Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism

Molecular Systems Biology

Volumn 9, Issue , 2013, Pages

  Stout, Gerdine J ^a,b   Stigter, Edwin C A ^a,b   Essers, Paul B ^d   Mulder, Klaas W ^c   Kolkman, Annemieke ^a,b,e   Snijders, Dorien S ^a,b   Van Den Broek, Niels J F ^a,b   Betist, Marco C ^d   Korswagen, Hendrik C ^d   MacInnes, Alyson W ^d   Brenkman, Arjan B ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b Netherlands Metabolomics Centre   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e KWR WATERCYCLE RESEARCH INSTITUTE   (Netherlands)

Author keywords

ageingx; high throughput analysis; metabolism; protein metabolism; translation

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; INSULIN; MESSENGER RNA; PROTEASOME; SOMATOMEDIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR DAF2; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; DAF 16 PROTEIN, C ELEGANS; DAF 2 PROTEIN, C ELEGANS; DAF-16 PROTEIN, C ELEGANS; DAF-2 PROTEIN, C ELEGANS; INSULIN RECEPTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; LONGEVITY; NONHUMAN; PHENOTYPE; POLYSOME; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SYNTHESIS; PROTEOMICS; REGULATORY MECHANISM; RNA INTERFERENCE; RNA PROCESSING; RNA TRANSLATION; RNA TRANSPORT; SIGNAL TRANSDUCTION; ADULT; DIET RESTRICTION; DOWN REGULATION; ENZYME ACTIVITY; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; TRANSLATION INITIATION; WILD TYPE; YOUNG ADULT; ANIMAL; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; METABOLISM; MUTATION;

CAENORHABDITIS ELEGANS;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE EXPRESSION REGULATION; GENOTYPE; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; MUTATION; PHENOTYPE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BIOSYNTHESIS; RECEPTOR, INSULIN; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84880085087     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2013.35     Document Type: Article

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