Identification of dicarboxylate carrier Slc25a10 as malate transporter in de Novo fatty acid synthesis

Journal of Biological Chemistry

Volumn 280, Issue 37, 2005, Pages 32434-32441

  Mizuarai, Shinji ^a   Miki, Satomi ^a   Araki, Hiromitsu ^a   Takahashi, Kazuhiko ^a   Kotani, Hidehito ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; ESTERS; FATTY ACIDS; GENES; SYNTHESIS (CHEMICAL); TISSUE;

ADIPOSE TISSUES; CITRATE TRANSPORTERS; DICARBOXYLATE CARRIERS; FATTY ACID SYNTHESIS;

CARBOXYLATION;

ACETYL COENZYME A CARBOXYLASE; CARRIER PROTEIN; CITRIC ACID; DICARBOXYLIC ACID; MALIC ACID; MALONYL COENZYME A; MITOCHONDRIAL PROTEIN; PROTEIN SLC25A10; SMALL INTERFERING RNA; SUCCINIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CELL STRAIN HEPG2; CONTROLLED STUDY; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; LIPID STORAGE; LIPOGENESIS; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

3T3-L1 CELLS; ACETATES; ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; AZO COMPOUNDS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CARBOXYLIC ACIDS; CELL DIFFERENTIATION; CELL LINE; CITRATES; CYTOSOL; DICARBOXYLIC ACID TRANSPORTERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FATTY ACIDS; GENE EXPRESSION REGULATION; HUMANS; LIPID METABOLISM; MALATES; MALONYL COENZYME A; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, OBESE; MITOCHONDRIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS; TRANSFECTION;

EID: 25444512870     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M503152200     Document Type: Article

References (32)

1. Kaplan, R. S., Mayor, J. A., Johnston, N., and Oliveira, D. L. (1990) J. Biol. Chem. 265, 13379-13385
2. Wakil, S. J., Stoops, J. K., and Joshi, V. C. (1983) Annu. Rev. Biochem. 52, 537-579
3. Munday, M. R. (2002) Biochem. Soc. Trans. 30, 1059-1064
4. Matsuzaka, T., Shimano, H., Yahagi, N., Yoshikawa, T., Amemiya-Kudo, M., Hasty, A. H., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K., Osuga, J., Takahashi, A., Yato, S., Sone, H., Ishibashi, S., and Yamada, N. (2002) J. Lipid. Res. 43, 911-920
5. Ntambi, I. M., Miyazaki, M., Stoehr, J. P., Lan, H., Kendziorski, C. M., Yandell, B. S., Song, Y., Cohen, P., Friedman, J. M., and Attie, A. D. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 11482-11496
6. Das, K., Lewis, R. Y., Combatsiaris, T. P., Lin, Y., Shapiro, L., Charron, M. J., and Scherer, P. E. (1999) Biochem. J. 344, 313-320
7. Unami, A., Shinohara, Y., Kajimoto, K., and Baba, Y. (2004) Biochem. Pharmacol. 67, 555-564
8. Fiermonte, G., Palmieri, L., Dolce, V., Lasorsa, F. M., Palmieri, F., Runswick, M. J., and Walker, J. E. (1998) J. Biol. Chem. 273, 24754-24759
9. Robinson, B. H., Williams, G. R., Halperin, M. L., and Leznoff, C. C. (1970) Eur. J. Biochem. 15, 263-272
10. Lin, Y., Berg, A. H., Iyengar, P., Lam, T. K., Giacca, A., Combs, T. P., Rajala, M. W., Du, X., Rollman, B., Li, W., Hawkins, M., Barzilai, N., Rhodes, C. J., Fantus, I. G., Brownlee, M., and Scherer, P. E. (2005) J. Biol. Chem. 280, 4617-4626
11. Deng, X., Elam, M. B., Wilcox, H. G., Cagen, L. M., Park, E. A., Raghow, R., Patel, D., Kumar, P., Sheybani, A., and Russell, J. C. (2004) Endocrinology 145, 5847-5861
12. Lopez, I. P., Marti, A., Milagro, F. I., Zulet, M. A., Moreno-Aliaga, M. J., Martinez, J. A., and De Miguel, C. (2003) Obes. Res. 11, 188-194
13. Takahashi, K., Mizuarai, S., Araki, H., Mashiko, S., Ishihara, A., Kanatani, A., Itadani, H., and Kotani, H. (2003) J. Biol. Chem. 278, 46654-46660
14. Smith, S. I., Cases, S., Jensen, D. R., Chen, H. C., Sande, E., Tow, B., Sanan, D. A., Raber, I., Eckel, R. H., and Farese, R. V., Jr. (2000) Nat. Genet. 25, 87-90
15. Ashrafi, K., Chang, F. Y., Watts, J. L., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003) Nature 421, 268-272
16. Tang, Q. Q., Otto, T. C., and Lane, M. D. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 850-855
17. Robinson, B. H., Williams, G. R., Halperin, M. L., Leznoff, C. C. (1971) Eur. J. Biochem. 20, 65-71
18. Indiveri, C., Prezioso, G., Dierks, T., Kramer, R., and Palmieri, F. (1993) Biochim. Biophys. Acta 1143, 310-318
19. Lowry, O. H., and Passonneau, J. V. (1972) Flexible System of Enzymatic Analysis, pp. 149-218, Academic Press, New York
20. Majima, E., Ishida, M., Miki, S., Shinohara, Y., and Terada, H. (2001) J. Biol. Chem. 276, 9792-9799
21. Harwood, H. J., Jr., Petras, S. F., Shelly, L. D., Zaccaro, L. M., Perry, D. A., Makowski, M. R., Hargrove, D. M., Martin, K. A., Tracey, W. R., Chapman, J. G., Magee, W. P., Dalvie, D. K., Soliman, V. F., Martin, W. H., Mularski, C. J., and Eisenbeis, S. A. (2003) J. Biol. Chem. 278, 37099-37111
22. Keay, S., and Grossberg, S. E. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 4099-40103
23. Mashiko, S., Ishihara, A., Iwaasa, H., Sano, H., Oda, Z., Ito, J., Yumoto, M., Okawa, M., Suzuki, I., Fukuroda, T., Jitsuoka, M., Morin, N. R., MacNeil, D. J., Van der Ploeg, L. H., Ihara, M., Fukami, T., and Kanatani, A. (2003) Endocrinology. 144, 1793-1801
24. Guo, K. Y., Halo, P., Leibel, R. L., and Zhang, Y. (2004) Am. J. Physiol. 28, R112-R119
25. Watson, J. A., and Lowenstein, J. M. (1970) J. Biol. Chem. 245, 5993-6002
26. Hannah, V. C., Ou, J., Luong, A., Goldstein, J. L., and Brown, M. S. (2001) J. Biol. Chem. 276, 4365-4372
27. Zara, V., and Gnoni, G. V. (1995) Biochim. Biophys. Acta. 1239, 33-38
28. Kajimoto, K., Terada, H., Baba, Y., and Shinohara, Y. (2005) Mol. Genet. Metab. 85, 46-53
29. Rogina, B., Reenan, R. A., Nilsen, S. P., and Helfand, S. L. (2000) Science. 290, 2137-2140
30. Inoue, K., Fei, Y. I., Huang, W., Zhuang, L., Chen, Z., and Ganapathy, V. (2002) Biochem. J. 367, 313-319
31. Fei, Y. J., Liu, J. C., Inoue, K., Zhuang, L., Miyake, K., Miyauchi, S., and Ganapathy, V. (2004) Biochem. J. 379, 191-198
32. Mao, J., Chirala, S. S., and Wakil, S. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 7515-7520