Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90 RSK in the control of mTORC1 protein signaling by phorbol esters

Journal of Biological Chemistry

Volumn 286, Issue 31, 2011, Pages 27111-27122

  Fonseca, Bruno D ^a,b,d   Alain, Tommy ^d   Finestone, Leona K ^d   Huang, Brandon P H ^b   Rolfe, Mark ^a   Jiang, Tian ^b   Yao, Zhong ^b   Hernandez, Greco ^d   Bennett, Christopher F ^d   Proud, Christopher G ^a,b,c  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL TYPES; COMPLEX 1; EFFICIENT STRATEGY; EXTRACELLULAR SIGNAL-REGULATED KINASE; GENETIC EVALUATION; HYPERACTIVATION; ISOFORMS; MAMMALIAN TARGET; MITOGEN ACTIVATED PROTEIN KINASE; NATURALLY OCCURRING; ONCOGENIC PATHWAYS; PHORBOL 12 MYRISTATE 13 ACETATES; PHORBOL ESTERS; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN SIGNALING; RELATIVE IMPORTANCE; S6 KINASE; SIGNAL-REGULATED KINASE; SIGNALING CASCADES;

CHEMICAL ACTIVATION; ENZYMES; ESTERS; GROWTH KINETICS; MAMMALS; PHOSPHORYLATION; PROTEINS;

SIGNALING;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; BI D 1870; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN SERINE THREONINE KINASE INHIBITOR; RAPAMYCIN; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SPECIFICITY; EMBRYO; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; HUMANS; MICE; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PTERIDINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTORS;

MAMMALIA; RAPTORES; RODENTIA;

EID: 79961011264     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.260794     Document Type: Article

References (54)

1. Huang, J., and Manning, B. D. (2008) Biochem. J. 412, 179-190
2. Neshat, M. S., Mellinghoff, I. K., Tran, C., Stiles, B., Thomas, G., Petersen, R., Frost, P., Gibbons, J. J., Wu, H., and Sawyers, C. L. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 10314-10319
3. Kwiatkowski, D. J., Zhang, H., Bandura, J. L., Heiberger, K. M., Glogauer, M., el-Hashemite, N., and Onda, H. (2002) Hum. Mol. Genet. 11, 525-534
4. Onda, H., Crino, P. B., Zhang, H., Murphey, R. D., Rastelli, L., Gould Rothberg, B. E., and Kwiatkowski, D. J. (2002) Mol. Cell. Neurosci. 21, 561-574
5. Johannessen, C. M., Reczek, E. E., James, M. F., Brems, H., Legius, E., and Cichowski, K. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 8573-8578
6. James, M. F., Han, S., Polizzano, C., Plotkin, S. R., Manning, B. D., Stemmer-Rachamimov, A. O., Gusella, J. F., and Ramesh, V. (2009) Mol. Cell. Biol. 29, 4250-4261
7. Gibbons, J. J., Abraham, R. T., and Yu, K. (2009) Semin. Oncol. 36, S3-S17
8. Easton, J. B., and Houghton, P. J. (2006) Oncogene 25, 6436-6446
9. Faivre, S., Kroemer, G., and Raymond, E. (2006) Nat. Rev. Drug Discov. 5, 671-688
10. Guertin, D. A., and Sabatini, D. M. (2009) Sci. Signal. 2, pe24
11. Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., and Sabatini, D. M. (2008) Science 320, 1496-1501
12. Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., and Guan, K. L. (2008) Nat. Cell. Biol. 10, 935-945
13. Li, Y., Corradetti, M. N., Inoki, K., and Guan, K. L. (2004) Trends Biochem. Sci. 29, 32-38
14. Corradetti, M. N., and Guan, K. L. (2006) Oncogene 25, 6347-6360
15. Manning, B. D., and Cantley, L. C. (2003) Trends Biochem. Sci. 28, 573-576
16. Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., and Avruch, J. (2005) Curr. Biol. 15, 702-713
17. Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., and Cantley, L. C. (2002) Mol. Cell 10, 151-162
18. Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K. L. (2002) Nat. Cell. Biol. 4, 648-657
19. Dan, H. C., Sun, M., Yang, L., Feldman, R. I., Sui, X. M., Ou, C. C., Nellist, M., Yeung, R. S., Halley, D. J., Nicosia, S. V., Pledger, W. J., and Cheng, J. Q. (2002) J. Biol. Chem. 277, 35364-35370
20. Cai, S. L., Tee, A. R., Short, J. D., Bergeron, J. M., Kim, J., Shen, J., Guo, R., Johnson, C. L., Kiguchi, K., and Walker, C. L. (2006) J. Cell Biol. 173, 279-289
21. Wang, L., and Proud, C. G. (2002) Circ. Res. 91, 821-829
22. Herbert, T. P., Kilhams, G. R., Batty, I. H., and Proud, C. G. (2000) J. Biol. Chem. 275, 11249-11256
23. Roux, P. P., Ballif, B. A., Anjum, R., Gygi, S. P., and Blenis, J. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 13489-13494
24. Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P., and Pandolfi, P. P. (2005) Cell 121, 179-193
25. Wang, L., Rolfe, M., and Proud, C. G. (2003) Biochem. J. 373, 603-611
26. Fonseca, B. D., Lee, V. H., and Proud, C. G. (2008) Biochem. J. 411, 141-149
27. Fan, Q. W., Cheng, C., Knight, Z. A., Haas-Kogan, D., Stokoe, D., James, C. D., McCormick, F., Shokat, K. M., and Weiss, W. A. (2009) Sci. Signal. 2, ra4
28. Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marmé, D., and Rapp, U. R. (1993) Nature 364, 249-252
29. Rolfe, M., McLeod, L. E., Pratt, P. F., and Proud, C. G. (2005) Biochem. J. 388, 973-984
30. Ballif, B. A., Roux, P. P., Gerber, S. A., MacKeigan, J. P., Blenis, J., and Gygi, S. P. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 667-672
31. Carrière, A., Cargnello, M., Julien, L. A., Gao, H., Bonneil, E., Thibault, P., and Roux, P. P. (2008) Curr. Biol. 18, 1269-1277
32. Sebolt-Leopold, J. S., Dudley, D. T., Herrera, R., Van Becelaere, K., Wiland, A., Gowan, R. C., Tecle, H., Barrett, S. D., Bridges, A., Przybranowski, S., Leopold, W. R., and Saltiel, A. R. (1999) Nat. Med. 5, 810-816
33. Davies, S. P., Reddy, H., Caivano, M., and Cohen, P. (2000) Biochem. J. 351, 95-105
34. Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frodin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P., and Alessi, D. R. (2007) Biochem. J. 401, 29-38
35. Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C., and Blenis, J. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 13571-13576
36. Fonseca, B. D., Smith, E. M., Lee, V. H., MacKintosh, C., and Proud, C. G. (2007) J. Biol. Chem. 282, 24514-24524
37. Tee, A. R., and Proud, C. G. (2000) Oncogene 19, 3021-3031
38. Bradford, M. M. (1976) Anal. Biochem. 77, 248-254
39. Scheper, G. C., Parra, J. L., Wilson, M., van Kollenburg, B., Vertegaal, A. C., Han, Z. G., and Proud, C. G. (2003) Mol. Cell. Biol. 23, 5692-5705
40. Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2002) Cell 110, 163-175
41. Kim, D. H., Sarbassov, D. D., Ali, S. M., Latek, R. R., Guntur, K. V., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2003) Mol. Cell 11, 895-904
42. Yu, Y., Kudchodkar, S. B., and Alwine, J. C. (2005) J. Virol. 79, 6882- 6889
43. Chen, S., and Mackintosh, C. (2009) Cell Signal. 21, 1984-1993
44. Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., McLauchlan, H., Klevernic, I., Arthur, J. S., Alessi, D. R., and Cohen, P. (2007) Biochem. J.408, 297-315
45. Squires, M. S., Nixon, P. M., and Cook, S. J. (2002) Biochem. J. 366, 673-680
46. Meng, X. W., Chandra, J., Loegering, D., Van Becelaere, K., Kottke, T. J., Gore, S. D., Karp, J. E., Sebolt-Leopold, J., and Kaufmann, S. H. (2003) J. Biol. Chem. 278, 47326-47339
47. Solit, D. B., Garraway, L. A., Pratilas, C. A., Sawai, A., Getz, G., Basso, A., Ye, Q., Lobo, J. M., She, Y., Osman, I., Golub, T. R., Sebolt-Leopold, J., Sellers, W. R., and Rosen, N. (2006) Nature 439, 358-362
48. Lauchle, J. O., Kim, D., Le, D. T., Akagi, K., Crone, M., Krisman, K., Warner, K., Bonifas, J. M., Li, Q., Coakley, K. M., Diaz-Flores, E., Gorman, M., Przybranowski, S., Tran, M., Kogan, S. C., Roose, J. P., Copeland, N. G., Jenkins, N. A., Parada, L., Wolff, L., Sebolt-Leopold, J., and Shannon, K. (2009) Nature 461, 411-414
49. Podsypanina, K., Lee, R. T., Politis, C., Hennessy, I., Crane, A., Puc, J., Neshat, M., Wang, H., Yang, L., Gibbons, J., Frost, P., Dreisbach, V., Blenis, J., Gaciong, Z., Fisher, P., Sawyers, C., Hedrick-Ellenson, L., and Parsons, R. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 10320-10325
50. Smith, J. A., Poteet-Smith, C. E., Xu, Y., Errington, T. M., Hecht, S. M., and Lannigan, D. A. (2005) Cancer Res. 65, 1027-1034
51. Wang, L., Gout, I., and Proud, C. G. (2001) J. Biol. Chem. 276, 32670-32677
52. Hannan, R. D., Jenkins, A., Jenkins, A. K., and Brandenburger, Y. (2003) Clin. Exp. Pharmacol. Physiol. 30, 517-527
53. McMullen, J. R., Sherwood, M. C., Tarnavski, O., Zhang, L., Dorfman, A. L., Shioi, T., and Izumo, S. (2004) Circulation 109, 3050-3055
54. Shioi, T., McMullen, J. R., Tarnavski, O., Converso, K., Sherwood, M. C., Manning, W. J., and Izumo, S. (2003) Circulation 107, 1664-1670