A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate

Biochemical Pharmacology

Volumn 84, Issue 9, 2012, Pages 1207-1214

  Miyamoto, Yohei ^a   Iwao, Yasunori ^b   Mera, Katsumi ^a   Watanabe, Hiroshi ^a   Kadowaki, Daisuke ^a   Ishima, Yu ^a   Chuang, Victor Tuan Giam ^c   Sato, Keizo ^d   Otagiri, Masaki ^a,e   Maruyama, Toru ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c CURTIN UNIVERSITY   (Australia)

^d KYUSHU UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^e SOJO UNIVERSITY   (Japan)

Author keywords

3 Carboxy 4 methyl 5 propyl 2 furanpropionate; Chronic kidney disease; Oxidative stress; Reactive oxygen species; Uremic toxin

Indexed keywords

3 CARBOXY 4 METHYL 5 PROPYL 2 FURANPROPIONATE; ANGIOTENSIN II; FERROUS CHLORIDE; LUMINOL; PEROXY RADICAL; PROBENECID; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UREMIC TOXIN;

ARTICLE; CELL DAMAGE; CELL VIABILITY; CHEMOLUMINESCENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RELEASE; DOSE RESPONSE; ELECTRON SPIN RESONANCE; FENTON REACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; OXIDATIVE STRESS; PRIORITY JOURNAL;

CELL LINE; CELL SURVIVAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; EPITHELIAL CELLS; FREE RADICALS; FURANS; HUMANS; INTRACELLULAR SPACE; KIDNEY TUBULES, PROXIMAL; LUMINESCENT MEASUREMENTS; OXIDATION-REDUCTION; PEROXIDES; PROPIONATES; SUPEROXIDES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84866623691     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.07.033     Document Type: Article

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