Isolation and identification of three bactericidal domains in the bovine α-lactalbumin molecule

Biochimica et Biophysica Acta - General Subjects

Volumn 1426, Issue 3, 1999, Pages 439-448

  Pellegrini, Antonio ^a   Thomas, Ursula ^a   Bramaz, Nadine ^a   Hunziker, Peter ^a   Von Fellenberg, Roland ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Lactalbumin; Antibacterial activity; Antibiotic; Bactericidal peptide

Indexed keywords

ALPHA LACTALBUMIN; CHYMOTRYPSIN; PEPSIN A; TRYPSIN;

AMINO ACID SEQUENCE; ARTICLE; BACTERICIDAL ACTIVITY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN ISOLATION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; CATTLE; CHYMOTRYPSIN; LACTALBUMIN; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; OSMOLAR CONCENTRATION; PEPSIN A; PEPTIDE FRAGMENTS; TRYPSIN;

EID: 0033022708     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(98)00165-2     Document Type: Article

References (28)

1. R.I. Lehrer, A.K. Lichtenstein, T. Ganz, Defensins: antimicrobial and cytotoxic peptides of mammalian cells, Annu. Rev. Immunol. 11 (1993) 105-128.
2. R. Gennaro, B. Skerlavaj, D. Romeo, Purification, composition and activity of two bactenecins, antibacterial peptides of bovine neutrophils, Infect. Immun. 57 (1989) 3142-3146.
3. P. Elsbach, J. Weiss, Bactericidal/permeability increasing protein and host defense against Gram-negative bacteria and endotoxin, Curr. Opin. Immun. 5 (1993) 103-107.
4. J.Y. Lee, A. Boman, S. Chuanxin, M. Andersonn, H. Jörnvall, V. Mutt, H.G. Boman, Antibacterial peptides from pig intestine: isolation of a mammalian cecropin, Proc. Natl. Acad. Sci. USA 86 (1989) 9159-9162.
5. C.L. Bevins, M. Zasloff, Peptide from frog skin, Annu. Rev. Biochem. 59 (1990) 395-414.
6. M. Simmaco, G. Mignogna, D. Barra, F. Bossa, Antimicrobial peptides from skin secretions of Rana esculenta, J. Biol. Chem. 269 (1994) 11956-11961.
7. G. Boman, Peptide antibiotics and their role in innate immunity, Annu. Rev. Immunol. 13 (1995) 61-92.
8. J.A. Hoffmann, C. Hetru, Insect defensins inducible antibacterial peptides, Immunol. Today 13 (1992) 411-415.
9. P. Casteels, C. Ampe, F. Jacobs, P. Tempst, Functional and chemical characterizations of Hymenoptaecin, an antibacterial polypeptide that is infection inducible in honeybee (Apis mellifera), J. Biol. Chem. 268 (1993) 7044-7054.
10. A. Bangalore, J. Travis, V.C. Onunka, J. Pohl, W.M. Shafer, Identification of the primary antimicrobial domains in human neutrophil cathepsin G, J. Biol. Chem. 265 (1990) 13584-13588.
11. A. Pellegrini, U. Thomas, N. Bramaz, S. Klauser, P. Hunziker, R. von Fellenberg, Identification and isolation of the bactericidal domains in the proteinase inhibitor aprotinin, Biochem. Biophys. Res. Commun. 222 (1996) 559-565.
12. A. Pellegrini, U. Thomas, N. Bramaz, S. Klauser, P. Hunziker, R. von Fellenberg, Identification and isolation of a bactericidal domain in chicken egg white lysozyme, J. Appl. Bacteriol. 82 (1997) 372-378.
13. W. Bellamy, M. Takase, H. Wakabayashi, K. Kawase, M. Tomita, Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin, J. Appl. Bacteriol. 73 (1992) 472-479.
14. R.P. Darveau, J. Blake, C.I. Seachord, W.L. Cosand, M.D. Cunningham, L. Cassiano-Clough, G. Maloney, Peptides related to the carboxyl terminus of human platelet factor IV with antibacterial activity, J. Clin. Invest. 90 (1992) 447-455.
15. J. Weiss, P. Elsbach, C. Shu, J. Castillo, L. Grinn, A. Horwitz, G. Theofan, Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant Gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria, J. Clin. Invest. 90 (1992) 1122-1130.
16. E. Schlimme, H. Meisel, Bioactive peptides derived from milk proteins. Structural, physiological and analytical aspects, Die Nahrung 39 (1995) 1-20.
17. D. Migliore-Samour, P. Jollés, Casein, a prohormone with an immunomodulating role for the newborn?, Experientia 44 (1988) 188-193.
18. s2 derived peptide exhibits antibacterial activity, FEBS Lett. 372 (1995) 185-188.
19. H.A. McKenzie, F.H. White Jr., Lysozyme and α-lactalbumin: structure, function and interrelationships, Adv. Protein Chem. 41 (1991) 173-315.
20. L. Hall, P.N. Campbell, α-Lactalbumin and related proteins: a versatile gene family with interesting parentage, Essay in Biochem. 22 (1986) 1-26.
21. K.R. Acharya, D.I. Stuart, N.P. Walker, M. Lewis, D.C. Phillips, Refined structure of baboon α-lactalbumin at 1.7 Å resolution, J. Mol. Biol. 208 (1989) 99-127.
22. P.K. Qasba, S. Kumar, Molecular divergence of lysozymes and α-lactalbumin, Crit. Rev. Biochem. Mol. Biol. 32 (1997) 255-306.
23. C.G. Wilde, J.E. Griffith, M.N. Marra, J.L. Snable, R.W. Scott, Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family, J. Biol. Chem. 264 (1989) 11200-11203.
24. W.M. Shafer, J. Pohl, V.C. Onunka, N. Bangalore, J. Travis, Human lysosomal cathepsin G and gramicidin B share a functionally conserved broad spectrum antibacterial peptide, J. Biol. Chem. 266 (1991) 112-116.
25. A. Pellegrini, U. Thomas, R. von Fellenberg, P. Wild, Bactericidal activity of lysozyme and aprotinin against Gramnegative and Gram-positive bacteria related to their basic character, J. Appl. Bacteriol. 72 (1992) 180-187.
26. B.L. Kagan, T. Ganz, R.I. Lehrer, Defensins: a family of antimicrobial and cytotoxic peptides, Toxicology 87 (1994) 131-149.
27. H.V. Westerhoff, D. Juretic, R.W. Hendler, M. Zasloff, Magainins and the disruption of membrane-linked free-energy transduction, Proc. Natl. Acad. Sci. USA 86 (1989) 6597-6601.
28. W.M. Shafer, V.C. Onunka, L.E. Martin, Antigonococcal activity of human neutrophil cathepsin G, Infect. Immun. 54 (1986) 184-188.