Urinary MicroRNA-10a and MicroRNA-30d Serve as Novel, Sensitive and Specific Biomarkers for Kidney Injury

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Wang, Nan ^a   Zhou, Yang ^b   Jiang, Lei ^b   Li, Donghai ^a   Yang, Junwei ^b   Zhang, Chen Yu ^a   Zen, Ke ^a  

^a NANJING UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 10A; MICRORNA 30D; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE MARKER; EARLY DIAGNOSIS; FOCAL GLOMERULOSCLEROSIS; HIGH THROUGHPUT SCREENING; HUMAN; KIDNEY INJURY; KIDNEY ISCHEMIA; MALE; MOUSE; NONHUMAN; QUANTITATIVE STUDY; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SENSITIVITY AND SPECIFICITY; STREPTOZOCIN DIABETES; UPREGULATION; UREA NITROGEN BLOOD LEVEL;

ANIMALS; BIOLOGICAL MARKERS; BLOOD UREA NITROGEN; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION REGULATION; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; ISCHEMIA; KIDNEY; KIDNEY DISEASES; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; REPERFUSION INJURY; STREPTOZOCIN;

EID: 84871347378     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051140     Document Type: Article

References (36)

1. Gilbertson DT, Liu J, Xue JL, Louis TA, Solid CA, et al. (2005) Projecting the number of patients with end-stage renal disease in the United States to the year 2015. J Am Soc Nephrol 16: 3736-3741.
2. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, et al. (2005) Acute renal failure in critically ill patients: a multinational, multicenter study. Jama 294: 813-818.
3. Dieterle F, Marrer E, Suzuki E, Grenet O, Cordier A, et al. (2008) Monitoring kidney safety in drug development: emerging technologies and their implications. Curr Opin Drug Discov Devel 11: 60-71.
4. Hewitt SM, Dear J, Star RA, (2004) Discovery of protein biomarkers for renal diseases. J Am Soc Nephrol 15: 1677-1689.
5. Vaidya VS, Ford GM, Waikar SS, Wang Y, Clement MB, et al. (2009) A rapid urine test for early detection of kidney injury. Kidney Int 76: 108-114.
6. Vaidya VS, Ozer JS, Dieterle F, Collings FB, Ramirez V, et al. (2010) Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol 28: 478-485.
7. Lorenzen JM, Haller H, Thum T, (2011) MicroRNAs as mediators and therapeutic targets in chronic kidney disease. Nat Rev Nephrol 7: 286-294.
8. Shi S, Yu L, Chiu C, Sun Y, Chen J, et al. (2008) Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol 19: 2159-2169.
9. Ho J, Ng KH, Rosen S, Dostal A, Gregory RI, et al. (2008) Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol 19: 2069-2075.
10. Kato M, Zhang J, Wang M, Lanting L, Yuan H, et al. (2007) MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A 104: 3432-3437.
11. Godwin JG, Ge X, Stephan K, Jurisch A, Tullius SG, et al. (2010) Identification of a microRNA signature of renal ischemia reperfusion injury. Proc Natl Acad Sci U S A 107: 14339-14344.
12. Chen X, Ba Y, Ma L, Cai X, Yin Y, et al. (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18: 997-1006.
13. Li LM, Hu ZB, Zhou ZX, Chen X, Liu FY, et al. (2010) Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res 70: 9798-9807.
14. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, et al. (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 105: 10513-10518.
15. Contu R, Latronico MV, Condorelli G, (2010) Circulating microRNAs as potential biomarkers of coronary artery disease: a promise to be fulfilled? Circ Res 107: 573-574.
16. Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, et al. (2010) Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circ Res 107: 810-817.
17. Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, et al. (2009) Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci U S A 106: 4402-4407.
18. Fichtlscherer S, De Rosa S, Fox H, Schwietz T, Fischer A, et al. (2010) Circulating microRNAs in patients with coronary artery disease. Circ Res 107: 677-684.
19. Chim SS, Shing TK, Hung EC, Leung TY, Lau TK, et al. (2008) Detection and characterization of placental microRNAs in maternal plasma. Clin Chem 54: 482-490.
20. Wang G, Tam L, Li EK, Kwan BC, Chow K, et al. (2012) Serum and urinary free microRNA level in patients with systemic lupus erythematosus. Lupus 21 (11):: 1190-5.
21. Kumar S, Allen DA, Kieswich JE, Patel NS, Harwood S, et al. (2009) Dexamethasone ameliorates renal ischemia-reperfusion injury. J Am Soc Nephrol 20: 2412-2425.
22. Chow FY, Nikolic-Paterson DJ, Ozols E, Atkins RC, Rollin BJ, et al. (2006) Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice. Kidney Int 69: 73-80.
23. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, et al. (2005) Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33: e179.
24. Ho J, Pandey P, Schatton T, Sims-Lucas S, Khalid M, et al. (2011) The Pro-Apoptotic Protein Bim Is a MicroRNA Target in Kidney Progenitors. J Am Soc Nephrol 22: 1053-1063.
25. Girard M, Jacquemin E, Munnich A, Lyonnet S, Henrion-Caude A, (2008) miR-122, a paradigm for the role of microRNAs in the liver. J Hepatol 48: 648-656.
26. Ko GJ, Grigoryev DN, Linfert D, Jang HR, Watkins T, et al. (2010) Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition. Am J Physiol Renal Physiol 298: F1472-1483.
27. Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, et al. (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14: 2534-2543.
28. Jiang T, Huang Z, Lin Y, Zhang Z, Fang D, et al. (2010) The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes 59: 850-860.
29. Westhuyzen J, Endre ZH, Reece G, Reith DM, Saltissi D, et al. (2003) Measurement of tubular enzymuria facilitates early detection of acute renal impairment in the intensive care unit. Nephrol Dial Transplant 18: 543-551.
30. Zen K, Zhang CY, (2012) Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers. Med Res Rev 32 (2):: 326-48.
31. Lorenzen JM, Volkmann I, Fiedler J, Schmidt M, Scheffner I, et al. (2011) Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients. Am J Transplant 11: 2221-2227.
32. Xue X, Feng T, Yao S, Wolf KJ, Liu CG, et al. (2011) Microbiota Downregulates Dendritic Cell Expression of miR-10a, Which Targets IL-12/IL-23p40. J Immunol 187: 5879-5886.
33. Ho J, Pandey P, Schatton T, Sims-Lucas S, Khalid M, et al. (2011) The pro-apoptotic protein Bim is a microRNA target in kidney progenitors. J Am Soc Nephrol 22: 1053-1063.
34. Li N, Kaur S, Greshock J, Lassus H, Zhong X, et al. (2011) A combined array-based comparative genomic hybridization (aCGH) and functional library screening approach identifies mir-30d as an oncomir in cancer. Cancer Res 72 (1):: 154-64.
35. Kumar M, Lu Z, Takwi AA, Chen W, Callander NS, et al. (2011) Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene 30: 843-853.
36. Waltering KK, Porkka KP, Jalava SE, Urbanucci A, Kohonen PJ, et al. (2011) Androgen regulation of micro-RNAs in prostate cancer. Prostate 71: 604-614.