Dairy-derived antimicrobial peptides: Action mechanisms, pharmaceutical uses and production proposals

Trends in Food Science and Technology

Volumn 36, Issue 2, 2014, Pages 79-95

  Sibel Akalin, A ^a  

^a EGE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; FOOD TECHNOLOGY;

ACTION MECHANISMS; ANTIMICROBIAL PEPTIDE; BIOLOGICALLY ACTIVE PEPTIDES; KNOWLEDGE PERTAINING; LARGE-SCALE PRODUCTION; MECHANISM OF ACTION; PHARMACEUTICAL INDUSTRY; PROCESSING TECHNOLOGIES;

PEPTIDES;

EID: 84897112056     PISSN: 09242244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tifs.2014.01.002     Document Type: Review

References (107)

1. Agyei D., Danquah M.K. Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides. Biotechnology Advances 2011, 29:272-277.
2. Agyei D., Danquah M.K. Rethinking food-derived bioactive peptides for antimicrobial and immunomodulatory activities. Trends in Food Science and Technology 2012, 23:62-69.
3. Almaas H., Berner V., Holm H., Langsrud T., Vegarud G.R. Degradation of whey from caprine milk by human proteolytic enzymes, and the resulting antibacterial effect against Listeria monocytogenes. Small Ruminant Research 2008, 79:11-15.
4. Almaas H., Holm H., Langsrud T., Flengsrud R., Vegarud G.R. Invitro studies of the digestion of caprine whey proteins by human gastric and duodenal juice and the effects on selected microorganisms. British Journal of Nutrition 2006, 96:562-569.
5. Alvarez-Ordóñez A., Begley M., Clifford T., Deasy T., Considine K., Hill C. Structure-activity relationship of synthetic variants of the milk-derived antimicrobial peptide α s2-casein f(183-207). Applied and Environmental Microbiology 2013, 79:5179-5185.
6. Arruda M.S., Silva F.O., Egito A.S., Silva T.M.S., Lima J.L., Porto A.L.F., et al. New peptides obtained by hydrolysis of caseins from bovine milk by protease extracted from the latex Jacaratia corumbensis. LWT - Food Science and Technology 2012, 49:73-79.
7. Bargeman G., Koops G.H., Houwing J., Breebart I., van der Horst H.C., Wessling M. The development of electromembrane filtration for the isolation of bioactive peptides: the effect of membrane selection and operating parameters on the transport rate. Desalination 2002, 149:369-374.
8. Benkerroum N. Antimicrobial peptides generated from milk proteins: a survey and prospects for application in the food industry. A review. International Journal of Dairy Technology 2010, 63:320-338.
9. Brady R., Woonton B., Gee M.L., O'Connor A.J. Hierarchical mesoporous silica materials for separation of functional food ingredients - a review. Innovative Food Science and Emerging Technologies 2008, 9:243-248.
10. Brück W.M., Kelleher S.L., Gibson G.R., Graverholt G.G., Lönnerdal B.L. The effects of α-lactalbumin and glycomacropeptide on the association of Caco-2 cells by enteropathogenic Escherichia coli, Salmonella typhimurium and Shigella flexneri. FEMS Microbiology Letters 2006, 259:158-162.
11. Brück W.M., Kelleher S.L., Gibson G.R., Nielsen K.E., Chatterton D.E., Lönnerdal B. rRNA probes used to quantify the effects of glycomacropeptide and α-lactalbumin supplementation on the predominant groups of intestinal bacteria of infant rhesus monkeys challenged with enteropathogenic Escherichia coli. Journal of Pediatric Gastroenterology and Nutrition 2003, 37:273-280.
12. Chatterton D.E.W., Smithers G., Roupas Pp., Brodkorb A. Bioactivity of β-lactoglobulin and α-lactalbumin - technological implications for processing. International Dairy Journal 2006, 16:1229-1240.
13. Clare D.A., Catignani G.L., Swaisgood H.E. Biodefense properties of milk: the role of antimicrobial proteins and peptides. Current Pharmaceutical Design 2003, 9:1239-1255.
14. Clare D.A., Swaisgood H.E. Bioactive milk peptides: a prospectus. Journal of Dairy Science 2000, 83:1187-1195.
15. Coste M., Rochet V., Léonil J., Mollé D., Bouhallab S., Tomé D. Identification of C-terminal peptides of bovine β-casein that enhance proliferation of rat lymphocytes. Immunology Letters 1992, 33:41-46.
16. Dashper S.G., Liu S.W., Reynolds E.C. Antibacterial peptides and their potential as oral therapeutic agents. International Journal of Peptide Research and Therapeutics 2007, 13:505-516.
17. Dashper S.G., O'Brien-Simpson N.M., Cross K.J., Paolini R.A., Hoffman B., Catmull D.V., et al. Divalent metal cations increase the activity of the antimicrobial peptide kappacin. Antimicrobial Agents and Chemotherapy 2005, 49:2322-2328.
18. Demers-Mathieu V., Gauthier S.F., Britten M., Fliss I., Robitaille G., Jean J. Antibacterial activity of peptides extracted from tryptic hydrolyzate of whey protein by nanofiltration. International Dairy Journal 2013, 28:94-101.
19. Demers-Mathieu V., Gauthier S.F., Britten M., Fliss I., Robitaille G., Jean J. Inhibition of Listeria monocytogenes growth in Cheddar cheese by an anionic peptides-enriched extract from whey proteins. International Dairy Journal 2013, 32:6-12.
20. Elbarbary H.A., Abdou A.M., Nakamura Y., Park E.Y., Mohamed H.A., Sato K. Identification of novel antibacterial peptides isolated from a commercially available casein hydrolysate by autofocusing technique. Biofactors 2012, 38:309-315.
21. Ellegård K.H., Gammelgård-Larsen C., Sörensen E.S., Fedosov S. Process scale chromatographic isolation, characterization and identification of tryptic bioactive casein phosphopeptides. International Dairy Journal 1999, 9:639-652.
22. El-Zahar K., Sitohy M., Choiset Y., Metro F., Haertlé T., Chobert J.M. Antimicrobial activity of ovine whey proteinand their peptic hydrolysates. Milchwissenschaft 2004, 59:653-656.
23. Fjell C.D., Hiss J.A., Hancock R.E.W., Schneider G. Designing antimicrobial peptides: form follows function. Nature Reviews/Drug Discovery 2012, 11:37-51.
24. Foltz M., van der Pijl P.C., Duchateau G.S. Current invitro testing of bioactive peptides is not valuable. Journal of Nutrition 2010, 140:117-118.
25. Forssmann, W. G., Zucht, H. D., Raida, M., Adermann, K., & Mägert, H. J. (2001). Antibiotic peptides from bovine milk. European Patent EP19960910013. 20 June 2001.
26. Forssmann, W. G., Zucht, H. D., Raida, M., Adermann, K., & Mägert, H. J. (2003). Antibiotic peptides from bovine milk. United States Patent 657984917. 17 June 2003.
27. Gagnaire V., Mollé D., Herrouin M., Léonil J. Peptides identified during Emmental cheese ripening: origin and proteolytic systems involved. Journal of Agricultural and Food Chemistry 2001, 49:4402-4413.
28. Ginger M.R., Grigor M.R. Comparative aspects of milk caseins. Comparative Biochemistry and Physiology 1999, 124:133-145.
29. Gobbetti M., Minervini F., Rizzello C.G. Angiotensin I-converting enzyme-inhibitory and antimicrobial bioactive peptides. International Journal of Dairy Technology 2004, 57:173-188.
30. Gómez-Ruiz J.A., Recio I., Pihlanto A. Antimicrobial activity of ovine hydrolysates. A preliminary study. Milchwissenschaft 2005, 60:41-44.
31. Gustafsson L., Hallgren O., Mossberg A.K., Pettersson J., Fischer W., Aronsson A., et al. HAMLET kills tumour cells by apoptosis: structure, cellular mechanisms and therapy. Journal of Nutrition 2005, 135:1299-1303.
32. Håkansson A., Malin S., Mossberg A.K., Sabharwal H., Linse S., Lazou I., et al. A folding variant of α-lactalbumin with bactericidal activity against Streptococcus pneumonia. Molecular Microbiology 2000, 35:589-600.
33. Håkansson A., Zhivotovski B., Orrenius S., Sabharwal H., Svanborg C. Apoptosis induced by a human milk protein. Proceedings of the National Academy of Sciences of the USA 1995, 92:8064-8068.
34. Hancock R.E.W., Leher R. Cationic peptides: a new source of antibiotics. Trends in Biotechnology 1998, 16:82-88.
35. Hancock R.E.W., Sahl H.G. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nature Biotechnology 2006, 24:1551-1557.
36. Haque E., Chand R. Antihypertensive and antimicrobial bioactive peptides from milk proteins. European Food Research and Technology 2008, 227:7-15.
37. Haque E., Chand R., Kapila S. Biofunctional properties of bioactive peptides of milk origin. Food Reviews International 2009, 25:28-43.
38. Hartmann R., Meisel H. Food-derived peptides with biological activity: from research to food applications. Current Opinion in Biotechnology 2007, 18:163-169.
39. Hayes M., Ross R.P., Fitzgerald G.F., Hill C., Stanton C. Casein-derived antimicrobial peptides generated by Lactobacillus acidophilus DPC6026. Applied and Environmental Microbiology 2006, 72:2260-2264.
40. Hill R.D., Lahov E., Givol D. A rennin-sensitive bond in alpha-s1 β-casein. Journal of Dairy Research 1974, 41:147-153.
41. Ibrahim H., Taniyama N., Aoki T. Distinct dimerization between α-lactalbumin and lysozyme exhibiting novel antimicrobial activity against gram-positive and gram-negative bacteria. Letters in Drug Design and Discovery 2004, 1:101-109.
42. Isaacs C.E. Human milk inactives pathogens, individually, additively and synergistically. Journal of Nutrition 2005, 135:1286-1288.
43. Isaacs C.E., Kashyap S., Heird W.C., Thormar H. Antiviral and antibacterial lipids and human milk and infant formula feed. Archives of Diseases in Childhood 1990, 65:861-864.
44. Iwaniak A., Dziuba J., Niklewicz M. The BIOBEP database - a tool for the in silico method of classification of food proteins as the source of peptides with antihypertensive activity. Acta Alimentaria 2005, 34:417-425.
45. Jenssen H., Hamill P., Hancock R.E.W. Peptide antimicrobial agents. Clinical Microbiology Reviews 2006, 19:491-511.
46. Jones F.S., Simms H.S. The bacterial growth inhibitor (lactenin) of milk. Journal of Experimental Medicine 1930, 51:327-339.
47. Kagan B.L., Ganz T., Lehrer R.I. Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology 1994, 87:131-149.
48. Kamau S.M., Cheison S.C., Chen W., Liu X.M., Lu R.R. Alpha-lactalbumin: its production technologies and bioactive peptides. Comprehensive Reviews in Food Science and Food Safety 2010, 9:197-212.
49. Kent R.M., Guinane C.M., O'Connor P.M., Fitzgerald G.F., Hill C., Stanton C., et al. Production of antimicrobial peptides Caseicin A and B by Bacillus isolates growing on sodium caseinate. Letters in Applied Microbiology 2012, 55:141-148.
50. Kim S.K., Wijesekara I. Development and biological activities of marine-derived bioactive peptides: a review. Journal of Functional Foods 2010, 2:1-9.
51. Kolb A.F. The prospects of modifying the antimicrobial properties of milk. Biotechnology Advances 2001, 19:299-316.
52. Korhonen H. Milk-derived bioactive peptides: from science to applications. Journal of Functional Foods 2009, I:177-187.
53. Korhonen H., Pihlanto A. Bioactive peptides: production and functionality. International Dairy Journal 2006, 16:945-960.
54. Lahov E., Edelsten D., Sode-Morgensen M.T., Sofer E. Properties of basic glycopeptides released from cow milk protein by heat. Milchwissenschaft 1971, 26:489-495.
55. Lahov E., Regelson W. Antibacterial and immunostimulating casein-derived substances from milk: casecidin, isracidin peptides. Food and Chemical Toxicology 1996, 34:131-145.
56. Liepke C., Zucht H.D., Forsmann W.G., Standker L. Purification of novel peptide antibiotics from milk. Journal of Chromatography B 2001, 752:369-377.
57. Lignitto L., Segato S., Balzan S., Cavatorta V., Oulahal N., Sforza S., et al. Preliminary investigation on the presence of peptides inhibiting the growth of Listeria innocua and Listeria monocytogenes in Asiago d'Allevo cheese. Dairy Science and Technology 2012, 92:297-308.
58. López-Expósito I., Amigo L., Recio I. Identification of the initial binding sites of alpha s2-casein f (183-207) and effect on bacterial membranes and cell morphology. Biochimica et Biophysica Acta (BBA) - Biomembranes 2008, 1778:2444-2449.
59. López-Expósito I., Gomez-Ruiz J.A., Amigo L., Recio I. Identification of antibacterial peptides from ovine α s2-casein. International Dairy Journal 2006, 16:1072-1080.
60. López-Expósito I., Minervini F., Amigo L., Recio I. Identification of antibacterial peptides from bovine kappa-casein. Journal of Food Protection 2006, 69:2992-2997.
61. López-Expósito I., Recio I. Antibacterial activity of peptides and folding variants from milk proteins. International Dairy Journal 2006, 16:1294-1305.
62. López-Expósito I., Recio I. Protective effect of milk peptides: antibacterial and antitumor properties. Bioactive components of milk, Advances in experimental medicine and biology 2008, Vol. 606:271-293. Springer Science+Business Media, LLC.
63. Malkoski M., Dashper S.G., O'Brien-Simpson N.M., Talbo G.H., Macris M., Cross K.J. Kappacin, a novel antibacterial peptide from bovine milk. Antimicrobial Agents and Chemotherapy 2001, 45:2309-2315.
64. Marx V. Watching peptides grow up. Chemical and Engineering News 2005, 83:17-24.
65. Matin M.A., Monnai M., Otani H. Isolation and characterization of a cytotoxic pentapeptide κ-casecidin from bovine κ-casein digested with bovine trypsin. Animal Science Journal 2000, 71:197-207.
66. Matsuzaki K. Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes. Biochimica et Biophysica Acta 1999, 1462:1-10.
67. McCann K.B., Shiell B.J., Michalski W.P., Lee A., Wan J., Roginski H., et al. Isolation and characterisation of antibacterial peptides derived from the f (164-207) region of bovine α s2-casein. International Dairy Journal 2005, 15:133-143.
68. McCann K.B., Shiell B.J., Michalski W.P., Lee A., Wan J., Roginski H., et al. Isolation and characterisation of a novel antibacterial peptide from bovine α si-casein. International Dairy Journal 2006, 16:316-323.
69. Meira S.M.M., Daroit D.J., Helfer V.E., Corrêa A.P.F., Jéferson S., Carro S., et al. Bioactive peptides in water-soluble extracts of ovine cheeses from Southern Brazil and Uruguay. Food Research International 2012, 48:322-329.
70. Meisel H. Biochemical properties of bioactive peptides derived from milk proteins: potential nutraceuticals for food and pharmaceutical applications. Livestock Production Science 1997, 50:125-138.
71. Meisel H. Overview on milk protein-derived peptides. International Dairy Journal 1998, 8:363-373.
72. Meisel H. Multifunctional peptides encrypted in milk proteins. BioFactors 2004, 21:55-61.
73. Meisel H. Biochemical properties of peptides encrypted in bovine milk proteins. Current Medicinal Chemistry 2005, 12:1905-1919.
74. Minervini F., Algaron F., Rizzello C.G., Fox P.F., Monnet V., Gobbetti M. Angiotensin I-converting-enzyme-inhibitory and antibacterial peptides from Lactobacillus helveticus PR4 proteinase-hydrolyzed caseins of milk from six species. Applied and Environmental Microbiology 2003, 69:5297-5305.
75. Morrow A.L., Ruiz-Palacios G.M., Jiang X., Newburg D.S. Human milk glycans that inhibit pathogen binding protect breast-feeding infants against infectious diarrhea. Journal of Nutrition 2005, 135:1304-1307.
76. Nguyen L.T., Haney E.F., Vogel H.J. The expanding scope of antimicrobial peptide structures and their modes of action. Trends in Biotechnology 2011, 29:464-471.
77. Norberg S., O'Connor P.M., Stanton C., Ross R.P., Hill C., Fitzgerald G.F., et al. Altering the composition of caseicins A and B as a means of determining the contribution of specific residues to antimicrobial activity. Applied and Environmental Microbiology 2011, 77:2496-2501.
78. Norberg S., O'Connor P.M., Stanton C., Ross R.P., Hill C., Fitzgerald G.F., et al. Extensive manipulation of caseicins A and B highlights the tolerance of these antimicrobial peptides to change. Applied and Environmental Microbiology 2012, 78:2353-2358.
79. Otani H., Watanabe T., Tashiro Y. Effects of bovine β-casein (1-28) and its chemically synthesized partial fragments on proliferative responses and immunoglobulin production in mouse spleen cell cultures. Bioscience, Biotechnology and Biochemistry 2001, 65:2489-2495.
80. Panchaud A., Affolter M., Kussmann M. Mass spectrometry for nutritional peptidomics: how to analyze food bioactives and their health effects. Journal of Proteomics 2012, 75:3546-3559.
81. Paul M., Somkuti G.A. Degradation of milk-based bioactive peptides by yogurt fermentation bacteria. Letters in Applied Microbiology 2009, 49:345-350.
82. Pedroche J., Yust M.M., Lqari H., Megias C., Giron-Calle J., Alaiz M., et al. Obtaining of Brassica carinata protein hydrolysates enriched in bioactive peptides using immobilized digestive proteases. Food Research International 2007, 40:931-938.
83. Pellegrini A., Dettling C., Thomas U., Hunziker P. Isolation and identification of four bactericidal domains in the bovine β-lactoglobulin. Biochimica et Biophysica Acta 2001, 1526:131-140.
84. Pellegrini A., Thomas U., Bramaz N., Hunziker P., von Fellenberg R. Isolation and identification of three bactericidal domains in the bovine α-lactalbumin molecule. Biochimica et Biophysica Acta 1999, 1426:439-448.
85. Pellegrini A., Thomas U., von Fellenberg R., Wild P. Bactericidal activities of lysozyme and aprotinin against gram-negative and gram-positive bacteria related to their basic character. Journal of Applied Bacteriology 1992, 72:180-187.
86. Phelan M., Aherne A., FitzGeral R.J., O'Brien N.M. Casein-derived bioactive peptides: biological effects, industrial uses, safety aspects and regulatory status. International Dairy Journal 2009, 19:643-654.
87. Pihlanto-Leppälä A. Milk proteins I bioactive peptides. Encyclopedia of dairy sciences 2002, 1960. Elsevier, Oxford. R. Hubert (Ed.).
88. Pihlanto-Leppälä A., Marnila P., Hubert L., Rokka T., Korhonen H.J.T., Karp M. The effect of α-lactalbumin and β-lactoglobulin hydrolysates on the metabolic activity of E. coli JM103. Journal of Applied Microbiology 1999, 87:540-545.
89. Recio I., Visser S. Identification of two distinct antibacterial domains within the sequence of bovine α s2-casein. Biochimica et Biophysica Acta 1999, 1428:314-326.
90. Reddy K.V.R., Yedery R.D., Aranha C. Antimicrobial peptides: premises and promises. International Journal of Antimicrobial Agents 2004, 24:536-547.
91. Rizzello C.G., Gobbetti L.M., Carbonara T., de Bari M.D., Zambonin P.G. Antibacterial activities of peptides from the water-soluble extracts of Italian cheese varieties. Journal of Dairy Science 2005, 88:2348-2360.
92. Silva S.V., Malcata F.X. Caseins as source of bioactive peptides. International Dairy Journal 2005, 15:1-15.
93. Singh B., Singh R. Antimicrobial effect of peptides isolated from bovine milk fermented with Lactobacillus helveticus. Milchwissenschaft 2011, 66:262-265.
94. Somkuti G.A., Paul M. Enzymatic fragmentation of the microbial peptides casocidin and isracidin by Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus. Applied Microbiology and Biotechnology 2010, 87:235-242.
95. Stromqvist M., Falk P., Bergstrom S., Hansson L., Lonnerdal B., Normark S., et al. Human milk kappa-casein and inhibition of Helicobacter pylori adhesion to human gastric mucosa. Journal of Pediatric Gastroenterology and Nutrition 1995, 21:288-296.
96. Svensson M., Sabharwal H., Håkansson A., Mossberg A.C., Lipniunas P., Leffler H., et al. Molecular characterization of folding variants of α-lactalbumin that induces apoptosis in human cells. Journal of Biological Chemistry 1999, 274:6388-6396.
97. Tadros T., Izquierdo P., Esquena J., Solans C. Formation and stability of nano-emulsions. Advances in Colloid and Interface Science 2004, 108-109:303-318.
98. Théolier J., Hammami R., Labelle P., Fliss I., Jean J. Isolation and identification of antimicrobial peptides derived by peptic cleavage of whey protein isolate. Journal of Functional Foods 2013, 5:706-714.
99. Tomita M., Wakabayashi H., Yamauchi K., Teraguchi S., Hayasawa H. Bovine lactoferrin and lactoferricin derived from milk: production and applications. Biochemistry and Cell Biology 2002, 80:109-112.
100. USFDA Innovation/stagnation: Challenge and opportunity on the critical path to new medical products 2004, Retrieved 12th September, 2010, from. http://www.fda.gov/ohrms/dockets/ac/04/briefing/2004-4052B1_11_ExecSum-Critical-Path.pdf2004.
101. Uteng M., Hague H.H., Markwick P.R., Fimland G., Mantzilas D., Nissen-Meyer J., et al. Three-dimensional structure in lipid micelles of the pediocin-like antimicrobial peptide sakacin P and a sakacin P variant that is structurally stabilized by an inserted C-terminal disulfide bridge. Biochemistry 2003, 42:11417-11426.
102. Vasiljevic T., Shah N.P. Probiotics-from Metchnikoff to bioactives. International Dairy Journal 2008, 18:714-728.
103. Wang Z., Wang G. APD: the antimicrobial peptide database. Nucleic Acids Research 2004, 32:D590-D592.
104. West N.P., Pyne D.B., Renshaw G., Cripps A.W. Antimicrobial peptides and proteins, exercise and innate mucosal immunity. FEMS Immunology & Medical Microbiology 2006, 48:293-304.
105. Wimley W.C. Describing the mechanism of antimicrobial peptide action with the interfacial activity model. ACS Chemical Biology 2010, 10:905-917.
106. Yamamoto N., Ejiri M., Mizuno S. Biogenic peptides and their potential use. Current Pharmaceutical Design 2003, 9:1345-1355.
107. Zucht H.D., Raida M., Adermann K., Magert H.J., Forssmann W.G. Casocidin-I: a casein-alpha s2 derived peptide exhibits antibacterial activity. FEBS Letters 1995, 372:185-188.