Cellular and molecular mechanisms in liver fibrogenesis

Archives of Biochemistry and Biophysics

Volumn 548, Issue , 2014, Pages 20-37

  Novo, Erica ^a   Cannito, Stefania ^a   Paternostro, Claudia ^a   Bocca, Claudia ^a   Miglietta, Antonella ^a   Parola, Maurizio ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Chronic inflammation; Chronic liver injury; Extracellular matrix; Fibrogenic mechanisms; Hepatic myofibroblasts; Liver fibrogenesis

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ALPHA FETOPROTEIN; APELIN; CALVASCULIN; CASPASE 3; CD1 ANTIGEN; COLLAGENASE 3; GAMMA INTERFERON; GELATINASE B; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 4; INTERLEUKIN 8; LEPTIN; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; RESISTIN; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SONIC HEDGEHOG PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ADAPTIVE IMMUNITY; ANGIOGENESIS; AUTOPHAGOSOME; AUTOPHAGY; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC LIVER DISEASE; EPITHELIAL MESENCHYMAL TRANSITION; FIBROGENESIS; HISTOGENESIS; HUMAN; HYPOXIA; INNATE IMMUNITY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FAILURE; LIVER FIBROGENESIS; LIVER FIBROSIS; METABOLIC SYNDROME X; MYOFIBROBLAST; NATURAL KILLER T CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STELLATE CELL; WOUND HEALING;

CHRONIC INFLAMMATION; CHRONIC LIVER INJURY; EXTRACELLULAR MATRIX; FIBROGENIC MECHANISMS; HEPATIC MYOFIBROBLASTS; LIVER FIBROGENESIS;

ANIMALS; CHRONIC DISEASE; DISEASE PROGRESSION; EXTRACELLULAR MATRIX; HUMANS; INFLAMMATION; LIVER; LIVER CIRRHOSIS; MYOFIBROBLASTS; OXIDATIVE STRESS;

EID: 84897897591     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2014.02.015     Document Type: Review

References (149)

1. S.L. Friedman Gastroenterology 134 2008 1655 1669
2. M. Parola, F. Marra, and M. Pinzani Mol. Aspects Med. 29 2008 58 66
3. J.A. Dranoff, and R.G. Wells Hepatology 51 2010 1438 1444
4. S.J. Forbes, and M. Parola Best Pract. Res. Clin. Gastroenterol. 25 2011 207 218
5. D.Y. Zhang, and S.L. Friedman Hepatology 56 2012 769 775
6. M. Rosselli, J. MacNaughtan, R. Jalan, and M. Pinzani Gut 62 2013 1234 1241
7. J. Rehm, A.V. Samokhvalov, and K.D. Shield J. Hepatol. 59 2013 160 168
8. H.B. El-Serag, and N. Engl J. Med. 365 2011 1118 1127
9. H.B. El-Serag Gastroenterology 142 2012 1264 1273
10. M. Pinzani, and K. Rombouts Dig. Liver Dis. 36 2004 231 242
11. J.P. Iredale, A. Thompson, and N.C. Henderson Biochim. Biophys. Acta 1832 2013 876 883
12. M.R. Watson, K. Wallace, R.G. Gieling, D.M. Manas, E. Jaffray, R.T. Hay, D.A. Mann, and F. Oakley J. Hepatol. 48 2008 589 597
13. E. Novo, F. Marra, E. Zamara, L. Valfrè di Bonzo, L. Monitillo, S. Cannito, I. Petrai, A. Mazzocca, A. Bonacchi, R.S. De Franco, S. Colombatto, R. Autelli, M. Pinzani, and M. Parola Gut 55 2006 1174 1182
14. T.J. Kendall, S. Hennedige, R.L. Aucott, S.N. Hartland, M.A. Vernon, R.C. Benyon, and J.P. Iredale Hepatology 49 2009 901 910
15. V.J. Desmet, and T. Roskams J. Hepatol. 40 2004 860 867
16. D. Cassiman, L. Libbrecht, V. Desmet, C. Denef, and T. Roskams J. Hepatol. 36 2002 200 209
17. S.S. Choi, and A.M. Diehl Hepatology 50 2009 2007 2013
18. E. Novo, and M. Parola Fibrogenesis Tissue Repair 1 2008 1 5
19. E. Novo, C. Busletta, L.V. Bonzo, D. Povero, C. Paternostro, K. Mareschi, I. Ferrero, E. David, C. Bertolani, A. Caligiuri, S. Cannito, E. Tamagno, A. Compagnone, S. Colombatto, F. Marra, F. Fagioli, M. Pinzani, and M. Parola J. Hepatol. 54 2011 964 974
20. E. Novo, D. Povero, C. Busletta, C. Paternostro, L.V. di Bonzo, S. Cannito, A. Compagnone, A. Bandino, F. Marra, S. Colombatto, E. David, M. Pinzani, and M. Parola J. Pathol. 226 2012 588 597
21. E. Albano Mol. Aspects Med. 29 2008 9 16
22. L. Boulter, O. Govaere, T.G. Bird, S. Radulescu, P. Ramachandran, A. Pellicoro, R.A. Ridgway, S.S. Seo, B. Spee, N. Van Rooijen, O.J. Sansom, J.P. Iredale, S. Lowell, T. Roskams, and S.J. Forbes Nat. Med. 18 2012 572 579
23. R. Kalluri, and R.A. Weinberg J. Clin. Invest. 119 2009 1420 1428
24. S. Cannito, E. Novo, L.V. di Bonzo, C. Busletta, S. Colombatto, and M. Parola Antioxid. Redox Signal. 12 2010 1383 1430
25. M. Zeisberg, C. Yang, M. Martino, M.B. Duncan, F. Rieder, H. Tanjore, and R. Kalluri J. Biol. Chem. 282 2007 23337 23347
26. S. Dooley, J. Hamzavi, L. Ciuclan, P. Godoy, I. Ilkavets, S. Ehnert, E. Ueberham, R. Gebhardt, S. Kanzler, A. Geier, K. Breitkopf, H. Weng, and P.R. Mertens Gastroenterology 135 2008 642 659
27. J.L. Xia, C. Dai, G.K. Michalopoulos, and Y. Liu Am. J. Pathol. 168 2006 1500 1512
28. Y. Chen, S. Zheng, D. Qi, S. Zheng, J. Guo, S. Zhang, and Z. Weng PloS One 7 2012 e46512
29. G. Xie, G. Karaca, M. Swiderska-Syn, G.A. Michelotti, L. Kruger, Y. Chen, R.T. Premont, S.S. Choi, and A.M. Diehl Hepatology 58 2013 1801 1813
30. X. Liu, J. Li, J. Xiong, M. Li, Y. Zhang, and Q. Zheng Hepatol. Res. 42 2012 1024 1038
31. K. Taura, K. Miura, K. Iwaisako, C.H. Osterreicher, Y. Kodama, M. Penz-Osterreicher, and D.A. Brenner Hepatology 51 2010 1027 1036
32. D. Scholten, C.H. Osterreicher, A. Scholten, K. Iwaisako, G. Gu, D.A. Brenner, and T. Kisseleva Gastroenterology 139 2010 987 998
33. C.H. Österreicher, M. Penz-Österreicher, S.I. Grivennikov, M. Guma, E.K. Koltsova, C. Datz, R. Sasik, G. Hardiman, M. Karin, and D.A. Brenner Proc. Natl. Acad. Sci. USA 108 2011 308 313
34. A.S. Chu, R. Diaz, J.-J. Hui, K. Yanger, Y. Zong, G. Alpini, B.Z. Stanger, and R.G. Wells Hepatology 53 2011 1685 1695
35. J.S. Troeger, I. Mederacke, G.Y. Gwak, D.H. Dapito, X. Mu, C.C. Hsu, J.P. Pradere, R.A. Friedman, and R.F. Schwabe Gastroenterology 143 2012 1073 1083
36. T. Kisseleva, H. Uchinami, N. Feirt, O. Quintana-Bustamante, J.C. Segovia, R.F. Schwabe, and D.A. Brenner J. Hepatol. 45 2006 429 438
37. I. Mederacke, C.C. Hsu, J.S. Troeger, P. Huebener, X. Mu, D.H. Dapito, J.P. Pradere, and R.F. Schwabe Nat. Commun. 4 2013 2823 10.1038/ncomms3823
38. G. Xie, and A.M. Diehl Am. J. Physiol. Gastrointest. Liver Physiol. 305 2013 G881 G890
39. A. Omenetti, S. Choi, G. Michelotti, and A.M. Diehl J. Hepatol. 54 2011 366 373
40. S. Dennler, J. Andre, F. Verrecchia, and A. Mauvie J. Biol. Chem. 284 2009 31523 31531
41. D. Jenkins Cell Signal. 21 2009 1023 1034
42. M.A. Huber, N. Kraut, and H. Beug Curr. Opin. Cell Biol. 17 2005 548 558
43. Y. Katoh, and M. Katoh Curr. Mol. Med. 9 2009 873 886
44. J.K. Sicklick, Y.X. Li, A. Melhem, E. Schmelzer, M. Zdanowicz, J. Huang, Y.X. Li, M. Rojkind, and A.M. Diehl Am. J. Physiol. Gastrointest. Liver Physiol. 290 2006 G859 G870
45. L. Yang, Y. Wang, H. Mao, S. Fleig, A. Omenetti, K.D. Brown, J.K. Sicklick, Y.X. Li, and A.M. Diehl J. Hepatol. 48 2008 98 106
46. A. Omenetti, W.K. Syn, Y. Jung, H. Francis, A. Porrello, R.P. Witek, S.S. Choi, L. Yang, M.J. Mayo, M.E. Gershwin, G. Alpini, and A.M. Diehl Hepatology 50 2009 518 527
47. W.K. Syn, Y.H. Oo, T.A. Pereira, G.F. Karaca, Y. Jung, A. Omenetti, R.P. Witek, S.S. Choi, C.D. Guy, C.M. Fearing, V. Teaberry, F.E. Pereira, D.H. Adams, and A.M. Diehl Hepatology 51 2010 1998 2007
48. W.K. Syn, R.P. Witek, S.M. Curbishley, Y. Jung, S.S. Choi, B. Enrich, A. Omenetti, K.M. Agboola, C.M. Fearing, H. Tilg, D.H. Adams, and A.M. Diehl Eur. J. Immunol. 39 2009 1879 1892
49. F. Marra, and C. Bertolani Hepatology 50 2009 957 969
50. A. Lonardo, L.E. Adinolfi, P. Loria, N. Carulli, G. Ruggiero, and C.P. Day Gastroenterology 126 2004 586 597
51. F. Marra J. Hepatol. 46 2007 12 18
52. S. Aleffi, I. Petrai, C. Bertolani, M. Parola, S. Colombatto, E. Novo, F. Vizzutti, F.A. Anania, S. Milani, K. Rombouts, G. Laffi, M. Pinzani, and F. Marra Hepatology 42 2005 1339 1348
53. N.K. Saxena, K. Ikeda, D.C. Rockey, S.L. Friedman, and F.A. Anania Hepatology 35 2002 762 771
54. Q. Cao, K.M. Mak, C. Ren, and C.S. Lieber J. Biol. Chem. 279 2004 4292 4304
55. N.K. Saxena, M.A. Titus, X. Ding, J. Floyd, S. Srinivasan, S.V. Sitaraman, and F.A. Anania FASEB J. 18 2004 1612 1614
56. S. de Minicis, E. Seki, C. Oesterreicher, B. Schnabl, R.F. Schwabe, and D.A. Brenner Hepatology 48 2008 2016 2026
57. M.R. Sierra-Honigmann, A.K. Nath, C. Murakami, G. García- Cardeña, A. Papapetropoulos, W.C. Sessa, L.A. Madge, J.S. Schechner, M.B. Schwabb, P.J. Polverini, and J.R. Flores-Riveros Science 281 1998 1683 1686
58. A.M. Diehl Am. J. Physiol. Gastrointest. Liver Physiol. 282 2002 G1 G5
59. J. Wang, I. Leclercq, J.M. Brymora, N. Xu, M. Ramezani-Moghadam, R.M. London, D. Brigstock, and J. George Gastroenterology 137 2009 713 723
60. T. Kadowaki, T. Yamauchi, N. Kubota, K. Hara, K. Ueki, and K. Tobe J. Clin. Invest. 116 2006 1784 1792
61. A. Xu, Y. Wang, H. Keshaw, L.Y. Xu, K.S. Lam, and G.J. Cooper J. Clin. Invest. 112 2003 91 100
62. Y. Kamada, S. Tamura, S. Kiso, H. Matsumoto, Y. Saji, Y. Yoshida, K. Fukui, N. Maeda, H. Nishizawa, H. Nagaretani, Y. Okamoto, S. Kihara, J. Miyagawa, Y. Shinomura, T. Funahashi, and Y. Matsuzawa Gastroenterology 125 2003 1796 1807
63. T. Asano, K. Watanabe, N. Kubota, T. Gunji, M. Omata, T. Kadowaki, and S. Ohnishi J. Gastroenterol. Hepatol. 24 2009 1669 1676
64. Y. Kamada, H. Matsumoto, S. Tamura, J. Fukushima, S. Kiso, K. Fukui, T. Igura, N. Maeda, S. Kihara, T. Funahashi, Y. Matsuzawa, I. Shimomura, and N. Hayashi J. Hepatol. 47 2007 556 564
65. N. Ouchi, S. Kihara, Y. Arita, Y. Okamoto, K. Maeda, H. Kuriyama, K. Hotta, M. Nishida, M. Takahashi, M. Muraguchi, Y. Ohmoto, T. Nakamura, S. Yamashita, T. Funahashi, and Y. Matsuzawa Circulation 102 2000 1296 1301
66. A. Gastaldelli, K. Cusi, M. Pettiti, J. Hardies, Y. Miyazaki, R. Berria, E. Buzzigoli, A.M. Sironi, E. Cersosimo, E. Ferrannini, and R.A. Defronzo Gastroenterology 133 2007 496 506
67. A. Caligiuri, C. Bertolani, C.T. Guerra, S. Aleffi, S. Galastri, M. Trappoliere, F. Vizzutti, S. Gelmini, G. Laffi, M. Pinzani, and F. Marra Hepatology 47 2008 668 676
68. X. Ding, N.K. Saxena, S. Lin, A. Xu, S. Srinivasan, and F.A. Anania Am. J. Pathol. 166 2005 1655 1669
69. K. Tomita, Y. Oike, T. Teratani, T. Taguchi, M. Noguchi, T. Suzuki, A. Mizutani, H. Yokoyama, R. Irie, H. Sumimoto, A. Takayanagi, K. Miyashita, M. Akao, M. Tabata, G. Tamiya, T. Ohkura, and T. Hibi Hepatology 48 2008 458 473
70. C.M. Steppan, S.T. Bailey, S. Bhat, E.J. Brown, R.R. Banerjee, C.M. Wright, H.R. Patel, R.S. Ahima, and M.A. Lazar Nature 409 2001 307 312
71. S. Kaser, A. Kaser, A. Sandhofer, C.F. Ebenbichler, H. Tilg, and J.R. Patsch Biochem. Biophys. Res. Commun. 309 2003 286 290
72. M. Lehrke, M.P. Reilly, S.C. Millington, N. Iqbal, D.J. Rader, and M.A. Lazar PLoS Med. 1 2004 e45
73. C. Bertolani, P. Sancho-Bru, P. Failli, R. Bataller, S. Aleffi, R. DeFranco, B. Mazzinghi, P. Romagnani, S. Milani, P. Ginés, J. Colmenero, M. Parola, S. Gelmini, R. Tarquini, G. Laffi, M. Pinzani, and F. Marra Am. J. Pathol. 169 2006 2042 2053
74. A. Kasai, N. Shintani, M. Oda, M. Kakuda, H. Hashimoto, T. Matsuda, S. Hinuma, and A. Baba Biochem. Biophys. Res. Commun. 325 2004 395 400
75. J. Boucher, B. Masri, D. Daviaud, S. Gesta, C. Guigné, A. Mazzucotelli, I. Castan-Laurell, I. Tack, B. Knibiehler, C. Carpé né, Y. Audigier, J.S. Saulnier-Blache, and P. Valet Endocrinology 146 2005 1764 1771
76. A. Principe, P. Melgar-Lesmes, G. Fernandez-Varo, L.R. del Arbol, J. Ros, M. Morales-Ruiz, M. Bernardi, V. Arroyo, and W. Jiménez Hepatology 48 2008 1193 1201
77. P. Melgar-Lesmes, G. Casals, M. Pauta, J. Ros, V. Reichenbach, R. Bataller, M. Morales-Ruiz, and W. Jimenez Endocrinology 151 2010 5306 5314
78. P. Melgar-Lesmes, M. Pauta, V. Reichenbach, J. Ros, R. Bataller, M. Morales-Ruiz, and W. Jiménez Gut 60 2011 1404 1411
79. G.L. Semenza Cell 148 2012 399 408
80. P. Carmeliet, and R.K. Jain Nature 473 2011 298 307
81. M. Fernández, D. Semela, J. Bruix, I. Colle, M. Pinzani, and J. Bosch J. Hepatol. 50 2009 604 620
82. L. Valfrè di Bonzo, E. Novo, S. Cannito, C. Busletta, C. Paternostro, D. Povero, and M. Parola Histol. Histopathol. 23 2009 1324 1341
83. E. Novo, S. Cannito, E. Zamara, L. Valfrè di Bonzo, A. Caligiuri, C. Cravanzola, A. Compagnone, S. Colombatto, F. Marra, M. Pinzani, and M. Parola Am. J. Pathol. 170 2007 1942 1953
84. O. Rosmorduc, and C. Housset Semin. Liver. Dis. 30 2010 258 270
85. J.-K. Moon, T.P. Welch, F.J. Gonzalez, and B.L. Copple Am. J. Physiol. - Gastrointest. Liver Physiol. 296 2009 G582 G592
86. E. Novo, D. Povero, C. Busletta, C. Paternostro, L. Valfrè di Bonzo, S. Cannito, A. Compagnone, A. Bandino, F. Marra, S. Colombatto, E. David, M. Pinzani, and M. Parola J. Pathol. 226 2012 588 597
87. A. Qu, M. Taylor, X. Xue, T. Matsubara, D. Metzger, P. Chambon, F.J. Gonzalez, and Y.M. Shah Hepatology 54 2011 472 483
88. D. Semela, A. Das, D. Langer, N. Kang, E. Leof, and V. Shah Gastroenterology 135 2008 671 679
89. S. Aleffi, N. Navari, W. Delogu, S. Galastri, E. Novo, K. Rombouts, M. Pinzani, M. Parola, and F. Marra Am. J. Physiol. Gastrointest. Liver Physiol. 301 2011 G210 G219
90. R.P. Witek, L. Yang, R. Liu, Y. Jung, A. Omenetti, W.K. Syn, S.S. Choi, Y. Cheong, C.M. Fearing, K.M. Agboola, W. Chen, and A.M. Diehl Gastroenterology 136 2009 320 330
91. M. Hilscher, V. Hernandez-Gea, and S.L. Friedman Biochim. Biophys. Acta 1832 2013 972 978
92. Z. Xie, and D.J. Klionsky Nat. Cell Biol. 9 2007 1102 1109
93. S.A. Tooze, and T. Yoshimori Nat. Cell Biol. 12 2010 831 835
94. H. Nakatogawa, K. Suzuki, Y. Kamada, and Y. Ohsumi Nat. Rev. Mol. Cell Biol. 10 2009 458 467
95. T. Kirisako, Y. Ichimura, H. Okada, Y. Kabeya, N. Mizushima, T. Yoshimori, M. Ohsumi, T. Takao, T. Noda, and Y. Ohsumi J. Cell Biol. 151 2000 263 276
96. I. Tanida, N. Minematsu-Ikeguchi, T. Ueno, and E. Kominami Autophagy 1 2005 84 91
97. V. Hernandez-Gea, Z. Ghiassi-Nejad, R. Rozenfeld, R. Gordon, M.I. Fiel, Z. Yue, M.J. Czaja, and S.L. Friedman Gastroenterology 142 2012 938 946
98. L.F. Thoen, E.L. Guimaraes, L. Dolle, I. Mannaerts, M. Najimi, E. Sokal, and L.A. van Grunsven J. Hepatol. 55 2011 1353 1360
99. V. Hernández-Gea, M. Hilscher, R. Rozenfeld, M.P. Lim, N. Nieto, S. Werner, L.A. Devi, and S.L. Friedman J. Hepatol. 59 2013 98 104
100. T. Kawai, and S. Akira Nat. Immunol. 11 2010 373 384
101. P. Scaffidi, T. Misteli, and M.E. Bianchi Nature 418 2002 191 195
102. F.J. Quintana, and I.R. Cohen J. Immunol. 175 2005 2777 2782
103. K.A. Scheibner, M.A. Lutz, S. Boodoo, M.J. Fenton, J.D. Powell, and M.R. Horton J. Immunol. 177 2006 1272 1281
104. A. Babelova, K. Moreth, W. Tsalastra-Greul, J. Zeng-Brouwers, O. Eickelberg, M.F. Young, P. Bruckner, J. Pfeilschifter, R.M. Schaefer, H.J. Grone, and L. Schaefer J. Biol. Chem. 284 2009 24035 24048
105. H. Kono, C.J. Chen, F. Ontiveros, and K.L. Rock J. Clin. Invest. 120 2010 1939 1949
106. D.V. Krysko, P. Agostinis, O. Krysko, A.D. Garg, C. Bachert, B.N. Lambrecht, and P. Vandenabeele Trends Immunol. 32 2011 157 164
107. K. Schroder, and J. Tschopp Cell 140 2010 821 832
108. B.K. Davis, H. Wen, and J.P. Ting Annu. Rev. Immunol. 29 2011 707 735
109. T. Ichinohe, I.K. Pang, and A. Iwasaki Nat. Immunol. 11 2010 404 410
110. F. Martinon, A. Mayor, and J. Tschopp Annu. Rev. Immunol. 27 2009 229 265
111. K. Nakahira, J.A. Haspel, V.A. Rathinam, S.J. Lee, T. Dolinay, H.C. Lam, J.A. Englert, M. Rabinovitch, M. Cernadas, H.P. Kim, K.A. Fitzgerald, S.W. Ryter, and A.M. Choi Nat. Immunol. 12 2011 222 230
112. G. Guarda, M. Braun, F. Staehli, A. Tardivel, C. Mattmann, I. Forster, M. Farlik, T. Decker, R.A.Du. Pasquier, P. Romero, and J. Tschopp Immunity 34 2011 213 223
113. X. Ouyang, A. Ghani, and W.Z. Mehal Biochim. Biophys. Acta 1832 2013 979 988
114. J.S. Duffield, S.J. Forbes, C.M. Constandinou, S. Clay, M. Partolina, S. Vuthoori, S. Wu, R. Lang, and J.P. Iredale J. Clin. Invest. 115 2005 56 65
115. A. Watanabe, M.A. Sohail, D.A. Gomes, A. Hashmi, J. Nagata, F.S. Sutterwala, S. Mahmood, M.N. Jhandier, Y. Shi, R.A. Flavell, and W.Z. Mehal Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 G1248 G1257
116. T. Csak, M. Ganz, J. Pespisa, K. Kodys, A. Dolganiuc, and G. Szabo Hepatology 54 2011 133 144
117. M.K. Connolly, A.S. Bedrosian, J. Mallen-St Clair, A.P. Mitchell, J. Ibrahim, A. Stroud, H.L. Pachter, D. Bar-Sagi, A.B. Frey, and G. Miller J. Clin. Invest. 119 2009 3213 3225
118. T. Uesugi, M. Froh, G.E. Arteel, B.U. Bradford, and R.G. Thurman Hepatology 34 2001 101 108
119. Y. Adachi, L.E. Moore, B.U. Bradford, W. Gao, and R.G. Thurman Gastroenterology 108 1995 218 224
120. J. Petrasek, S. Bala, T. Csak, D. Lippai, K. Kodys, V. Menashy, M. Barrieau, S.Y. Min, E.A. Kurt-Jones, and G. Szabo J. Clin. Invest. 122 2012 3476 3489
121. T.H. Frazier, J.K. DiBaise, and C.J. McClain J. Parenter. Enteral Nutr. 35 2011 14S 20S
122. K. Miura, Y. Kodama, S. Inokuchi, B. Schnabl, T. Aoyama, H. Ohnishi, J.M. Olefsky, D.A. Brenner, and E. Seki Gastroenterology 139 323-334 2010 e327
123. C.A. Rivera, P. Adegboyega, N. van Rooijen, A. Tagalicud, M. Allman, and M. Wallace J. Hepatol. 47 2007 571 579
124. A. Spruss, G. Kanuri, S. Wagnerberger, S. Haub, S.C. Bischoff, and I. Bergheim Hepatology 50 2009 1094 1104
125. J. Petrasek, A. Dolganiuc, T. Csak, E.A. Kurt-Jones, and G. Szabo Gastroenterology 140 2011 697 708
126. R.G. Gieling, K. Wallace, and Y.P. Han Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 G1324 G1331
127. B. Gao, and S. Radaeva Biochim. Biophys. Acta 1832 2013 1061 1069
128. L.L. Lanier Annu. Rev. Immunol. 23 2005 225 274
129. M. Kronenberg Annu. Rev. Immunol. 23 2005 877 900
130. S. Radaeva, R. Sun, B. Jaruga, V.T. Nguyen, Z. Tian, and B. Gao Gastroenterology 130 2006 435 452
131. W.I. Jeong, O. Park, S. Radaeva, and B. Gao Hepatology 44 2006 1441 1451
132. V. Krizhanovsky, M. Yon, R.A. Dickins, S. Hearn, J. Simon, C. Miething, H. Yee, L. Zender, and S.W. Lowe Cell 134 2008 657 667
133. B. Schnabl, C.A. Purbeck, Y.H. Choi, C.H. Hagedorn, and D. Brenner Hepatology 37 2003 653 664
134. B. Krämer, C. Körner, M. Kebschull, A. Glässner, M. Eisenhardt, H.D. Nischalke, M. Alexander, T. Sauerbruch, U. Spengler, and J. Nattermann Hepatology 56 2012 1201 1213
135. M. Eisenhardt, A. Glassner, B. Kramer, C. Korner, B. Sibbing, P. Kokordelis, H.D. Nischalke, T. Sauerbruch, U. Spengler, and J. Nattermann PLoS One 7 2012 e38846
136. C. de Lalla, G. Galli, L. Aldrighetti, R. Romeo, M. Mariani, A. Monno, S. Nuti, M. Colombo, F. Callea, S.A. Porcelli, P. Panina-Bordignon, S. Abrignani, G. Casorati, and P. Dellabona J. Immunol. 173 2004 1417 1425
137. A.D. Mann, and F. Oakley Biochim. Biophys. Acta 1832 2013 905 910
138. M. Berger, J.A. Gray, and B.L. Roth Annu. Rev. Med. 60 2009 355 366
139. D.E. Nichols, and C.D. Nichols Chem. Rev. 108 2008 1614 1641
140. P.A. Lang, C. Contaldo, P. Georgiev, A.M. El-Badry, M. Recher, M. Kurrer, L. Cervantes-Barragan, B. Ludewig, T. Calzascia, B. Bolinger, D. Merkler, B. Odermatt, M. Bader, R. Graf, P.A. Clavien, A.N. Hegazy, M. Lohning, N.L. Harris, P.S. Ohashi, H. Hengartner, R.M. Zinkernagel, and K.S. Lang Nat. Med. 14 2008 756 761
141. F. Soga, N. Katoh, T. Inoue, and S. Kishimoto J. Invest. Dermatol. 127 2007 1947 1955
142. M.R. Young, J.L. Kut, M.P. Coogan, M.A. Wright, M.E. Young, and J. Matthews Immunology 80 1993 395 400
143. D.O. Slauson, C. Walker, F. Kristensen, Y. Wang, and A.L. de Weck Cell. Immunol. 84 1984 240 252
144. C.B. Zhu, R.D. Blakely, and W.A. Hewlett Neuropsychopharmacology 31 2006 2121 2131
145. M. Lesurtel, R. Graf, B. Aleil, D.J. Walther, Y. Tian, W. Jochum, C. Gachet, M. Bader, and P.A. Clavien Science 312 2006 104 107
146. A. Nocito, P. Georgiev, F. Dahm, W. Jochum, M. Bader, R. Graf, and P.A. Clavien Hepatology 45 2007 369 376
147. A. Omenetti, L. Yang, R.R. Gainetdinov, C.D. Guy, S.S. Choi, W. Chen, M.G. Caron, and A.M. Diehl Am. J. Physiol. Gastrointest. Liver Physiol. 300 2011 G303 G315
148. R.G. Ruddell, F. Oakley, Z. Hussain, I. Yeung, L.J. Bryan-Lluka, G.A. Ramm, and D.A. Mann Am. J. Pathol. 169 2006 861 876
149. M.R. Ebrahimkhani, F. Oakley, L.B. Murphy, J. Mann, A. Moles, M.J. Perugorria, E. Ellis, A.F. Lakey, A.D. Burt, A. Douglass, M.C. Wright, S.A. White, F. Jaffre, L. Maroteaux, and D.A. Mann Nat. Med. 17 2011 1668 1673