Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Shizu, Ryota ^a   Benoki, Satoshi ^a   Numakura, Yuki ^a   Kodama, Susumu ^a   Miyata, Masaaki ^a   Yamazoe, Yasushi ^a   Yoshinari, Kouichi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS(3,5 DICHLORO 2 PYRIDYLOXY)BENZENE; 16ALPHA CYANOPREGNENOLONE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYCLIN B1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYTOCHROME P450; CYTOCHROME P450 2B10; CYTOCHROME P450 3A11; CYTOCHROME P450 4A10; F BOX PROTEIN; KI 67 ANTIGEN; MESSENGER RNA; MINICHROMOSOME MAINTENANCE PROTEIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHENOBARBITAL; PIRINIXIC ACID; PREGNANE X RECEPTOR; PROTEIN P130; RNA; S PHASE KINASE ASSOCIATED PROTEIN 2; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; 1,4-BIS(2-(3,5-DICHLOROPYRIDYLOXY))BENZENE; CELL RECEPTOR; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; STEROID RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; LIVER CARCINOGENESIS; LIVER CELL; LIVER HYPERPLASIA; MALE; MOUSE; NONHUMAN; PHASE TRANSITION; RECEPTOR UPREGULATION; RNA ANALYSIS; WILD TYPE; AGONISTS; ANIMAL; C57BL MOUSE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INTRAPERITONEAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; LIVER; METABOLISM; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION;

MUS; RODENTIA;

ANIMALS; CELL PROLIFERATION; GENE EXPRESSION REGULATION; HEPATOCYTES; INJECTIONS, INTRAPERITONEAL; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOBARBITAL; PPAR ALPHA; PREGNENOLONE CARBONITRILE; PRIMARY CELL CULTURE; PYRIDINES; PYRIMIDINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SIGNAL TRANSDUCTION; XENOBIOTICS;

EID: 84876559530     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061802     Document Type: Article

References (37)

1. Timsit YE, Negishi M, (2007) CAR and PXR: the xenobiotic-sensing receptors. Steroids 72: 231-246.
2. Handschin C, Meyer UA, (2003) Induction of drug metabolism: the role of nuclear receptors. Pharmacol Rev 55: 649-673.
3. Willson TM, Kliewer SA, (2002) PXR, CAR and drug metabolism. Nat Rev Drug Discov 1: 259-266.
4. Konno Y, Negishi M, Kodama S, (2008) The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. Drug Metab Pharmacokinet 23: 8-13.
5. Gao J, Xie W, (2010) Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism. Drug Metab Dispos 38: 2091-2095.
6. Butler WH, (1978) Long-term effects of phenobarbitone-Na on male Fischer rats. Br J Cancer 37: 418-423.
7. Williams GM, Whysner J, (1996) Epigenetic carcinogens: evaluation and risk assessment. Exp Toxicol Pathol 48: 189-195.
8. Yamamoto Y, Moore R, Goldsworthy TL, Negishi M, Maronpot RR, (2004) The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res 64: 7197-7200.
9. Columbano A, Ledda-Columbano GM, Pibiri M, Cossu C, Menegazzi M, et al. (2005) Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia. Hepatology 42: 1118-1126.
10. Yamamoto Y, Moore R, Flavell RA, Lu B, Negishi M, (2010) Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B. PLoS One 5: e10121.
11. Osabe M, Sugatani J, Takemura A, Yamazaki Y, Ikari A, et al. (2008) Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation. Biochem Biophys Res Commun 369: 1027-1033.
12. Blanco-Bose WE, Murphy MJ, Ehninger A, Offner S, Dubey C, et al. (2008) C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia. Hepatology 48: 1302-1311.
13. Thatcher NJ, Caldwell J, (1994) Origins of hepatomegaly produced by dexamethasone (DEX), pregnenolone 16 alpha-carbonitrile (PCN) and phenobarbitone (PB) in female Sprague-Dawley rats. Biochem Soc Trans 22: 132S.
14. Staudinger J, Liu Y, Madan A, Habeebu S, Klaassen CD, (2001) Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metab Dispos 29: 1467-1472.
15. Barton KM, Levine EM, (2008) Expression patterns and cell cycle profiles of PCNA, MCM6, cyclin D1, cyclin A2, cyclin B1, and phosphorylated histone H3 in the developing mouse retina. Dev Dyn 237: 672-682.
16. Ouyang N, Ke S, Eagleton N, Xie Y, Chen G, et al. (2010) Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells. Br J Cancer 102: 1753-1761.
17. Misawa A, Inoue J, Sugino Y, Hosoi H, Sugimoto T, et al. (2005) Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification. Cancer Res 65: 10233-10242.
18. Hays T, Rusyn I, Burns AM, Kennett MJ, Ward JM, et al. (2005) Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis 26: 219-227.
19. Klaunig JE, Babich MA, Baetcke KP, Cook JC, Corton JC, et al. (2003) PPARalpha agonist-induced rodent tumors: modes of action and human relevance. Crit Rev Toxicol 33: 655-780.
20. Gonzalez FJ, Shah YM, (2008) PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology 246: 2-8.
21. Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, et al. (2001) The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A 98: 3369-3374.
22. Seglen PO, (1976) Preparation of isolated rat liver cells. Methods Cell Biol 13: 29-83.
23. Liu W, Hou Y, Chen H, Wei H, Lin W, et al. (2011) Sample preparation method for isolation of single-cell types from mouse liver for proteomic studies. Proteomics 11: 3556-3564.
24. Scholzen T, Gerdes J, (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol 182: 311-322.
25. Lehmann K, Tschuor C, Rickenbacher A, Jang JH, Oberkofler CE, et al. (2012) Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration. Gastroenterology 143: 1609-1619.
26. Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, et al. (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275: 15122-15127.
27. Cattley RC, Popp JA, (1989) Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver. Cancer Res 49: 3246-3251.
28. Ross PK, Woods CG, Bradford BU, Kosyk O, Gatti DM, et al. (2009) Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver. Toxicol Appl Pharmacol 235: 199-207.
29. Darzynkiewicz Z, Traganos F, Melamed MR, (1980) New cell cycle compartments identified by multiparameter flow cytometry. Cytometry 1: 98-108.
30. Peffer RC, Moggs JG, Pastoor T, Currie RA, Wright J, et al. (2007) Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicol Sci 99: 315-325.
31. Reynisdottir I, Polyak K, Iavarone A, Massague J, (1995) Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 9: 1831-1845.
32. Sun A, Bagella L, Tutton S, Romano G, Giordano A, (2007) From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway. J Cell Biochem 102: 1400-1404.
33. Schaffer BE, Park KS, Yiu G, Conklin JF, Lin C, et al. (2010) Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Res 70: 3877-3883.
34. Huynh H, (2004) Overexpression of tumour suppressor retinoblastoma 2 protein (pRb2/p130) in hepatocellular carcinoma. Carcinogenesis 25: 1485-1494.
35. Sun D, Ren H, Oertel M, Sellers RS, Shafritz DA, et al. (2008) Inactivation of p27Kip1 promotes chemical mouse liver tumorigenesis in the resistant strain C57BL/6J. Mol Carcinog 47: 47-55.
36. Dotto GP, (2000) p21(WAF1/Cip1): more than a break to the cell cycle? Biochim Biophys Acta 1471: M43-56.
37. Warbrick E, (2000) The puzzle of PCNA's many partners. Bioessays 22: 997-1006.