Performance of comet and micronucleus assays in metabolic competent HepaRG cells to predict in vivo genotoxicity

Toxicological Sciences

Volumn 138, Issue 2, 2014, Pages 300-309

  Hégarat, Ludovic Le ^a   Mourot, Annick ^a   Huet, Sylvie ^a   Vasseur, Lucie ^a   Camus, Sandrine ^b   Chesné, Christophe ^b   Fessard, Valérie ^a  

^a FRENCH AGENCY FOR FOOD   (France)

^b BIOPREDIC   (France)

Author keywords

Bioactivation; Genotoxicity; Hepatocytes; Predictivity; Sensitivity; Specificity

Indexed keywords

CYTOCHROME P450;

ARTICLE; CELL DIFFERENTIATION; COMET ASSAY; GENETIC TOXICOLOGY; GENOTOXICITY; IN VIVO STUDY; LIVER CELL; MICRONUCLEUS TEST; SENSITIVITY AND SPECIFICITY;

BIOACTIVATION; GENOTOXICITY; HEPATOCYTES; PREDICTIVITY; SENSITIVITY; SPECIFICITY;

CELL LINE, TUMOR; COMET ASSAY; CRYOPRESERVATION; CYTOCHROME P-450 ENZYME SYSTEM; DNA DAMAGE; HUMANS; LIVER; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MUTAGENS; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY;

EID: 84896455156     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu004     Document Type: Article

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