Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated atherosclerosis

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  States, J Christopher ^a,b   Singh, Amar V ^b,f   Knudsen, Thomas B ^b,e   Rouchka, Eric C ^b,c   Ngalame, Ntube O ^a,g   Arteel, Gavin E ^a,b   Piao, Yulan ^d   Ko, Minoru S H ^d  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c University of Louisville   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^f SYNGENTA BIOTECHNOLOGY INC   (United States)

^g NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ARSENIC; ASPARTATE AMINOTRANSFERASE; CYCLIN DEPENDENT KINASE INHIBITOR 2D; E1A ASSOCIATED P300 PROTEIN; HEAT SHOCK PROTEIN 70; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HOMEOBOX C8; HOMEODOMAIN PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M; MESSENGER RNA; MICRORNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARMET GENE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATHEROSCLEROSIS; BINDING SITE; CDCA5 GENE; CDKN2D GENE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FETUS; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; GLUCONEOGENESIS; GLYCOLYSIS; INFLAMMATION; KPNB1 GENE; LIVER DEVELOPMENT; LIVER INJURY; MALE; MICROARRAY ANALYSIS; MOUSE; NEWBORN; NONHUMAN; OSGEP GENE; PHENOTYPE; POSTNATAL DEVELOPMENT; PRENATAL EXPOSURE; PROTEIN EXPRESSION; PROTEIN METABOLISM; SEC23B GENE; SREBP1 GENE; TRANSCRIPTOMICS;

ANIMALS; ARSENIC; ATHEROSCLEROSIS; BLOTTING, WESTERN; FEMALE; GENE EXPRESSION REGULATION; LIVER; MICE; MICE, KNOCKOUT; MICRORNAS; MODELS, ANIMAL; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RNA, MESSENGER;

EID: 84862490178     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038713     Document Type: Article

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