Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

Journal of Biological Chemistry

Volumn 287, Issue 6, 2012, Pages 3642-3658

  Koole, Cassandra ^a   Wootten, Denise ^a   Simms, John ^a   Miller, Laurence J ^b   Christopoulos, Arthur ^a   Sexton, Patrick M ^a  

^a MONASH UNIVERSITY   (Australia)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE-SCANNING MUTAGENESIS; DIABETES MELLITUS; EXTRACELLULAR LOOPS; EXTRACELLULAR SIGNAL-REGULATED KINASES 1 AND 2; G-PROTEIN COUPLED RECEPTORS; INTRACELLULAR CA; LIGAND BINDING; LIGAND-RECEPTOR INTERACTIONS; LOOP RESIDUES; PEPTIDE BINDING; RECEPTOR ACTIVATION; RECEPTOR EXPRESSION; SIGNALING PATHWAYS; TYPE II; WILD TYPES;

AMINO ACIDS; ENZYME ACTIVITY; LIGANDS; PEPTIDES; PHOSPHORYLATION; PHYSIOLOGY; PIGMENTS;

BIOACTIVITY;

ALANINE; CALCIUM ION; CYCLIC AMP; EXTRACELLULAR LOOP 2 PROTEIN; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL SURFACE; CONTROLLED STUDY; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; GLUCAGON-LIKE PEPTIDE 1; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUTATION, MISSENSE; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCAGON;

EID: 84856731249     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.309328     Document Type: Article

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