Hypoxia and proinflammatory factors upregulate apelin receptor expression in human stellate cells and hepatocytes

Gut

Volumn 60, Issue 10, 2011, Pages 1404-1411

  Melgar Lesmes, Pedro ^a   Pauta, Montserrat ^a   Reichenbach, Vedrana ^a   Casals, Gregori ^a   Ros, Josefa ^a   Bataller, Ramon ^a,b   Morales Ruiz, Manuel ^a,b   Jiménez, Wladimiro ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOPOIETIN 1; ANGIOTENSIN II; APELIN; APELIN RECEPTOR; LIPOPOLYSACCHARIDE; PLATELET DERIVED GROWTH FACTOR BB; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A;

ARTICLE; CELL HYPOXIA; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOCALIZATION; INFLAMMATION; LIVER CIRRHOSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL; UPREGULATION;

ANOXIA; BLOTTING, WESTERN; CELLS, CULTURED; DISEASE PROGRESSION; HEPATIC STELLATE CELLS; HEPATITIS C, CHRONIC; HEPATOCYTES; HUMANS; LIVER; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

EID: 80052585243     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2010.234690     Document Type: Article

References (29)

1. Rappaport AM, MacPhee PJ, Fisher MM, et al. The scarring of the liver acini (cirrhosis). Tridimensional and microcirculatory considerations. Virchows Arch A Pathol Anat Histopathol 1983;402:107-37.
2. Bissell DM. Hepatic fibrosis as wound repair: a progress report. J Gastroenterol 1998;33:295-302.
3. Muñoz-Luque J, Ros J, Fernández-Varo G, et al. Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. J Pharmacol Exp Ther 2008;324:475-83.
4. Tugues S, Fernandez-Varo G, Muñoz-Luque J, et al. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology 2007;46:1919-26.
5. Rosmorduc O, Wendum D, Corpechot C, et al. Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis. Am J Pathol 1999;155:1065-73.
6. Cohen T, Nahari D, Cerem LW, et al. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem 1996;271:736-41.
7. Morales-Ruiz M, Jiménez W. Neovascularization, angiogenesis, and vascular remodeling in portal hypertension. In: Sanyal AJ, Shah VH, eds. Portal Hypertension: Pathobiology, Evaluation, and Treatment. Totowa, NJ: Humana Press, 2005:99-112.
8. Melgar-Lesmes P, Casals G, Pauta M, et al. Apelin mediates the induction of profibrogenic genes in human hepatic stellate cells. Endocrinology 2010;151:5306-14.
9. Principe A, Melgar-Lesmes P, Fernández-Varo G, et al. The hepatic apelin, system; a new therapeutic target for liver disease. Hepatology 2008;48:1193-201.
10. Masri B, Morin N, Cornu M, et al. Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. FASEB J 2004;18:1909-11.
11. Cox CM, D'Agostino SL, Miller MK, et al. Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo. Dev Biol 2006;296:177-89.
12. Daviaud D, Boucher J, Gesta S, et al. TNF-α up-regulates apelin expression in human and mouse adipose tissue. FASEB J 2006;20:1528-30.
13. Bataller R, Sancho-Bru P, Ginès P, et al. Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II. Gastroenterology 2003;125:117-25.
14. Bataller R, Schwabe RF, Choi YH, et al. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest 2003;112:1383-94.
15. Yang L, Bataller R, Dulyx J, et al. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol 2005;43:317-23.
16. Pinzani M, Milani S, De Franco R, et al. Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 1996;110:534-48.
17. Leivas A, Jiménez W, Bruix J, et al. Gene expression of endothelin-1 and ET(A) and ET(B) receptors in human cirrhosis: relationship with hepatic hemodynamics. J Vasc Res 1998;35:186-93.
18. Xu L, Hui AY, Albanis E, et al. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut 2005;54:142-51.
19. Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008;88:125-72.
20. Han S, Wang G, Qi X, et al. Involvement of a Stat3 binding site in inflammation-induced enteric apelin expression. Am J Physiol Gastrointest Liver Physiol 2008;295:G1068-78.
21. Han S, Wang G, Qi X, et al. A possible role for hypoxia-induced apelin expression in enteric cell proliferation. Am J Physiol Regul Integr comp Physiol 2008;294:R1832-9.
22. Eyries M, Siegfried G, Ciumas M, et al. Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis. Circ Res 2008;103:432-40.
23. Navasa M, Follo A, Filella X, et al. Tumor necrosis factor and interleukin-6 in spontaneous bacterial peritonitis in cirrhosis: relationship with the development of renal impairment and mortality. Hepatology 1998;27:1227-32.
24. Ruiz-del-Arbol L, Urman J, Fernández J, et al. Systemic, renal, and hepatic hemodynamic derangement in cirrhotic patients with spontaneous bacterial peritonitis. Hepatology 2003;38:1210-18.
25. Sandhu R, Teichert-Kuliszewska K, Nag S, et al. Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat. Cardiovasc Res 2004;64:115-24.
26. Taura K, De Minicis S, Seki E, et al. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology 2008;135:1729-38.
27. Marra F, Gentilini A, Pinzani M, et al. Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells. Gastroenterology 1997;112:1297-306.
28. Melgar-Lesmes P, Tugues S, Ros J, et al. Vascular endothelial growth factor and angiopoietin-2 play a major role in the pathogenesis of vascular leakage in cirrhotic rats. Gut 2009;58:285-92.
29. Kleinz MJ, Davenport AP. Emerging roles of apelin in biology and medicine. Pharmacol Ther 2005;107:198-211.