In vitro studies of the digestion of caprine whey proteins by human gastric and duodenal juice and the effects on selected microorganisms

British Journal of Nutrition

Volumn 96, Issue 3, 2006, Pages 562-569

  Almaa, Hilde ^a   Holm, Halvor ^b   Langsrud, Thor ^a   Flengsrud, Ragnar ^a   Vegarud, Gerd E ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Antibacterial; Caprine whey proteins; Digestion; Duodenal juice; Gastric juice

Indexed keywords

ALBUMIN; ALPHA LACTALBUMIN; BETA LACTOGLOBULIN; CHYMOTRYPSIN; IMMUNOGLOBULIN; LACTOFERRIN; MILK PROTEIN; NORLEUCINE; PEPSIN A; TRYPSIN; SERUM ALBUMIN; WHEY PROTEIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; BACTERIAL CELL; BACTERIAL STRAIN; BACTERIUM CULTURE; DIGESTION; DUODENUM FLUID; ENZYMATIC DEGRADATION; ESCHERICHIA COLI; HUMAN; IN VITRO STUDY; LACTOBACILLUS RHAMNOSUS; MICROORGANISM; NONHUMAN; PH; PROTEIN DEGRADATION; SCREENING; STOMACH JUICE; STREPTOCOCCUS MUTANS; SURVIVAL; WHEY; ANIMAL; BACTERIAL COUNT; DUODENUM; GOAT; GROWTH, DEVELOPMENT AND AGING; HYDROLYSIS; METABOLISM; METHODOLOGY; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DENATURATION;

BACILLUS CEREUS; CAPRA; ESCHERICHIA COLI; LACTOBACILLUS RHAMNOSUS; STREPTOCOCCUS MUTANS;

ANIMALS; BACILLUS CEREUS; CHYMOTRYPSIN; COLONY COUNT, MICROBIAL; DUODENUM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; GASTRIC JUICE; GOATS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LACTOBACILLUS RHAMNOSUS; LACTOFERRIN; MILK PROTEINS; PEPSIN A; PROTEIN DENATURATION; SERUM ALBUMIN; STREPTOCOCCUS MUTANS; TRYPSIN;

EID: 33750129519     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1079/BJN20061739     Document Type: Article

References (31)

1. Arnold RR, Brewer M & Gautheir I (1980) Bactericidal activity of human lactoferrin: sensitivity of a variety of microorganisms. Infect Immun 28, 893-898.
2. Arnold RR, Cole MF & McGhee JR (1977) Bactericidal activity of human lactoferrin. Science 127, 263-265.
3. Bellamy W, Takase M, Wakabayashi H, Kawase K & Tomita M (1992) Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin. J Appl Bacteriol 73, 472-479.
4. Bellamy W, Wakabayashi H, Takase M, Kawase K, Shimamura S & Tomita M (1993) Killing of candida-albicans by lactoferricin B, a potent antimicrobial peptide derived from the N-terminal region of bovine lactoferrin. Med Microbiol Immunol 182, 97-105.
5. Chatterton DEW, Rasmussen JT, Heegaard CW, Sørensen ES & Petersen TE (2004) In vitro digestion of novel milk protein ingredients for use in infant formulas: research on biological functions. Trends Food Sci Technol 15, 373-383.
6. Dunn BM (2002) Structure and mechanism of the pepsin-like family of aspartic peptidases. Chem Rev 102, 4431-4458.
7. Farnaud S & Ewans RW (2003) Lactoferrin - a multifunctional protein with antimicrobial properties. Mol Immunol 40, 395-405.
8. FitzGerald RJ & Meisel H (2003) Milk protein hydrolysates and bioactive peptides. In Advanced Dairy Chemistry, 3rd ed. Vol. 1, pp. 675-691 [PF Fox and LH McSweeney, editors]. New York: Kluwer Academic/Plenum Publishers.
9. Guillou H, Miranda G & Pelisser JP (1991) Hydrolysis of beta-casein by gastric proteases. I. Comparison of proteolytic action of bovine chymosin and pepsin A. Int J Pept Protein Res 37, 494-501.
10. Holm H, Hanssen LE, Krogdahl Å & Florholmen J (1988) High and low inhibitor soybean meals affect human duodenal proteinase activity differently: in vivo comparison with bovine serum albumin. J Nutr 118, 515-520.
11. International Dairy Federation (1993) Milk - Determination of Nitrogen Content. Part 3, Block Digestion Method, Semi-micro Rapid Routine Method, IDF Standard 20B. Brussels: International Dairy Federation.
12. Kimura M, Nam M-S, Ohkouchi Y, Kumura H, Shimazaki K-I & Yu D-Y (2000) Antimicrobial peptide of Korean native goat lactoferrin and identification of the part essential for this activity. Biochem Biophys Res Commun 268, 333-336.
13. Kirkpatrick CH, Green I, Rich RR & Schade AL (1971) Inhibition of growth of candida-albicans by iron-unsaturated lactoferrin - relation of host-defence mechanism in chronic mucocutaneous candidiasis. J Infect Dis 124, 539.
14. Korhonen H, Marnilla P & Gill HS (2000a) Milk immunoglobulins and complement factors. Br J Nutr 84, 75-80.
15. Korhonen H, Marnilla P & Gill HS (2000b) Bovine milk antibodies for health. Br J Nutr 84, 135-146.
16. Krogdahl Å & Holm H (1979) Inhibition of human and rat pancreatic proteinases by crude and purified soybean proteinase inhibitors. J Nutr 109, 551-558.
17. Kuwata H, Yip T-T, Tomita M & Hutchens TW (1998) Direct evidence of the generation in Human stomach of an antimicrobial peptide domain (lactoferricin) from ingested lactoferrin. Biochim Biophys Acta 1429, 129-141.
18. 4. Nature 227, 680-685.
19. Meisel H & Schlimme E (1996) Bioactive peptides derived from milk proteins: ingredients for functional foods? Kieler Milchwirtschaftliche Forschungsberichte 48, 343-357.
20. Miranda G, Mahé M-F, Leroux C & Martin P (2004) Proteomic tools to characterize the protein fraction of Equidae milk. Proteomics 4, 2496-2509.
21. Panyam D & Kilara A (1996) Enhancing the functionality of food proteins by enzymatic modification. Trends Food Sci Technol 7, 120-125.
22. Pihlanto A & Korhonen H (2003) Advances in Food and Nutrition Research - Bioactive Peptides and Proteins, Vol. 47. Amsterdam: Elsevier Academic Press.
23. Pihlanto-Leppälä A (2000) Bioactive peptides derived from bovine whey proteins: opoid and ace-inhibitory peptides. Trends Food Sci Technol 11, 347-356.
24. Recio I, Slangen CJ & Visser S (2000) Method for the production of antibacterial peptides from biological fluids at an ionic membrane - application to the isolation of nisin and caprine lactoferrin. Le Lait 80, 187-195.
25. Recio I & Visser S (2000) Antibacterial and binding characteristics of bovine, ovine and caprine lactoferrins: a comparative study. Int Dairy J 10, 597-605.
26. Sanchez-Chiang L, Cisternas E & Ponce O (1987) Partial purification of pepsins from adult and juvenile salmon fish - effect of NaCl on proteolytic activities. Comp Biochem Physiol 87, 793-797.
27. Schägger H & von Jagow G (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrotrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem 166, 368-379.
28. Scheele G, Bartelt D & Bieger W (1981) Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing/ sodium dodecyl sulphate gel electrophoresis. Gastroenterology 80, 461-473.
29. Soukka T, Tenovuo J & Lenanderlumikari M (1992) Fungicidal effect of human lactoferrin against candida-albicans. FEMS Microbiol Lett 90, 223-228.
30. Tomita M, Bellamy W & Takase M (1991) Potent antibacterial peptides generated by pepsin digestion of bovine lactoferrin. J Dairy Sci 74, 4137-4142.
31. Tomita M, Takase M, Bellamy W & Shimamura S (1994) A review: the active peptide of lactoferrin. Acta Paediatr Jpn 36, 585-591.