Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function

Journal of Biological Chemistry

Volumn 287, Issue 6, 2012, Pages 3659-3673

  Koole, Cassandra ^a   Wootten, Denise ^a   Simms, John ^a   Savage, Emilia E ^a   Miller, Laurence J ^b   Christopoulos, Arthur ^a   Sexton, Patrick M ^a  

^a MONASH UNIVERSITY   (Australia)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE-SCANNING MUTAGENESIS; DIFFERENT EFFECTS; EXTRACELLULAR LOOPS; EXTRACELLULAR SIGNAL-REGULATED KINASES 1 AND 2; G PROTEIN COUPLED RECEPTORS; PEPTIDE MIMETICS; PEPTIDE SIGNALING; RECEPTOR ACTIVATION; SMALL MOLECULES;

AMINO ACIDS; ENZYME ACTIVITY; LIGANDS; PHOSPHORYLATION;

PEPTIDES;

6,7 DICHLORO 2 METHYLSULFONYL 3 TERT BUTYLAMINOQUINOXALINE; ALANINE; CALCIUM ION; CYCLIC AMP; EXENDIN 4; EXTRACELLULAR LOOP 2 PROTEIN; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OXYNTOMODULIN; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; BIOMIMETIC MATERIALS; CELL LINE; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUTATION, MISSENSE; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCAGON;

EID: 84856693524     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.309369     Document Type: Article

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