Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke

EMBO Molecular Medicine

Volumn 5, Issue 4, 2013, Pages 531-547

  Yu, Yung Luen ^a,b   Chou, Ruey Hwang ^a,b   Shyu, Woei Cherng ^a   Hsieh, Shu Ching ^a   Wu, Chen Shiou ^a   Chiang, Shu Ya ^a   Chang, Wei Jung ^a   Chen, Jia Ni ^a   Tseng, Yen Ju ^a   Lin, Yu Hsuan ^a   Lee, Wei ^a   Yeh, Su Peng ^c   Hsu, Jennifer L ^d   Yang, Cheng Chieh ^e   Hung, Shih Chieh ^e   Hung, Mien Chie ^a,d  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

EZH2; Human mesenchymal stem cells (hMSCs); Ischaemic neuronal injury; Neuron differentiation; Smurf2

Indexed keywords

LYSINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEASOME; ROSIGLITAZONE; TRANSCRIPTION FACTOR EZH2; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE E3 SMURF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN DYSFUNCTION; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; CONVALESCENCE; DNA MODIFICATION; DOWN REGULATION; ENZYME DEGRADATION; GENE EXPRESSION; GENE SILENCING; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROARRAY ANALYSIS; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; RAT; UBIQUITINATION;

ANIMALS; HUMANS; MALE; NEUROGENESIS; NEURONS; POLYCOMB REPRESSIVE COMPLEX 2; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; STROKE; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

EID: 84875811405     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201201783     Document Type: Article

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