LC-MS proteomics analysis of the insulin/IGF-1-deficient caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism

Journal of Proteome Research

Volumn 13, Issue 4, 2014, Pages 1938-1956

  Depuydt, Geert ^a   Xie, Fang ^b   Petyuk, Vladislav A ^b   Smolders, Arne ^a   Brewer, Heather M ^b   Camp, David G ^b   Smith, Richard D ^b   Braeckman, Bart P ^a  

^a GHENT UNIVERSITY   (Belgium)

^b PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

aging; Caenorhabditis elegans; gene expression; mass spectrometry; metabolism; physiology

Indexed keywords

ALCOHOL DEHYDROGENASE; CARBON; COMPLEX V; ENOLASE; GLUCOKINASE; GLUCOSE 6 PHOSPHATE ISOMERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; GLYOXYLIC ACID; HEXOKINASE; INSULIN; LACTATE DEHYDROGENASE; MALATE DEHYDROGENASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOGLYCERATE DEHYDROGENASE; PHOSPHOGLYCERATE KINASE; PHOSPHOGLYCERATE MUTASE; PROPIONIC ACID; PROTEIN; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE; PYRUVATE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SOMATOMEDIN C; SUCCINATE DEHYDROGENASE (UBIQUINONE); TRANSCRIPTION FACTOR DAF 16; TRIOSEPHOSPHATE ISOMERASE; TYROSINE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; DAF-16 PROTEIN, C ELEGANS; DAF-2 PROTEIN, C ELEGANS; INSULIN RECEPTOR; PROTEOME; TRANSCRIPTION FACTOR;

ARTICLE; CAENORHABDITIS ELEGANS; CARBON METABOLISM; CITRIC ACID CYCLE; ENERGY METABOLISM; FATTY ACID OXIDATION; GLYCOGEN SYNTHESIS; GLYCOLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEOMICS; RESPIRATORY CHAIN; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; ANIMAL; CHEMISTRY; GENE SILENCING; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; PROCEDURES;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE KNOCKDOWN TECHNIQUES; INSULIN; INSULIN-LIKE GROWTH FACTOR I; METABOLIC NETWORKS AND PATHWAYS; MUTATION; PROTEOME; PROTEOMICS; RECEPTOR, INSULIN; TRANSCRIPTION FACTORS;

EID: 84898750022     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr401081b     Document Type: Article

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