New trends in the treatment of obesity and diabetes mellitus

West Indian Medical Journal

Volumn 51, Issue SUPPL. 1, 2002, Pages 51-54

  Wright Pascoe, Rosemarie ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; GLYCOGEN; INSULIN; TRIACYLGLYCEROL;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; LIVER; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; RISK FACTOR; SKELETAL MUSCLE; VASCULAR DISEASE;

EID: 0036114419     PISSN: 00433144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. The spread of the obesity epidemic in the United States, 1991-1998
2. Insulin resistance and hypersecretion in obesity
3. Non-esterified fatty acids in blood of obese and lean subjects
4. Measurement of plasma glucose, free fatty acid, lactate and insulin for 24 h in patients with NIDDM
5. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men
6. Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes
7. Mechanisms of free fatty acid induced insulin resistance in humans
8. Free fatty acids and insulin resistance during pregnancy
9. Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and non-diabetic subjects
10. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
11. The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
12. Mechanisms of fatty acid-induced inhibition of glucose uptake
13. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and ù-3 fatty acids in muscle phospholipid
14. Skeletal muscle triglyceride levels are inversely related to insulin action
15. Tissue triglycerides, insulin resistance, and insulin production: Implications for hyperinsulinemia of obesity
16. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women
17. Intra-muscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
18. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
19. 1H-MR spectroscopy
20. Measurement of intracellular triglyceride stores by H spectroscopy: Validation in vivo
21. Effects of acute changes of plasma fatty free acids on intramuscular fat content and insulin resistance in healthy subjects
22. Protein kinase C
23. Diacylglycerol activation of protein kinase C is modulated by long-chain acyl-CoA
24. Effect of fatty acids and their acyl-CoA esters on protein kinase C activity in fibroblasts: Possible implications in fatty acid oxidation defects
25. Overexpression of protein kinase C isoenzymes alpha, beta I, gamma and episilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling
26. Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase
27. Protein kinase C-æ phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin
28. Lipid induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C and IêB-á
29. Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine
30. Effect of fatty acids on glucose production and utilization in man
31. Operation of Randle's cycle in patients with NIDDM
32. Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans
33. Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism
34. Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in Type 2 diabetic patients
35. FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis
36. Effects of fat infusions on glucose tolerance and plasma insulin levels
37. Effect of acute elevation of plasma glycerol, triglyceride and FFA levels on glucose utilization and plasma insulin
38. Stimulation of insulin secretion by long-chain free fatty acids
39. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and â-cell oxidation through a process likely coupled to fatty acid oxidation
40. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
41. Chronic exposure to free fatty acids reduced pancreatic â cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
42. Effects of a 48-h fat infusion on insulin secretion and glucose utilization
43. Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects
44. Fuel metabolism in pregnancy and in gestational diabetes mellitus
45. Role of insulin resistance in human disease
46. Atherosclerosis - An inflammatory disease
47. Free fatty acids, a link between obesity and insulin resistance
48. Free fatty acids - The link between obesity and insulin resistance
49. Effects of fatty acids and ketone bodies on basal insulin secretion in Type 2 diabetes