메뉴 건너뛰기




Volumn 13, Issue 4, 2014, Pages 516-527

Roles of enhancer of zeste homolog 2: From skeletal muscle differentiation to rhabdomyosarcoma carcinogenesis

Author keywords

Cancer epigenetics; Differentiation; EZH2; Myogenesis; Polycomb group proteins; Rhabdomyosarcoma

Indexed keywords

ATROGIN 1; BMI1 PROTEIN; CHAPERONE; HISTONE CHAPERONE SPT6; LONG UNTRANSLATED RNA; MICRORNA 214; MICRORNA 29A; MYOD PROTEIN; POLYCOMB GROUP PROTEIN; POLYCOMB REPRESSIVE COMPLEX 2; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; HISTONE; MICRORNA;

EID: 84896858736     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.27921     Document Type: Review
Times cited : (30)

References (167)
  • 1
    • 0036965325 scopus 로고    scopus 로고
    • From epigenesis to epigenetics: The case of C. H. Waddington
    • PMID:12547674
    • Van Speybroeck L. From epigenesis to epigenetics: the case of C. H. Waddington. Ann N Y Acad Sci 2002; 981:61-81; PMID:12547674; http://dx.doi.org/10.1111/j.1749-6632.2002.tb04912.x
    • (2002) Ann N Y Acad Sci , vol.981 , pp. 61-81
    • Van Speybroeck, L.1
  • 2
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • PMID:14732866
    • Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer 2004; 4:143-53; PMID:14732866; http://dx.doi.org/10.1038/nrc1279
    • (2004) Nat Rev Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 3
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • PMID:17522673
    • Berger SL. The complex language of chromatin regulation during transcription. Nature 2007; 447:407-12; PMID:17522673; http://dx.doi.org/10. 1038/nature05915
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 4
    • 60949096069 scopus 로고    scopus 로고
    • Epigenetic inheritance during the cell cycle
    • PMID:19234478
    • Probst AV, Dunleavy E, Almouzni G. Epigenetic inheritance during the cell cycle. Nat Rev Mol Cell Biol 2009; 10:192-206; PMID:19234478; http://dx.doi.org/10.1038/nrm2640
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 192-206
    • Probst, A.V.1    Dunleavy, E.2    Almouzni, G.3
  • 5
    • 84868014111 scopus 로고    scopus 로고
    • On the role of retinoblastoma family proteins in the establishment and maintenance of the epigenetic landscape
    • PMID:22718354
    • Fiorentino FP, Marchesi I, Giordano A. On the role of retinoblastoma family proteins in the establishment and maintenance of the epigenetic landscape. J Cell Physiol 2013; 228:276-84; PMID:22718354; http://dx.doi.org/10. 1002/jcp.24141
    • (2013) J Cell Physiol , vol.228 , pp. 276-284
    • Fiorentino, F.P.1    Marchesi, I.2    Giordano, A.3
  • 7
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • PMID:16369569
    • Feinberg AP, Ohlsson R, Henikoff S. The epigenetic progenitor origin of human cancer. Nat Rev Genet 2006; 7:21-33; PMID:16369569; http://dx.doi.org/10. 1038/nrg1748
    • (2006) Nat Rev Genet , vol.7 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 8
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • PMID:17320506
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128:683-92; PMID:17320506; http://dx.doi.org/10.1016/j.cell.2007.01.029
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 9
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • PMID:17339880
    • Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 2007; 8:286-98; PMID:17339880; http://dx.doi.org/10.1038/ nrg2005
    • (2007) Nat Rev Genet , vol.8 , pp. 286-298
    • Esteller, M.1
  • 11
    • 21744457108 scopus 로고    scopus 로고
    • Global histone modification patterns predict risk of prostate cancer recurrence
    • PMID:15988529
    • Seligson DB, Horvath S, Shi T, Yu H, Tze S, Grunstein M, Kurdistani SK. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 2005; 435:1262-6; PMID:15988529; http://dx.doi.org/10.1038/nature03672
    • (2005) Nature , vol.435 , pp. 1262-1266
    • Seligson, D.B.1    Horvath, S.2    Shi, T.3    Yu, H.4    Tze, S.5    Grunstein, M.6    Kurdistani, S.K.7
  • 12
    • 55949136562 scopus 로고    scopus 로고
    • Roles of the EZH2 histone methyltransferase in cancer epigenetics
    • PMID:18723033
    • Simon JA, Lange CA. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res 2008; 647:21-9; PMID:18723033; http://dx.doi.org/10. 1016/j.mrfmmm.2008.07.010
    • (2008) Mutat Res , vol.647 , pp. 21-29
    • Simon, J.A.1    Lange, C.A.2
  • 14
    • 9644281546 scopus 로고    scopus 로고
    • Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes
    • PMID:15516932
    • Umlauf D, Goto Y, Cao R, Cerqueira F, Wagschal A, Zhang Y, Feil R. Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet 2004; 36:1296-300; PMID:15516932; http://dx.doi.org/10.1038/ng1467
    • (2004) Nat Genet , vol.36 , pp. 1296-1300
    • Umlauf, D.1    Goto, Y.2    Cao, R.3    Cerqueira, F.4    Wagschal, A.5    Zhang, Y.6    Feil, R.7
  • 17
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • PMID:16618801
    • Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 2006; 20:1123-36; PMID:16618801; http://dx.doi.org/10.1101/gad.381706
    • (2006) Genes Dev , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 18
    • 41749108163 scopus 로고    scopus 로고
    • Stem cell regulation by polycomb repressors: Postponing commitment
    • PMID:18291635
    • Pietersen AM, van Lohuizen M. Stem cell regulation by polycomb repressors: postponing commitment. Curr Opin Cell Biol 2008; 20:201-7; PMID:18291635; http://dx.doi.org/10.1016/j.ceb.2008.01.004
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 201-207
    • Pietersen, A.M.1    Van Lohuizen, M.2
  • 19
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • PMID:17060944
    • Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006; 6:846-56; PMID:17060944; http://dx.doi.org/10.1038/nrc1991
    • (2006) Nat Rev Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    Van Lohuizen, M.2
  • 20
    • 33745225872 scopus 로고    scopus 로고
    • Genome-wide analysis of Polycomb targets in Drosophila melanogaster
    • PMID:16732288
    • Schwartz YB, Kahn TG, Nix DA, Li X-Y, Bourgon R, Biggin M, Pirrotta V. Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet 2006; 38:700-5; PMID:16732288; http://dx.doi.org/10.1038/ng1817
    • (2006) Nat Genet , vol.38 , pp. 700-705
    • Schwartz, Y.B.1    Kahn, T.G.2    Nix, D.A.3    Li, X.-Y.4    Bourgon, R.5    Biggin, M.6    Pirrotta, V.7
  • 21
    • 33646856965 scopus 로고    scopus 로고
    • Chromosomal distribution of PcG proteins during Drosophila development
    • PMID:16613483
    • Nègre N, Hennetin J, Sun LV, Lavrov S, Bellis M, White KP, Cavalli G. Chromosomal distribution of PcG proteins during Drosophila development. PLoS Biol 2006; 4:e170; PMID:16613483; http://dx.doi.org/10.1371/journal.pbio. 0040170
    • (2006) PLoS Biol , vol.4
    • Nègre, N.1    Hennetin, J.2    Sun, L.V.3    Lavrov, S.4    Bellis, M.5    White, K.P.6    Cavalli, G.7
  • 22
    • 33745258986 scopus 로고    scopus 로고
    • Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster
    • PMID:16628213
    • Tolhuis B, de Wit E, Muijrers I, Teunissen H, Talhout W, van Steensel B, van Lohuizen M. Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat Genet 2006; 38: 694-9; PMID:16628213; http://dx.doi.org/10.1038/ng1792
    • (2006) Nat Genet , vol.38 , pp. 694-699
    • Tolhuis, B.1    De Wit, E.2    Muijrers, I.3    Teunissen, H.4    Talhout, W.5    Van Steensel, B.6    Van Lohuizen, M.7
  • 23
    • 57049141484 scopus 로고    scopus 로고
    • Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila
    • PMID:18993116
    • Oktaba K, Gutiérrez L, Gagneur J, Girardot C, Sengupta AK, Furlong EEM, Müller J. Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila. Dev Cell 2008; 15:877-89; PMID:18993116; http://dx.doi.org/10.1016/j.devcel.2008.10.005
    • (2008) Dev Cell , vol.15 , pp. 877-889
    • Oktaba, K.1    Gutiérrez, L.2    Gagneur, J.3    Girardot, C.4    Sengupta, A.K.5    Furlong, E.E.M.6    Müller, J.7
  • 24
    • 70350149728 scopus 로고    scopus 로고
    • Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice
    • PMID:19820181
    • Schuettengruber B, Cavalli G. Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development 2009; 136:3531-42; PMID:19820181; http://dx.doi.org/10.1242/dev.033902
    • (2009) Development , vol.136 , pp. 3531-3542
    • Schuettengruber, B.1    Cavalli, G.2
  • 25
    • 77954758157 scopus 로고    scopus 로고
    • Polycomb group protein-mediated repression of transcription
    • PMID:20346678
    • Morey L, Helin K. Polycomb group protein-mediated repression of transcription. Trends Biochem Sci 2010; 35:323-32; PMID:20346678; http://dx.doi.org/10.1016/j.tibs.2010.02.009
    • (2010) Trends Biochem Sci , vol.35 , pp. 323-332
    • Morey, L.1    Helin, K.2
  • 26
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • PMID:21248841
    • Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature 2011; 469:343-9; PMID:21248841; http://dx.doi.org/10.1038/nature09784
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 27
    • 0033538578 scopus 로고    scopus 로고
    • Stabilization of chromatin structure by PRC1, a Polycomb complex
    • PMID:10412979
    • Shao Z, Raible F, Mollaaghababa R, Guyon JR, Wu CT, Bender W, Kingston RE. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 1999; 98:37-46; PMID:10412979; http://dx.doi.org/10.1016/S0092-8674(00)80604-2
    • (1999) Cell , vol.98 , pp. 37-46
    • Shao, Z.1    Raible, F.2    Mollaaghababa, R.3    Guyon, J.R.4    Wu, C.T.5    Bender, W.6    Kingston, R.E.7
  • 28
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    • PMID:12351676
    • Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002; 298:1039-43; PMID:12351676; http://dx.doi.org/10.1126/science. 1076997
    • (2002) Science , vol.298 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3    Xia, L.4    Erdjument-Bromage, H.5    Tempst, P.6    Jones, R.S.7    Zhang, Y.8
  • 29
    • 0037131523 scopus 로고    scopus 로고
    • Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    • PMID:12408863
    • Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 2002; 111:185-96; PMID:12408863; http://dx.doi.org/10.1016/S0092-8674(02)00975-3
    • (2002) Cell , vol.111 , pp. 185-196
    • Czermin, B.1    Melfi, R.2    McCabe, D.3    Seitz, V.4    Imhof, A.5    Pirrotta, V.6
  • 30
    • 0037111831 scopus 로고    scopus 로고
    • Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
    • PMID:12435631
    • Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 2002; 16:2893-905; PMID:12435631; http://dx.doi.org/10.1101/gad.1035902
    • (2002) Genes Dev , vol.16 , pp. 2893-2905
    • Kuzmichev, A.1    Nishioka, K.2    Erdjument-Bromage, H.3    Tempst, P.4    Reinberg, D.5
  • 32
    • 77956202054 scopus 로고    scopus 로고
    • Polycomb group proteins set the stage for early lineage commitment
    • PMID:20804966
    • Surface LE, Thornton SR, Boyer LA. Polycomb group proteins set the stage for early lineage commitment. Cell Stem Cell 2010; 7:288-98; PMID:20804966; http://dx.doi.org/10.1016/j.stem.2010.08.004
    • (2010) Cell Stem Cell , vol.7 , pp. 288-298
    • Surface, L.E.1    Thornton, S.R.2    Boyer, L.A.3
  • 33
    • 9444244427 scopus 로고    scopus 로고
    • Chromatin compaction by a polycomb group protein complex
    • PMID:15567868
    • Francis NJ, Kingston RE, Woodcock CL. Chromatin compaction by a polycomb group protein complex. Science 2004; 306:1574-7; PMID:15567868; http://dx.doi.org/10.1126/science.1100576
    • (2004) Science , vol.306 , pp. 1574-1577
    • Francis, N.J.1    Kingston, R.E.2    Woodcock, C.L.3
  • 34
    • 70349469565 scopus 로고    scopus 로고
    • Mechanisms of polycomb gene silencing: Knowns and unknowns
    • PMID:19738629
    • Simon JA, Kingston RE. Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol 2009; 10:697-708; PMID:19738629
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 697-708
    • Simon, J.A.1    Kingston, R.E.2
  • 35
    • 3042801308 scopus 로고    scopus 로고
    • SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
    • PMID:15225548
    • Cao R, Zhang Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol Cell 2004; 15:57-67; PMID:15225548; http://dx.doi.org/10.1016/j.molcel.2004.06.020
    • (2004) Mol Cell , vol.15 , pp. 57-67
    • Cao, R.1    Zhang, Y.2
  • 36
    • 3042702970 scopus 로고    scopus 로고
    • Polycomb group proteins in cell cycle progression and cancer
    • PMID:14752272
    • Pasini D, Bracken AP, Helin K. Polycomb group proteins in cell cycle progression and cancer. Cell Cycle 2004; 3:396-400; PMID:14752272; http://dx.doi.org/10.4161/cc.3.4.773
    • (2004) Cell Cycle , vol.3 , pp. 396-400
    • Pasini, D.1    Bracken, A.P.2    Helin, K.3
  • 38
    • 55949132133 scopus 로고    scopus 로고
    • Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
    • PMID:19026781
    • Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL, Dynlacht BD, Reinberg D. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell 2008; 32:503-18; PMID:19026781; http://dx.doi.org/10.1016/ j.molcel.2008.11.004
    • (2008) Mol Cell , vol.32 , pp. 503-518
    • Margueron, R.1    Li, G.2    Sarma, K.3    Blais, A.4    Zavadil, J.5    Woodcock, C.L.6    Dynlacht, B.D.7    Reinberg, D.8
  • 39
    • 55949124844 scopus 로고    scopus 로고
    • EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
    • PMID:19026780
    • Shen X, Liu Y, Hsu Y-J, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell 2008; 32:491-502; PMID:19026780; http://dx.doi.org/10.1016/j.molcel.2008.10.016
    • (2008) Mol Cell , vol.32 , pp. 491-502
    • Shen, X.1    Liu, Y.2    Hsu, Y.-J.3    Fujiwara, Y.4    Kim, J.5    Mao, X.6    Yuan, G.C.7    Orkin, S.H.8
  • 40
    • 80052571043 scopus 로고    scopus 로고
    • Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells
    • PMID:21892963
    • Stojic L, Jasencakova Z, Prezioso C, Stützer A, Bodega B, Pasini D, Klingberg R, Mozzetta C, Margueron R, Puri PL, et al. Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells. Epigenetics Chromatin 2011; 4:16; PMID:21892963; http://dx.doi.org/10.1186/1756-8935-4-16
    • (2011) Epigenetics Chromatin , vol.4 , pp. 16
    • Stojic, L.1    Jasencakova, Z.2    Prezioso, C.3    Stützer, A.4    Bodega, B.5    Pasini, D.6    Klingberg, R.7    Mozzetta, C.8    Margueron, R.9    Puri, P.L.10
  • 41
    • 84856237597 scopus 로고    scopus 로고
    • Polycomb protein Ezh1 promotes RNA polymerase II elongation
    • PMID:22196887
    • Mousavi K, Zare H, Wang AH, Sartorelli V. Polycomb protein Ezh1 promotes RNA polymerase II elongation. Mol Cell 2012; 45:255-62; PMID:22196887; http://dx.doi.org/10.1016/j.molcel.2011.11.019
    • (2012) Mol Cell , vol.45 , pp. 255-262
    • Mousavi, K.1    Zare, H.2    Wang, A.H.3    Sartorelli, V.4
  • 42
    • 76149142791 scopus 로고    scopus 로고
    • Polycomb complexes act redundantly to repress genomic repeats and genes
    • PMID:20123906
    • Leeb M, Pasini D, Novatchkova M, Jaritz M, Helin K, Wutz A. Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev 2010; 24:265-76; PMID:20123906; http://dx.doi.org/10.1101/gad.544410
    • (2010) Genes Dev , vol.24 , pp. 265-276
    • Leeb, M.1    Pasini, D.2    Novatchkova, M.3    Jaritz, M.4    Helin, K.5    Wutz, A.6
  • 44
    • 2942574510 scopus 로고    scopus 로고
    • Hierarchical recruitment of polycomb group silencing complexes
    • PMID:15175158
    • Wang L, Brown JL, Cao R, Zhang Y, Kassis JA, Jones RS. Hierarchical recruitment of polycomb group silencing complexes. Mol Cell 2004; 14:637-46; PMID:15175158; http://dx.doi.org/10.1016/j.molcel.2004.05.009
    • (2004) Mol Cell , vol.14 , pp. 637-646
    • Wang, L.1    Brown, J.L.2    Cao, R.3    Zhang, Y.4    Kassis, J.A.5    Jones, R.S.6
  • 45
    • 29144487990 scopus 로고    scopus 로고
    • Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing
    • PMID:16359901
    • Cao R, Tsukada Y, Zhang Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 2005; 20:845-54; PMID:16359901; http://dx.doi.org/10.1016/j.molcel.2005.12.002
    • (2005) Mol Cell , vol.20 , pp. 845-854
    • Cao, R.1    Tsukada, Y.2    Zhang, Y.3
  • 46
    • 77951947926 scopus 로고    scopus 로고
    • Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination
    • PMID:20471950
    • Eskeland R, Leeb M, Grimes GR, Kress C, Boyle S, Sproul D, Gilbert N, Fan Y, Skoultchi AI, Wutz A, et al. Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell 2010; 38:452-64; PMID:20471950; http://dx.doi.org/10.1016/j.molcel.2010.02.032
    • (2010) Mol Cell , vol.38 , pp. 452-464
    • Eskeland, R.1    Leeb, M.2    Grimes, G.R.3    Kress, C.4    Boyle, S.5    Sproul, D.6    Gilbert, N.7    Fan, Y.8    Skoultchi, A.I.9    Wutz, A.10
  • 47
    • 80053427396 scopus 로고    scopus 로고
    • Roles of the Polycomb group proteins in stem cells and cancer
    • PMID:21881606
    • Richly H, Aloia L, Di Croce L. Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis 2011; 2:e204-7; PMID:21881606; http://dx.doi.org/10.1038/cddis.2011.84
    • (2011) Cell Death Dis , vol.2
    • Richly, H.1    Aloia, L.2    Di Croce, L.3
  • 49
    • 0032751323 scopus 로고    scopus 로고
    • Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
    • PMID:10581039
    • van der Vlag J, Otte AP. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet 1999; 23:474-8; PMID:10581039; http://dx.doi.org/10.1038/70602
    • (1999) Nat Genet , vol.23 , pp. 474-478
    • Van Der Vlag, J.1    Otte, A.P.2
  • 51
    • 0142105414 scopus 로고    scopus 로고
    • EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
    • PMID:14532106
    • Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 2003; 22:5323-35; PMID:14532106; http://dx.doi.org/10.1093/emboj/ cdg542
    • (2003) EMBO J , vol.22 , pp. 5323-5335
    • Bracken, A.P.1    Pasini, D.2    Capra, M.3    Prosperini, E.4    Colli, E.5    Helin, K.6
  • 52
    • 37349036525 scopus 로고    scopus 로고
    • Importance of Ezh2 polycomb protein in tumorigenesis process interfering with the pathway of growth suppressive key elements
    • PMID:17786943
    • Tonini T, D'Andrilli G, Fucito A, Gaspa L, Bagella L. Importance of Ezh2 polycomb protein in tumorigenesis process interfering with the pathway of growth suppressive key elements. J Cell Physiol 2008; 214:295-300; PMID:17786943; http://dx.doi.org/10.1002/jcp.21241
    • (2008) J Cell Physiol , vol.214 , pp. 295-300
    • Tonini, T.1    D'Andrilli, G.2    Fucito, A.3    Gaspa, L.4    Bagella, L.5
  • 53
    • 84859189630 scopus 로고    scopus 로고
    • Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms
    • PMID:21941025
    • Koh CM, Iwata T, Zheng Q, Bethel C, Yegnasubramanian S, De Marzo AM. Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms. Oncotarget 2011; 2:669-83; PMID:21941025
    • (2011) Oncotarget , vol.2 , pp. 669-683
    • Koh, C.M.1    Iwata, T.2    Zheng, Q.3    Bethel, C.4    Yegnasubramanian, S.5    De Marzo, A.M.6
  • 54
    • 84862154100 scopus 로고    scopus 로고
    • PRC2 during vertebrate organogenesis: A complex in transition
    • PMID:22565092
    • Aldiri I, Vetter ML. PRC2 during vertebrate organogenesis: a complex in transition. Dev Biol 2012; 367:91-9; PMID:22565092; http://dx.doi.org/10.1016/j. ydbio.2012.04.030
    • (2012) Dev Biol , vol.367 , pp. 91-99
    • Aldiri, I.1    Vetter, M.L.2
  • 55
    • 84856770024 scopus 로고    scopus 로고
    • Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells
    • PMID:22184065
    • Neri F, Zippo A, Krepelova A, Cherubini A, Rocchigiani M, Oliviero S. Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells. Mol Cell Biol 2012; 32:840-51; PMID:22184065; http://dx.doi.org/10.1128/MCB.06148-11
    • (2012) Mol Cell Biol , vol.32 , pp. 840-851
    • Neri, F.1    Zippo, A.2    Krepelova, A.3    Cherubini, A.4    Rocchigiani, M.5    Oliviero, S.6
  • 56
    • 84877807808 scopus 로고    scopus 로고
    • Non-coding RNAs and EZH2 interactions in cancer: Long and short tales from the transcriptome
    • PMID:23001607
    • Benetatos L, Voulgaris E, Vartholomatos G, Hatzimichael E. Non-coding RNAs and EZH2 interactions in cancer: long and short tales from the transcriptome. Int J Cancer 2013; 133:267-74; PMID:23001607; http://dx.doi.org/10.1002/ijc.27859
    • (2013) Int J Cancer , vol.133 , pp. 267-274
    • Benetatos, L.1    Voulgaris, E.2    Vartholomatos, G.3    Hatzimichael, E.4
  • 57
    • 84860758213 scopus 로고    scopus 로고
    • Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2
    • PMID:22399519
    • Esposito F, Tornincasa M, Pallante P, Federico A, Borbone E, Pierantoni GM, Fusco A. Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2. J Clin Endocrinol Metab 2012; 97:E710-8; PMID:22399519; http://dx.doi.org/10. 1210/jc.2011-3068
    • (2012) J Clin Endocrinol Metab , vol.97
    • Esposito, F.1    Tornincasa, M.2    Pallante, P.3    Federico, A.4    Borbone, E.5    Pierantoni, G.M.6    Fusco, A.7
  • 58
    • 84863343713 scopus 로고    scopus 로고
    • Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM
    • PMID:22442719
    • Kong D, Heath E, Chen W, Cher ML, Powell I, Heilbrun L, Li Y, Ali S, Sethi S, Hassan O, et al. Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. PLoS One 2012; 7:e33729; PMID:22442719; http://dx.doi.org/10.1371/journal.pone.0033729
    • (2012) PLoS One , vol.7
    • Kong, D.1    Heath, E.2    Chen, W.3    Cher, M.L.4    Powell, I.5    Heilbrun, L.6    Li, Y.7    Ali, S.8    Sethi, S.9    Hassan, O.10
  • 61
    • 50549091334 scopus 로고    scopus 로고
    • The polycomb repressive complex 2 is a potential target of SUMO modifications
    • PMID:18628979
    • Riising EM, Boggio R, Chiocca S, Helin K, Pasini D. The polycomb repressive complex 2 is a potential target of SUMO modifications. PLoS One 2008; 3:e2704; PMID:18628979; http://dx.doi.org/10.1371/journal.pone.0002704
    • (2008) PLoS One , vol.3
    • Riising, E.M.1    Boggio, R.2    Chiocca, S.3    Helin, K.4    Pasini, D.5
  • 62
    • 78149285100 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2
    • PMID:20935635
    • Chen S, Bohrer LR, Rai AN, Pan Y, Gan L, Zhou X, Bagchi A, Simon JA, Huang H. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nat Cell Biol 2010; 12:1108-14; PMID:20935635; http://dx.doi.org/10.1038/ncb2116
    • (2010) Nat Cell Biol , vol.12 , pp. 1108-1114
    • Chen, S.1    Bohrer, L.R.2    Rai, A.N.3    Pan, Y.4    Gan, L.5    Zhou, X.6    Bagchi, A.7    Simon, J.A.8    Huang, H.9
  • 63
    • 78649807567 scopus 로고    scopus 로고
    • Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
    • PMID:21123648
    • Kaneko S, Li G, Son J, Xu CF, Margueron R, Neubert TA, Reinberg D. Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev 2010; 24:2615-20; PMID:21123648; http://dx.doi.org/10.1101/gad.1983810
    • (2010) Genes Dev , vol.24 , pp. 2615-2620
    • Kaneko, S.1    Li, G.2    Son, J.3    Xu, C.F.4    Margueron, R.5    Neubert, T.A.6    Reinberg, D.7
  • 65
    • 79951909917 scopus 로고    scopus 로고
    • Phosphorylation of EZH2 by CDK1 and CDK2: A possible regulatory mechanism of transmission of the H3K27me3 epigenetic mark through cell divisions
    • PMID:21278485
    • Zeng X, Chen S, Huang H. Phosphorylation of EZH2 by CDK1 and CDK2: a possible regulatory mechanism of transmission of the H3K27me3 epigenetic mark through cell divisions. Cell Cycle 2011; 10:579-83; PMID:21278485; http://dx.doi.org/10.4161/cc.10.4.14722
    • (2011) Cell Cycle , vol.10 , pp. 579-583
    • Zeng, X.1    Chen, S.2    Huang, H.3
  • 66
    • 78650511231 scopus 로고    scopus 로고
    • CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells
    • PMID:21131960
    • Wei Y, Chen Y-H, Li L-Y, Lang J, Yeh S-P, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, et al. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol 2011; 13:87-94; PMID:21131960; http://dx.doi.org/10.1038/ ncb2139
    • (2011) Nat Cell Biol , vol.13 , pp. 87-94
    • Wei, Y.1    Chen, Y.-H.2    Li, L.-Y.3    Lang, J.4    Yeh, S.-P.5    Shi, B.6    Yang, C.C.7    Yang, J.Y.8    Lin, C.Y.9    Lai, C.C.10
  • 67
  • 68
    • 77957357566 scopus 로고    scopus 로고
    • TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration
    • PMID:20887952
    • Palacios D, Mozzetta C, Consalvi S, Caretti G, Saccone V, Proserpio V, Marquez VE, Valente S, Mai A, Forcales SV, et al. TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration. Cell Stem Cell 2010; 7:455-69; PMID:20887952; http://dx.doi.org/10.1016/j.stem.2010.08.013
    • (2010) Cell Stem Cell , vol.7 , pp. 455-469
    • Palacios, D.1    Mozzetta, C.2    Consalvi, S.3    Caretti, G.4    Saccone, V.5    Proserpio, V.6    Marquez, V.E.7    Valente, S.8    Mai, A.9    Forcales, S.V.10
  • 69
    • 84875811405 scopus 로고    scopus 로고
    • Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke
    • PMID:23526793
    • Yu Y-L, Chou R-H, Shyu W-C, Hsieh S-C, Wu C-S, Chiang S-Y, Chang WJ, Chen JN, Tseng YJ, Lin YH, et al. Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke. EMBO Mol Med 2013; 5:531-47; PMID:23526793; http://dx.doi.org/10.1002/emmm. 201201783
    • (2013) EMBO Mol Med , vol.5 , pp. 531-547
    • Yu, Y.-L.1    Chou, R.-H.2    Shyu, W.-C.3    Hsieh, S.-C.4    Wu, C.-S.5    Chiang, S.-Y.6    Chang, W.J.7    Chen, J.N.8    Tseng, Y.J.9    Lin, Y.H.10
  • 71
    • 33748419671 scopus 로고    scopus 로고
    • Polycomb response elements and targeting of Polycomb group proteins in Drosophila
    • PMID:16914306
    • Müller J, Kassis JA. Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Curr Opin Genet Dev 2006; 16:476-84; PMID:16914306; http://dx.doi.org/10.1016/j.gde.2006.08.005
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 476-484
    • Müller, J.1    Kassis, J.A.2
  • 72
    • 33846983276 scopus 로고    scopus 로고
    • Polycomb/Trithorax response elements and epigenetic memory of cell identity
    • PMID:17185323
    • Ringrose L, Paro R. Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development 2007; 134:223-32; PMID:17185323; http://dx.doi.org/10.1242/dev.02723
    • (2007) Development , vol.134 , pp. 223-232
    • Ringrose, L.1    Paro, R.2
  • 74
    • 78649855140 scopus 로고    scopus 로고
    • The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets
    • PMID:20671031
    • Van Dessel N, Beke L, Görnemann J, Minnebo N, Beullens M, Tanuma N, Shima H, Van Eynde A, Bollen M. The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets. Nucleic Acids Res 2010; 38:7500-12; PMID:20671031; http://dx.doi.org/10.1093/nar/gkq643
    • (2010) Nucleic Acids Res , vol.38 , pp. 7500-7512
    • Van Dessel, N.1    Beke, L.2    Görnemann, J.3    Minnebo, N.4    Beullens, M.5    Tanuma, N.6    Shima, H.7    Van Eynde, A.8    Bollen, M.9
  • 76
    • 84861309032 scopus 로고    scopus 로고
    • Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A/Arf locus in mesenchymal stem cells
    • PMID:22290439
    • Cakouros D, Isenmann S, Cooper L, Zannettino A, Anderson P, Glackin C, Gronthos S. Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A/Arf locus in mesenchymal stem cells. Mol Cell Biol 2012; 32:1433-41; PMID:22290439; http://dx.doi.org/10.1128/MCB.06315-11
    • (2012) Mol Cell Biol , vol.32 , pp. 1433-1441
    • Cakouros, D.1    Isenmann, S.2    Cooper, L.3    Zannettino, A.4    Anderson, P.5    Glackin, C.6    Gronthos, S.7
  • 77
    • 42149149895 scopus 로고    scopus 로고
    • Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo
    • PMID:18285464
    • Sarma K, Margueron R, Ivanov A, Pirrotta V, Reinberg D. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol 2008; 28:2718-31; PMID:18285464; http://dx.doi.org/10.1128/MCB.02017-07
    • (2008) Mol Cell Biol , vol.28 , pp. 2718-2731
    • Sarma, K.1    Margueron, R.2    Ivanov, A.3    Pirrotta, V.4    Reinberg, D.5
  • 78
    • 40749126138 scopus 로고    scopus 로고
    • Role of hPHF1 in H3K27 methylation and Hox gene silencing
    • PMID:18086877
    • Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, Zhang Y. Role of hPHF1 in H3K27 methylation and Hox gene silencing. Mol Cell Biol 2008; 28:1862-72; PMID:18086877; http://dx.doi.org/10.1128/MCB.01589-07
    • (2008) Mol Cell Biol , vol.28 , pp. 1862-1872
    • Cao, R.1    Wang, H.2    He, J.3    Erdjument-Bromage, H.4    Tempst, P.5    Zhang, Y.6
  • 79
    • 84875415642 scopus 로고    scopus 로고
    • Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: Functional and therapeutic implications
    • PMID:23362253
    • Corvetta D, Chayka O, Gherardi S, D'Acunto CW, Cantilena S, Valli E, Piotrowska I, Perini G, Sala A. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem 2013; 288:8332-41; PMID:23362253; http://dx.doi.org/10.1074/jbc.M113.454280
    • (2013) J Biol Chem , vol.288 , pp. 8332-8341
    • Corvetta, D.1    Chayka, O.2    Gherardi, S.3    D'Acunto, C.W.4    Cantilena, S.5    Valli, E.6    Piotrowska, I.7    Perini, G.8    Sala, A.9
  • 80
    • 72249119297 scopus 로고    scopus 로고
    • Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells
    • PMID:20064375
    • Peng JC, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, Wysocka J. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 2009; 139:1290-302; PMID:20064375; http://dx.doi.org/10.1016/j.cell.2009.12.002
    • (2009) Cell , vol.139 , pp. 1290-1302
    • Peng, J.C.1    Valouev, A.2    Swigut, T.3    Zhang, J.4    Zhao, Y.5    Sidow, A.6    Wysocka, J.7
  • 81
    • 72249104107 scopus 로고    scopus 로고
    • Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells
    • PMID:20064376
    • Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan G-C, Lee Y, Orkin SH. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell 2009; 139:1303-14; PMID:20064376; http://dx.doi.org/10.1016/j.cell.2009.12.003
    • (2009) Cell , vol.139 , pp. 1303-1314
    • Shen, X.1    Kim, W.2    Fujiwara, Y.3    Simon, M.D.4    Liu, Y.5    Mysliwiec, M.R.6    Yuan, G.-C.7    Lee, Y.8    Orkin, S.H.9
  • 82
    • 76749083433 scopus 로고    scopus 로고
    • Jarid2 and PRC2, partners in regulating gene expression
    • PMID:20123894
    • Li G, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev 2010; 24:368-80; PMID:20123894; http://dx.doi.org/10.1101/gad.1886410
    • (2010) Genes Dev , vol.24 , pp. 368-380
    • Li, G.1    Margueron, R.2    Ku, M.3    Chambon, P.4    Bernstein, B.E.5    Reinberg, D.6
  • 84
    • 70449787940 scopus 로고    scopus 로고
    • Polycomb group complexes - Many combinations, many functions
    • PMID:19889541
    • Kerppola TK. Polycomb group complexes - many combinations, many functions. Trends Cell Biol 2009; 19:692-704; PMID:19889541; http://dx.doi.org/10.1016/j.tcb.2009.10.001
    • (2009) Trends Cell Biol , vol.19 , pp. 692-704
    • Kerppola, T.K.1
  • 87
  • 88
    • 0142178215 scopus 로고    scopus 로고
    • Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2
    • New York Breast Cancer Study Group. PMID:14576434
    • King MC, Marks JH, Mandell JB; New York Breast Cancer Study Group. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 2003; 302:643-6; PMID:14576434; http://dx.doi.org/10.1126/science.1088759
    • (2003) Science , vol.302 , pp. 643-646
    • King, M.C.1    Marks, J.H.2    Mandell, J.B.3
  • 90
    • 1342332096 scopus 로고    scopus 로고
    • Polycomb CBX7 has a unifying role in cellular lifespan
    • PMID:14647293
    • Gil J, Bernard D, Martínez D, Beach D. Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol 2004; 6:67-72; PMID:14647293; http://dx.doi.org/10.1038/ncb1077
    • (2004) Nat Cell Biol , vol.6 , pp. 67-72
    • Gil, J.1    Bernard, D.2    Martínez, D.3    Beach, D.4
  • 91
    • 1642633053 scopus 로고    scopus 로고
    • Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
    • PMID:15029199
    • Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, Saremaslani P, Van Lohuizen M, Marino S. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 2004; 428:337-41; PMID:15029199; http://dx.doi.org/10.1038/nature02385
    • (2004) Nature , vol.428 , pp. 337-341
    • Leung, C.1    Lingbeek, M.2    Shakhova, O.3    Liu, J.4    Tanger, E.5    Saremaslani, P.6    Van Lohuizen, M.7    Marino, S.8
  • 93
    • 33747587608 scopus 로고    scopus 로고
    • Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
    • PMID:16921403
    • Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 2006; 7:667-77; PMID:16921403; http://dx.doi.org/10.1038/nrm1987
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 667-677
    • Gil, J.1    Peters, G.2
  • 94
    • 33947576177 scopus 로고    scopus 로고
    • Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus
    • PMID:17332741
    • Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH. Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J 2007; 26:1637-48; PMID:17332741; http://dx.doi.org/10.1038/sj.emboj.7601632
    • (2007) EMBO J , vol.26 , pp. 1637-1648
    • Dietrich, N.1    Bracken, A.P.2    Trinh, E.3    Schjerling, C.K.4    Koseki, H.5    Rappsilber, J.6    Helin, K.7    Hansen, K.H.8
  • 95
    • 65249093055 scopus 로고    scopus 로고
    • Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus
    • PMID:19390090
    • Chen H, Gu X, Su I-H, Bottino R, Contreras JL, Tarakhovsky A, Kim SK. Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev 2009; 23:975-85; PMID:19390090; http://dx.doi.org/10.1101/gad.1742509
    • (2009) Genes Dev , vol.23 , pp. 975-985
    • Chen, H.1    Gu, X.2    Su, I.-H.3    Bottino, R.4    Contreras, J.L.5    Tarakhovsky, A.6    Kim, S.K.7
  • 96
    • 65249121864 scopus 로고    scopus 로고
    • Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation
    • PMID:19390085
    • Dhawan S, Tschen SI, Bhushan A. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev 2009; 23:906-11; PMID:19390085; http://dx.doi.org/10.1101/gad.1742609
    • (2009) Genes Dev , vol.23 , pp. 906-911
    • Dhawan, S.1    Tschen, S.I.2    Bhushan, A.3
  • 97
    • 77952430646 scopus 로고    scopus 로고
    • The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells
    • PMID:20395008
    • Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A. The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells. J Hepatol 2010; 52:854-63; PMID:20395008; http://dx.doi.org/10.1016/j.jhep.2010. 01.027
    • (2010) J Hepatol , vol.52 , pp. 854-863
    • Aoki, R.1    Chiba, T.2    Miyagi, S.3    Negishi, M.4    Konuma, T.5    Taniguchi, H.6    Ogawa, M.7    Yokosuka, O.8    Iwama, A.9
  • 98
    • 62149122634 scopus 로고    scopus 로고
    • Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
    • PMID:19303854
    • Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su I-H, Hannon G, Tarakhovsky A, Fuchs E. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 2009; 136:1122-35; PMID:19303854; http://dx.doi.org/10.1016/j.cell.2008.12.043
    • (2009) Cell , vol.136 , pp. 1122-1135
    • Ezhkova, E.1    Pasolli, H.A.2    Parker, J.S.3    Stokes, N.4    Su, I.-H.5    Hannon, G.6    Tarakhovsky, A.7    Fuchs, E.8
  • 99
    • 84864607981 scopus 로고    scopus 로고
    • Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation
    • PMID:22911650
    • Shore AN, Kabotyanski EB, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JM. Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation. PLoS Genet 2012; 8:e1002840; PMID:22911650; http://dx.doi.org/10.1371/journal. pgen.1002840
    • (2012) PLoS Genet , vol.8
    • Shore, A.N.1    Kabotyanski, E.B.2    Roarty, K.3    Smith, M.A.4    Zhang, Y.5    Creighton, C.J.6    Dinger, M.E.7    Rosen, J.M.8
  • 100
    • 56249129313 scopus 로고    scopus 로고
    • Differentiation of neural stem cells into oligodendrocytes: Involvement of the polycomb group protein Ezh2
    • PMID:18687996
    • Sher F, Rössler R, Brouwer N, Balasubramaniyan V, Boddeke E, Copray S. Differentiation of neural stem cells into oligodendrocytes: involvement of the polycomb group protein Ezh2. Stem Cells 2008; 26:2875-83; PMID:18687996; http://dx.doi.org/10.1634/stemcells.2008-0121
    • (2008) Stem Cells , vol.26 , pp. 2875-2883
    • Sher, F.1    Rössler, R.2    Brouwer, N.3    Balasubramaniyan, V.4    Boddeke, E.5    Copray, S.6
  • 101
    • 79951761651 scopus 로고    scopus 로고
    • Ezh2 expression in astrocytes induces their dedifferentiation toward neural stem cells
    • PMID:20979531
    • Sher F, Boddeke E, Copray S. Ezh2 expression in astrocytes induces their dedifferentiation toward neural stem cells. Cell Reprogram 2011; 13:1-6; PMID:20979531; http://dx.doi.org/10.1089/cell.2010.0052
    • (2011) Cell Reprogram , vol.13 , pp. 1-6
    • Sher, F.1    Boddeke, E.2    Copray, S.3
  • 102
    • 69949085080 scopus 로고    scopus 로고
    • Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition
    • PMID:19755104
    • Hirabayashi Y, Suzki N, Tsuboi M, Endo TA, Toyoda T, Shinga J, Koseki H, Vidal M, Gotoh Y. Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. Neuron 2009; 63:600-13; PMID:19755104; http://dx.doi.org/10.1016/j.neuron.2009.08.021
    • (2009) Neuron , vol.63 , pp. 600-613
    • Hirabayashi, Y.1    Suzki, N.2    Tsuboi, M.3    Endo, T.A.4    Toyoda, T.5    Shinga, J.6    Koseki, H.7    Vidal, M.8    Gotoh, Y.9
  • 103
    • 77957680712 scopus 로고    scopus 로고
    • Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
    • PMID:20798045
    • Pereira JD, Sansom SN, Smith J, Dobenecker M-W, Tarakhovsky A, Livesey FJ. Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci U S A 2010; 107:15957-62; PMID:20798045; http://dx.doi.org/10.1073/pnas.1002530107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15957-15962
    • Pereira, J.D.1    Sansom, S.N.2    Smith, J.3    Dobenecker, M.-W.4    Tarakhovsky, A.5    Livesey, F.J.6
  • 104
    • 77952208495 scopus 로고    scopus 로고
    • Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis
    • PMID:20368440
    • Wang L, Jin Q, Lee JE, Su I-H, Ge K. Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc Natl Acad Sci U S A 2010; 107:7317-22; PMID:20368440; http://dx.doi.org/10.1073/pnas.1000031107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7317-7322
    • Wang, L.1    Jin, Q.2    Lee, J.E.3    Su, I.-H.4    Ge, K.5
  • 105
    • 84862777974 scopus 로고    scopus 로고
    • Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    • PMID:22267199
    • Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet 2012; 44:343-7; PMID:22267199; http://dx.doi.org/10.1038/ ng.1068
    • (2012) Nat Genet , vol.44 , pp. 343-347
    • Delgado-Olguín, P.1    Huang, Y.2    Li, X.3    Christodoulou, D.4    Seidman, C.E.5    Seidman, J.G.6    Tarakhovsky, A.7    Bruneau, B.G.8
  • 106
    • 84856505104 scopus 로고    scopus 로고
    • Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival
    • PMID:22312437
    • Chen L, Ma Y, Kim EY, Yu W, Schwartz RJ, Qian L, Wang J. Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival. PLoS One 2012; 7:e31005; PMID:22312437; http://dx.doi.org/10.1371/journal.pone.0031005
    • (2012) PLoS One , vol.7
    • Chen, L.1    Ma, Y.2    Kim, E.Y.3    Yu, W.4    Schwartz, R.J.5    Qian, L.6    Wang, J.7
  • 107
    • 84879765041 scopus 로고    scopus 로고
    • EZH2 and ALDH1 expression in ductal carcinoma in situ: Complex association with recurrence and progression to invasive breast cancer
    • PMID:23759596
    • Knudsen ES, Dervishaj O, Kleer CG, Pajak T, Schwartz GF, Witkiewicz AK. EZH2 and ALDH1 expression in ductal carcinoma in situ: complex association with recurrence and progression to invasive breast cancer. Cell Cycle 2013; 12:2042-50; PMID:23759596; http://dx.doi.org/10.4161/cc.25065
    • (2013) Cell Cycle , vol.12 , pp. 2042-2050
    • Knudsen, E.S.1    Dervishaj, O.2    Kleer, C.G.3    Pajak, T.4    Schwartz, G.F.5    Witkiewicz, A.K.6
  • 108
    • 79954471872 scopus 로고    scopus 로고
    • EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression
    • PMID:21383005
    • Fan T, Jiang S, Chung N, Alikhan A, Ni C, Lee CCR, Hornyak TJ. EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. Mol Cancer Res 2011; 9:418-29; PMID:21383005; http://dx.doi.org/10.1158/1541-7786.MCR-10-0511
    • (2011) Mol Cancer Res , vol.9 , pp. 418-429
    • Fan, T.1    Jiang, S.2    Chung, N.3    Alikhan, A.4    Ni, C.5    Lee, C.C.R.6    Hornyak, T.J.7
  • 109
    • 84866455756 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 is overexpressed and contributes to epigenetic inactivation of p21 and phosphatase and tensin homolog in B-cell acute lymphoblastic leukemia
    • (Maywood) PMID:22956625
    • Chen J, Li J, Han Q, Sun Z, Wang J, Wang S, Zhao RCH. Enhancer of zeste homolog 2 is overexpressed and contributes to epigenetic inactivation of p21 and phosphatase and tensin homolog in B-cell acute lymphoblastic leukemia. Exp Biol Med (Maywood) 2012; 237:1110-6; PMID:22956625; http://dx.doi.org/10.1258/ebm. 2012.012075
    • (2012) Exp Biol Med , vol.237 , pp. 1110-1116
    • Chen, J.1    Li, J.2    Han, Q.3    Sun, Z.4    Wang, J.5    Wang, S.6    Zhao, R.C.H.7
  • 110
    • 20444475352 scopus 로고    scopus 로고
    • Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer
    • PMID:15817459
    • Chen H, Tu SW, Hsieh JT. Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. J Biol Chem 2005; 280:22437-44; PMID:15817459; http://dx.doi.org/10.1074/jbc. M501379200
    • (2005) J Biol Chem , vol.280 , pp. 22437-22444
    • Chen, H.1    Tu, S.W.2    Hsieh, J.T.3
  • 111
    • 77950866779 scopus 로고    scopus 로고
    • Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression
    • PMID:19893569
    • Wu ZL, Zheng SS, Li ZM, Qiao YY, Aau MY, Yu Q. Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression. Cell Death Differ 2010; 17:801-10; PMID:19893569; http://dx.doi.org/10.1038/cdd.2009.162
    • (2010) Cell Death Differ , vol.17 , pp. 801-810
    • Wu, Z.L.1    Zheng, S.S.2    Li, Z.M.3    Qiao, Y.Y.4    Aau, M.Y.5    Yu, Q.6
  • 114
    • 3042781030 scopus 로고    scopus 로고
    • Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27
    • PMID:15231737
    • Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, Farnham PJ. Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev 2004; 18:1592-605; PMID:15231737; http://dx.doi.org/10.1101/gad.1200204
    • (2004) Genes Dev , vol.18 , pp. 1592-1605
    • Kirmizis, A.1    Bartley, S.M.2    Kuzmichev, A.3    Margueron, R.4    Reinberg, D.5    Green, R.6    Farnham, P.J.7
  • 115
  • 116
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
    • PMID:21078963
    • Sneeringer CJ, Scott MP, Kuntz KW, Knutson SK, Pollock RM, Richon VM, Copeland RA. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci U S A 2010; 107:20980-5; PMID:21078963; http://dx.doi.org/10.1073/pnas.1012525107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 20980-20985
    • Sneeringer, C.J.1    Scott, M.P.2    Kuntz, K.W.3    Knutson, S.K.4    Pollock, R.M.5    Richon, V.M.6    Copeland, R.A.7
  • 125
    • 0033804899 scopus 로고    scopus 로고
    • Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications
    • PMID:11025438
    • Puri PL, Sartorelli V. Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications. J Cell Physiol 2000; 185:155-73; PMID:11025438; http://dx.doi.org/10.1002/1097- 4652(200011)185:2〈155::AID-JCP1〉3.0.CO;2-Z
    • (2000) J Cell Physiol , vol.185 , pp. 155-173
    • Puri, P.L.1    Sartorelli, V.2
  • 126
    • 0036204443 scopus 로고    scopus 로고
    • Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression
    • PMID:11931766
    • Bergstrom DA, Penn BH, Strand A, Perry RL, Rudnicki MA, Tapscott SJ. Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression. Mol Cell 2002; 9:587-600; PMID:11931766; http://dx.doi.org/10.1016/S1097-2765(02)00481-1
    • (2002) Mol Cell , vol.9 , pp. 587-600
    • Bergstrom, D.A.1    Penn, B.H.2    Strand, A.3    Perry, R.L.4    Rudnicki, M.A.5    Tapscott, S.J.6
  • 127
    • 3042763342 scopus 로고    scopus 로고
    • p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci
    • PMID:15208625
    • Simone C, Forcales SV, Hill DA, Imbalzano AN, Latella L, Puri PL. p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci. Nat Genet 2004; 36:738-43; PMID:15208625; http://dx.doi.org/10.1038/ng1378
    • (2004) Nat Genet , vol.36 , pp. 738-743
    • Simone, C.1    Forcales, S.V.2    Hill, D.A.3    Imbalzano, A.N.4    Latella, L.5    Puri, P.L.6
  • 129
    • 84872812675 scopus 로고    scopus 로고
    • Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation
    • PMID:23060074
    • Marchesi I, Nieddu V, Caracciolo V, Maioli M, Gaspa L, Giordano A, Bagella L. Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation. J Cell Biochem 2013; 114:728-34; PMID:23060074; http://dx.doi.org/10.1002/jcb.24414
    • (2013) J Cell Biochem , vol.114 , pp. 728-734
    • Marchesi, I.1    Nieddu, V.2    Caracciolo, V.3    Maioli, M.4    Gaspa, L.5    Giordano, A.6    Bagella, L.7
  • 130
    • 7544230144 scopus 로고    scopus 로고
    • The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
    • PMID:15520282
    • Caretti G, Di Padova M, Micales B, Lyons GE, Sartorelli V. The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev 2004; 18:2627-38; PMID:15520282; http://dx.doi.org/ 10.1101/gad.1241904
    • (2004) Genes Dev , vol.18 , pp. 2627-2638
    • Caretti, G.1    Di Padova, M.2    Micales, B.3    Lyons, G.E.4    Sartorelli, V.5
  • 132
    • 36749082438 scopus 로고    scopus 로고
    • Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases
    • PMID:18003914
    • Hong S, Cho Y-W, Yu L-R, Yu H, Veenstra TD, Ge K. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci U S A 2007; 104:18439-44; PMID:18003914; http://dx.doi.org/10.1073/ pnas.0707292104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18439-18444
    • Hong, S.1    Cho, Y.-W.2    Yu, L.-R.3    Yu, H.4    Veenstra, T.D.5    Ge, K.6
  • 134
    • 35348993743 scopus 로고    scopus 로고
    • Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
    • PMID:17761849
    • Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science 2007; 318:447-50; PMID:17761849; http://dx.doi.org/10. 1126/science.1149042
    • (2007) Science , vol.318 , pp. 447-450
    • Lee, M.G.1    Villa, R.2    Trojer, P.3    Norman, J.4    Yan, K.P.5    Reinberg, D.6    Di Croce, L.7    Shiekhattar, R.8
  • 135
    • 38549115170 scopus 로고    scopus 로고
    • P-TEFb is critical for the maturation of RNA polymerase II into productive elongation in vivo
    • PMID:18070927
    • Ni Z, Saunders A, Fuda NJ, Yao J, Suarez J-R, Webb WW, Lis JT. P-TEFb is critical for the maturation of RNA polymerase II into productive elongation in vivo. Mol Cell Biol 2008; 28:1161-70; PMID:18070927; http://dx.doi.org/10.1128/ MCB.01859-07
    • (2008) Mol Cell Biol , vol.28 , pp. 1161-1170
    • Ni, Z.1    Saunders, A.2    Fuda, N.J.3    Yao, J.4    Suarez, J.-R.5    Webb, W.W.6    Lis, J.T.7
  • 138
    • 70349764482 scopus 로고    scopus 로고
    • Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells
    • PMID:19818710
    • Juan AH, Kumar RM, Marx JG, Young RA, Sartorelli V. Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Mol Cell 2009; 36:61-74; PMID:19818710; http://dx.doi.org/10.1016/j. molcel.2009.08.008
    • (2009) Mol Cell , vol.36 , pp. 61-74
    • Juan, A.H.1    Kumar, R.M.2    Marx, J.G.3    Young, R.A.4    Sartorelli, V.5
  • 139
    • 44349086037 scopus 로고    scopus 로고
    • MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis
    • PMID:18281287
    • Wong CF, Tellam RL. MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis. J Biol Chem 2008; 283:9836-43; PMID:18281287; http://dx.doi.org/10.1074/jbc.M709614200
    • (2008) J Biol Chem , vol.283 , pp. 9836-9843
    • Wong, C.F.1    Tellam, R.L.2
  • 140
    • 34250218193 scopus 로고    scopus 로고
    • NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes
    • PMID:17438126
    • Wang H, Hertlein E, Bakkar N, Sun H, Acharyya S, Wang J, Carathers M, Davuluri R, Guttridge DC. NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol 2007; 27:4374-87; PMID:17438126; http://dx.doi.org/10.1128/MCB.02020-06
    • (2007) Mol Cell Biol , vol.27 , pp. 4374-4387
    • Wang, H.1    Hertlein, E.2    Bakkar, N.3    Sun, H.4    Acharyya, S.5    Wang, J.6    Carathers, M.7    Davuluri, R.8    Guttridge, D.C.9
  • 141
    • 8344251881 scopus 로고    scopus 로고
    • Isolation of adult mouse myogenic progenitors: Functional heterogeneity of cells within and engrafting skeletal muscle
    • PMID:15537543
    • Sherwood RI, Christensen JL, Conboy IM, Conboy MJ, Rando TA, Weissman IL, Wagers AJ. Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell 2004; 119:543-54; PMID:15537543; http://dx.doi.org/10.1016/j.cell.2004.10.021
    • (2004) Cell , vol.119 , pp. 543-554
    • Sherwood, R.I.1    Christensen, J.L.2    Conboy, I.M.3    Conboy, M.J.4    Rando, T.A.5    Weissman, I.L.6    Wagers, A.J.7
  • 142
    • 22744438723 scopus 로고    scopus 로고
    • Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche
    • PMID:16051152
    • Collins CA, Olsen I, Zammit PS, Heslop L, Petrie A, Partridge TA, Morgan JE. Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell 2005; 122:289-301; PMID:16051152; http://dx.doi.org/10.1016/j.cell.2005.05.010
    • (2005) Cell , vol.122 , pp. 289-301
    • Collins, C.A.1    Olsen, I.2    Zammit, P.S.3    Heslop, L.4    Petrie, A.5    Partridge, T.A.6    Morgan, J.E.7
  • 144
    • 37548999686 scopus 로고    scopus 로고
    • Niche regulation of muscle satellite cell self-renewal and differentiation
    • PMID:18371418
    • Kuang S, Gillespie MA, Rudnicki MA. Niche regulation of muscle satellite cell self-renewal and differentiation. Cell Stem Cell 2008; 2:22-31; PMID:18371418; http://dx.doi.org/10.1016/j.stem.2007.12.012
    • (2008) Cell Stem Cell , vol.2 , pp. 22-31
    • Kuang, S.1    Gillespie, M.A.2    Rudnicki, M.A.3
  • 145
    • 30444440735 scopus 로고    scopus 로고
    • Regulation of skeletal muscle gene expression by p38 MAP kinases
    • PMID:16325404
    • Lluís F, Perdiguero E, Nebreda AR, Muñoz-Cánoves P. Regulation of skeletal muscle gene expression by p38 MAP kinases. Trends Cell Biol 2006; 16:36-44; PMID:16325404; http://dx.doi.org/10.1016/j.tcb.2005.11.002
    • (2006) Trends Cell Biol , vol.16 , pp. 36-44
    • Lluís, F.1    Perdiguero, E.2    Nebreda, A.R.3    Muñoz-Cánoves, P.4
  • 146
    • 0034664770 scopus 로고    scopus 로고
    • Pax7 is required for the specification of myogenic satellite cells
    • PMID:11030621
    • Seale P, Sabourin LA, Girgis-Gabardo A, Mansouri A, Gruss P, Rudnicki MA. Pax7 is required for the specification of myogenic satellite cells. Cell 2000; 102:777-86; PMID:11030621; http://dx.doi.org/10.1016/S0092-8674(00)00066-0
    • (2000) Cell , vol.102 , pp. 777-786
    • Seale, P.1    Sabourin, L.A.2    Girgis-Gabardo, A.3    Mansouri, A.4    Gruss, P.5    Rudnicki, M.A.6
  • 147
    • 4444235631 scopus 로고    scopus 로고
    • Pax7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification
    • PMID:15282552
    • Oustanina S, Hause G, Braun T. Pax7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification. EMBO J 2004; 23:3430-9; PMID:15282552; http://dx.doi.org/10.1038/sj.emboj.7600346
    • (2004) EMBO J , vol.23 , pp. 3430-3439
    • Oustanina, S.1    Hause, G.2    Braun, T.3
  • 148
    • 79551525429 scopus 로고    scopus 로고
    • Selective control of Pax7 expression by TNF-activated p38α/polycomb repressive complex 2 (PRC2) signaling during muscle satellite cell differentiation
    • PMID:21220942
    • Mozzetta C, Consalvi S, Saccone V, Forcales SV, Puri PL, Palacios D. Selective control of Pax7 expression by TNF-activated p38α/polycomb repressive complex 2 (PRC2) signaling during muscle satellite cell differentiation. Cell Cycle 2011; 10:191-8; PMID:21220942; http://dx.doi.org/10. 4161/cc.10.2.14441
    • (2011) Cell Cycle , vol.10 , pp. 191-198
    • Mozzetta, C.1    Consalvi, S.2    Saccone, V.3    Forcales, S.V.4    Puri, P.L.5    Palacios, D.6
  • 149
    • 34447287334 scopus 로고    scopus 로고
    • Skeletal muscle progenitor cells and the role of Pax genes
    • PMID:17631448
    • Buckingham M. Skeletal muscle progenitor cells and the role of Pax genes. C R Biol 2007; 330:530-3; PMID:17631448; http://dx.doi.org/10.1016/j.crvi.2007. 03.015
    • (2007) C R Biol , vol.330 , pp. 530-533
    • Buckingham, M.1
  • 150
  • 151
    • 0033588883 scopus 로고    scopus 로고
    • Rhabdomyosarcoma - Working out the pathways
    • PMID:10498887
    • Merlino G, Helman LJ. Rhabdomyosarcoma - working out the pathways. Oncogene 1999; 18:5340-8; PMID:10498887; http://dx.doi.org/10.1038/sj.onc. 1203038
    • (1999) Oncogene , vol.18 , pp. 5340-5348
    • Merlino, G.1    Helman, L.J.2
  • 153
    • 0037634085 scopus 로고    scopus 로고
    • Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas
    • PMID:12783965
    • Sebire NJ, Malone M. Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas. J Clin Pathol 2003; 56:412-6; PMID:12783965; http://dx.doi.org/10.1136/jcp.56.6.412
    • (2003) J Clin Pathol , vol.56 , pp. 412-416
    • Sebire, N.J.1    Malone, M.2
  • 155
    • 84860572092 scopus 로고    scopus 로고
    • Genome-wide DNA methylation studies suggest distinct DNA methylation patterns in pediatric embryonal and alveolar rhabdomyosarcomas
    • PMID:22419069
    • Mahoney SE, Yao Z, Keyes CC, Tapscott SJ, Diede SJ. Genome-wide DNA methylation studies suggest distinct DNA methylation patterns in pediatric embryonal and alveolar rhabdomyosarcomas. Epigenetics 2012; 7:400-8; PMID:22419069; http://dx.doi.org/10.4161/epi.19463
    • (2012) Epigenetics , vol.7 , pp. 400-408
    • Mahoney, S.E.1    Yao, Z.2    Keyes, C.C.3    Tapscott, S.J.4    Diede, S.J.5
  • 156
    • 84868014011 scopus 로고    scopus 로고
    • The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation
    • PMID:22983009
    • Marchesi I, Fiorentino FP, Rizzolio F, Giordano A, Bagella L. The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. Cell Cycle 2012; 11:3828-36; PMID:22983009; http://dx.doi.org/10.4161/cc.22025
    • (2012) Cell Cycle , vol.11 , pp. 3828-3836
    • Marchesi, I.1    Fiorentino, F.P.2    Rizzolio, F.3    Giordano, A.4    Bagella, L.5
  • 157
    • 84905868284 scopus 로고    scopus 로고
    • The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx)
    • The Polycomb group. PMID:24213577
    • Ciarapica R, De Salvo M, Carcarino E, Bracaglia G, Adesso L, Leoncini PP, Dall'agnese A, Walters ZS, Verginelli F, De Sio L, et al.; The Polycomb group. The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx). Oncogene 2013; PMID:24213577; http://dx.doi.org/10.1038/onc.2013.471
    • (2013) Oncogene
    • Ciarapica, R.1    De Salvo, M.2    Carcarino, E.3    Bracaglia, G.4    Adesso, L.5    Leoncini, P.P.6    Dall'agnese, A.7    Walters, Z.S.8    Verginelli, F.9    De Sio, L.10
  • 159
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • PMID:17437993
    • Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL, Karuturi RKM, Tan PBO, Liu ET, Yu Q. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 2007; 21:1050-63; PMID:17437993; http://dx.doi.org/10.1101/gad.1524107
    • (2007) Genes Dev , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3    Jiang, X.4    Chen, W.5    Lee, P.L.6    Karuturi, R.K.M.7    Tan, P.B.O.8    Liu, E.T.9    Yu, Q.10
  • 160
    • 84867401194 scopus 로고    scopus 로고
    • Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells
    • PMID:22925699
    • Kikuchi J, Takashina T, Kinoshita I, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Marquez VE, Nishimura M, Dosaka-Akita H. Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer 2012; 78:138-43; PMID:22925699; http://dx.doi.org/10.1016/j.lungcan. 2012.08.003
    • (2012) Lung Cancer , vol.78 , pp. 138-143
    • Kikuchi, J.1    Takashina, T.2    Kinoshita, I.3    Kikuchi, E.4    Shimizu, Y.5    Sakakibara-Konishi, J.6    Oizumi, S.7    Marquez, V.E.8    Nishimura, M.9    Dosaka-Akita, H.10
  • 162
    • 84879773777 scopus 로고    scopus 로고
    • Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition
    • PMID:23759589
    • Amatangelo MD, Garipov A, Li H, Conejo-Garcia JR, Speicher DW, Zhang R. Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition. Cell Cycle 2013; 12:2113-9; PMID:23759589; http://dx.doi.org/10.4161/cc.25163
    • (2013) Cell Cycle , vol.12 , pp. 2113-2119
    • Amatangelo, M.D.1    Garipov, A.2    Li, H.3    Conejo-Garcia, J.R.4    Speicher, D.W.5    Zhang, R.6
  • 163
    • 84871841675 scopus 로고    scopus 로고
    • Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
    • PMID:23236167
    • Qi W, Chan H, Teng L, Li L, Chuai S, Zhang R, Zeng J, Li M, Fan H, Lin Y, et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A 2012; 109:21360-5; PMID:23236167; http://dx.doi.org/10.1073/pnas.1210371110
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 21360-21365
    • Qi, W.1    Chan, H.2    Teng, L.3    Li, L.4    Chuai, S.5    Zhang, R.6    Zeng, J.7    Li, M.8    Fan, H.9    Lin, Y.10
  • 166
    • 80053139713 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells
    • PMID:21798853
    • Choudhury SR, Balasubramanian S, Chew YC, Han B, Marquez VE, Eckert RL. (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis 2011; 32:1525-32; PMID:21798853; http://dx.doi.org/10.1093/carcin/bgr171
    • (2011) Carcinogenesis , vol.32 , pp. 1525-1532
    • Choudhury, S.R.1    Balasubramanian, S.2    Chew, Y.C.3    Han, B.4    Marquez, V.E.5    Eckert, R.L.6
  • 167
    • 81255127260 scopus 로고    scopus 로고
    • 16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expression of histone-modifying enzymes PRC2 complex and induces apoptosis in CML K562 cells
    • PMID:21983300
    • Lin Y-H, Lee C-C, Chang F-R, Chang W-H, Wu Y-C, Chang J-G. 16-hydroxycleroda-3,13-dien-15,16-olide regulates the expression of histone-modifying enzymes PRC2 complex and induces apoptosis in CML K562 cells. Life Sci 2011; 89:886-95; PMID:21983300; http://dx.doi.org/10.1016/j.lfs.2011. 09.011
    • (2011) Life Sci , vol.89 , pp. 886-895
    • Lin, Y.-H.1    Lee, C.-C.2    Chang, F.-R.3    Chang, W.-H.4    Wu, Y.-C.5    Chang, J.-G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.