Dealing with methionine/homocysteine sulfur: Cysteine metabolism to taurine and inorganic sulfur

Journal of Inherited Metabolic Disease

Volumn 34, Issue 1, 2011, Pages 17-32

  Stipanuk, Martha H ^a   Ueki, Iori ^a  

^a Department of Molecular Biology and Genetics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 MERCAPTOPYRUVATE SULFURTRANSFERASE; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; CYSTEINE DIOXYGENASE; CYSTEINESULFINATE; HOMOCYSTEINE; HYDROGEN SULFIDE; METHIONINE; S ADENOSYLMETHIONINE; SULFATE; SULFIDE; SULFITE; SULFUR; SULFUR AMINO ACID; SULFURTRANSFERASE; TAURINE; UNCLASSIFIED DRUG; SULFUR DERIVATIVE;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ARTICLE; CATABOLISM; CATALYSIS; DEGRADATION; DESULFURIZATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; NONHUMAN; OXIDATION; PROTEIN RESTRICTION; TRANSAMINATION; ANIMAL; BIOLOGICAL MODEL; METABOLISM; RAT; REVIEW;

ANIMALS; CYSTEINE; HOMOCYSTEINE; HUMANS; METABOLIC NETWORKS AND PATHWAYS; METHIONINE; MODELS, BIOLOGICAL; RATS; SULFUR; SULFUR COMPOUNDS; TAURINE;

EID: 79953715220     PISSN: 01418955     EISSN: 15732665     Source Type: Journal    
DOI: 10.1007/s10545-009-9006-9     Document Type: Article

References (108)

1. Akagi R (1982) Purification and characterization of cysteine aminotransferase from rat liver cytosol. Acta Med Okayama 36:187-197
2. Bagley PJ, Stipanuk MH (1995) Rats fed a low protein diet supplemented with sulfur amino acids have increased cysteine dioxygenase activity and increased taurine production in hepatocytes. J Nutr 125:933-940
3. Banerjee R, Zou CG (2005) Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein. Arch Biochem Biophys 433:144-156 (Pubitemid 39586589)
4. Bella DL, Stipanuk MH (1995) Effects of protein, methionine, or chloride on acid-base balance and on cysteine catabolism. Am J Physiol 269:E910-E917 (Pubitemid 3005911)
5. Bella DL, Kwon YH, Stipanuk MH (1996) Variations in dietary protein but not in dietary fat plus cellulose or carbohydrate levels affect cysteine metabolism in rat isolated hepatocytes. J Nutr 126:2179-2187 (Pubitemid 26313595)
6. Bella DL, Hahn C, Stipanuk MH (1999a) Effects of nonsulfur and sulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism. Am J Physiol 277:E144-E153 (Pubitemid 29356738)
7. Bella DL, Hirschberger LL, Hosokawa Y, Stipanuk MH (1999b) Mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo. Am J Physiol 276:E326-E335 (Pubitemid 29100589)
8. Bradley H, Gough A, Sokhi RS, Hassell A, Waring R, Emery P (1994) Sulfate metabolism is abnormal in patients with rheumatoid arthritis. Confirmation by in vivo biochemical findings. J Rheumatol 21:1192-1196 (Pubitemid 24234650)
9. Brand A, Leibfritz D, Hamprecht B, Dringen R (1998) Metabolism of cysteine in astroglial cells: synthesis of hypotaurine and taurine. J Neurochem 71:827-832 (Pubitemid 28480432)
10. Braunstein AE, Goryachenkova EV, Tolosa EA, Willhardt IH, Yefremova LL (1971) Specificity and some other properties of liver serine sulphhydrase: evidence for its identity with cystathionine β-synthase. Biochim Biophys Acta 242:247-260
11. Burlina A, Zacchello F, Dionisi-Vici C, Bertini E, Sabetta G, Bennet MJ, Hale DE, Schmidt-Sommerfeld E, Rinaldo P (1991) New clinical phenotype of branched-chain acyl-CoA oxidation defect. Lancet 338:1522-1523
12. Cavallini D, Mondovi B, De Marco C, Scioscia-Santoro A (1962a) Inhibitory effect of mercaptoethanol and hypotaurine on the desulfhydration of cysteine by cystathionase. Arch Biochem Biophys 96:456-457
13. Cavallini D, Mondovi B, De Marco C, Scioscia-Santoro A (1962b) The mechanism of desulphhydration of cysteine. Enzymologia 24:253-266
14. Chen X, Jhee KH, Kruger WD (2004) Production of the neuromodulator H2S by cystathionine β-synthase via the condensation of cysteine and homocysteine. J Biol Chem 279:52082-52086 (Pubitemid 39656580)
15. 2S biogenesis by human cystathionine γ-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem 284:11601-11612
16. Coloso RM, Stipanuk MH (1989) Metabolism of cyst(e)ine in rat enterocytes. J Nutr 119:1914-1924 (Pubitemid 20063885)
17. Coloso RM, Drake MR, Stipanuk MH (1990) Effect of bathocuproine disulfonate, a copper chelator, on cyst(e)ine metabolism by freshly isolated rat hepatocytes. Am J Physiol 259:E443-E450 (Pubitemid 20320769)
18. Crawhall JC (1985) A review of the clinical presentation and laboratory findings in two uncommon hereditary disorders ofsulfur amino acid metabolism, β-mercaptolactate cysteine disulfideuria and sulfite oxidase deficiency. Clin Biochem 18:139-142
19. Crawhall JC, Parker R, Sneddon W, Young EP (1969) Beta-mercaptolactate- cysteine disulfide in the urine of a mentally retarded patient. Am J Dis Child 117:71-82
20. Cresenzi CL, Lee JI, Stipanuk MH (2003) Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats. J Nutr 133:2697-2702 (Pubitemid 37099747)
21. Davies MH, Ngong JM, Pean A, Vickers CR, Waring RH, Elias E (1995) Sulphoxidation and sulphation capacity in patients with primary biliary cirrhosis. J Hepatol 22:551-560
22. Dominy JE, Stipanuk MH (2004) New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant. Nutr Rev 62:348-353 (Pubitemid 39299136)
23. Dominy JE Jr, Hirschberger LL, Coloso RM, Stipanuk MH (2006a) Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26S proteasome system in the living rat. Biochem J 394:267-273 (Pubitemid 43259677)
24. Dominy JE Jr, Hirschberger LL, Coloso RM, Stipanuk MH (2006b) In vivo regulation of cysteine dioxygenase via the ubiquitin-26S proteasome system. Adv Exp Med Biol 583:37-47
25. Dominy JE Jr, Simmons CR, Karplus PA, Gehring AM, Stipanuk MH (2006c) Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria. J Bacteriol 188:5561-5569 (Pubitemid 44157313)
26. Dominy JE Jr, Hwang J, Stipanuk MH (2007) Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells. Am J Physiol Endocrinol Metab 293:E62-E69 (Pubitemid 47105917)
27. Dominy JE Jr, Hwang J, Guo S, Hirschberger LL, Zhang S, Stipanuk MH (2008) Synthesis of amino acid cofactor in cysteine dioxygenase is regulated by substrate and represents a novel post-translational regulation of activity. J Biol Chem 283:12188-12201
28. Dorman DC, Moulin FJ, McManus BE, Mahle KC, James RA, Struve MF (2002) Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium. Toxicol Sci 65:18-25 (Pubitemid 34092686)
29. Drake MR, De La Rosa J, Stipanuk MH (1987) Metabolism of cysteine in rat hepatocytes. Evidence for cysteinesulphinatein-dependent pathways. Biochem J 244:279-286
30. Ensunsa JL, Hirschberger LL, Stipanuk MH (1993) Catabolism of cysteine, cystine, cysteinesulfinate, and OTC by isolated perfused rat hindquarter. Am J Physiol 264:E782-789
31. Feng C, Tollin G, Enemark JH (2007) Sulfite oxidizing enzymes. Biochim Biophys Acta 1774:527-539 (Pubitemid 46670806)
32. Fiedler H, Wood JL (1956) Specificity studies on the β- mercaptopyruvate-cyanide transsulfuration system. J Biol Chem 222:387-397
33. Finkelstein JD, Kyle WE, Harris BJ, Martin JJ (1982) Methionine metabolism in mammals: concentration of metabolites in rat tissues. J Nutr 112:1011-1018 (Pubitemid 12015903)
34. Fiorucci S, Distrutti E, Cirino G, Wallace JL (2006) The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver. Gastroenterology 131:259-271 (Pubitemid 44043128)
35. Garcia RA, Stipanuk MH (1992) The splanchnic organs, liver and kidney have unique roles in the metabolism of sulfur amino acids and their metabolites in rats. J Nutr 122:1693-1701
36. García-Silva MT, Campos Y, Ribes A, Briones P, Cabello A, Santos Borbujo J, Arenas J, Garavaglia B (1994) Encephalopathy, petechiae, and acrocyanosis with ethylmalonic aciduria associated with muscle cytochrome c oxidase deficiency. J Pediatr 125:843-844 (Pubitemid 24350203)
37. Goubern M, Andriamihaja M, Nübel T, Blachier F, Bouillaud F (2007) Sulfide, the first inorganic substrate for human cells. FASEB J 21:1699-1706 (Pubitemid 46855615)
38. Guion-Rain MC, Portemer C, Chaatagner F (1975) Rat liver cysteine sulfinate decarboxylase: purification, new appraisal of the molecular weight and determination of catalytic properties. Biochim Biophys Acta 384:265-276
39. Hannestad U, Mårtensson J, Sjödahl R, Sörbo B (1981) 3-mercaptolactate cysteine disulfiduria: biochemical studies on affected and unaffected members of a family. Biochem Med 26:106-114 (Pubitemid 11052860)
40. Heafield MT, Schmid D, Breitkreutz R, Stahl-Henning C, Drings P et al (1990) Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease. Neurosci Lett 110:216-220
41. Hildebrandt TM, Grieshaber MK (2008) Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. FEBS J 275:3352-3361 (Pubitemid 351813547)
42. Huang J, Khan S, O'Brien PJ (1998) The glutathione dependence of inorganic sulfate formation from L- or D-cysteine in isolated rat hepatocytes. Chem Biol Interact 110:189-202 (Pubitemid 28218267)
43. Ip MP, Thibert RJ, Schmidt DE Jr (1977) Purification and partial characterization of cysteine-glutamate transaminase from rat liver. Can J Biochem 55:958-964 (Pubitemid 8199005)
44. Jaffrey SR, Erdjument-Bromage H, Ferris CD, Tempst P, Snyder SH (2001) Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol 3:193-197 (Pubitemid 32118373)
45. Janosík M, Kery V, Gaustadnes M, Maclean KN, Kraus JP (2001) Regulation of human cystathionine β-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region. Biochemistry 40:10625-10633 (Pubitemid 32816674)
46. Johnson JL, Rajagopalan KV (1995) An HPLC assay for detection of elevated urinary S-sulphocysteine, a metabolic marker of sulphite oxidase deficiency. J Inherit Metab Dis 18:40-47
47. Jones DP, Go YM, Anderson CL, Ziegler TR, Kinkade JM Jr, Kirlin WG (2004) Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control. FASEB J 18:1246-1248 (Pubitemid 39561565)
48. Karlsen RL, Grofova I, Malthe-Sorenssen D, Fonnum F (1981) Morphological changes in rat brain induced by L-cysteine injection in newborn animals. Brain Res 208:167-180 (Pubitemid 11130297)
49. 35S]Thiosulphate oxidation by rat liver mitochondria in the presence of glutathione. Biochem J 103:791-795
50. Kun E, Fanshier DW (1958) Isolation and identification of β-mercaptopyruvate desulfurase. Biochim Biophys Acta 27:659
51. Kun E, Fanshier DW (1959a) Enzymic transfer of sulfur from β-mercaptopyruvate to cyanide. Biochim Biophys Acta 33:26-18
52. Kun E, Fanshier DW (1959b) Isolation and properties of a β-mercaptopyruvate-cleaving copper enzyme. Biochim Biophys Acta 32:338-348
53. Kwon YH, Stipanuk MH (2001) Cysteine regulates expression of cysteine dioxygenase and γ-glutamylcysteine synthetase in cultured rat hepatocytes. Am J Physiol Endocrinol Metab 280:E804-815
54. Lak ND, Goryachenkova EV, Braunstein AE (1970) Investigation of substrate specificity of serine sulfhydrase from the hen liver and its relation to some inhibitors. Biokhimia 35:270-277
55. Lee JI, Londono M, Hirschberger LL, Stipanuk MH (2004) Regulation of cysteine dioxygenase and gamma-glutamylcysteine synthetase is associated with hepatic cysteine level. J Nutr Biochem 15:112-122 (Pubitemid 38224351)
56. Linden DR, Sha L, Mazzone A, Stoltz GJ, Bernard CE, Furne JK, Levitt MD, Farrugia G, Szurszewski JH (2008) Production of the gaseous signal molecule hydrogen sulfide in mouse tissues. J Neurochem 106:1577-15785
57. Lloyd D (2006) Hydrogen sulfide: clandestine microbial messenger? Trends Microbiol 14:456-462
58. Mancardi D, Penna C, Merlino A, Del Soldato P, Wink DA, Pagliaro P (2009) Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide. Biochim Biophys Acta 1787:864-872
59. Mathisen GA, Fonnum F, Paulsen RE (1996) Contributing mechanisms for cysteine excitotoxicity in cultured cerebellar granule cells. Neurochem Res 21:293-298 (Pubitemid 26134609)
60. McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN Jr (2006) Structure and mechanism of mouse cysteine dioxygenase. Proc Natl Acad Sci U S 103:3084-3089 (Pubitemid 43346428)
61. Meister A, Fraser PE, Tice SV (1954) Enzymatic desulfuration of β-mercaptopyruvate to pyruvate. J Biol Chem 206:561-575
62. Mudd SH, Ebert MH, Scriver CR (1980) Labile methyl group balances in the human: the role of sarcosine. Metabolism 29:707-720 (Pubitemid 10035078)
63. Mustafa AK, Gadalla MM, Snyder SH, Mustafa AK, Gadalla MM, Snyder SH (2009) Signaling by gasotransmitters. Sci Signal 2:re2
64. Niederwiesler A, Giliberti P, Baerlocher K (1973) β-Mercaptolactate cysteine disulfiduria in two normal sisters. Isolation and characterization of β-mercaptolactate cysteine disulfide. Clin Chim Acta 43:405-416
65. Oertel WH, Schmechel DE, Weise VK, Ransom DH, Tappax ML et al (1981) Comparison of cysteine sulphininc acid decarboxylase isoenzymes and glutamic acid decarboxylase in rat liver and brain. Neuroscience 6:2701-2714 (Pubitemid 12247058)
66. Pedersen OO, Karlsen RL (1980) The toxic effect of L-cysteine on the rat retina. A morphological and biochemical study. Invest Ophthalmol Vis Sci 19:886-892
67. Perry TL, Krieger C, Hansen S, Tabatabaei A (1991) Amyotrophic lateral sclerosis: fasting plasma levels of cysteine and inorganic sulfate are normal, as are brain contents of cysteine. Neurology 41:487-490
68. Poole JR, Mudd SH, Conerly EB, Edwards WA (1975) Homocystinuria due to cystathionine synthase deficiency: studies of nitrogen balance and sulfur excretion. J Clin Invest 55:1033-1048
69. Porter PN, Grishaver MS, Jones OW (1974) Characterization of human cystathionine β-synthase. Evidence for the identity of human L-serine dehydratase and cystathionine β-synthase. Biochim Biophys Acta 364:128-139
70. Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R (2006) S-adenosylmethionine stabilizes cystathionine β-synthase and modulates redox capacity. Proc Natl Acad Sci U S A 103:6489-6494
71. Qu K, Lee SW, Bian JS, Low CM, Wong PT (2008) Hydrogen sulfide: neurochemistry and neurobiology. Neurochem Int 52:155-165 (Pubitemid 350235691)
72. Recasens M, Benezra R, Basset P, Mandel P (1980) Cysteine sulfinate aminotransferase and aspartate aminotransferase isoenzymes of rat brain: purification, characterization, and further evidence for identity. Biochemistry 19:4583-4589
73. Rentschler LA, Hirschberger LL, Stipanuk MH (1986) Response of the kitten to dietary taurine depletion: effects on renal reabsorption, bile acid conjugation and activities of enzymes involved in taurine synthesis. Comp Biochem Physiol B 84:319-325
74. Rupar CA, Gillettt J, Gordon BA, Ramsay DA, Johnson JL et al (1996) Isolated sulfite oxidase deficiency. Neuropediatrics 27:299-304 (Pubitemid 27067358)
75. Sandberg M, Orwar O, Hehmann A (1991) L-Cysteine toxicity: effects on non-sulfur amino acids, sulfur-containing excitatory amino acids and γ-glutamyl peptides in the immature brain. J Neurochem 57:S152
76. Shibuya N, Tanaka M, Yoshida M, Ogasawara Y, Togawa T, Ishii K, Kimura H (2009) 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid Redox Signal 11:703-714
77. Simmons CR, Hirschberger LL, Machi MS, Stipanuk MH (2006a) Expression, purification, and kinetic characterization of recombinant rat cysteine dioxygenase, a non-heme metalloenzyme necessary for regulation of cellular cysteine levels. Protein Expr Purif 47:74-81
78. Simmons CR, Liu Q, Huang Q, Hao Q, Begley TP, Karplus PA, Stipanuk MH (2006b) Crystal structure of mammalian cysteine dioxygenase. A novel mononuclear ironcenter for cysteine thiol oxidation. J Biol Chem 281:18723-18733 (Pubitemid 44035533)
79. 2+-bound persulfenate intermediate in cysteine dioxygenase. Biochemistry 47:11390-11392
80. 2S biogenesis via alternative transsulfuration reactions. J Biol Chem 284:22457-22466
81. Sörbo B (1987) 3-Mercaptopyruvate, 3-mercaptolactate and mercaptoacetate. Methods Enzymol 143:178-182
82. Stipanuk MH (1986) Metabolism of sulfur-containing amino acids. Annu Rev Nutr 6:179-209
83. Stipanuk MH (2004) Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 24:539-577
84. Stipanuk MH, Beck PW (1982) Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat. Biochem J 206:267-277
85. Stipanuk MH, Rotter MA (1984) Metabolism of cysteine, cysteine-sulfinate and cysteinesulfonate in rats fed adequate and excess levels of sulfur-containing amino acids. J Nutr 114:1426-1437 (Pubitemid 14052490)
86. Stipanuk MH, De la Rosa J, Hirschberger LL (1990) Catabolism of cyst(e)ine by rat renal cortical tubules. J Nutr 120:450-458 (Pubitemid 20181666)
87. Stipanuk MH, Londono M, Lee JI, Hu M, Yu AF (2002) Enzymes and metabolites of cysteine metabolism in nonhepatic tissues of rats show little response to changes in dietary protein or sulfur amino acid levels. J Nutr 132:3369-3378 (Pubitemid 35304246)
88. Stipanuk MH, Hirschberger LL, Londono MP, Cresenzi CL, Yu AF (2004a) The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver. Am J Physiol Endocrinol Metab 286:E439-E448 (Pubitemid 38292695)
89. Stipanuk MH, Londono M, Hirschberger LL, Hickey C, Thiel DJ, Wang L (2004b) Evidence for expression of a single distinct form of mammalian cysteine dioxygenase. Amino Acids 26:99-106 (Pubitemid 38270763)
90. Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM (2006) Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr 136:1652S-1659S
91. Storch KJ, Wagner DA, Burke JF, Young VR (1988) Quantitative study in vivo of methionine cycle in humans using [methyl-2H3]- and [1-13C]methionine. Am J Physiol 255:E322-E331
92. Szczepkowski TW, Wood JL (1967) The cystathionase-rhodanese system. Biochim Biophys Acta 139:469-478
93. Szczepkowski TW, Skarzynski B, Weber M (1961) The metabolic state of thiosulphate. Nature 189:1007-1008
94. Taniguchi T, Kimura T (1974) Role of 3-mercaptopyruvate sulfur-transferase in the formation of the iron-sulfur chromophore of adrenal ferredoxin. Biochim Biophys Acta 364:284-295
95. Tiranti V, Viscomi C, Hildebrandt T, Di Meo I, Mineri R, Tiveron C, Levitt MD, Prelle A, Fagiolari G, Rimoldi M, Zeviani M (2009) Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy. Nat Med 15:200-205
96. Touati G, Rusthoven E, Depondt E, Dorche C, Duran M, Heron B, Rabier D, Russo M, Saudubray JM (2000) Dietary therapy in two patients with a mild form of sulphite oxidase deficiency. Evidence for clinical and biological improvement. J Inherit Metab Dis 23:45-53 (Pubitemid 30071960)
97. Ubuka T, Umemura S, Ishimoto Y, Shimomura M (1977a) Transaminase of L-cysteine in rat liver mitochondria. Physiol Chem Phys 9:91-96
98. Ubuka T, Yuasa S, Ishimoto Y, Shimomura M (1977b) Desulfuration of L-cysteine through transamination and transsulfuration in rat liver. Physiol Chem Phys 9:241-246
99. Ubuka T, Umemura S, Yuasa S, Kinuta M, Watanabe K (1978) Purification and characterization of mitochondrial cysteine aminotransferase from rat liver. Physiol Chem Phys 10:483-500
100. Ueki I, Stipanuk MH (2009) 3T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/ cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways. J Nutr 139:207-214
101. Uren JR, Ragin R, Chaykovsky M (1978) Modulation of cysteine metabolism in mice-effects of propargylglycine and L-cyst(e)inedegrading enzymes. Biochem Pharmacol 27:2807-2814 (Pubitemid 9078480)
102. Wang R (2002) Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J 16:1792-1798
103. Wang XB, Jin HF, Tang CS, Du JB (2009) Significance of endogenous sulfur-containing gases in the cardiovascular system. Clin Exp Pharmacol Physiol.. doi:10.1111/j.1440-1681.2009.05249
104. Yagi T, Kagamiyama H, Nozaki M (1979) Cysteine sulfinate transamination activity of aspartate aminotransferase. Biochem Biophys Res Commun 90:447-452
105. Yamaguchi K, Hosokawa Y, Kohashi N, Kori Y, Sakakibara S, Ueda I (1978) Rat liver cysteine dioxygenase (cysteine oxidase). Further purification, characterization, and analysis of the activation and inactivation. J Biochem 83:479-491 (Pubitemid 8282048)
106. 2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science 322:587-590
107. Yao K, Kinuta M, Akagi R (1979) Cat liver cystathionase. Physiol Chem Phys 11:257-260
108. Ye S, Wu X, Wei L, Tang D, Sun P, Bartlam M, Rao Z (2007) An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. J Biol Chem 282:3391-3402 (Pubitemid 47084325)