The role of the 8-18 helix of CGRP 8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions

British Journal of Pharmacology

Volumn 138, Issue 2, 2003, Pages 325-332

  Howitt, Stephen G ^a   Kilk, Kalle ^b   Wang, Yang ^a   Smith, David M ^c   Langel, Ulo ^b   Poyner, David R ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Bpa CGRP 8 37; CGRP; CGRP 1 receptor; CGRP 8 37; L6 cells; SK N MC cells; Structure activity studies

Indexed keywords

ARGININE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE[8-37]; CYCLIC AMP; GLUTAMIC ACID; LEUCINE; PHENYLALANINE DERIVATIVE; SERINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOSPECIFICITY;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSTATICS; HUMANS; HYDROGEN BONDING; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; STEREOISOMERISM; TUMOR CELLS, CULTURED;

EID: 0037275217     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705040     Document Type: Article

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