Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies

Journal of the Royal Society Interface

Volumn 10, Issue 79, 2013, Pages

  Vohra, Shabana ^a,d   Taddese, Bruck ^a   Conner, Alex C ^b   Poyner, David R ^c   Hay, Debbie L ^c,e   Barwell, James ^c   Reeves, Philip J ^a   Upton, Graham J G ^a   Reynolds, Christopher A ^a  

^a UNIVERSITY OF ESSEX   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c ASTON UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Calcitonin gene related peptide; Family A G protein coupled receptor; Family B G protein coupled receptor; GCR1; Molecular dynamics; Motifs

Indexed keywords

ALIGNMENT; ENZYME ACTIVITY; GENES; MACHINERY; MOLECULAR DYNAMICS; MUTAGENESIS; PEPTIDES;

CALCITONIN GENE-RELATED PEPTIDES; CLASS A; CLASS B; DRY MOTIF; G PROTEIN COUPLED RECEPTORS; GCR1; HOMOLOGY MODELS; INTRACELLULAR LOOP; MOLECULAR FEATURE; MOTIFS; SITE DIRECTED MUTAGENESIS; STRUCTURAL TEMPLATES; TRANSMEMBRANE REGIONS;

EQUIVALENCE CLASSES;

CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR CLASS A; G PROTEIN COUPLED RECEPTOR CLASS B; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; ARABIDOPSIS PROTEIN; GCR1 PROTEIN, ARABIDOPSIS;

ARTICLE; ENTROPY; ENZYME ACTIVATION; ENZYME SYNTHESIS; GENE EXPRESSION; HYDROPHOBICITY; MUTAGENESIS; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; ANIMAL; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; GENETIC VARIABILITY; GENETICS; HUMAN; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR GENETICS; SEQUENCE ALIGNMENT;

AMINO ACID MOTIFS; ANIMALS; ARABIDOPSIS PROTEINS; CATTLE; GENETIC VARIATION; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE ALIGNMENT;

EID: 84872233573     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2012.0846     Document Type: Article

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