메뉴 건너뛰기




Volumn 20, Issue 2, 2008, Pages 201-207

Stem cell regulation by polycomb repressors: postponing commitment

Author keywords

[No Author keywords available]

Indexed keywords

POLYCOMB GROUP PROTEIN; TRANSCRIPTION FACTOR GATA;

EID: 41749108163     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2008.01.004     Document Type: Review
Times cited : (219)

References (48)
  • 1
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
    • Jaenisch R., and Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 Suppl (2003) 245-254
    • (2003) Nat Genet , vol.33 , Issue.SUPPL , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 2
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • Sparmann A., and van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 6 (2006) 846-856
    • (2006) Nat Rev Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    van Lohuizen, M.2
  • 7
    • 33846019277 scopus 로고    scopus 로고
    • Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark
    • Ruthenburg A.J., Allis C.D., and Wysocka J. Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell 25 (2007) 15-30
    • (2007) Mol Cell , vol.25 , pp. 15-30
    • Ruthenburg, A.J.1    Allis, C.D.2    Wysocka, J.3
  • 8
    • 0028910338 scopus 로고
    • The eed mutation disrupts anterior mesoderm production in mice
    • Faust C., Schumacher A., Holdener B., and Magnuson T. The eed mutation disrupts anterior mesoderm production in mice. Development 121 (1995) 273-285
    • (1995) Development , vol.121 , pp. 273-285
    • Faust, C.1    Schumacher, A.2    Holdener, B.3    Magnuson, T.4
  • 9
    • 34248169728 scopus 로고    scopus 로고
    • The Polycomb group protein Suz12 is required for embryonic stem cell differentiation
    • Pasini D., Bracken A.P., Hansen J.B., Capillo M., and Helin K. The Polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol 27 (2007) 3769-3779
    • (2007) Mol Cell Biol , vol.27 , pp. 3769-3779
    • Pasini, D.1    Bracken, A.P.2    Hansen, J.B.3    Capillo, M.4    Helin, K.5
  • 10
    • 3242759042 scopus 로고    scopus 로고
    • Defective long-term repopulating ability in hematopoietic stem cells lacking the Polycomb-group gene rae28
    • Kim J.Y., Sawada A., Tokimasa S., Endo H., Ozono K., Hara J., and Takihara Y. Defective long-term repopulating ability in hematopoietic stem cells lacking the Polycomb-group gene rae28. Eur J Haematol 73 (2004) 75-84
    • (2004) Eur J Haematol , vol.73 , pp. 75-84
    • Kim, J.Y.1    Sawada, A.2    Tokimasa, S.3    Endo, H.4    Ozono, K.5    Hara, J.6    Takihara, Y.7
  • 12
    • 0242667922 scopus 로고    scopus 로고
    • Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    • Molofsky A.V., Pardal R., Iwashita T., Park I.K., Clarke M.F., and Morrison S.J. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425 (2003) 962-967
    • (2003) Nature , vol.425 , pp. 962-967
    • Molofsky, A.V.1    Pardal, R.2    Iwashita, T.3    Park, I.K.4    Clarke, M.F.5    Morrison, S.J.6
  • 13
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • Liu S., Dontu G., Mantle I.D., Patel S., Ahn N.S., Jackson K.W., Suri P., and Wicha M.S. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 66 (2006) 6063-6071
    • (2006) Cancer Res , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3    Patel, S.4    Ahn, N.S.5    Jackson, K.W.6    Suri, P.7    Wicha, M.S.8
  • 15
    • 33646882068 scopus 로고    scopus 로고
    • Polycomb complexes repress developmental regulators in murine embryonic stem cells
    • In addition to mapping PcG targets in mES cells, these authors show experimentally that the majority of targets become expressed in the absence of PRC2-member EED or after ES cell differentiation.
    • Boyer L.A., Plath K., Zeitlinger J., Brambrink T., Medeiros L.A., Lee T.I., Levine S.S., Wernig M., Tajonar A., Ray M.K., et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441 (2006) 349-353. In addition to mapping PcG targets in mES cells, these authors show experimentally that the majority of targets become expressed in the absence of PRC2-member EED or after ES cell differentiation.
    • (2006) Nature , vol.441 , pp. 349-353
    • Boyer, L.A.1    Plath, K.2    Zeitlinger, J.3    Brambrink, T.4    Medeiros, L.A.5    Lee, T.I.6    Levine, S.S.7    Wernig, M.8    Tajonar, A.9    Ray, M.K.10
  • 16
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • First description of regions simultaneously marked by H3K27me3 and H3K4me3 by analysing ∼2.5% of the genome in mES cells. The authors suggest that these bivalent domains are primed for activation and mainly unique to ES cells.
    • Bernstein B.E., Mikkelsen T.S., Xie X., Kamal M., Huebert D.J., Cuff J., Fry B., Meissner A., Wernig M., Plath K., et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125 (2006) 315-326. First description of regions simultaneously marked by H3K27me3 and H3K4me3 by analysing ∼2.5% of the genome in mES cells. The authors suggest that these bivalent domains are primed for activation and mainly unique to ES cells.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3    Kamal, M.4    Huebert, D.J.5    Cuff, J.6    Fry, B.7    Meissner, A.8    Wernig, M.9    Plath, K.10
  • 18
    • 34548434716 scopus 로고    scopus 로고
    • Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells
    • This study uses ChIP and microarray to map H3K4me3 and H3K27me3 in hES cells. Three gene categories can be distinguished: K4 only, bivalent or no mark. For a small subset of genes, the authors examine the changes is histone marks and expression after differentiation of ES cells or in human fibroblasts.
    • Pan G., Tian S., Nie J., Yang C., Ruotti V., Wei H., Jonsdottir G.A., Stewart R., and Thomson J.A. Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell 1 (2007) 299-312. This study uses ChIP and microarray to map H3K4me3 and H3K27me3 in hES cells. Three gene categories can be distinguished: K4 only, bivalent or no mark. For a small subset of genes, the authors examine the changes is histone marks and expression after differentiation of ES cells or in human fibroblasts.
    • (2007) Cell Stem Cell , vol.1 , pp. 299-312
    • Pan, G.1    Tian, S.2    Nie, J.3    Yang, C.4    Ruotti, V.5    Wei, H.6    Jonsdottir, G.A.7    Stewart, R.8    Thomson, J.A.9
  • 20
    • 34547624303 scopus 로고    scopus 로고
    • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    • The authors use Solexa 1G sequencing to analyse the H3K4me3 and H3K27me3 ChIPs from mouse ES, neural precursor and embryonic fibroblast cells. They find that CpG-high promoters virtually all contain all the H3K4me3 marks which can be concurrent with H3K27me3, whereas CpG-poor promoters mostly lack both marks. The analysis in more committed cells suggests that bivalent domains are primed for alternative developmental fates.
    • Mikkelsen T.S., Ku M., Jaffe D.B., Issac B., Lieberman E., Giannoukos G., Alvarez P., Brockman W., Kim T.K., Koche R.P., et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448 (2007) 553-560. The authors use Solexa 1G sequencing to analyse the H3K4me3 and H3K27me3 ChIPs from mouse ES, neural precursor and embryonic fibroblast cells. They find that CpG-high promoters virtually all contain all the H3K4me3 marks which can be concurrent with H3K27me3, whereas CpG-poor promoters mostly lack both marks. The analysis in more committed cells suggests that bivalent domains are primed for alternative developmental fates.
    • (2007) Nature , vol.448 , pp. 553-560
    • Mikkelsen, T.S.1    Ku, M.2    Jaffe, D.B.3    Issac, B.4    Lieberman, E.5    Giannoukos, G.6    Alvarez, P.7    Brockman, W.8    Kim, T.K.9    Koche, R.P.10
  • 21
    • 34548446754 scopus 로고    scopus 로고
    • Human ES cell profiling broadens the reach of bivalent domains
    • Sharov A.A., and Ko M.S. Human ES cell profiling broadens the reach of bivalent domains. Cell Stem Cell 1 (2007) 237-238
    • (2007) Cell Stem Cell , vol.1 , pp. 237-238
    • Sharov, A.A.1    Ko, M.S.2
  • 22
    • 33750488431 scopus 로고    scopus 로고
    • The genomic landscape of histone modifications in human T cells
    • Roh T.Y., Cuddapah S., Cui K., and Zhao K. The genomic landscape of histone modifications in human T cells. Proc Natl Acad Sci 103 (2006) 15782-15787
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 15782-15787
    • Roh, T.Y.1    Cuddapah, S.2    Cui, K.3    Zhao, K.4
  • 23
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • This study illustrates the added value of not only analysing genome wide but also examining PcG occupancy and expression of individual genes before and after differentiation.
    • Bracken A.P., Dietrich N., Pasini D., Hansen K.H., and Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 20 (2006) 1123-1136. This study illustrates the added value of not only analysing genome wide but also examining PcG occupancy and expression of individual genes before and after differentiation.
    • (2006) Genes Dev , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 24
    • 34548644772 scopus 로고    scopus 로고
    • The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
    • The authors demonstrate that Jmjd3 is a H3K27 demethylase that it is specifically induced in macrophages upon LPS stimulation. This results in local, not global, H3K27me3 loss, suggesting specific recruitment. Induction of Jmjd3 resolves bivalent Bmp2 to an active gene, marked by H3K4me3 alone.
    • De Santa F., Totaro M.G., Prosperini E., Notarbartolo S., Testa G., and Natoli G. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 130 (2007) 1083-1094. The authors demonstrate that Jmjd3 is a H3K27 demethylase that it is specifically induced in macrophages upon LPS stimulation. This results in local, not global, H3K27me3 loss, suggesting specific recruitment. Induction of Jmjd3 resolves bivalent Bmp2 to an active gene, marked by H3K4me3 alone.
    • (2007) Cell , vol.130 , pp. 1083-1094
    • De Santa, F.1    Totaro, M.G.2    Prosperini, E.3    Notarbartolo, S.4    Testa, G.5    Natoli, G.6
  • 26
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs J.J., Kieboom K., Marino S., DePinho R.A., and van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397 (1999) 164-168
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    van Lohuizen, M.5
  • 33
  • 34
    • 34547730282 scopus 로고    scopus 로고
    • A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation
    • Zhu P., Zhou W., Wang J., Puc J., Ohgi K.A., Erdjument-Bromage H., Tempst P., Glass C.K., and Rosenfeld M.G. A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell 27 (2007) 609-621
    • (2007) Mol Cell , vol.27 , pp. 609-621
    • Zhu, P.1    Zhou, W.2    Wang, J.3    Puc, J.4    Ohgi, K.A.5    Erdjument-Bromage, H.6    Tempst, P.7    Glass, C.K.8    Rosenfeld, M.G.9
  • 37
    • 33847383585 scopus 로고    scopus 로고
    • Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein
    • Lee M.G., Norman J., Shilatifard A., and Shiekhattar R. Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell 128 (2007) 877-887
    • (2007) Cell , vol.128 , pp. 877-887
    • Lee, M.G.1    Norman, J.2    Shilatifard, A.3    Shiekhattar, R.4
  • 38
    • 34249080596 scopus 로고    scopus 로고
    • Theoretical analysis of epigenetic cell memory by nucleosome modification
    • The use of a computational model generates interesting predictions for how nucleosome modifications can contribute to a dynamic but robust epigenetic memory system.
    • Dodd I.B., Micheelsen M.A., Sneppen K., and Thon G. Theoretical analysis of epigenetic cell memory by nucleosome modification. Cell 129 (2007) 813-822. The use of a computational model generates interesting predictions for how nucleosome modifications can contribute to a dynamic but robust epigenetic memory system.
    • (2007) Cell , vol.129 , pp. 813-822
    • Dodd, I.B.1    Micheelsen, M.A.2    Sneppen, K.3    Thon, G.4
  • 42
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K., and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006) 663-676
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 46
    • 33845943728 scopus 로고    scopus 로고
    • Bmi-1 regulates the differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a...
    • Cui H., Ma J., Ding J., Li T., Alam G., and Ding H.F. Bmi-1 regulates the differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a.... J Biol Chem 281 (2006) 34696-34704
    • (2006) J Biol Chem , vol.281 , pp. 34696-34704
    • Cui, H.1    Ma, J.2    Ding, J.3    Li, T.4    Alam, G.5    Ding, H.F.6
  • 47
    • 33947693747 scopus 로고    scopus 로고
    • On the use of the word 'epigenetic'
    • Ptashne M. On the use of the word 'epigenetic'. Curr Biol 17 (2007) R233-R236
    • (2007) Curr Biol , vol.17
    • Ptashne, M.1
  • 48
    • 37249012276 scopus 로고    scopus 로고
    • Nucleosome destabilization in the epigenetic regulation of gene expression
    • Henikoff S. Nucleosome destabilization in the epigenetic regulation of gene expression. Nat Rev Genet 9 (2008) 15-26
    • (2008) Nat Rev Genet , vol.9 , pp. 15-26
    • Henikoff, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.