The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells

Journal of Hepatology

Volumn 52, Issue 6, 2010, Pages 854-863

  Aoki, Ryutaro ^a   Chiba, Tetsuhiro ^a,b   Miyagi, Satoru ^a   Negishi, Masamitsu ^a   Konuma, Takaaki ^a   Taniguchi, Hideki ^c   Ogawa, Makoto ^a   Yokosuka, Osamu ^a   Iwama, Atsushi ^a,b  

^a CHIBA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Bmi1; Differentiation; Ezh2; Hepatic stem progenitor cells; Ink4a Arf; Self renewal

Indexed keywords

ARF PROTEIN; BETA4 INTEGRIN; BMI1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYTOKERATIN 19; CYTOKERATIN 7; GENE PRODUCT; LENTIVIRUS VECTOR; POLYCOMB GROUP PROTEIN; PROTEIN SALL4; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; EMBRYO; FEMALE; FETUS; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE SILENCING; GENE TARGETING; LIVER CELL; LIVER STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; UPREGULATION;

ADP-RIBOSYLATION FACTOR 1; ANIMALS; BILE DUCTS; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HEPATOCYTES; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HOMEOSTASIS; LIVER; METHYLATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR PROTEINS; PREGNANCY; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; STEM CELLS;

EID: 77952430646     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.01.027     Document Type: Article

References (29)

1. Fausto N. Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 39 (2004) 1477-1487
2. Tanimizu N., Nishikawa M., Saito H., Tsujimura T., and Miyajima A. Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci 116 (2003) 1775-1786
3. + hepatoblasts. J Cell Sci 117 (2004) 6425-6434
4. Pietersen A.M., and van Lohuizen M. Stem cell regulation by polycomb repressors: postponing commitment. Curr Opin Cell Biol 20 (2008) 201-207
5. Yonemitsu Y., Imazeki F., Chiba T., Fukai K., Nagai Y., Miyagi S., et al. Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma. Hum Pathol 40 (2009) 1304-1311
6. Chiba T., Zheng Y.W., Kita K., Yokosuka O., Saisho H., Onodera M., et al. Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation. Gastroenterology 133 (2007) 937-950
7. Kamiya A., Kinoshita T., Ito Y., Matsui T., Morikawa Y., Senba E., et al. Fetal liver development requires a paracrine, action of oncostatin M through the gp 130 signal transducer. EMBO J 18 (1999) 2127-2136
8. Nishikawa Y., Tokusashi Y., Kadohama T., Nishimori H., and Ogawa K. Hepatocytic cells form bile duct-like structures within a three-dimensional collagen gel matrix. Exp Cell Res 223 (1996) 357-371
9. Negishi M., Saraya A., Miyagi S., Nagao K., Inagaki Y., Nishikawa M., et al. Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing. Biochem Biophys Res Commun 353 (2007) 992-998
10. Tzatsos A., Pfau R., Kampranis S.C., and Tsichlis P.N. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc Natl Acad Sci USA 106 (2009) 2641-2646
11. Oikawa T., Kamiya A., Kakinuma S., Zeniya M., Nishinakamura R., Tajiri H., et al. Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells. Gastroenterology 136 (2009) 1000-1011
12. Sher F., Roβler R., Brouwer N., Balasubramaniyan V., Boddeke E., and Copray S. Differentiation of neural stem cells into oligodendrocytes: involvement of the polycomb group protein Ezh2. Stem Cells 26 (2008) 2875-2883
13. Ezhkova E., Pasolli H.A., Parker J.S., Stokes N., Su I.H., Hannon G., et al. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136 (2009) 1122-1135
14. Oguro H., Iwama A., Morita Y., Kamijo T., van Lohuizen M., and Nakauchi H. Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med 203 (2006) 2247-2253
15. Arf senescence pathways. Genes Dev 19 (2005) 1432-1437
16. Bracken A.P., Kleine-Kohlbrecher D., Dietrich N., Pasini D., Gargiulo G., Beekman C., et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev 21 (2007) 525-530
17. Bernstein B.E., Mikkelsen T.S., Xie X., Kamal M., Huebert D.J., Cuff J., et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125 (2006) 315-326
18. Ku M., Koche R.P., Rheinbay E., Mendenhall E.M., Endoh M., Mikkelsen T.S., et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet 4 (2008) e1000242
19. Pietersen A.M., Horlings H.M., Hauptmann M., Langerød A., Ajouaou A., Cornelissen-Steijger P., et al. EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer. Breast Cancer Res 10 (2008) R109
20. Chen H., Gu X., Su I.H., Bottino R., Contreras J.L., Tarakhovsky A., et al. Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev 23 (2009) 975-985
21. Sasaki M., Yamaguchi J., Itatsu K., Ikeda H., and Nakanuma Y. Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis. J Pathol 215 (2008) 175-183
22. Nagy P., Bisgaard H.C., and Thorgeirsson S.S. Expression of hepatic transcription factors during liver development and oval cell differentiation. J Cell Biol 126 (1994) 223-233
23. Sund N.J., Ang S.L., Sackett S.D., Shen W., Daigle N., Magnuson M.A., et al. Hepatocyte nuclear factor 3b (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol 20 (2000) 5175-5183
24. Ishizaka S., Shiroi A., Kanda S., Yoshikawa M., Tsujinoue H., Kuriyama S., et al. Development of hepatocytes from ES cells after transfection with the HNF-3beta gene. FASEB J 16 (2002) 1444-1446
25. Ishii K., Yoshida Y., Akechi Y., Sakabe T., Nishio R., Ikeda R., et al. Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta. Hepatology 48 (2008) 597-606
26. Tan E.H., Ma F.J., Gopinadhan S., Sakban R.B., and Wang N.D. C/EBP alpha knock-in hepatocytes exhibit increased albumin secretion and urea production. Cell Tissue Res 330 (2007) 427-435
27. Zaret K.S. Regulatory phases of early liver development: paradigms of organogenesis. Nat Rev Genet 3 (2002) 499-512
28. Boyer L.A., Plath K., Zeitlinger J., Brambrink T., Medeiros L.A., Lee T.I., et al. Polycomb complexes repress developmental regulators in embryonic stem cells. Nature 441 (2006) 349-353
29. Kuzmichev A., Margueron R., Vaquero A., Preissner T.S., Scher M., Kirmizis A., et al. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci USA 102 (2005) 1859-1864