The role of ECL2 in CGRP receptor activation: A combined modelling and experimental approach

Journal of the Royal Society Interface

Volumn 10, Issue 88, 2013, Pages

  Woolley, Michael J ^a   Watkins, Harriet A ^b   Taddese, Bruck ^c   Karakullukcu, Z Gamze ^c   Barwell, James ^d   Smith, Kevin J ^c   Hay, Debbie L ^b   Poyner, David R ^d   Reynolds, Christopher A ^c   Conner, Alex C ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF ESSEX   (United Kingdom)

^d ASTON UNIVERSITY   (United Kingdom)

Author keywords

Calcitonin gene related peptide; Calcitonin receptor like receptor; Class B G protein coupled receptor; Loop modelling; Site directed mutagenesis

Indexed keywords

AMINO ACIDS; BINS; CHEMICAL ACTIVATION; ENZYME ACTIVITY; GENES; MUTAGENESIS; PEPTIDES;

CALCITONIN GENE-RELATED PEPTIDES; CALCITONIN RECEPTOR-LIKE RECEPTORS; EXPERIMENTAL APPROACHES; EXTRACELLULAR LOOPS; G PROTEIN COUPLED RECEPTORS; RECEPTOR ACTIVATION; RECEPTOR ACTIVITY-MODIFYING PROTEINS; SITE DIRECTED MUTAGENESIS;

PROTEINS;

ADRENOMEDULLIN; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN RECEPTOR LIKE RECEPTOR; CALCITONIN RECEPTOR LIKE RECEPTOR SECOND EXTRACELLULAR LOOP; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG; CALCRL PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SEQUENCE ANALYSIS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COS 1 CELL LINE; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ADRENOMEDULLIN; ANIMALS; CALCITONIN RECEPTOR-LIKE PROTEIN; COS CELLS; CYCLIC AMP; HUMANS; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE;

EID: 84896588857     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2013.0589     Document Type: Article

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