Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling

Journal of Biological Chemistry

Volumn 286, Issue 18, 2011, Pages 15895-15907

  Miller, Laurence J ^a   Chen, Quan ^a   Lam, Polo C H ^b,c   Pinon, Delia I ^a   Sexton, Patrick M ^d   Abagyan, Ruben ^b,c   Dong, Maoqing ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c MOLSOFT LLC   (United States)

^d MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINUS; AMINO-TERMINAL DOMAIN; CARBOXYL-TERMINAL; CHO CELL; CONCENTRATION-DEPENDENT; DRUG TARGETS; EXTRACELLULAR LOOPS; G PROTEIN COUPLED RECEPTORS; GAIN INSIGHT; HELICAL BUNDLE; HIGH AFFINITY; L-PHENYLALANINE; LIGAND-RECEPTOR COMPLEX; LOOP REGIONS; MOLECULAR BASIS; RECEPTOR SITES; TRANSMEMBRANE SEGMENTS; TYPE 2 DIABETES MELLITUS;

AMINO ACIDS; FETAL MONITORING; LIGANDS; PEPTIDES;

PROBES;

1,4 BENZOYLPHENYLALANINE; CYCLIC AMP; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [7-36]; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; LEUCINE; PHENYLALANINE DERIVATIVE; PROTEINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL LEVEL; CHO CELL; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME DEGRADATION; FEMALE; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; MOLECULAR PROBE; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN DOMAIN; RADIOCHEMISTRY; RECEPTOR BINDING;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GLUCAGON-LIKE PEPTIDE 1; HUMANS; MODELS, MOLECULAR; MOLECULAR PROBES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, GLUCAGON; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955540676     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.217901     Document Type: Article

References (71)

1. Mayo, K. E., Miller, L. J., Bataille, D., Dalle, S., Göke, B., Thorens, B., and Drucker, D. J. (2003) Pharmacol. Rev. 55, 167-194
2. Estall, J. L., and Drucker, D. J. (2006) Curr. Pharm. Des. 12, 1731-1750
3. Cao, Y. J., Gimpl, G., and Fahrenholz, F. (1995) Biochem. Biophys. Res. Commun. 212, 673-680
4. Gourlet, P., Vilardaga, J. P., De Neef, P., Waelbroeck, M., Vandermeers, A., and Robberecht, P. (1996) Peptides 17, 825-829
5. Graziano, M. P., Hey, P. J., and Strader, C. D. (1996) Receptors Channels 4, 9-17
6. Holtmann, M. H., Hadac, E. M., and Miller, L. J. (1995) J. Biol. Chem. 270, 14394-14398
7. Jüppner, H., Schipani, E., Bringhurst, F. R., McClure, I., Keutmann, H. T., Potts, J. T., Jr., Kronenberg, H. M., Abou-Samra, A. B., Segre, G. V., and Gardella, T. J. (1994) Endocrinology 134, 879-884
8. Stroop, S. D., Nakamuta, H., Kuestner, R. E., Moore, E. E., and Epand, R. M. (1996) Endocrinology 137, 4752-4756
9. Dong, M., Lam, P. C., Gao, F., Hosohata, K., Pinon, D. I., Sexton, P. M., Abagyan, R., and Miller, L. J. (2007) Mol. Pharmacol. 72, 280-290
10. Dong, M., Pinon, D. I., Cox, R. F., and Miller, L. J. (2004) J. Biol. Chem. 279, 1167-1175
11. Tan, Y. V., Couvineau, A., Murail, S., Ceraudo, E., Neumann, J. M., Lacapère, J. J., and Laburthe, M. (2006) J. Biol. Chem. 281, 12792-12798
12. Chorev, M. (2002) Receptors Channels 8, 219-242
13. Grace, C. R., Perrin, M. H., DiGruccio, M. R., Miller, C. L., Rivier, J. E., Vale, W. W., and Riek, R. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 12836-12841
14. Grace, C. R., Perrin, M.H., Gulyas, J., Digruccio, M.R., Cantle, J. P., Rivier, J. E., Vale, W. W., and Riek, R. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 4858-4863
15. Pioszak, A. A., Parker, N. R., Suino-Powell, K., and Xu, H. E. (2008) J. Biol. Chem. 283, 32900-32912
16. Parthier, C., Kleinschmidt, M., Neumann, P., Rudolph, R., Manhart, S., Schlenzig, D., Fanghänel, J., Rahfeld, J. U., Demuth, H. U., and Stubbs, M. T. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 13942-13947
17. Runge, S., Thøgersen, H., Madsen, K., Lau, J., and Rudolph, R. (2008) J. Biol. Chem. 283, 11340-11347
18. Underwood, C. R., Garibay, P., Knudsen, L. B., Hastrup, S., Peters, G. H., Rudolph, R., and Reedtz-Runge, S. (2010) J. Biol. Chem. 285, 723-730
19. Sun, C., Song, D., Davis-Taber, R. A., Barrett, L. W., Scott, V. E., Richardson, P. L., Pereda-Lopez, A., Uchic, M. E., Solomon, L. R., Lake, M. R., Walter, K. A., Hajduk, P. J., and Olejniczak, E. T. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 7875-7880
20. Pioszak, A. A., and Xu, H. E. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 5034-5039
21. ter Haar, E., Koth, C. M., Abdul-Manan, N., Swenson, L., Coll, J. T., Lippke, J. A., Lepre, C. A., Garcia-Guzman, M., and Moore, J. M. (2010) Structure 18, 1083-1093
22. Koth, C. M., Abdul-Manan, N., Lepre, C. A., Connolly, P. J., Yoo, S., Mohanty, A. K., Lippke, J. A., Zwahlen, J., Coll, J. T., Doran, J. D., Garcia- Guzman, M., and Moore, J. M. (2010) Biochemistry 49, 1862-1872
23. Holtmann, M. H., Ganguli, S., Hadac, E. M., Dolu, V., and Miller, L. J. (1996) J. Biol. Chem. 271, 14944-14949
24. Chen, Q., Pinon, D. I., Miller, L. J., and Dong, M. (2009) J. Biol. Chem. 284, 34135-34144
25. Chen, Q., Pinon, D. I., Miller, L. J., and Dong, M. (2010) J. Biol. Chem. 285, 24508-24518
26. Adelhorst, K., Hedegaard, B. B., Knudsen, L. B., and Kirk, O. (1994) J. Biol. Chem. 269, 6275-6278
27. Powers, S. P., Pinon, D. I., and Miller, L. J. (1988) Int. J. Pept. Protein Res. 31, 429-434
28. Ulrich, C. D., 2nd, Pinon, D. I., Hadac, E. M., Holicky, E. L., Chang-Miller, A., Gates, L. K., and Miller, L. J. (1993) Gastroenterology 105, 1534-1543
29. Dong, M., Gao, F., Pinon, D. I., and Miller, L. J. (2008) Mol. Endocrinol. 22, 1489-1499
30. Hadac, E. M., Ghanekar, D. V., Holicky, E. L., Pinon, D. I., Dougherty, R. W., and Miller, L. J. (1996) Pancreas 13, 130-139
31. Munson, P. J., and Rodbard, D. (1980) Anal. Biochem. 107, 220-239
32. Dong, M., Wang, Y., Pinon, D. I., Hadac, E. M., and Miller, L. J. (1999) J. Biol. Chem. 274, 903-909
33. Ji, Z., Hadac, E. M., Henne, R. M., Patel, S. A., Lybrand, T. P., and Miller, L. J. (1997) J. Biol. Chem. 272, 24393-24401
34. Abagyan, R., Totrov, M., and Kuznetsov, D. (1994) J. Comput. Chem. 15, 488-506
35. Abagyan, R., and Totrov, M. (1994) J. Mol. Biol. 235, 983-1002
36. Metropolis, N., Rosenbluth, A. W., Rosenbluth, M. N., Teller, A. H., and Teller, E. (1953) J. Chem. Phys. 21, 1087-1092
37. Hooft, R. W., Vriend, G., Sander, C., and Abola, E. E. (1996) Nature 381, 272-272
38. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
39. Michino, M., Abola, E., Brooks, C. L., 3rd, Dixon, J. S., Moult, J., and Stevens, R. C. (2009) Nat. Rev. Drug Discov. 8, 455-463
40. Dong, M., Lam, P. C., Pinon, D. I., Orry, A., Sexton, P. M., Abagyan, R., and Miller, L. J. (2010) J. Biol. Chem. 285, 9919-9931
41. Tokuyama, Y., Matsui, K., Egashira, T., Nozaki, O., Ishizuka, T., and Kanatsuka, A. (2004) Diabetes Res. Clin. Pract. 66, 63-69
42. Pham, V., Wade, J. D., Purdue, B. W., and Sexton, P. M. (2004) J. Biol. Chem. 279, 6720-6729
43. Zang, M., Dong, M., Pinon, D. I., Ding, X. Q., Hadac, E. M., Li, Z., Lybrand, T. P., and Miller, L. J. (2003) Mol. Pharmacol. 63, 993-1001
44. Ceraudo, E., Murail, S., Tan, Y. V., Lacapère, J. J., Neumann, J. M., Couvineau, A., and Laburthe, M. (2008) Mol. Endocrinol. 22, 147-155
45. Ceraudo, E., Tan, Y. V., Nicole, P., Couvineau, A., and Laburthe, M. (2008) J. Mol. Neurosci. 36, 245-248
46. Gensure, R. C., Gardella, T. J., and Jüppner, H. (2001) J. Biol. Chem. 276, 28650-28658
47. Adams, A. E., Bisello, A., Chorev, M., Rosenblatt, M., and Suva, L. J. (1998) Mol. Endocrinol. 12, 1673-1683
48. Wittelsberger, A., Corich, M., Thomas, B. E., Lee, B. K., Barazza, A., Czodrowski, P., Mierke, D. F., Chorev, M., and Rosenblatt, M. (2006) Biochemistry 45, 2027-2034
49. Zhou, A. T., Bessalle, R., Bisello, A., Nakamoto, C., Rosenblatt, M., Suva, L. J., and Chorev, M. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 3644-3649
50. Gaylinn, B. D. (2002) Receptors Channels 8, 155-162
51. Carter, P. H., Shimizu, M., Luck, M. D., and Gardella, T. J. (1999) J. Biol. Chem. 274, 31955-31960
52. Couvineau, A., Gaudin, P., Maoret, J. J., Rouyer-Fessard, C., Nicole, P., and Laburthe, M. (1995) Biochem. Biophys. Res. Commun. 206, 246-252
53. Olde, B., Sabirsh, A., and Owman, C. (1998) J. Mol. Neurosci. 11, 127-134
54. Dong, M., Cox, R. F., and Miller, L. J. (2009) J. Biol. Chem. 284, 21839-21847
55. Mann, R. J., Al-Sabah, S., de Maturana, R. L., Sinfield, J. K., and Donnelly, D. (2010) Peptides 31, 2289-2293
56. Al-Sabah, S., and Donnelly, D. (2003) FEBS Lett. 553, 342-346
57. Liaw, C. W., Grigoriadis, D. E., Lovenberg, T. W., De Souza, E. B., and Maki, R. A. (1997) Mol. Endocrinol. 11, 980-985
58. Dautzenberg, F. M., Higelin, J., Brauns, O., Butscha, B., and Hauger, R. L. (2002) Mol. Pharmacol. 61, 1132-1139
59. Lee, C., Luck, M. D., Jüppner, H., Potts, J. T., Jr., Kronenberg, H. M., and Gardella, T. J. (1995) Mol. Endocrinol. 9, 1269-1278
60. Bergwitz, C., Jusseaume, S. A., Luck, M. D., Jüppner, H., and Gardella, T. J. (1997) J. Biol. Chem. 272, 28861-28868
61. Runge, S., Gram, C., Brauner-Osborne, H., Madsen, K., Knudsen, L. B., and Wulff, B. S. (2003) J. Biol. Chem. 278, 28005-28010
62. Assil-Kishawi, I., and Abou-Samra, A. B. (2002) J. Biol. Chem. 277, 32558-32561
63. Kraetke, O., Holeran, B., Berger, H., Escher, E., Bienert, M., and Beyermann, M. (2005) Biochemistry 44, 15569-15577
64. Bisello, A., Adams, A. E., Mierke, D. F., Pellegrini, M., Rosenblatt, M., Suva, L. J., and Chorev, M. (1998) J. Biol. Chem. 273, 22498-22505
65. Dong, M., Li, Z., Pinon, D. I., Lybrand, T. P., and Miller, L. J. (2004) J. Biol. Chem. 279, 2894-2903
66. Dong, M., Pinon, D. I., Cox, R. F., and Miller, L. J. (2004) J. Biol. Chem. 279, 31177-31182
67. Dong, M., Lam, P. C., Pinon, D. I., Sexton, P. M., Abagyan, R., and Miller, L. J. (2008) Mol. Pharmacol. 74, 413-422
68. Gensure, R. C., Shimizu, N., Tsang, J., and Gardella, T. J. (2003) Mol. Endocrinol. 17, 2647-2658
69. Greenberg, Z., Bisello, A., Mierke, D. F., Rosenblatt, M., and Chorev, M. (2000) Biochemistry 39, 8142-8152
70. Lin, F., and Wang, R. (2009) J. Mol. Model. 15, 53-65
71. López de Maturana, R., Treece-Birch, J., Abidi, F., Findlay, J. B., and Donnelly, D. (2004) Protein Pept. Lett. 11, 15-22