Charged extracellular residues, conserved throughout a G-protein-coupled receptor family, are required for ligand binding, receptor activation, and cell-surface expression

Journal of Biological Chemistry

Volumn 281, Issue 50, 2006, Pages 38487-38488

  Hawtin, Stuart R ^a,c   Simms, John ^a   Conner, Matthew ^a   Lawson, Zoe ^a   Parslow, Rosemary A ^a   Trim, Julie ^b   Sheppard, Andrew ^b   Wheatley, Mark ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b Ferring Research Ltd   (United Kingdom)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CHEMICAL BONDS; CYTOLOGY; MOLECULAR BIOLOGY; NEUROLOGY;

G-PROTEIN-COUPLED RECEPTORS (GPCR); LIGAND BINDING; PEPTIDE; RECEPTOR; TRANSMEMBRANE HELICES (TM);

PROTEINS;

ARGININE; ASPARTIC ACID; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; LYSINE; RECEPTOR SUBTYPE; VASOPRESSIN V1A RECEPTOR; LIGAND; PRIMER DNA;

ARTICLE; BINDING SITE; CELL SURFACE; CONTROLLED STUDY; DISULFIDE BOND; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MODEL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SPECIES DIFFERENCE; AMINO ACID SEQUENCE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; RADIOASSAY; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL MEMBRANE; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 33845975660     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607639200     Document Type: Article

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