Intercellular transport of microRNAs. Arterioscler. Thromb. Vasc. Biol. 2013, 33:186-192.
75. Allegra A., Alonci A., Campo S., Penna G., Petrungaro A., Gerace D., Musolino C. Circulating microRNAs: new biomarkers in diagnosis, prognosis and treatment of cancer (review). Int. J. Oncol. 2012, 41:1897-1912.
76. Xu L., Yang B.F., Ai J. MicroRNA transport: a new way in cell communication. J. Cell. Physiol. 2013, 228:1713-1719.
77. Mause S.F., Weber C. Microparticles: protagonists of a novel communication network for intercellular information exchange. Circ. Res. 2010, 107:1047-1057.
78. Turchinovich A., Weiz L., Langheinz A., Burwinkel B. Characterization of extracellular circulating microRNA. Nucleic Acids Res. 2011, 39:7223-7233.
79. Chen X., Ba Y., Ma L., Cai X., Yin Y., Wang K., Guo J., Zhang Y., Chen J., Guo X., Li Q., Li X., Wang W., Wang J., Jiang X., Xiang Y., Xu C., Zheng P., Zhang J., Li R., Zhang H., Shang X., Gong T., Ning G., Zen K., Zhang C.Y. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008, 18:997-1006.
80. Hunter M.P., Ismail N., Zhang X., Aguda B.D., Lee E.J., Yu L., Xiao T., Schafer J., Lee M.L., Schmittgen T.D., Nana-Sinkam S.P., Jarjoura D., Marsh C.B. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 2008, 3:e3694.
81. Scholer N., Langer C., Kuchenbauer F. Circulating microRNAs as biomarkers - true Blood?. Genome Med. 2011, 3:72.
82. Keller A., Leidinger P., Bauer A., Elsharawy A., Haas J., Backes C., Wendschlag A., Giese N., Tjaden C., Ott K., Werner J., Hackert T., Ruprecht K., Huwer H., Huebers J., Jacobs G., Rosenstiel P., Dommisch H., Schaefer A., Muller-Quernheim J., Wullich B., Keck B., Graf N., Reichrath J., Vogel B., Nebel A., Jager S.U., Staehler P., Amarantos I., Boisguerin V., Staehler C., Beier M., Scheffler M., Buchler M.W., Wischhusen J., Haeusler S.F., Dietl J., Hofmann S., Lenhof H.P., Schreiber S., Katus H.A., Rottbauer W., Meder B., Hoheisel J.D., Franke A., Meese E. Toward the blood-borne miRNome of human diseases. Nat. Methods 2011, 8:841-843.
83. Weber J.A., Baxter D.H., Zhang S., Huang D.Y., Huang K.H., Lee M.J., Galas D.J., Wang K. The microRNA spectrum in 12 body fluids. Clin. Chem. 2010, 56:1733-1741.
84. Buckley E. Epigenetic effects of chemicals not ready for regulatory "primetime". Pestic. Toxic Chem. News 2009, 37. http://www.agra-net.com/aius/home.jsp?pagetitle=aiusfp&pubId=ag100.
85. Goodman J.I., Augustine K.A., Cunnningham M.L., Dixon D., Dragan Y.P., Falls J.G., Rasoulpour R.J., Sills R.C., Storer R.D., Wolf D.C., Pettit S.D. What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?. Toxicol. Sci. 2010, 116:375-381.
86. Hileman B. Chemicals can turn genes on and off. Environ. Health News 2009, 3(August).
87. ECETOC WR 23 - Epigenetics and Chemical Safety Rome, 2011.
88. Priestley C.C., Anderton M., Doherty A.T., Duffy P., Mellor H.R., Powell H., Roberts R. Epigenetics - relevance to drug safety science. Toxicol. Res. 2012, 1:23-31.
89. Hou L., Zhang X., Wang D., Baccarelli A. Environmental chemical exposures and human epigenetics. Int. J. Epidemiol. 2012, 41:79-105.
90. Zhang Y., Jia Y., Zheng R., Guo Y., Wang Y., Guo H., Fei M., Sun S. Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases. Clin. Chem. 2010, 56:1830-1838.
91. Wang K., Zhang S., Marzolf B., Troisch P., Brightman A., Hu Z., Hood L.E., Galas D.J. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:4402-4407.
92. Yokoi T., Nakajima M. Toxicological implications of modulation of gene expression by microRNAs. Toxicol. Sci. 2011, 123:1-14.
93. Banerjee A., Luettich K. MicroRNAs as potential biomarkers of smoking-related diseases. Biomark Med. 2012, 6:671-684.
94. Takahashi K., Yokota S., Tatsumi N., Fukami T., Yokoi T., Nakajima M. Cigarette smoking substantially alters plasma microRNA profiles in healthy subjects. Toxicol. Appl. Pharmacol. 2013, 272:154-160.
95. Bollati V., Marinelli B., Apostoli P., Bonzini M., Nordio F., Hoxha M., Pegoraro V., Motta V., Tarantini L., Cantone L., Schwartz J., Bertazzi P.A., Baccarelli A. Exposure to metal-rich particulate matter modifies the expression of candidate microRNAs in peripheral blood leukocytes. Environ. Health Perspect. 2010, 118:763-768.
96. Dickinson B.A., Semus H.M., Montgomery R.L., Stack C., Latimer P.A., Lewton S.M., Lynch J.M., Hullinger T.G., Seto A.G., van Rooij E. Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure. Eur. J. Heart Fail. 2010, 15:650-659.
97. Lorenzen J.M., Thum T. Circulating and urinary microRNAs in kidney disease. Clin. J. Am. Soc. Nephrol. 2012, 7:1528-1533.
98. Wang N., Zhou Y., Jiang L., Li D., Yang J., Zhang C.Y., Zen K. Urinary microRNA-10a and microRNA-30d serve as novel, sensitive and specific biomarkers for kidney injury. PloS One 2012, 7:e51140.
99. Du J., Cao X., Zou L., Chen Y., Guo J., Chen Z., Hu S., Zheng Z. MicroRNA-21 and risk of severe acute kidney injury and poor outcomes after adult cardiac surgery. PloS One 2013, 8:e63390.
100. Wang F., Li C., Liu W., Jin Y. Effect of exposure to volatile organic compounds (VOCs) on airway inflammatory response in mice. J. Toxicol. Sci. 2012, 37:739-748.
101. Bolleyn J., Fraczek J., Vinken M., Lizarraga D., Gaj S., van Delft J.H., Rogiers V., Vanhaecke T. Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes. Toxicol. In Vitro 2011, 25:1173-1182.
102. Marsit C.J., Eddy K., Kelsey K.T. MicroRNA responses to cellular stress. Cancer Res. 2006, 66:10843-10848.
103. Cao Y., Yu S.L., Wang Y., Guo G.Y., Ding Q., An R.H. MicroRNA-dependent regulation of PTEN after arsenic trioxide treatment in bladder cancer cell line T24. Tumour Biol. 2011, 32:179-188.
104. Pogue A.I., Li Y.Y., Cui J.G., Zhao Y., Kruck T.P., Percy M.E., Tarr M.A., Lukiw W.J. Characterization of an NF-kappaB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells. J. Inorg. Biochem. 2009, 103:1591-1595.
105. Lukiw W.J., Pogue A.I. Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells. J. Inorg. Biochem. 2007, 101:1265-1269.
106. Bollati V., Marinelli B., Apostoli P., Bonzini M., Nordio F., Hoxha M., Pegoraro V., Motta V., Tarantini L., Cantone L., Schwartz J., Bertazzi P.A., Baccarelli A. Exposure to metal-rich particulate matter modifies the expression of candidate microRNAs in peripheral blood leukocytes. Environ. Health. Perspect. 2010, 118:763-768.
107. Izzotti A., Calin G.A., Arrigo P., Steele V.E., Croce C.M., De Flora S. Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J. 2009, 23:806-812.
108. Schembri F., Sridhar S., Perdomo C., Gustafson A.M., Zhang X., Ergun A., Lu J., Liu G., Zhang X., Bowers J., Vaziri C., Ott K., Sensinger K., Collins J.J., Brody J.S., Getts R., Lenburg M.E., Spira A. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2319-2324.
109. Kalscheuer S., Zhang X., Zeng Y., Upadhyaya P. Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 2008, 29:2394-2399.
110. Zhang B., Pan X. RDX induces aberrant expression of microRNAs in mouse brain and liver. Environ. Health Perspect. 2009, 117:231-240.
111. Fukushima T., Hamada Y., Yamada H., Horii I. Changes of micro-RNA expression in rat liver treated by acetaminophen or carbon tetrachloride--regulating role of micro-RNA for RNA expression. J. Toxicol. Sci. 2007, 32:401-409.
112. Elyakim E., Sitbon E., Faerman A., Tabak S., Montia E., Belanis L., Dov A., Marcusson E.G., Bennett C.F., Chajut A., Cohen D., Yerushalmi N. hsa-miR-191 is a candidate oncogene target for hepatocellular carcinoma therapy. Cancer Res. 2010, 70:8077-8087.
113. Avissar-Whiting M., Veiga K.R., Uhl K.M., Maccani M.A., Gagne L.A., Moen E.L., Marsit C.J., Bisphenol A. exposure leads to specific microRNA alterations in placental cells. Reprod. Toxicol. 2010, 29:401-406.
114. Lee J.S., Semela D., Iredale J., Shah V.H. Sinusoidal remodeling and angiogenesis: a new function for the liver-specific pericyte?. Hepatology (Baltimore, Md.) 2007, 45:817-825.
115. Sathyan P., Golden H.B., Miranda R.C. Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium. J. Neurosci. 2007, 27:8546-8557.
116. Pogribny I.P., Tryndyak V.P., Boyko A., Rodriguez-Juarez R., Beland F.A., Kovalchuk O. Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. Mutat. Res. 2007, 619:30-37.
117. Rossi L., Bonmassar E., Faraoni I. Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro. Pharmacol. Res. 2007, 56:248-253.
118. Farraj A.K., Hazari M.S., Haykal-Coates N., Lamb C., Winsett D.W., Ge Y., Ledbetter A.D., Carll A.P., Bruno M., Ghio A., Costa D.L. ST depression, arrhythmia, vagal dominance, and reduced cardiac micro-RNA in particulate-exposed rats. Am. J. Resp. Cell Mol. Biol. 2011, 44:185-196.
119. Izzotti A., Balansky R., D'Agostini F., Longobardi M., Cartiglia C., La Maestra S., Micale R.T., Camoirano A., Ganchev G., Iltcheva M., Steele V.E., De Flora S. Relationships between pulmonary micro-RNA and proteome profiles, systemic cytogenetic damage and lung tumors in cigarette smoke-exposed mice treated with chemopreventive agents. Carcinogenesis 2013, 34:2322-2329.
120. Taki K., Fukushima T., Ise R., Horii I., Yoshida T. Microarray analysis of 6-mercaptopurine-induced-toxicity-related genes and microRNAs in the rat placenta. J. Toxicol. Sci. 2013, 38:159-167.
121. Wu J., Yang T., Li X., Yang Q., Liu R., Huang J., Li Y., Yang C., Jiang Y. Alteration of serum miR-206 and miR-133b is associated with lung carcinogenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Toxicol. Appl. Pharmacol. 2013, 267:238-246.
122. Cui F.M., Li J.X., Chen Q., Du H.B., Zhang S.Y., Nie J.H., Cao J.P., Zhou P.K., Hei T.K., Tong J. Radon-induced alterations in micro-RNA expression profiles in transformed BEAS2B cells. J. Toxicol. Environ. Health 2013, 76:107-119.
123. Juhasz K., Gombos K., Szirmai M., Gocze K., Wolher V., Revesz P., Magda I., Sebestyen A., Nemeth A., Ember I. Very early effect of DMBA and MNU on microRNA expression. In vivo 2013, 27:113-117.
124. Starckx S., Batheja A., Verheyen G.R., Jonghe S.D., Steemans K., Dijck B.V., Singer M., Bogdan N., Snoeys J., Vinken P., Sasaki J.C., Gompel J.V., Guzzie-Peck P., Lampo A., Lammens L. Evaluation of miR-122 and Other Biomarkers in Distinct Acute Liver Injury in Rats. Toxicol. Pathol. 2013, 41:795-804.
125. Singh N.P., Singh U.P., Guan H., Nagarkatti P., Nagarkatti M. Prenatal exposure to TCDD triggers significant modulation of microRNA expression profile in the thymus that affects consequent gene expression. PLoS One 2012, 7:e45054.
126. Jenny M.J., Aluru N., Hahn M.E. Effects of short-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on microRNA expression in zebrafish embryos. Toxicol. Appl. Pharmacol. 2012, 264:262-273.
127. Vacchi-Suzzi C., Bauer Y., Berridge B.R., Bongiovanni S., Gerrish K., Hamadeh H.K., Letzkus M., Lyon J., Moggs J., Paules R.S., Pognan F., Staedtler F., Vidgeon-Hart M.P., Grenet O., Couttet P. Perturbation of micro RNAs in rat heart during chronic doxorubicin treatment. PLoS One 2012, 7:e40395.
128. Brzuzan P., Wozny M., Wolinska L., Piasecka A. Expression profiling in vivo demonstrates rapid changes in liver microRNA levels of whitefish (Coregonus lavaretus) following microcystin-LR exposure. Aquat. Toxicol. 2012, 122-123:188-196.
129. Dippold R.P., Vadigepalli R., Gonye G.E., Hoek J.B. Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in rats. Am. J. Physiol. 2012, 303:G733-G743.
130. Bourdon J.A., Saber A.T., Halappanavar S., Jackson P.A., Wu D., Hougaard K.S., Jacobsen N.R., Williams A., Vogel U., Wallin H., Yauk C.L. Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung. Environ. Mol. Mutagen. 2012, 53:462-468.
131. States J.C., Singh A.V., Knudsen T.B., Rouchka E.C., Ngalame N.O., Arteel G.E., Piao Y., Ko M.S. Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated atherosclerosis. PLoS One 2012, 7:e38713.
132. Ward J., Bala S., Petrasek J., Szabo G. Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study. World J. Gastroenterol. 2012, 18:2798-2804.
133. Saikumar J., Hoffmann D., Kim T.M., Gonzalez V.R., Zhang Q., Goering P.L., Brown R.P., Bijol V., Park P.J., Waikar S.S., Vaidya V.S. Expression, circulation, and excretion profile of microRNA-21, -155, and -18a following acute kidney injury. Toxicol. Sci. 2012, 129:256-267.
134. Parasramka M.A., Ali S., Banerjee S., Deryavoush T., Sarkar F.H., Gupta S. Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures. Mol. Nutr. Food Res. 2013, 57:235-248.
135. Wang F., Liu W., Ma J., Yu M., Jin Y., Dai J. Prenatal and neonatal exposure to perfluorooctane sulfonic acid results in changes in miRNA expression profiles and synapse associated proteins in developing rat brains. Environ. Sci. Technol. 2012, 46:6822-6829.
136. Fabbri M., Urani C., Sacco M.G., Procaccianti C., Gribaldo L. Whole genome analysis and microRNAs regulation in HepG2 cells exposed to cadmium. Altex 2012, 29:173-182.
137. Zhang G., Sun L., Lu X., Chen Z., Duerksen-Hughes P.J., Hu H., Zhu X., Yang J. Cisplatin treatment leads to changes in nuclear protein and microRNA expression. Mutat. Res. 2012, 746:66-77.
138. Song M.K., Song M., Choi H.S., Kim Y.J., Park Y.K., Ryu J.C. Identification of molecular signatures predicting the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). Toxicol. Lett. 2012, 212:18-28.
139. Dai B.H., Geng L., Wang Y., Sui C.J., Xie F., Shen R.X., Shen W.F., Yang J.M. microRNA-199a-5p protects hepatocytes from bile acid-induced sustained endoplasmic reticulum stress. Cell Death Dis. 2013, 4:e604.
140. Teng Y., Manavalan T.T., Hu C., Medjakovic S., Jungbauer A., Klinge C.M. Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells. Toxicol. Sci. 2013, 131:71-83.
141. Tilghman S.L., Bratton M.R., Segar H.C., Martin E.C., Rhodes L.V., Li M., McLachlan J.A., Wiese T.E., Nephew K.P., Burow M.E. Endocrine disruptor regulation of microRNA expression in breast carcinoma cells. PLoS One 2012, 7:e32754.
142. Choi J.S., Oh J.H., Park H.J., Choi M.S., Park S.M., Kang S.J., Oh M.J., Kim S.J., Hwang S.Y., Yoon S. miRNA regulation of cytotoxic effects in mouse Sertoli cells exposed to nonylphenol. Reprod. Biol. Endocrinol. 2011, 9:126.
143. Benoit C., Ould-Hamouda H., Crepin D., Gertler A., Amar L., Taouis M. Early leptin blockade predisposes fat-fed rats to overweight and modifies hypothalamic microRNAs. J. Endocrinol. 2013, 218:35-47.
144. Ahn J., Lee H., Jung C.H., Ha T. Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet. Mol. Nutr. Food Res. 2012, 56:1665-1674.
145. Yang Y.M., Seo S.Y., Kim T.H., Kim S.G. Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid. Hepatology 2012, 56:2209-2220.
146. Boesch-Saadatmandi C., Wagner A.E., Wolffram S., Rimbach G. Effect of quercetin on inflammatory gene expression in mice liver in vivo - role of redox factor 1, miRNA-122 and miRNA-125b. Pharmacol. Res. 2012, 65:523-530.
147. Yin H., Hu M., Zhang R., Shen Z., Flatow L., You M. MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1. J. Biol. Chem. 2012, 287:9817-9826.
148. Wagner A.E., Boesch-Saadatmandi C., Dose J., Schultheiss G., Rimbach G. Anti-inflammatory potential of allyl-isothiocyanate--role of Nrf2, NF-(kappa) B and microRNA-155. J. Cell. Mol. Med. 2012, 16:836-843.
149. Kim Y.J., Hwang S.H., Cho H.H., Shin K.K., Bae Y.C., Jung J.S. MicroRNA 21 regulates the proliferation of human adipose tissue-derived mesenchymal stem cells and high-fat diet-induced obesity alters microRNA 21 expression in white adipose tissues. J. Cell. Physiol. 2012, 227:183-193.
150. Parra P., Serra F., Palou A. Expression of adipose microRNAs is sensitive to dietary conjugated linoleic acid treatment in mice. PLoS One 2010, 5:e13005.
151. Takanabe R., Ono K., Abe Y., Takaya T., Horie T., Wada H., Kita T., Satoh N., Shimatsu A., Hasegawa K. Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem. Biophys. Res. Commun. 2008, 376:728-732.
152. Ng E.K., Chong W.W., Jin H., Lam E.K., Shin V.Y., Yu J., Poon T.C., Ng S.S., Sung J.J. Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening. Gut 2009, 58:1375-1381.
153. Ueda T., Volinia S., Okumura H., Shimizu M., Taccioli C., Rossi S., Alder H., Liu C.G., Oue N., Yasui W., Yoshida K., Sasaki H., Nomura S., Seto Y., Kaminishi M., Calin G.A., Croce C.M. Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol. 2010, 11:136-146.
154. Brase J.C., Johannes M., Schlomm T., Falth M., Haese A., Steuber T., Beissbarth T., Kuner R., Sultmann H. Circulating miRNAs are correlated with tumor progression in prostate cancer. Int. J. Cancer 2011, 128:608-616.
155. Li X., Zhang Y., Ding J., Wu K., Fan D. Survival prediction of gastric cancer by a seven-microRNA signature. Gut 2010, 59:579-585.
156. Bandres E., Cubedo E., Agirre X., Malumbres R., Zarate R., Ramirez N., Abajo A., Navarro A., Moreno I., Monzo M., Garcia-Foncillas J. Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol. Cancer 2006, 5:29.
157. Bloomston M., Frankel W.L., Petrocca F., Volinia S., Alder H., Hagan J.P., Liu C.G., Bhatt D., Taccioli C., Croce C.M. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 2007, 297:1901-1908.
158. Pu X.X., Huang G.L., Guo H.Q., Guo C.C., Li H., Ye S., Ling S., Jiang L., Tian Y., Lin T.Y. Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression. J. Gastroenterol. Hepatol. 2010, 25:1674-1680.
159. Morimura R., Komatsu S., Ichikawa D., Takeshita H., Tsujiura M., Nagata H., Konishi H., Shiozaki A., Ikoma H., Okamoto K., Ochiai T., Taniguchi H., Otsuji E. Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer. Br. J. Cancer 2011, 105:1733-1740.
160. Cheng H., Zhang L., Cogdell D.E., Zheng H., Schetter A.J., Nykter M., Harris C.C., Chen K., Hamilton S.R., Zhang W. Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One 2011, 6:e17745.
161. Gabriely G., Wurdinger T., Kesari S., Esau C.C., Burchard J., Linsley P.S., Krichevsky A.M. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol. Cell. Biol. 2008, 28:5369-5380.
162. Mitchell P.S., Parkin R.K., Kroh E.M., Fritz B.R., Wyman S.K., Pogosova-Agadjanyan E.L., Peterson A., Noteboom J., O'Briant K.C., Allen A., Lin D.W., Urban N., Drescher C.W., Knudsen B.S., Stirewalt D.L., Gentleman R., Vessella R.L., Nelson P.S., Martin D.B., Tewari M. Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:10513-10518.
163. Schaefer A., Jung M., Mollenkopf H.J., Wagner I., Stephan C., Jentzmik F., Miller K., Lein M., Kristiansen G., Jung K. Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma. Int. J. Cancer 2010, 126:1166-1176.
164. Tanaka M., Oikawa K., Takanashi M., Kudo M., Ohyashiki J., Ohyashiki K., Kuroda M. Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients. PLoS One 2009, 4:e5532.
165. Huang Z., Huang D., Ni S., Peng Z., Sheng W., Du X. Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. Int. J. Cancer 2010, 127:118-126.
166. Mahn R., Heukamp L.C., Rogenhofer S., von Ruecker A., Muller S.C., Ellinger J. Circulating microRNAs (miRNA) in serum of patients with prostate cancer. Urology 2011, 77. 1265 e1269-1216.
167. Lodes M.J., Caraballo M., Suciu D., Munro S., Kumar A., Anderson B. Detection of cancer with serum miRNAs on an oligonucleotide microarray. PLoS One 2009, 4:e6229.
168. Heneghan H.M., Miller N., Lowery A.J., Sweeney K.J., Kerin M.J. MicroRNAs as novel biomarkers for breast cancer. J. Oncol. 2009, 2009:950201.
169. Yanaihara N., Caplen N., Bowman E., Seike M., Kumamoto K., Yi M., Stephens R.M., Okamoto A., Yokota J., Tanaka T., Calin G.A., Liu C.G., Croce C.M., Harris C.C. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006, 9:189-198.
170. Spizzo R., Nicoloso M.S., Lupini L., Lu Y., Fogarty J., Rossi S., Zagatti B., Fabbri M., Veronese A., Liu X., Davuluri R., Croce C.M., Mills G., Negrini M., Calin G.A. miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. Cell Death Differ. 2010, 17:246-254.
171. Yu S.L., Chen H.Y., Chang G.C., Chen C.Y., Chen H.W., Singh S., Cheng C.L., Yu C.J., Lee Y.C., Chen H.S., Su T.J., Chiang C.C., Li H.N., Hong Q.S., Su H.Y., Chen C.C., Chen W.J., Liu C.C., Chan W.K., Li K.C., Chen J.J., Yang P.C. MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell 2008, 13:48-57.
172. Roth C., Rack B., Muller V., Janni W., Pantel K., Schwarzenbach H. Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res. 2010, 12:R90.
173. Garofalo M., Di Leva G., Romano G., Nuovo G., Suh S.S., Ngankeu A., Taccioli C., Pichiorri F., Alder H., Secchiero P., Gasparini P., Gonelli A., Costinean S., Acunzo M., Condorelli G., Croce C.M. miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 2009, 16:498-509.
174. Si H., Sun X., Chen Y., Cao Y., Chen S., Wang H., Hu C. Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer. J. Cancer Res. Clin. Oncol. 2013, 139:223-229.
175. Gilad S., Meiri E., Yogev Y., Benjamin S., Lebanony D., Yerushalmi N., Benjamin H., Kushnir M., Cholakh H., Melamed N., Bentwich Z., Hod M., Goren Y., Chajut A. Serum microRNAs are promising novel biomarkers. PLoS One 2008, 3:e3148.
176. Silva J., Garcia V., Zaballos A., Provencio M., Lombardia L., Almonacid L., Garcia J.M., Dominguez G., Pena C., Diaz R., Herrera M., Varela A., Bonilla F. Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival. Eur. Respir. J. 2011, 37:617-623.
177. Murata K., Yoshitomi H., Tanida S., Ishikawa M., Nishitani K., Ito H., Nakamura T. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res. Ther. 2010, 12:R86.
178. Fichtlscherer S., De Rosa S., Fox H., Schwietz T., Fischer A., Liebetrau C., Weber M., Hamm C.W., Roxe T., Muller-Ardogan M., Bonauer A., Zeiher A.M., Dimmeler S. Circulating microRNAs in patients with coronary artery disease. Circ. Res. 2010, 107:677-684.
179. Zahm A.M., Thayu M., Hand N.J., Horner A., Leonard M.B., Friedman J.R. Circulating microRNA is a biomarker of pediatric Crohn disease. J. Pediatr. Gastroenterol. Nutr. 2011, 53:26-33.
180. Karolina D.S., Armugam A., Tavintharan S., Wong M.T., Lim S.C., Sum C.F., Jeyaseelan K. MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus. PLoS One 2011, 6:e22839.
181. Cogswell J.P., Ward J., Taylor I.A., Waters M., Shi Y., Cannon B., Kelnar K., Kemppainen J., Brown D., Chen C., Prinjha R.K., Richardson J.C., Saunders A.M., Roses A.D., Richards C.A. Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J. Alzheimers Dis. 2008, 14:27-41.
182. Mizuno H., Nakamura A., Aoki Y., Ito N., Kishi S., Yamamoto K., Sekiguchi M., Takeda S., Hashido K. Identification of muscle-specific microRNAs in serum of muscular dystrophy animal models: promising novel blood-based markers for muscular dystrophy. PLoS One 2011, 6:e18388.
183. Abu-Halima M., Hammadeh M., Schmitt J., Leidinger P., Keller A., Meese E., Backes C. Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments. Fertil. Steril. 2013, 99:1249-1255. e1216.
184. Liu T., Cheng W., Gao Y., Wang H., Liu Z. Microarray analysis of microRNA expression patterns in the semen of infertile men with semen abnormalities. Mol. Med. Rep. 2012, 6:535-542.
185. Wu W., Hu Z., Qin Y., Dong J., Dai J., Lu C., Zhang W., Shen H., Xia Y., Wang X. Seminal plasma microRNAs: potential biomarkers for spermatogenesis status. Mol. Hum. Reprod. 2012, 18:489-497.