The mechanism of insulin-stimulated 4E-BP protein binding to mammalian Target of Rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling

Journal of Biological Chemistry

Volumn 286, Issue 44, 2011, Pages 38043-38053

  Rapley, Joseph ^a,b   Oshiro, Noriko ^a,b   Ortiz Vega, Sara ^a,b   Avruch, Joseph ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEX 1; HELA CELL; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); OVER-EXPRESSION; PROTEIN BINDING; SUBSTRATE BINDING;

AMINO ACIDS; ANTIBIOTICS; BIOCHEMISTRY; CATALYST ACTIVITY; MAMMALS; PHOSPHORYLATION; SIGNALING; SUBSTRATES;

INSULIN;

INITIATION FACTOR 4E BINDING PROTEIN; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PRAS40 PROTEIN; PROTEIN KINASE B; RHEB PROTEIN; S6K1 PROTEIN; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE; HELA CELLS; HUMANS; INSULIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

MAMMALIA; RAPTORES;

EID: 80055073635     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.245449     Document Type: Article

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