-
1
-
-
65649128580
-
Amino acid regulation of TOR complex 1
-
J. Avruch, X. Long, S. Ortiz-Vega, J. Rapley, A. Papageorgiou, and N. Dai Amino acid regulation of TOR complex 1 Am. J. Physiol. Endocrinol. Metab. 296 2009 E592 E602
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.296
-
-
Avruch, J.1
Long, X.2
Ortiz-Vega, S.3
Rapley, J.4
Papageorgiou, A.5
Dai, N.6
-
2
-
-
70350560562
-
Metabolomics applied to diabetes research: Moving from information to knowledge
-
J.R. Bain, R.D. Stevens, B.R. Wenner, O. Ilkayeva, D.M. Muoio, and C.B. Newgard Metabolomics applied to diabetes research: moving from information to knowledge Diabetes 58 2009 2429 2443
-
(2009)
Diabetes
, vol.58
, pp. 2429-2443
-
-
Bain, J.R.1
Stevens, R.D.2
Wenner, B.R.3
Ilkayeva, O.4
Muoio, D.M.5
Newgard, C.B.6
-
3
-
-
3042591440
-
Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue
-
DOI 10.1074/jbc.M401167200
-
A. Boucher, D. Lu, S. Burgess, S. Telemaque-Potts, M. Jensen, H. Mulder, M.-Y. Wang, R.H. Unger, A.D. Sherry, and C.B. Newgard Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue J. Biol. Chem. 279 2004 27263 27271 (Pubitemid 38812565)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.26
, pp. 27263-27271
-
-
Boucher, A.1
Lu, D.2
Burgess, S.C.3
Telemaque-Potts, S.4
Jensen, M.V.5
Mulder, H.6
Wang, M.-Y.7
Unger, R.H.8
Sherry, A.D.9
Newgard, C.B.10
-
4
-
-
77950228972
-
Diabetes: Treatment of type 2 diabetes mellitus with bariatric surgery
-
P. Clifton Diabetes: treatment of type 2 diabetes mellitus with bariatric surgery Nat Rev Endocrinol 6 2010 191 193
-
(2010)
Nat Rev Endocrinol
, vol.6
, pp. 191-193
-
-
Clifton, P.1
-
5
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
DOI 10.1126/science.1124147
-
D. Cota, K. Proulx, K.A. Smith, S.C. Kozma, G. Thomas, S.C. Woods, and R.J. Seeley Hypothalamic mTOR signaling regulates food intake Science 312 2006 927 930 (Pubitemid 43727328)
-
(2006)
Science
, vol.312
, Issue.5775
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Blake Smith, K.A.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
Seeley, R.J.7
-
6
-
-
0014669160
-
Plasma amino acid levels and insulin secretion in obesity
-
P. Felig, E. Marliss, and G.F. Cahill Jr. Plasma amino acid levels and insulin secretion in obesity N. Engl. J. Med. 281 1969 811 816
-
(1969)
N. Engl. J. Med.
, vol.281
, pp. 811-816
-
-
Felig, P.1
Marliss, E.2
Cahill, Jr.G.F.3
-
8
-
-
20344386484
-
Branched-chain amino acids and brain function
-
J.D. Fernstrom Branched-chain amino acids and brain function J. Nutr. 135 6, Suppl 2005 1539S 1546S (Pubitemid 40791667)
-
(2005)
Journal of Nutrition
, vol.135
, Issue.6 SUPPL.
-
-
Fernstrom, J.D.1
-
9
-
-
0037048669
-
Prevalence and trends in obesity among US adults, 1999-2000
-
K.M. Flegal, M.D. Carroll, C.L. Ogden, and C.L. Johnson Prevalence and trends in obesity among US adults, 1999-2000 JAMA 288 2002 1723 1727
-
(2002)
JAMA
, vol.288
, pp. 1723-1727
-
-
Flegal, K.M.1
Carroll, M.D.2
Ogden, C.L.3
Johnson, C.L.4
-
10
-
-
38149137359
-
Determinants of whole-body protein metabolism in subjects with and without type 2 diabetes
-
R. Gougeon, J.A. Morais, S. Chevalier, S. Pereira, M. Lamarche, and E.B. Marliss Determinants of whole-body protein metabolism in subjects with and without type 2 diabetes Diabetes Care 31 2008 128 133
-
(2008)
Diabetes Care
, vol.31
, pp. 128-133
-
-
Gougeon, R.1
Morais, J.A.2
Chevalier, S.3
Pereira, S.4
Lamarche, M.5
Marliss, E.B.6
-
11
-
-
77951232682
-
Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels
-
M.A. Herman, P. She, O.D. Peroni, C.J. Lynch, and B.B. Kahn Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels J. Biol. Chem. 285 2010 11348 11356
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 11348-11356
-
-
Herman, M.A.1
She, P.2
Peroni, O.D.3
Lynch, C.J.4
Kahn, B.B.5
-
12
-
-
82955233648
-
Old enzymes, new tricks: Sirtuins are NAD(+)-dependent de-acylases
-
M.D. Hirschey Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases Cell Metab. 14 2011 718 719
-
(2011)
Cell Metab.
, vol.14
, pp. 718-719
-
-
Hirschey, M.D.1
-
13
-
-
78650761736
-
Multi-tissue, selective PPARg modulation of insulin sensitivity and metabolic pathways in obese rats
-
10.1152/ajpendo.00219.2010 Published online October 19, 2010
-
G. Hsiao, J. Chapman, J.M. Ofrecio, J. Wilkes, J.L. Resnik, D. Thapar, S. Subramaniam, and D.D. Sears Multi-tissue, selective PPARg modulation of insulin sensitivity and metabolic pathways in obese rats Am. J. Physiol. 300 2011 E164 E174 10.1152/ajpendo.00219.2010 Published online October 19, 2010
-
(2011)
Am. J. Physiol.
, vol.300
-
-
Hsiao, G.1
Chapman, J.2
Ofrecio, J.M.3
Wilkes, J.4
Resnik, J.L.5
Thapar, D.6
Subramaniam, S.7
Sears, D.D.8
-
14
-
-
69549097700
-
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women
-
K.M. Huffman, S.H. Shah, R.D. Stevens, J.R. Bain, M. Muehlbauer, C.A. Slentz, C.J. Tanner, M. Kuchibhatla, J.A. Houmard, C.B. Newgard, and W.E. Kraus Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women Diabetes Care 32 2009 1678 1683
-
(2009)
Diabetes Care
, vol.32
, pp. 1678-1683
-
-
Huffman, K.M.1
Shah, S.H.2
Stevens, R.D.3
Bain, J.R.4
Muehlbauer, M.5
Slentz, C.A.6
Tanner, C.J.7
Kuchibhatla, M.8
Houmard, J.A.9
Newgard, C.B.10
Kraus, W.E.11
-
15
-
-
0034076660
-
Fuel selection in human skeletal muscle in insulin resistance: A reexamination
-
D.E. Kelley, and L.J. Mandarino Fuel selection in human skeletal muscle in insulin resistance: a reexamination Diabetes 49 2000 677 683 (Pubitemid 30339979)
-
(2000)
Diabetes
, vol.49
, Issue.5
, pp. 677-683
-
-
Kelley, D.E.1
Mandarino, L.J.2
-
16
-
-
25844432311
-
Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency
-
DOI 10.1074/jbc.M507621200
-
T.R. Koves, P. Li, J. An, D. Slentz, O. Ilkayeva, T. Akimoto, G.L. Dohm, Z. Yan, C.B. Newgard, and D.M. Muoio Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency J. Biol. Chem. 280 2005 33588 33598 (Pubitemid 41397160)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.39
, pp. 33588-33598
-
-
Koves, T.R.1
Li, P.2
An, J.3
Akimoto, T.4
Slentz, D.5
Ilkayeva, O.6
Dohm, G.L.7
Yan, Z.8
Newgard, C.B.9
Muoio, D.M.10
-
17
-
-
37449020075
-
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
-
T.R. Koves, J.R. Ussher, R.C. Noland, D. Slentz, M. Mosedale, O. Ilkayeva, J. Bain, R. Stevens, J.R. Dyck, and C.B. Newgard Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance Cell Metab. 7 2008 45 56
-
(2008)
Cell Metab.
, vol.7
, pp. 45-56
-
-
Koves, T.R.1
Ussher, J.R.2
Noland, R.C.3
Slentz, D.4
Mosedale, M.5
Ilkayeva, O.6
Bain, J.7
Stevens, R.8
Dyck, J.R.9
Newgard, C.B.10
-
18
-
-
0030871847
-
β-Cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy
-
K. Koyama, G. Chen, M.Y. Wang, Y. Lee, M. Shimabukuro, C.B. Newgard, and R.H. Unger beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy Diabetes 46 1997 1276 1280 (Pubitemid 27315275)
-
(1997)
Diabetes
, vol.46
, Issue.8
, pp. 1276-1280
-
-
Koyama, K.1
Chen, G.2
Wang, M.-Y.3
Lee, Y.4
Shimabukuro, M.5
Newgard, C.B.6
Unger, R.H.7
-
19
-
-
0036313574
-
Mechanism of amino acid-induced skeletal muscle insulin resistance in humans
-
M. Krebs, M. Krssak, E. Bernroider, C. Anderwald, A. Brehm, M. Meyerspeer, P. Nowotny, E. Roth, W. Waldhäusl, and M. Roden Mechanism of amino acid-induced skeletal muscle insulin resistance in humans Diabetes 51 2002 599 605 (Pubitemid 34760165)
-
(2002)
Diabetes
, vol.51
, Issue.3
, pp. 599-605
-
-
Krebs, M.1
Krssak, M.2
Bernroider, E.3
Anderwald, C.4
Brehm, A.5
Meyerspeer, M.6
Nowotny, P.7
Roth, E.8
Waldhausl, W.9
Roden, M.10
-
20
-
-
79955387227
-
Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss
-
B. Laferrère, D. Reilly, S. Arias, N. Swerdlow, P. Gorroochurn, B. Bawa, M. Bose, J. Teixeira, R.D. Stevens, and B.R. Wenner Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss Sci. Transl. Med. 3 2011 re2
-
(2011)
Sci. Transl. Med.
, vol.3
, pp. 2
-
-
Laferrère, B.1
Reilly, D.2
Arias, S.3
Swerdlow, N.4
Gorroochurn, P.5
Bawa, B.6
Bose, M.7
Teixeira, J.8
Stevens, R.D.9
Wenner, B.R.10
-
21
-
-
34047177401
-
GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
-
DOI 10.2337/db06-1532
-
M.G. Latour, T. Alquier, E. Oseid, C. Tremblay, T.L. Jetton, J. Luo, D.C. Lin, and V. Poitout GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo Diabetes 56 2007 1087 1094 (Pubitemid 46525064)
-
(2007)
Diabetes
, vol.56
, Issue.4
, pp. 1087-1094
-
-
Latour, M.G.1
Alquier, T.2
Oseid, E.3
Tremblay, C.4
Jetton, T.L.5
Luo, J.6
Lin, D.C.-H.7
Poitout, V.8
-
22
-
-
0031592795
-
Characterization of Citrate Synthase Purified from Drosophila melanogaster
-
S. Lee, C. Park, and J. Yim Characterization of citrate synthase purified from Drosophila melanogaster Mol. Cells 7 1997 599 604 (Pubitemid 127477541)
-
(1997)
Molecules and Cells
, vol.7
, Issue.5
, pp. 599-604
-
-
Lee, S.1
Park, C.2
Yim, J.3
-
23
-
-
0031048115
-
Increased lipogenic capacity of the islets of obese rats: A role in the pathogenesls of NIDDM
-
Y. Lee, H. Hirose, Y.T. Zhou, V. Esser, J.D. McGarry, and R.H. Unger Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM Diabetes 46 1997 408 413 (Pubitemid 27090269)
-
(1997)
Diabetes
, vol.46
, Issue.3
, pp. 408-413
-
-
Lee, Y.1
Hirose, H.2
Zhou, Y.-T.3
Esser, V.4
McGarry, J.D.5
Unger, R.H.6
-
24
-
-
0037474212
-
Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets
-
DOI 10.1074/jbc.M210577200
-
C. Li, H. Najafi, Y. Daikhin, I.B. Nissim, H.W. Collins, M. Yudkoff, F.M. Matschinsky, and C.A. Stanley Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets J. Biol. Chem. 278 2003 2853 2858 (Pubitemid 36801189)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.5
, pp. 2853-2858
-
-
Li, C.1
Najafi, H.2
Daikhin, Y.3
Nissim, I.B.4
Collins, H.W.5
Yudkoff, M.6
Matschinsky, F.M.7
Stanley, C.A.8
-
25
-
-
79959453305
-
Dietary leucine - An environmental modifier of insulin resistance acting on multiple levels of metabolism
-
Y. Macotela, B. Emanuelli, A.M. Bång, D.O. Espinoza, J. Boucher, K. Beebe, W. Gall, and C.R. Kahn Dietary leucine - an environmental modifier of insulin resistance acting on multiple levels of metabolism PLoS ONE 6 2011 e21187
-
(2011)
PLoS ONE
, vol.6
, pp. 21187
-
-
MacOtela, Y.1
Emanuelli, B.2
Bång, A.M.3
Espinoza, D.O.4
Boucher, J.5
Beebe, K.6
Gall, W.7
Kahn, C.R.8
-
26
-
-
0036092239
-
Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
-
J.D. McGarry Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes Diabetes 51 2002 7 18
-
(2002)
Diabetes
, vol.51
, pp. 7-18
-
-
McGarry, J.D.1
-
27
-
-
39749147110
-
Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
-
DOI 10.1038/nrm2327, PII NRM2327
-
D.M. Muoio, and C.B. Newgard Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes Nat. Rev. Mol. Cell Biol. 9 2008 193 205 (Pubitemid 351301824)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.3
, pp. 193-205
-
-
Muoio, D.M.1
Newgard, C.B.2
-
28
-
-
64049117998
-
Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice
-
A. Nairizi, P. She, T.C. Vary, and C.J. Lynch Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice J. Nutr. 139 2009 715 719
-
(2009)
J. Nutr.
, vol.139
, pp. 715-719
-
-
Nairizi, A.1
She, P.2
Vary, T.C.3
Lynch, C.J.4
-
29
-
-
63449111894
-
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
-
C.B. Newgard, J. An, J.R. Bain, M.J. Muehlbauer, R.D. Stevens, L.F. Lien, A.M. Haqq, S.H. Shah, M. Arlotto, and C.A. Slentz A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance Cell Metab. 9 2009 311 326
-
(2009)
Cell Metab.
, vol.9
, pp. 311-326
-
-
Newgard, C.B.1
An, J.2
Bain, J.R.3
Muehlbauer, M.J.4
Stevens, R.D.5
Lien, L.F.6
Haqq, A.M.7
Shah, S.H.8
Arlotto, M.9
Slentz, C.A.10
-
30
-
-
74149089019
-
Fermentative production of branched chain amino acids: A focus on metabolic engineering
-
J.H. Park, and S.Y. Lee Fermentative production of branched chain amino acids: a focus on metabolic engineering Appl. Microbiol. Biotechnol. 85 2010 491 506
-
(2010)
Appl. Microbiol. Biotechnol.
, vol.85
, pp. 491-506
-
-
Park, J.H.1
Lee, S.Y.2
-
31
-
-
83055173304
-
The first identification of lysine malonylation substrates and its regulatory enzyme
-
M111, 012658
-
C. Peng, Z. Lu, Z. Xie, Z. Cheng, Y. Chen, M. Tan, H. Luo, Y. Zhang, W. He, and K. Yang The first identification of lysine malonylation substrates and its regulatory enzyme Mol. Cell. Proteomics 10 2011 M111, 012658
-
(2011)
Mol. Cell. Proteomics
, vol.10
-
-
Peng, C.1
Lu, Z.2
Xie, Z.3
Cheng, Z.4
Chen, Y.5
Tan, M.6
Luo, H.7
Zhang, Y.8
He, W.9
Yang, K.10
-
32
-
-
38149100479
-
Insulin resistance of protein metabolism in type 2 diabetes
-
S. Pereira, E.B. Marliss, J.A. Morais, S. Chevalier, and R. Gougeon Insulin resistance of protein metabolism in type 2 diabetes Diabetes 57 2008 56 63
-
(2008)
Diabetes
, vol.57
, pp. 56-63
-
-
Pereira, S.1
Marliss, E.B.2
Morais, J.A.3
Chevalier, S.4
Gougeon, R.5
-
33
-
-
0032452225
-
Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years
-
DOI 10.1002/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C
-
P.J. Randle Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years Diabetes Metab. Rev. 14 1998 263 283 (Pubitemid 29110250)
-
(1998)
Diabetes/Metabolism Reviews
, vol.14
, Issue.4
, pp. 263-283
-
-
Randle, P.J.1
-
34
-
-
77957567397
-
Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle
-
A.K. Saha, X.J. Xu, E. Lawson, R. Deoliveira, A.E. Brandon, E.W. Kraegen, and N.B. Ruderman Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle Diabetes 59 2010 2426 2434
-
(2010)
Diabetes
, vol.59
, pp. 2426-2434
-
-
Saha, A.K.1
Xu, X.J.2
Lawson, E.3
Deoliveira, R.4
Brandon, A.E.5
Kraegen, E.W.6
Ruderman, N.B.7
-
35
-
-
34248581989
-
Disordered lipid metabolism and the pathogenesis of insulin resistance
-
DOI 10.1152/physrev.00024.2006
-
D.B. Savage, K.F. Petersen, and G.I. Shulman Disordered lipid metabolism and the pathogenesis of insulin resistance Physiol. Rev. 87 2007 507 520 (Pubitemid 47084679)
-
(2007)
Physiological Reviews
, vol.87
, Issue.2
, pp. 507-520
-
-
Savage, D.B.1
Petersen, K.F.2
Shulman, G.I.3
-
36
-
-
73249123069
-
Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
-
D.D. Sears, G. Hsiao, A. Hsiao, J.G. Yu, C.H. Courtney, J.M. Ofrecio, J. Chapman, and S. Subramaniam Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization Proc. Natl. Acad. Sci. USA 106 2009 18745 18750
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 18745-18750
-
-
Sears, D.D.1
Hsiao, G.2
Hsiao, A.3
Yu, J.G.4
Courtney, C.H.5
Ofrecio, J.M.6
Chapman, J.7
Subramaniam, S.8
-
37
-
-
0032861252
-
Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells
-
L. Segall, N. Lameloise, F. Assimacopoulos-Jeannet, E. Roche, P. Corkey, S. Thumelin, B.E. Corkey, and M. Prentki Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells Am. J. Physiol. 277 1999 E521 E528
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Segall, L.1
Lameloise, N.2
Assimacopoulos-Jeannet, F.3
Roche, E.4
Corkey, P.5
Thumelin, S.6
Corkey, B.E.7
Prentki, M.8
-
38
-
-
77953667219
-
Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events
-
S.H. Shah, J.R. Bain, M.J. Muehlbauer, R.D. Stevens, D.R. Crosslin, C. Haynes, J. Dungan, L.K. Newby, E.R. Hauser, and G.S. Ginsburg Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events Circ Cardiovasc Genet 3 2010 207 214
-
(2010)
Circ Cardiovasc Genet
, vol.3
, pp. 207-214
-
-
Shah, S.H.1
Bain, J.R.2
Muehlbauer, M.J.3
Stevens, R.D.4
Crosslin, D.R.5
Haynes, C.6
Dungan, J.7
Newby, L.K.8
Hauser, E.R.9
Ginsburg, G.S.10
-
39
-
-
84856728068
-
Branched chain amino acids levels are associated with improvement in insulin resistance with weight loss
-
10.1007/s00125-011-2356-5 Published online November 8, 2011
-
S.H. Shah, D.R. Crosslin, C. Haynes, S. Nelson, C.L. Boling, R.D. Stevens, M.J. Muehlbauer, B.R. Wenner, J.R. Bain, and B. Laferrere Branched chain amino acids levels are associated with improvement in insulin resistance with weight loss Diabetologia 55 2012 321 330 10.1007/s00125-011-2356-5 Published online November 8, 2011
-
(2012)
Diabetologia
, vol.55
, pp. 321-330
-
-
Shah, S.H.1
Crosslin, D.R.2
Haynes, C.3
Nelson, S.4
Boling, C.L.5
Stevens, R.D.6
Muehlbauer, M.J.7
Wenner, B.R.8
Bain, J.R.9
Laferrere, B.10
-
40
-
-
37149027613
-
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism
-
P. She, C. Van Horn, T. Reid, S.M. Hutson, R.N. Cooney, and C.J. Lynch Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism Am. J. Physiol. Endocrinol. Metab. 293 2007 E1552 E1563
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.293
-
-
She, P.1
Van Horn, C.2
Reid, T.3
Hutson, S.M.4
Cooney, R.N.5
Lynch, C.J.6
-
41
-
-
34548251464
-
Disruption of BCATm in Mice Leads to Increased Energy Expenditure Associated with the Activation of a Futile Protein Turnover Cycle
-
DOI 10.1016/j.cmet.2007.08.003, PII S1550413107002252
-
P. She, T.M. Reid, S.K. Bronson, T.C. Vary, A. Hajnal, C.J. Lynch, and S.M. Hutson Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle Cell Metab. 6 2007 181 194 (Pubitemid 47324140)
-
(2007)
Cell Metabolism
, vol.6
, Issue.3
, pp. 181-194
-
-
She, P.1
Reid, T.M.2
Bronson, S.K.3
Vary, T.C.4
Hajnal, A.5
Lynch, C.J.6
Hutson, S.M.7
-
42
-
-
0032478314
-
Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
-
DOI 10.1073/pnas.95.5.2498
-
M. Shimabukuro, Y.T. Zhou, M. Levi, and R.H. Unger Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes Proc. Natl. Acad. Sci. USA 95 1998 2498 2502 (Pubitemid 28145970)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.5
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.-T.2
Levi, M.3
Unger, R.H.4
-
43
-
-
31544461753
-
Branched-chain amino acid catabolism in exercise and liver disease
-
Y. Shimomura, T. Honda, M. Shiraki, T. Murakami, J. Sato, H. Kobayashi, K. Mawatari, M. Obayashi, and R.A. Harris Branched-chain amino acid catabolism in exercise and liver disease J. Nutr. 136 1, Suppl 2006 250S 253S (Pubitemid 43156518)
-
(2006)
Journal of Nutrition
, vol.136
, Issue.1
-
-
Shimomura, Y.1
Honda, T.2
Shiraki, M.3
Murakami, T.4
Sato, J.5
Kobayashi, H.6
Mawatari, K.7
Obayashi, M.8
Harris, R.A.9
-
44
-
-
21344444333
-
A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle
-
DOI 10.2337/diabetes.54.7.1926
-
L.M. Sparks, H. Xie, R.A. Koza, R. Mynatt, M.W. Hulver, G.A. Bray, and S.R. Smith A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle Diabetes 54 2005 1926 1933 (Pubitemid 40911253)
-
(2005)
Diabetes
, vol.54
, Issue.7
, pp. 1926-1933
-
-
Sparks, L.M.1
Xie, H.2
Koza, R.A.3
Mynatt, R.4
Hulver, M.W.5
Bray, G.A.6
Smith, S.R.7
-
45
-
-
70349567012
-
Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children
-
C.A. Stanley Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children Am. J. Clin. Nutr. 90 2009 862S 866S
-
(2009)
Am. J. Clin. Nutr.
, vol.90
-
-
Stanley, C.A.1
-
46
-
-
0029888870
-
Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
-
D.T. Stein, V. Esser, B.E. Stevenson, K.E. Lane, J.H. Whiteside, M.B. Daniels, S. Chen, and J.D. McGarry Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat J. Clin. Invest. 97 1996 2728 2735 (Pubitemid 26197087)
-
(1996)
Journal of Clinical Investigation
, vol.97
, Issue.12
, pp. 2728-2735
-
-
Stein, D.T.1
Esser, V.2
Stevenson, B.E.3
Lane, K.E.4
Whiteside, J.H.5
Daniels, M.B.6
Chen, S.7
McGarry, J.D.8
-
47
-
-
0030876806
-
The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation
-
D.T. Stein, B.E. Stevenson, M.W. Chester, M. Basit, M.B. Daniels, S.D. Turley, and J.D. McGarry The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation J. Clin. Invest. 100 1997 398 403 (Pubitemid 27349087)
-
(1997)
Journal of Clinical Investigation
, vol.100
, Issue.2
, pp. 398-403
-
-
Stein, D.T.1
Stevenson, B.E.2
Chester, M.W.3
Basit, M.4
Daniels, M.B.5
Turley, S.D.6
McGarry, J.D.7
-
48
-
-
40749141596
-
Comparison of strategies for sustaining weight loss: The weight loss maintenance randomized controlled trial
-
DOI 10.1001/jama.299.10.1139
-
L.P. Svetkey, V.J. Stevens, P.J. Brantley, L.J. Appel, J.F. Hollis, C.M. Loria, W.M. Vollmer, C.M. Gullion, K. Funk, P. Smith Weight Loss Maintenance Collaborative Research Group Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial JAMA 299 2008 1139 1148 (Pubitemid 351398428)
-
(2008)
JAMA - Journal of the American Medical Association
, vol.299
, Issue.10
, pp. 1139-1148
-
-
Svetkey, L.P.1
Stevens, V.J.2
Brantley, P.J.3
Appel, L.J.4
Hollis, J.F.5
Loria, C.M.6
Vollmer, W.M.7
Gullion, C.M.8
Funk, K.9
Smith, P.10
Samuel-Hodge, C.11
Myers, V.12
Lien, L.F.13
Laferriere, D.14
Kennedy, B.15
Jerome, G.J.16
Heinith, F.17
Harsha, D.W.18
Evans, P.19
Erlinger, T.P.20
Dalcin, A.T.21
Coughlin, J.22
Charleston, J.23
Champagne, C.M.24
Bauck, A.25
Ard, J.D.26
Aicher, K.27
more..
-
49
-
-
77949267650
-
Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men
-
E.-S. Tai, M.L.S. Tan, R.D. Stevens, Y.-L. Low, M.J. Muehlbauer, D.L.M. Goh, O.R. Ilkayeva, B.R. Wenner, J.R. Bain, and J.J.M. Lee Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men Diabetologia 53 2010 757 767
-
(2010)
Diabetologia
, vol.53
, pp. 757-767
-
-
Tai, E.-S.1
Tan, M.L.S.2
Stevens, R.D.3
Low, Y.-L.4
Muehlbauer, M.J.5
Goh, D.L.M.6
Ilkayeva, O.R.7
Wenner, B.R.8
Bain, J.R.9
Lee, J.J.M.10
-
50
-
-
0035851205
-
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
-
F. Tremblay, and A. Marette Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells J. Biol. Chem. 276 2001 38052 38060
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38052-38060
-
-
Tremblay, F.1
Marette, A.2
-
51
-
-
24144446404
-
Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
-
DOI 10.2337/diabetes.54.9.2674
-
F. Tremblay, M. Krebs, L. Dombrowski, A. Brehm, E. Bernroider, E. Roth, P. Nowotny, W. Waldhäusl, A. Marette, and M. Roden Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability Diabetes 54 2005 2674 2684 (Pubitemid 41233590)
-
(2005)
Diabetes
, vol.54
, Issue.9
, pp. 2674-2684
-
-
Tremblay, F.1
Krebs, M.2
Dombrowski, L.3
Brehm, A.4
Bernroider, E.5
Roth, E.6
Nowotny, P.7
Waldhausl, W.8
Marette, A.9
Roden, M.10
-
52
-
-
33744505375
-
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
-
DOI 10.1016/j.cmet.2006.05.003, PII S1550413106001586
-
S.H. Um, D. D'Alessio, and G. Thomas Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1 Cell Metab. 3 2006 393 402 (Pubitemid 43811780)
-
(2006)
Cell Metabolism
, vol.3
, Issue.6
, pp. 393-402
-
-
Um, S.H.1
D'Alessio, D.2
Thomas, G.3
-
53
-
-
79953737332
-
Metabolite profiles and the risk of developing diabetes
-
T.J. Wang, M.G. Larson, R.S. Vasan, S. Cheng, E.P. Rhee, E. McCabe, G.D. Lewis, C.S. Fox, P.F. Jacques, and C. Fernandez Metabolite profiles and the risk of developing diabetes Nat. Med. 17 2011 448 453
-
(2011)
Nat. Med.
, vol.17
, pp. 448-453
-
-
Wang, T.J.1
Larson, M.G.2
Vasan, R.S.3
Cheng, S.4
Rhee, E.P.5
McCabe, E.6
Lewis, G.D.7
Fox, C.S.8
Jacques, P.F.9
Fernandez, C.10
-
54
-
-
79952374033
-
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
-
F. Xiao, Z. Huang, H. Li, J. Yu, C. Wang, S. Chen, Q. Meng, Y. Cheng, X. Gao, and J. Li Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways Diabetes 60 2011 746 756
-
(2011)
Diabetes
, vol.60
, pp. 746-756
-
-
Xiao, F.1
Huang, Z.2
Li, H.3
Yu, J.4
Wang, C.5
Chen, S.6
Meng, Q.7
Cheng, Y.8
Gao, X.9
Li, J.10
-
55
-
-
34249680883
-
Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
-
DOI 10.2337/db07-0123
-
Y. Zhang, K. Guo, R.E. LeBlanc, D. Loh, G.J. Schwartz, and Y.-H. Yu Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms Diabetes 56 2007 1647 1654 (Pubitemid 46842599)
-
(2007)
Diabetes
, vol.56
, Issue.6
, pp. 1647-1654
-
-
Zhang, Y.1
Guo, K.2
LeBlanc, R.E.3
Loh, D.4
Schwartz, G.J.5
Yu, Y.-H.6
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