메뉴 건너뛰기




Volumn 1, Issue 1, 2012, Pages 23-31

Epigenetics - Relevance to drug safety science

Author keywords

[No Author keywords available]

Indexed keywords

DNA; UNTRANSLATED RNA; XENOBIOTIC AGENT;

EID: 84877931024     PISSN: 2045452X     EISSN: 20454538     Source Type: Journal    
DOI: 10.1039/c2tx00003b     Document Type: Review
Times cited : (14)

References (75)
  • 1
    • 33847032960 scopus 로고    scopus 로고
    • The mammalian epigenome
    • DOI 10.1016/j.cell.2007.01.033, PII S0092867407001286
    • B. E. Bernstein A. Meissner E. S. Lander The mammalian epigenome Cell 2007 128 669 681 (Pubitemid 46273573)
    • (2007) Cell , vol.128 , Issue.4 , pp. 669-681
    • Bernstein, B.E.1    Meissner, A.2    Lander, E.S.3
  • 2
    • 5444255150 scopus 로고    scopus 로고
    • The epigenetics of cancer etiology
    • DOI 10.1016/j.semcancer.2004.06.005, PII S1044579X04000483
    • A. P. Feinberg The epigenetics of cancer etiology Semin. Cancer Biol. 2004 14 6 427 432 (Pubitemid 39360990)
    • (2004) Seminars in Cancer Biology , vol.14 , Issue.6 , pp. 427-432
    • Feinberg, A.P.1
  • 4
    • 39749115590 scopus 로고    scopus 로고
    • Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: Studies in rodents
    • DOI 10.1002/em.20342
    • I. P. Pogribny I. Rusyn F. A. Beland Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents Environ. Mol. Mutagen. 2008 49 1 9 15 (Pubitemid 351293008)
    • (2008) Environmental and Molecular Mutagenesis , vol.49 , Issue.1 , pp. 9-15
    • Pogribny, I.P.1    Rusyn, I.2    Beland, F.A.3
  • 5
    • 84877931190 scopus 로고    scopus 로고
    • HESI
    • HESI, 2010, http://www.hesiglobal.org/files/public/ 2010%20Annual%20Meeting/Presentations/EI/05-Augustine-Epigenetics.pdf
    • (2010)
  • 6
    • 34447260528 scopus 로고    scopus 로고
    • A new paradigm in toxicology and teratology: Altering gene activity in the absence of DNA sequence variation
    • DOI 10.1016/j.reprotox.2007.05.002, PII S0890623807001785, Includes a Special Issue Section on the 35th Annual Conference of the European Teratology Society
    • S. M. Reamon-Buettner J. Borlak A new paradigm in toxicology and teratology: altering gene activity in the absence of DNA sequence variation Reprod. Toxicol. 2007 24 1 20 30 (Pubitemid 47042357)
    • (2007) Reproductive Toxicology , vol.24 , Issue.1 , pp. 20-30
    • Reamon-Buettner, S.M.1    Borlak, J.2
  • 7
    • 35448985442 scopus 로고    scopus 로고
    • The dynamic epigenome and its implications in toxicology
    • DOI 10.1093/toxsci/kfm177
    • M. Szyf The dynamic epigenome and its implications in toxicology Toxicol. Sci. 2007 100 1 7 23 (Pubitemid 47617798)
    • (2007) Toxicological Sciences , vol.100 , Issue.1 , pp. 7-23
    • Szyf, M.1
  • 9
    • 77955272554 scopus 로고    scopus 로고
    • Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and embryotoxicity
    • A. M. Osman D. A. van Dartel E. Zwart M. Blokland J. L. Pennings A. H. Piersma Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and embryotoxicity Reprod. Toxicol. 2010 30 2 322 332
    • (2010) Reprod. Toxicol. , vol.30 , Issue.2 , pp. 322-332
    • Osman, A.M.1    Van Dartel, D.A.2    Zwart, E.3    Blokland, M.4    Pennings, J.L.5    Piersma, A.H.6
  • 10
    • 77950023356 scopus 로고    scopus 로고
    • Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment
    • J. E. Trosko C. C. Chang Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment Toxicology 2010 270 1 18 34
    • (2010) Toxicology , vol.270 , Issue.1 , pp. 18-34
    • Trosko, J.E.1    Chang, C.C.2
  • 14
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • P. W. Laird The power and the promise of DNA methylation markers Nat. Rev. Cancer 2003 3 4 253 266 (Pubitemid 37328861)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.4 , pp. 253-266
    • Laird, P.W.1
  • 15
    • 0042386500 scopus 로고    scopus 로고
    • DNA methylation analysis techniques
    • DOI 10.1023/A:1025103319328
    • C. Dahl P. Guldberg DNA methylation analysis techniques Biogerontology 2003 4 4 233 250 (Pubitemid 37098463)
    • (2003) Biogerontology , vol.4 , Issue.4 , pp. 233-250
    • Dahl, C.1    Guldberg, P.2
  • 16
    • 34247136384 scopus 로고    scopus 로고
    • Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: An emphasis on fetal-based adult diseases
    • S. M. Ho W. Y. Tang Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases Reprod. Toxicol. 2007 23 3 267 282
    • (2007) Reprod. Toxicol. , vol.23 , Issue.3 , pp. 267-282
    • Ho, S.M.1    Tang, W.Y.2
  • 20
    • 0030776825 scopus 로고    scopus 로고
    • Two dominant mutations in the mouse Fused gene are the result of transposon insertions
    • T. J. Vasicek L. Zeng X. J. Guan T. Zhang F. Costantini S. M. Tilghman Two dominant mutations in the mouse fused gene are the result of transposon insertions Genetics 1997 147 777 786 (Pubitemid 27418585)
    • (1997) Genetics , vol.147 , Issue.2 , pp. 777-786
    • Vasicek, T.J.1    Zeng, L.2    Guan, X.-J.3    Zhang, T.4    Costantini, F.5    Tilghman, S.M.6
  • 21
    • 7444264729 scopus 로고    scopus 로고
    • Complex patterns of transcription at the insertion site of a retrotransposon in the mouse
    • DOI 10.1093/nar/gkh914
    • R. Druker T. J. Bruxner N. J. Lehrbach E. Whitelaw Complex patterns of transcription at the insertion site of a retrotransposon in the mouse Nucleic Acids Res. 2004 32 5800 5808 (Pubitemid 39619162)
    • (2004) Nucleic Acids Research , vol.32 , Issue.19 , pp. 5800-5808
    • Druker, R.1    Bruxner, T.J.2    Lehrbach, N.J.3    Whitelaw, E.4
  • 22
    • 0043093697 scopus 로고    scopus 로고
    • Transposable elements: Targets for early nutritional effects on epigenetic gene regulation
    • DOI 10.1128/MCB.23.15.5293-5300.2003
    • R. A. Waterland R. L. Jirtle Transposable elements: targets for early nutritional effects on epigenetic gene regulation Mol. Cell. Biol. 2003 23 5293 5300 (Pubitemid 36950884)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.15 , pp. 5293-5300
    • Waterland, R.A.1    Jirtle, R.L.2
  • 23
    • 33645633542 scopus 로고    scopus 로고
    • Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome
    • D. C. Dolinoy J. R. Weidman R. A. Waterland R. L. Jirtle Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome Environ. Health Perspect. 2006 114 567 572
    • (2006) Environ. Health Perspect. , vol.114 , pp. 567-572
    • Dolinoy, D.C.1    Weidman, J.R.2    Waterland, R.A.3    Jirtle, R.L.4
  • 24
    • 0031873353 scopus 로고    scopus 로고
    • Maternal epigenetics and methyl supplements affect agouti gene expression in A(vy)/a mice
    • G. L. Wolff R. L. Kodell S. R. Moore C. A. Cooney Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice FASEB J. 1998 12 949 957 (Pubitemid 28359576)
    • (1998) FASEB Journal , vol.12 , Issue.11 , pp. 949-957
    • Wolff, G.L.1    Kodell, R.L.2    Moore, S.R.3    Cooney, C.A.4
  • 25
    • 0347123629 scopus 로고    scopus 로고
    • Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
    • DOI 10.1016/j.nut.2003.09.011
    • R. A. Waterland R. L. Jirtle Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases Nutrition 2004 20 63 68 (Pubitemid 38091581)
    • (2004) Nutrition , vol.20 , Issue.1 , pp. 63-68
    • Waterland, R.A.1    Jirtle, R.L.2
  • 26
    • 0036322831 scopus 로고    scopus 로고
    • Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring
    • C. A. Cooney A. A. Dave G. L. Wolff Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring J. Nutr. 2002 132 2393S 2400S (Pubitemid 34848114)
    • (2002) Journal of Nutrition , vol.132 , Issue.8 SUPPL.
    • Cooney, C.A.1    Dave, A.A.2    Wolff, G.L.3
  • 29
    • 78649664485 scopus 로고    scopus 로고
    • Structural insights into histone lysine demethylation
    • H. Hou H. Yu Structural insights into histone lysine demethylation Curr. Opin. Struct. Biol. 2010 20 6 739 748
    • (2010) Curr. Opin. Struct. Biol. , vol.20 , Issue.6 , pp. 739-748
    • Hou, H.1    Yu, H.2
  • 32
    • 37749047490 scopus 로고    scopus 로고
    • Sequence census methods for functional genomics
    • B. Wold R. M. Myers Sequence census methods for functional genomics Nat. Methods 2008 5 19 21
    • (2008) Nat. Methods , vol.5 , pp. 19-21
    • Wold, B.1    Myers, R.M.2
  • 34
    • 73749088654 scopus 로고    scopus 로고
    • Epigenetic opportunities and challenges in cancer
    • J. D. Best N. Carey Epigenetic opportunities and challenges in cancer Drug Discovery Today 2010 15 65 70
    • (2010) Drug Discovery Today , vol.15 , pp. 65-70
    • Best, J.D.1    Carey, N.2
  • 35
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • D. P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 2004 116 281 297
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 36
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • DOI 10.1016/j.cell.2004.12.035, PII S0092867404012607
    • B. P. Lewis C. B. Burge D. P. Bartel Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 2005 120 1 15 20 (Pubitemid 40094598)
    • (2005) Cell , vol.120 , Issue.1 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 37
    • 33749516448 scopus 로고    scopus 로고
    • MicroRNAs and chromosomal abnormalities in cancer cells
    • DOI 10.1038/sj.onc.1209910, PII 1209910
    • G. A. Calin C. M. Croce MicroRNAs and chromosomal abnormalities in cancer cells Oncogene 2006 25 6202 6210 (Pubitemid 44527851)
    • (2006) Oncogene , vol.25 , Issue.46 , pp. 6202-6210
    • Calin, G.A.1    Croce, C.M.2
  • 38
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • DOI 10.1038/nrc1997, PII NRC1997
    • G. A. Calin C. M. Croce MicroRNA signatures in human cancers Nat. Rev. Cancer 2006 6 857 866 (Pubitemid 44629897)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 39
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - MicroRNAs with a role in cancer
    • A. Esquela-Kerscher F. J. Slack Oncomirs - microRNAs with a role in cancer Nat. Rev. Cancer 2006 6 259 269
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 40
    • 77951190661 scopus 로고    scopus 로고
    • Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression
    • A. Git H. Dvinge M. Salmon-Divon M. Osborne C. Kutter J. Hadfield P. Bertone C. Caldas Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression RNA 2010 16 5 991 1006
    • (2010) RNA , vol.16 , Issue.5 , pp. 991-1006
    • Git, A.1    Dvinge, H.2    Salmon-Divon, M.3    Osborne, M.4    Kutter, C.5    Hadfield, J.6    Bertone, P.7    Caldas, C.8
  • 41
    • 0141618477 scopus 로고    scopus 로고
    • The long (LINEs) and the short (SINEs) of it: Altered methylation as a precursor to toxicity
    • DOI 10.1093/toxsci/kfg138
    • A. N. Carnell J. I. Goodman The long (LINEs) and the short (SINEs) of it: altered methylation as a precursor to toxicity Toxicol. Sci. 2003 75 2 229 235 (Pubitemid 37220270)
    • (2003) Toxicological Sciences , vol.75 , Issue.2 , pp. 229-235
    • Carnell, A.N.1    Goodman, J.I.2
  • 42
    • 0036561649 scopus 로고    scopus 로고
    • Altered methylation patterns in cancer cell genomes: Cause or consequence?
    • DOI 10.1016/S1535-6108(02)00061-2
    • S. Baylin T. H. Bestor Altered methylation patterns in cancer cell genomes: cause or consequence? Cancer Cell 2002 1 4 299 305 (Pubitemid 41039130)
    • (2002) Cancer Cell , vol.1 , Issue.4 , pp. 299-305
    • Baylin, S.1    Bestor, T.H.2
  • 43
    • 34247109637 scopus 로고    scopus 로고
    • Epigenetic gene regulation: Linking early developmental environment to adult disease
    • DOI 10.1016/j.reprotox.2006.08.012, PII S0890623806001973
    • D. C. Dolinoy J. R. Weidman R. L. Jirtle Epigenetic gene regulation: linking early developmental environment to adult disease Reprod. Toxicol. 2007 23 3 297 307 (Pubitemid 46602921)
    • (2007) Reproductive Toxicology , vol.23 , Issue.3 , pp. 297-307
    • Dolinoy, D.C.1    Weidman, J.R.2    Jirtle, R.L.3
  • 44
    • 1842817557 scopus 로고    scopus 로고
    • Perturbation of epigenetic status by toxicants
    • DOI 10.1016/j.toxlet.2004.01.003, PII S037842740400013X
    • V. Bombail J. G. Moggs G. Orphanides Perturbation of epigenetic status by toxicants Toxicol. Lett. 2004 149 1-3 51 58 (Pubitemid 38469820)
    • (2004) Toxicology Letters , vol.149 , Issue.1-3 , pp. 51-58
    • Bombail, V.1    Moggs, J.G.2    Orphanides, G.3
  • 45
    • 0033566770 scopus 로고    scopus 로고
    • Frequent deletion of hSNF5/INI1, a component of the SWI/SNF complex, in chronic myeloid leukemia
    • F. Grand S. Kulkarni A. Chase J. M. Goldman M. Gordon N. C. Cross Frequent deletion of hSNF5/INI1, a component of the SWI/SNF complex, in chronic myeloid leukemia Cancer Res. 1999 59 16 3870 3874 (Pubitemid 29393542)
    • (1999) Cancer Research , vol.59 , Issue.16 , pp. 3870-3874
    • Grand, F.1    Kulkarni, S.2    Chase, A.3    Goldman, J.M.4    Gordon, M.5    Cross, N.C.P.6
  • 46
    • 0037960155 scopus 로고    scopus 로고
    • Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation
    • DOI 10.1016/S0014-4827(03)00062-4
    • M. Takiguchi W. E. Achanzar W. Qu G. Li M. P. Waalkes Effects of cadmium on DNA-(cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation Exp. Cell Res. 2003 286 355 365 (Pubitemid 36566447)
    • (2003) Experimental Cell Research , vol.286 , Issue.2 , pp. 355-365
    • Takiguchi, M.1    Achanzar, W.E.2    Qu, W.3    Li, G.4    Waalkes, M.P.5
  • 48
    • 49249116407 scopus 로고    scopus 로고
    • A work in progress: The clinical development of histone deacetylase inhibitors
    • S. Marsoni G. Damia G. Camboni A work in progress: the clinical development of histone deacetylase inhibitors Epigenetics 2008 3 3 164 171
    • (2008) Epigenetics , vol.3 , Issue.3 , pp. 164-171
    • Marsoni, S.1    Damia, G.2    Camboni, G.3
  • 53
    • 0030819981 scopus 로고    scopus 로고
    • Interaction of [glutarimide-2-14C]thalidomide with rat embryonic DNA in vivo
    • DOI 10.1002/(SICI)1520-6866(1997)17:1<1::AID-TCM2>3.0.CO;2-L
    • P. H. T. Huang W. G. McBride Interaction of [glutarimide-2-14C] thalidomide with rat embryonic DNA in vivo Teratog., Carcinog. Mutagen. 1997 17 1 5 (Pubitemid 27323182)
    • (1997) Teratogenesis Carcinogenesis and Mutagenesis , vol.17 , Issue.1 , pp. 1-5
    • Huang, P.H.T.1    McBride, W.G.2
  • 55
    • 33645357786 scopus 로고    scopus 로고
    • Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
    • N. M. Tsankova O. Berton W. Renthal A. Kumar R. L. Neve E. J. Nestler Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action Nat. Neurosci. 2006 9 519 525
    • (2006) Nat. Neurosci. , vol.9 , pp. 519-525
    • Tsankova, N.M.1    Berton, O.2    Renthal, W.3    Kumar, A.4    Neve, R.L.5    Nestler, E.J.6
  • 56
    • 70349751583 scopus 로고    scopus 로고
    • Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology
    • A. B. Csoka M. Szyf Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology Med. Hypotheses 2009 73 5 770 780
    • (2009) Med. Hypotheses , vol.73 , Issue.5 , pp. 770-780
    • Csoka, A.B.1    Szyf, M.2
  • 57
    • 78449257438 scopus 로고    scopus 로고
    • Systems properties of proteins encoded by imprinted genes
    • K. S. Sandhu Systems properties of proteins encoded by imprinted genes Epigenetics 2010 5 7 627 636
    • (2010) Epigenetics , vol.5 , Issue.7 , pp. 627-636
    • Sandhu, K.S.1
  • 58
    • 33646793302 scopus 로고    scopus 로고
    • Epigenetics, evolution, endocrine disruption, health, and disease
    • D. Crews J. A. McLachlan Epigenetics, evolution, endocrine disruption, health, and disease Endocrinology 2006 147 6 S4 S10
    • (2006) Endocrinology , vol.147 , Issue.6
    • Crews, D.1    McLachlan, J.A.2
  • 59
    • 33751533712 scopus 로고    scopus 로고
    • Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease
    • DOI 10.1210/en.2006-0640
    • M. D. Anway C. Leathers M. K. Skinner Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease Endocrinology 2006 147 5515 5523 (Pubitemid 44833467)
    • (2006) Endocrinology , vol.147 , Issue.12 , pp. 5515-5523
    • Anway, M.D.1    Leathers, C.2    Skinner, M.K.3
  • 60
    • 0031711585 scopus 로고    scopus 로고
    • Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol
    • DOI 10.1093/carcin/19.9.1655
    • R. R. Newbold R. B. Hanson W. N. Jefferson B. C. Bullock J. Haseman J. A. McLachlan Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol Carcinogenesis 1998 19 1655 1663 (Pubitemid 28441870)
    • (1998) Carcinogenesis , vol.19 , Issue.9 , pp. 1655-1663
    • Newbold, R.R.1    Hanson, R.B.2    Jefferson, W.N.3    Bullock, B.C.4    Haseman, J.5    McLachlan, J.A.6
  • 61
    • 0033922097 scopus 로고    scopus 로고
    • Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol
    • R. R. Newbold R. B. Hanson W. N. Jefferson B. C. Bullock J. Haseman J. A. McLachlan Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol Carcinogenesis 2000 21 1355 1363 (Pubitemid 30455995)
    • (2000) Carcinogenesis , vol.21 , Issue.7 , pp. 1355-1363
    • Newbold, R.R.1    Hanson, R.B.2    Jefferson, W.N.3    Bullock, B.C.4    Haseman, J.5    McLachlan, J.A.6
  • 62
    • 33751512673 scopus 로고    scopus 로고
    • Transgenerational epigenetic imprinting of the male germline by endocrine disruptor exposure during gonadal sex determination
    • H. S. Chang M. D. Anway S. S. Rekow M. K. Skinner Transgenerational epigenetic imprinting of the male germline by endocrine disruptor exposure during gonadal sex determination Endocrinology 2006 147 12 5524 5541
    • (2006) Endocrinology , vol.147 , Issue.12 , pp. 5524-5541
    • Chang, H.S.1    Anway, M.D.2    Rekow, S.S.3    Skinner, M.K.4
  • 64
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • DOI 10.1016/j.pharmthera.2007.09.004, PII S016372580700201X
    • M. Ingelman-Sundberg S. C. Sim A. Gomez C. Rodriguez-Antona Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects Pharmacol. Ther. 2007 116 3 496 526 (Pubitemid 350116943)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.3 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 65
    • 0035816343 scopus 로고    scopus 로고
    • Specific site methylation in the 5′-flanking region of CYP1A2: Interindividual differences in human livers
    • DOI 10.1016/S0024-3205(01)01175-4, PII S0024320501011754
    • G. J. Hammons Y. Yan-Sanders B. Jin E. Blann F. F. Kadlubar B. D. Lyn-Cook Specific site methylation in the 5′-flanking region of CYP1A2 interindividual differences in human livers Life Sci. 2001 69 7 839 845 (Pubitemid 32619196)
    • (2001) Life Sciences , vol.69 , Issue.7 , pp. 839-845
    • Hammons, G.J.1    Yan-Sanders, Y.2    Jin, B.3    Blann, E.4    Kadlubar, F.F.5    Lyn-Cook, B.D.6
  • 67
    • 79951777299 scopus 로고    scopus 로고
    • Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells
    • W. Habano T. Gamo J. Terashima T. Sugai K. Otsuka G. Wakabayashi S. Ozawa Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells BMC Cancer 2011 11 81
    • (2011) BMC Cancer , vol.11 , pp. 81
    • Habano, W.1    Gamo, T.2    Terashima, J.3    Sugai, T.4    Otsuka, K.5    Wakabayashi, G.6    Ozawa, S.7
  • 68
    • 77449136592 scopus 로고    scopus 로고
    • Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment
    • C. Rodriguez-Antona A. Gomez M. Karlgren S. C. Sim M. Ingelman-Sundberg Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment Hum. Genet. 2010 127 1 1 17
    • (2010) Hum. Genet. , vol.127 , Issue.1 , pp. 1-17
    • Rodriguez-Antona, C.1    Gomez, A.2    Karlgren, M.3    Sim, S.C.4    Ingelman-Sundberg, M.5
  • 69
    • 34548631473 scopus 로고    scopus 로고
    • HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation
    • DOI 10.1016/j.bbaexp.2007.07.002, PII S0167478107001236
    • M. Schnekenburger L. Peng A. Puga HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation Biochim. Biophys. Acta, Gene Struct. Expression 2007 1769 9-10 569 578 (Pubitemid 47404659)
    • (2007) Biochimica et Biophysica Acta - Gene Structure and Expression , vol.1769 , Issue.9-10 , pp. 569-578
    • Schnekenburger, M.1    Peng, L.2    Puga, A.3
  • 70
    • 1942471702 scopus 로고    scopus 로고
    • Epigenetics and cancer: Implications for drug discovery and safety assessment
    • DOI 10.1016/j.taap.2004.01.009, PII S0041008X04000596
    • J. G. Moggs J. I. Goodman J. E. Trosko R. A. Roberts Epigenetics and cancer: implications for drug discovery and safety assessment Toxicol. Appl. Pharmacol. 2004 196 3 422 430 (Pubitemid 38496465)
    • (2004) Toxicology and Applied Pharmacology , vol.196 , Issue.3 , pp. 422-430
    • Moggs, J.G.1    Goodman, J.I.2    Trosko, J.E.3    Roberts, R.A.4
  • 71
    • 0036094163 scopus 로고    scopus 로고
    • Epigenetics and DNA methylation come of age in toxicology
    • R. E. Watson J. I. Goodman Epigenetics and DNA methylation come of age in toxicology Toxicol. Sci. 2002 67 11 16 (Pubitemid 34520804)
    • (2002) Toxicological Sciences , vol.67 , Issue.1 , pp. 11-16
    • Watson, R.E.1    Goodman, J.I.2
  • 72
    • 77956183702 scopus 로고    scopus 로고
    • Epigenetic effects of chemicals not ready for regulatory "primetime"
    • E. Buckley Epigenetic effects of chemicals not ready for regulatory "primetime" Pestic. Toxic Chem. News 2009 37
    • (2009) Pestic. Toxic Chem. News , pp. 37
    • Buckley, E.1
  • 73
    • 77956185838 scopus 로고    scopus 로고
    • Chemicals can turn genes on and off; New tests needed, scientists say
    • (2009) August 3
    • B. Hileman, Chemicals can turn genes on and off; new tests needed, scientists say, Environ. Health News, 2009, (2009) August 3
    • (2009) Environ. Health News
    • Hileman, B.1
  • 74
    • 0029451066 scopus 로고
    • The use of biological data in addition to the carcinogen bioassay in quantitative risk assessment
    • R. J. Scheuplein The use of biological data in addition to the carcinogen bioassay in quantitative risk assessment Prog. Clin. Biol. Res. 1995 391 347 357
    • (1995) Prog. Clin. Biol. Res. , vol.391 , pp. 347-357
    • Scheuplein, R.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.