Structural determinants of salmon calcitonin bioactivity: The role of the Leu-based amphipathic α-helix

Journal of Biological Chemistry

Volumn 281, Issue 34, 2006, Pages 24193-24203

  Andreotti, Giuseppina ^a   Méndez, Blanca López ^a   Amodeo, Pietro ^a   Castiglione Morelli, Maria A ^b   Nakamuta, Hiromichi ^c   Motta, Andrea ^a  

^a CNR   (Italy)

^b UNIVERSITY OF BASILICATA   (Italy)

^c HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

BINDING AFFINITY; CIRCULAR DICHROISM; FLANKING RESIDUES; SALMON CALCITONIN (SCT);

DRUG PRODUCTS;

ALANINE; ARGININE; CALCITONIN; LEUCINE; PROLINE;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; BREAST CANCER; CALCULATION; CANCER CELL CULTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; DNA FLANKING REGION; DOSE RESPONSE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; HYPOCALCEMIA; IN VIVO STUDY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RECEPTOR BINDING; SALMON;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCITONIN; CELL LINE, TUMOR; CIRCULAR DICHROISM; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CALCITONIN; SALMON; SEQUENCE ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747711389     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M603528200     Document Type: Article

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