Impact of uncoupling protein-2 overexpression on proinsulin processing

Journal of Molecular Endocrinology

Volumn 37, Issue 3, 2006, Pages 517-526

  Kashemsant, Narudee ^a   Chan, Catherine B ^a  

^a UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GLUCOSE; INSULIN; MESSENGER RNA; POTASSIUM CHLORIDE; POTASSIUM ION; PROINSULIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; INSULIN RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE; GENE EXPRESSION; GLUCOSE; HIV ENVELOPE PROTEIN GP120; HUMANS; ION CHANNELS; MITOCHONDRIAL PROTEINS; OLIGOMYCINS; PROINSULIN; RATS; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 33846134696     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.02091     Document Type: Article

References (59)

1. 2+ oscillations and insulin secretion in pancreatic islets. Biochemical Journal 353 175-180.
2. Alarcon C, Leahy JL, Schuppin GT & Rhodes CJ 1995 Increased secretor demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation 95 1032-1039.
3. Alarcon C, Wicksteed B, Prentki M, Corkey BE & Rhodes CJ 2002 Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes 51 2496-2504.
4. Armengaud P, Breitling R & Amtmann A 2004 The potassium-dependent transcriptome of Arabidopsis reveals a prominent role of jasmonic acid in nutrient signaling. Plant Physiology 136 2556-2576.
5. Asfari M, Janjic D, Meda P, Li G, Halban PA & Wollheim CB 1992 Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130 167-178.
6. 2+ channels in insulin-secreting mouse pancreatic B cells. Biophysical Journal 81 3308-3323.
7. Chan CB, MacDonald PE, Saleh MC, Johns DC, Marban E & Wheeler MB 1999 Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48 1482-1486.
8. Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM & Wheeler MB 2001 Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 50 1302-1310.
9. Chan CB, Saleh MC, Koshkin V & Wheeler MB 2004 Uncoupling protein 2 and islet function. Diabetes 53 S136-S142.
10. Davidson HW, Rhodes CJ & Hutton JC 1988 Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct endopeptidases. Nature 333 93-96.
11. + pump. European Journal of Pharmacology 426 139-143.
12. Erecinska M, Bryla J, Michalik M, Meglasson M & Nelson D 1992 Energy metabolism in islets of Langerhans. Biochimica et Biophysica Acta 1101 273-295.
13. Fleurv C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS. Ricquier D et al. 1997 Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genetics 15 269-272.
14. Furuta M, Carroll R, Martin S, Swift HH, Ravazzola M, Orci L & Steiner DF 1998 Incomplete processing of proinsulin to insulin accompanied by elevation of dcs-31,32 proinsulin intermediates in islets of mice lacking active PC2. Journal of Biological Chemistry 273 3131-3437.
15. Garlid KD, Jaburek M & Jezek P 1998 The mechanism of Proton transport mediated by mitochondrial uncoupling proteins. FEBS Letters 438 10-14.
16. Gimeno RE, Dembski M, Weng X, Deng N, Shyvan AW, Gimeno CJ, Iris F, Ellis SJ, Woolf EA & Tartaglia LA 1997 Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 46 900-906.
17. Goodge KA & Hutton JC 2000 Translational regulation of ploinsulin biosynthesis and proinsulin conversion in the pancreatic β-cell. Seminars in Cell and Developmental Biology 11 235.
18. 2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell. Biochemical Journal 323 445-450.
19. Guest PC, Abdel-Halim SM. Gross DJ, Clark A, Poitout V, Amaria R. Ostenson CG & Hutton JC 2002 Proinsulin processing in the diabetic Goto-Kakizaki rat. Journal of Endocrinology 175 637-647.
20. Halban P & Irminger JC 1994 Sorting and processing of secretory proteins. Biochemical Journal 299 1-18.
21. Hanley AJG, D'Agostino R Jr, Wagenknecht LE, Saad MF, Savage PJ, Bergman R & Haffner SM 2002 Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the Insulin Resistance Atherosclerosis Study. Diabetes 51 1263-1270.
22. Hong Y, Fink BD, Dillon JS & Sivitz WI 2001 Effects of adenoviral overexpression of uncoupling protein-2 and -3 oil mitochondrial respiration in insulinoma cells. Endocrinology 142 249-256.
23. Irminger JC, Meyer K & Halban P 1996 Proinsulin processing in the rat insulinoma cell line INS after overexpression of the endoproteases PC2 or PC3 by recombinant adenovirus. Biochemical Journal 320 11-15.
24. Jiang Y & Gralla JD 1995 Nucleotide requirements for activated RNA polymerase II open complex formation in vitro. Journal of Biological Chemistry 270 1277-1281.
25. Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB & Wheeler MB 2002 Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 51 3211-3219.
26. Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB & Wheeler MB 2004 Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. Journal of Biological Chemistry 279 51049-51056.
27. Kahn SE & Halban PA 1997 Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. Diabetes 46 1725-1732.
28. Kassis N, Bernard C, Pusterla A, Casteilla L, Penicaud L, Richard D, Ricquier D & Ktorza A 2000 Correlation between pancreatic islet uncoupling protein-2 (UCP2) mRNA concentration and insulin status in rats. International Journal of Experimental Diabetes Research 1 185-193.
29. Klingenberg M 1999 Uncoupling protein - a useful energy dissipator. Journal of Bioenergetics and Biomembranes 31 419-430.
30. 2+ -responsive pathway involving calcineurin and nuclear factor of activated T cells. Molecular Endocrinology 15 1758-1767.
31. Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas J-C, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A et al. 2002 Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to β-cell survival during (chronic hyperglycemia. Diabetes 51 413-123.
32. Leahy JL, Halban PA & Weir GC 1991 Relative hypersecretion of proinsulin in rat model of NIDDM. Diabetes 40 985-989.
33. Leibowitz G, Yuli M, Donath MY, Nesher R, Melloul D, Cerasi E, Gross DJ & Kaiser N 2001 β-Cell glucotoxicity in the Psammomys obesus model of type 2 diabetes. Diabetes 50 (Suppl 1) S113-S117.
34. Leibowitz G, Uckaya G. Oprescu AI, Cerasi E, Gross DJ & Kaiser N 2002 Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure. Endocrinology 143 3214-3220.
35. McQuaid TS, Saleh MC, Joseph JW, Gyulkhandanyan A, Manning-Fox JE, MacLellan JD, Wheeler MB & Chan CB 2006 cAMP-mediated signaling normalizes glucose-stimulated insulin secretion in uncoupling protein-2 overexpressing β-cells. Journal of Endocrinology 190 669-680.
36. Maechler P 2003 Novel regulation of insulin secretion: the role of mitochondria. Current Opinion in Investigational Drug 4 1166-1172.
37. Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF & Verchere CB 2004 Role of beta-cell prohormone convertase (PC) 1/3 in processing of pro-islet amyloid polypeptide. Diabetes 53 141-148.
38. Mykkanen L, Zaccaro DJ, Hales CN, Festa A & Hallner SM 1999 The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed Type II diabetes: the Insulin Resistance Atherosclerosis Study. Diabetologia 42 1060.
39. Neerman-Arbez M, Sizoneviko SV & Halban PA 1993 Slow cleavage at the proinsulin B-chain/connecting peptide junction associated with low levels of endoprotease PC1/3 in transformed beta cells. Journal of Biological Chemistry 268 16098-16100.
40. Orci L, Halban P, Perrelet A, Amherdt M, Ravazzola M & Anderson RG 1994 pH-independent and -dependent cleavage of proinsulin in the same secretory vesicle. Journal of Cell Biology 126 1149-1156.
41. Orphanides G & Reinberg D 2002 A unified theory of gene expression. Cell 108 439-451.
42. 2+ calmodulin-dependent protein kinase II delta2 regulates gene expression of insulin in INS-1 rat insulinoma cells. Cell Calcium 33 175-184.
43. Pradhan AD, Manson JE, Meigs JB, Rifai N, Buring JE, Liu S & Ridker PM 2003 Insulin, proinsulin, proinsuli:insulin ratio, and the risk of developing type 2 diabetes mellitus in women. American Journal of Medicine 114 438.
44. Proudnikov D, Yuferov V, LaForge KS, Ho A & Jeanne Kreek M 2003 Quantification of multiple mRNA levels in rat brain regions using real time optical PCR. Molecular Brain Researh 112 182.
45. Ravnskjaer K, Boergesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P & Mandrup S 2005 Peroxisome prolifcrator-activated receptor α (PPARα) potentiates, whereas PPARγ attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells. Endocrinology 146 3266-3276.
46. Rhodes CJ & Halban PA 1987 Newly synthesized proinsulin/insulin and stored insulin are released front pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway. Journal of Cell Biology 105 145-153.
47. Rhodes CJ, Lucas CA, Mutkoski RL, Orci L & Halban PA 1987 Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump. Journal of Biological Chemistry 262 10712-10717.
48. Sasahara M, Nishi M, Kawashima H, Ueda K, Sakagashira S, Furuta H, Matsumoto E, Hanabusa T, Sasaki H & Nanjo K 2004 Uncoupling protein 2 promoter polyimorphism-866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients. Diabetes 53 482-485.
49. Schrauwen P & Hesselink M 2002 UCP2 and UCP3 in muscle controlling body metabolism. Journal of Experimental Biology 205 2275-2285.
50. Schuppin GT & Rhodes CJ 1996 Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells. Biochemical Journal 313 259-268.
51. Slee DJ, Jones PM & Howell SL 1990 Proinsulin processing in electrically, permeabilized rat islets of Langerhans. Journal of Molecular Endocrinology 5 275-280.
52. Steiner DF 1998 The proprotein convertases. Current Opinions in Chemical Biology 2 31-39.
53. Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP & Semenkovich cF 2002 PPARα suppresses insulin secretion and induces UCP2 in insulinoma cells. Journal of Lipid Research 43 936-943.
54. Toriumi C & Imai K 2003 Altered expression of insulins I and II and their mRNAs in the islets of Langerhans in dexamethasone-induced diabetic rats. Biomedical Chromatography 17 26-32.
55. Wang H, Iezzi M, Theander S, Antinozzi P, Gauthier B, Halban P & Wollheim C 2005 Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in LNS-1 cells. Diabetologia 48 720-731.
56. Woychik NA & Hampcey, M 2002 The RNA polymerase II machinery: structure illuminates function. Cell 108 453-463.
57. 2+ homeostasis, and insulin expression and secretion. Biochemistry 39 14912-14919.
58. Zethelius B, Byherg L, Hales CN, Lithell H & Berne C 2003 Proinsulin and acute insulin response indeperidently, predict Type 2 diabetes mellitus in men - report from 27 years of follow-up study. Diabetologia 46 20-26.
59. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB et al. 2001 Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105 745-755.