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Volumn 457, Issue 7226, 2009, Pages 210-214

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPID; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

EID: 58149339613     PISSN: 00280836     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/nature07536     Document Type: Article
Times cited : (256)

References (30)
  • 1
    • 0017301265 scopus 로고
    • Non-ageing developmental variant of Caenorhabditis elegans
    • Klass, M. & Hirsh, D. Non-ageing developmental variant of Caenorhabditis elegans. Nature 260, 523-525 (1976).
    • (1976) Nature , vol.260 , pp. 523-525
    • Klass, M.1    Hirsh, D.2
  • 2
    • 27544504430 scopus 로고    scopus 로고
    • Alternate metabolism during the dauer stage of the nematode Caenorhabditis elegans
    • Burnell, A. M., Houthoofd, K., O'Hanlon, K. & Vanfleteren, J. R. Alternate metabolism during the dauer stage of the nematode Caenorhabditis elegans. Exp. Gerontol. 40, 850-856 (2005).
    • (2005) Exp. Gerontol , vol.40 , pp. 850-856
    • Burnell, A.M.1    Houthoofd, K.2    O'Hanlon, K.3    Vanfleteren, J.R.4
  • 3
    • 0030813398 scopus 로고    scopus 로고
    • daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura, K. D., Tissenbaum, H. A., Liu, Y. & Ruvkun, G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946 (1997).
    • (1997) Science , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 4
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • McElwee, J., Bubb, K. & Thomas, J. H. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2, 111-121 (2003).
    • (2003) Aging Cell , vol.2 , pp. 111-121
    • McElwee, J.1    Bubb, K.2    Thomas, J.H.3
  • 5
    • 33646482549 scopus 로고    scopus 로고
    • Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans
    • McElwee, J. J., Schuster, E., Blanc, E., Thornton, J.&Gems, D. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. Mech. Ageing Dev. 127, 458-472 (2006).
    • (2006) Mech. Ageing Dev , vol.127 , pp. 458-472
    • McElwee, J.J.1    Schuster, E.2    Blanc, E.3    Thornton, J.4    Gems, D.5
  • 6
    • 0027771804 scopus 로고
    • elegans mutant that lives twice as long as wild type
    • Kenyon, C., Chang, J., Gensch, E., Rudner, A. & Tabtiang, R. A. C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464 (1993).
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.A.C.5
  • 7
    • 33645090940 scopus 로고    scopus 로고
    • Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling
    • Narbonne, P. & Roy, R. Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. Development 133, 611-619 (2006).
    • (2006) Development , vol.133 , pp. 611-619
    • Narbonne, P.1    Roy, R.2
  • 8
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
    • Hardie, D. G. AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy. Nature Rev. Mol. Cell Biol. 8, 774-785 (2007).
    • (2007) Nature Rev. Mol. Cell Biol , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 9
    • 10644282295 scopus 로고    scopus 로고
    • The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
    • Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S. & Curtis, R. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 18, 3004-3009 (2004).
    • (2004) Genes Dev , vol.18 , pp. 3004-3009
    • Apfeld, J.1    O'Connor, G.2    McDonagh, T.3    DiStefano, P.S.4    Curtis, R.5
  • 10
    • 0032693308 scopus 로고    scopus 로고
    • Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo
    • Fukushige, T., Hendzel, M. J., Bazett-Jones, D. P. & McGhee, J. D. Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo. Proc. Natl Acad. Sci. USA 96, 11883-11888 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 11883-11888
    • Fukushige, T.1    Hendzel, M.J.2    Bazett-Jones, D.P.3    McGhee, J.D.4
  • 11
    • 0028818537 scopus 로고
    • Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system
    • Maduro, M. & Pilgrim, D. Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141, 977-988 (1995).
    • (1995) Genetics , vol.141 , pp. 977-988
    • Maduro, M.1    Pilgrim, D.2
  • 12
    • 25844512127 scopus 로고    scopus 로고
    • Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18
    • Masse, I., Molin, L., Billaud, M. & Solari, F. Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18. Dev. Biol. 286, 91-101 (2005).
    • (2005) Dev. Biol , vol.286 , pp. 91-101
    • Masse, I.1    Molin, L.2    Billaud, M.3    Solari, F.4
  • 13
    • 0027451263 scopus 로고
    • Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans
    • Okkema, P. G., Harrison, S. W., Plunger, V., Aryana, A. & Fire, A. Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans. Genetics 135, 385-404 (1993).
    • (1993) Genetics , vol.135 , pp. 385-404
    • Okkema, P.G.1    Harrison, S.W.2    Plunger, V.3    Aryana, A.4    Fire, A.5
  • 14
    • 11244252136 scopus 로고    scopus 로고
    • lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans
    • Myers, T. R. & Greenwald, I. lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans. Dev. Cell 8, 117-123 (2005).
    • (2005) Dev. Cell , vol.8 , pp. 117-123
    • Myers, T.R.1    Greenwald, I.2
  • 15
    • 3242683216 scopus 로고    scopus 로고
    • Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans
    • McKay, S. J. et al. Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans. Cold Spring Harb. Symp. Quant. Biol. 68, 159-169 (2003).
    • (2003) Cold Spring Harb. Symp. Quant. Biol , vol.68 , pp. 159-169
    • McKay, S.J.1
  • 16
    • 22444446635 scopus 로고    scopus 로고
    • The abts and sulp families of anion transporters from Caenorhabditis elegans
    • Sherman, T. et al. The abts and sulp families of anion transporters from Caenorhabditis elegans. Am. J. Physiol. Cell Physiol. 289, C341-C351 (2005).
    • (2005) Am. J. Physiol. Cell Physiol , vol.289
    • Sherman, T.1
  • 17
    • 0442272486 scopus 로고    scopus 로고
    • A conserved postsynaptic transmembrane protein affecting neuromuscular signaling in Caenorhabditis elegans
    • Loria, P. M., Hodgkin, J. & Hobert, O. A conserved postsynaptic transmembrane protein affecting neuromuscular signaling in Caenorhabditis elegans. J. Neurosci. 24, 2191-2201 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 2191-2201
    • Loria, P.M.1    Hodgkin, J.2    Hobert, O.3
  • 18
    • 3042777524 scopus 로고    scopus 로고
    • FGF signaling functions in the hypodermis to regulate fluid balance in C. elegans
    • Huang, P.& Stern, M. J. FGF signaling functions in the hypodermis to regulate fluid balance in C. elegans. Development 131, 2595-2604 (2004).
    • (2004) Development , vol.131 , pp. 2595-2604
    • Huang, P.1    Stern, M.J.2
  • 19
    • 0025942107 scopus 로고
    • Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences
    • Mello, C. C., Kramer, J. M., Stinchcomb, D. & Ambros, V. Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970 (1991).
    • (1991) EMBO J , vol.10 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.3    Ambros, V.4
  • 20
    • 0032238299 scopus 로고    scopus 로고
    • The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
    • Ogg, S. & Ruvkun, G. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell 2, 887-893 (1998).
    • (1998) Mol. Cell , vol.2 , pp. 887-893
    • Ogg, S.1    Ruvkun, G.2
  • 21
    • 33846029180 scopus 로고    scopus 로고
    • Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
    • Schweiger, M. et al. Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J. Biol. Chem. 281, 40236-40241 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 40236-40241
    • Schweiger, M.1
  • 22
    • 8844226709 scopus 로고    scopus 로고
    • Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    • Zimmermann, R. et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306, 1383-1386 (2004).
    • (2004) Science , vol.306 , pp. 1383-1386
    • Zimmermann, R.1
  • 23
    • 26944489689 scopus 로고    scopus 로고
    • Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila
    • Gronke, S. et al. Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab. 1, 323-330 (2005).
    • (2005) Cell Metab , vol.1 , pp. 323-330
    • Gronke, S.1
  • 24
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • Gwinn, D. M. et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30, 214-226 (2008).
    • (2008) Mol. Cell , vol.30 , pp. 214-226
    • Gwinn, D.M.1
  • 25
    • 0021457201 scopus 로고
    • Functional study of the Caenorhabditis elegans secretory-excretory system using laser microsurgery
    • Nelson, F. K. & Riddle, D. L. Functional study of the Caenorhabditis elegans secretory-excretory system using laser microsurgery. J. Exp. Zool. 231, 45-56 (1984).
    • (1984) J. Exp. Zool , vol.231 , pp. 45-56
    • Nelson, F.K.1    Riddle, D.L.2
  • 26
    • 12144264839 scopus 로고    scopus 로고
    • Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress
    • Lamitina, S. T. & Strange, K. Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress. Am. J. Physiol. Cell Physiol. 288, C467-C474 (2005).
    • (2005) Am. J. Physiol. Cell Physiol , vol.288
    • Lamitina, S.T.1    Strange, K.2
  • 27
    • 33646926969 scopus 로고    scopus 로고
    • Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways
    • Curtis, R., O'Connor, G. & DiStefano, P. S. Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways. Aging Cell 5, 119-126 (2006).
    • (2006) Aging Cell , vol.5 , pp. 119-126
    • Curtis, R.1    O'Connor, G.2    DiStefano, P.S.3
  • 28
    • 34848850156 scopus 로고    scopus 로고
    • An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
    • Greer, E. L. et al. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr. Biol. 17, 1646-1656 (2007).
    • (2007) Curr. Biol , vol.17 , pp. 1646-1656
    • Greer, E.L.1
  • 29
    • 34748850786 scopus 로고    scopus 로고
    • Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    • Schulz, T. J. et al. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 6, 280-293 (2007).
    • (2007) Cell Metab , vol.6 , pp. 280-293
    • Schulz, T.J.1
  • 30
    • 0035515923 scopus 로고    scopus 로고
    • Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
    • Feng, J., Bussiere, F. & Hekimi, S. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell 1, 633-644 (2001).
    • (2001) Dev. Cell , vol.1 , pp. 633-644
    • Feng, J.1    Bussiere, F.2    Hekimi, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.