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Volumn 16, Issue 1, 2013, Pages 17-38

Safety evaluation and risk assessment of D-limonene

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBULIN; COSMETIC; FLAVORING AGENT; FRAGRANCE; LIMONENE; SOLVENT;

EID: 84878195789     PISSN: 10937404     EISSN: 15216950     Source Type: Journal    
DOI: 10.1080/10937404.2013.769418     Document Type: Article
Times cited : (167)

References (112)
  • 1
    • 0022474943 scopus 로고
    • A review of unique male rat hydrocarbon nephropathy
    • Alden, C. L. 1986. A review of unique male rat hydrocarbon nephropathy. Toxicol.Pathol. 14: 109-111.
    • (1986) Toxicol.Pathol. , vol.14 , pp. 109-111
    • Alden, C.L.1
  • 2
    • 0020969610 scopus 로고
    • Review: Natural volatile organic substances and their effect on air quality in the United States
    • Altshuller, A. P. 1983. Review: Natural volatile organic substances and their effect on air quality in the United States. Atmos. Environ. 17: 2131-2165.
    • (1983) Atmos. Environ. , vol.17 , pp. 2131-2165
    • Altshuller, A.P.1
  • 5
    • 0016430368 scopus 로고
    • Studies on the metabolism of d-limonene (p-mentha-1, 8-diene): III. Effects of d-limonene on the lipids and drug-metabolizing enzymes in rat livers
    • Ariyoshi, T., Arakaki, M., Ideguchi, K., Ishizuka, Y., and Ide, H. 1975. Studies on the metabolism of d-limonene (p-mentha-1, 8-diene): III. Effects of d-limonene on the lipids and drug-metabolizing enzymes in rat livers. Xenobiotica 5: 33-38.
    • (1975) Xenobiotica , vol.5 , pp. 33-38
    • Ariyoshi, T.1    Arakaki, M.2    Ideguchi, K.3    Ishizuka, Y.4    Ide, H.5
  • 7
    • 56649120586 scopus 로고    scopus 로고
    • Characterization of monoterpene biotransformation in two pseudomonads
    • Bicas, J. L., Fontanille, P., Pastore, G. M., and Larroche, C. 2008. Characterization of monoterpene biotransformation in two pseudomonads. J. Appl. Microbiol. 105: 1991-2001.
    • (2008) J. Appl. Microbiol. , vol.105 , pp. 1991-2001
    • Bicas, J.L.1    Fontanille, P.2    Pastore, G.M.3    Larroche, C.4
  • 8
    • 0027471797 scopus 로고
    • Assessment of binding of 2, 4, 4-trimethyl-2-pentanol to low-molecular-weight proteins isolated from kidneys of male rats and humans
    • Borghoff, S. J., and Lagarde, W. H. 1993. Assessment of binding of 2, 4, 4-trimethyl-2-pentanol to low-molecular-weight proteins isolated from kidneys of male rats and humans. Toxicol. Appl. Pharmacol. 119:228-235.
    • (1993) Toxicol. Appl. Pharmacol. , vol.119 , pp. 228-235
    • Borghoff, S.J.1    Lagarde, W.H.2
  • 9
    • 0025967574 scopus 로고
    • Characteristics of chemical binding to alpha 2u-globulin in vitro-Evaluating structure-activity relationships
    • Borghoff, S. J., Miller, A. B., Bowen, J. P., and Swenberg, J. A. 1991.Characteristics of chemical binding to alpha 2u-globulin in vitro-Evaluating structure-activity relationships. Toxicol. Appl. Pharmacol. 107: 228-238.
    • (1991) Toxicol. Appl. Pharmacol. , vol.107 , pp. 228-238
    • Borghoff, S.J.1    Miller, A.B.2    Bowen, J.P.3    Swenberg, J.A.4
  • 10
    • 0029792650 scopus 로고    scopus 로고
    • Effects of monoter-penes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases"
    • Broitman, S. A., Wilkinson, J. 4th, Cerda, S., and Branch, S. K. 1996. Effects of monoter-penes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases" in vivo. Adv. Exp. Med. Biol. 401: 111-130.
    • (1996) Vivo. Adv. Exp. Med. Biol. , vol.401 , pp. 111-130
    • Broitman, S.A.1    Wilkinson, I.V.J.2    Cerda, S.3    Branch, S.K.4
  • 12
    • 0032145829 scopus 로고    scopus 로고
    • Pharmacokinetics of d-limonene in the rat by GC-MS assay
    • Chen, H., Chan, K. K., and Budd, T. 1998. Pharmacokinetics of d-limonene in the rat by GC-MS assay. J. Pharm. Biomed. Anal. 17: 631-640.
    • (1998) J. Pharm. Biomed. Anal. , vol.17 , pp. 631-640
    • Chen, H.1    Chan, K.K.2    Budd, T.3
  • 15
    • 0027249414 scopus 로고
    • Identification and determination of biogenic and anthropogenic volatile organic compounds in forest areas of northern and southern Europe and a remote site of the himalaya region by high-resolution gas chromatography-mass spectrometry
    • Ciccioli, P., Brancaleoni, E., Cecinato, A., Sparapani, R., and Frattoni, M. 1993. Identification and determination of biogenic and anthropogenic volatile organic compounds in forest areas of northern and southern Europe and a remote site of the himalaya region by high-resolution gas chromatography-mass spectrometry. J. Chromatogr. A 643:55-69.
    • (1993) J. Chromatogr. A , vol.643 , pp. 55-69
    • Ciccioli, P.1    Brancaleoni, E.2    Cecinato, A.3    Sparapani, R.4    Frattoni, M.5
  • 16
    • 0021945997 scopus 로고
    • Genotoxicity of organic chemicals frequently found in the air of mobile homes
    • Connor, T. H., Theiss, J. C., Hanna, H. A., Monteith, D. K., and Matney, T. S. 1985. Genotoxicity of organic chemicals frequently found in the air of mobile homes. Toxicol. Lett. 25: 33-40.
    • (1985) Toxicol. Lett. , vol.25 , pp. 33-40
    • Connor, T.H.1    Theiss, J.C.2    Hanna, H.A.3    Monteith, D.K.4    Matney, T.S.5
  • 17
    • 84878199918 scopus 로고    scopus 로고
    • Cosmetic Toiletry and Fragrance Association Adult and baby exposures. Washington, DC: CTFA
    • Cosmetic, Toiletry, and Fragrance Association. 2005. Calculation of margin of safety. Adult and baby exposures. Washington, DC: CTFA.
    • (2005) Calculation of Margin of Safety
  • 18
    • 0026497014 scopus 로고
    • Identification of metabolites of the antitumor agent d-limonene capable of inhibiting protein isoprenylation and cell growth
    • Crowell, P. L., Lin, S., Vedejs, E., and Gould, M. N. 1992. Identification of metabolites of the antitumor agent d-limonene capable of inhibiting protein isoprenylation and cell growth. Cancer Chemother. Pharmacol. 31: 205-212.
    • (1992) Cancer Chemother. Pharmacol. , vol.31 , pp. 205-212
    • Crowell, P.L.1    Lin, S.2    Vedejs, E.3    Gould, M.N.4
  • 19
    • 84858702551 scopus 로고    scopus 로고
    • Evaluation of acute toxicity of a natural compound (+)-limonene epoxide and its anxiolytic-like action
    • de Almeida, A. A., Costa, J. P., de Carvalho, R. B., de Sousa, D. P., and de Freitas, R. M. 2012. Evaluation of acute toxicity of a natural compound (+)-limonene epoxide and its anxiolytic-like action. Brain Res. 1448: 56-62.
    • (2012) Brain Res. , vol.1448 , pp. 56-62
    • De Almeida, A.A.1    Costa, J.P.2    De Carvalho, R.B.3    De Sousa, D.P.4    De Freitas, R.M.5
  • 20
    • 0031059814 scopus 로고    scopus 로고
    • Adverse reactions to fragrances. A clinical review
    • de Groot, A. C., and Frosch, P. J. 1997. Adverse reactions to fragrances. A clinical review. Contact Derm. 36: 57-86.
    • (1997) Contact Derm. , vol.36 , pp. 57-86
    • De Groot, A.C.1    Frosch, P.J.2
  • 21
    • 0001456369 scopus 로고
    • Organic compounds in seawater and pack ice in Terra Nova Bay (Antarctica)
    • Desideri, P., Lepri, L., and Checchini, L. 1991. Organic compounds in seawater and pack ice in Terra Nova Bay (Antarctica). Ann. Chim. 81: 395-416.
    • (1991) Ann. Chim. , vol.81 , pp. 395-416
    • Desideri, P.1    Lepri, L.2    Checchini, L.3
  • 22
    • 0025933489 scopus 로고
    • The presence of α2u-globulin is necessary for d-limonene promotion of male rat kidney tumors
    • Dietrich, D. R., and Swenberg, J. A. 1991. The presence of α2u-globulin is necessary for d-limonene promotion of male rat kidney tumors. Cancer Res. 51: 3512-3521.
    • (1991) Cancer Res. , vol.51 , pp. 3512-3521
    • Dietrich, D.R.1    Swenberg, J.A.2
  • 24
    • 84878174181 scopus 로고    scopus 로고
    • European Commission (BEUC report January 2005). Scientific Committee on Health and Environmental Risks (SCHER)
    • European Commission. 2006. Opinion on the report "Emission of chemicals by air fresheners Tests on 74 consumer products sold in Europe" (BEUC report January 2005). Scientific Committee on Health and Environmental Risks (SCHER). http://ec. europa.eu/health/ph-risk/committees/04-scher/docs/ scher-o-026.pdf
    • (2006) Opinion on the Report "emission of Chemicals by Air Fresheners Tests on 74 Consumer Products Sold in Europe"
  • 25
    • 84878169319 scopus 로고    scopus 로고
    • European Commission Council Directive 76/768/EEC
    • European Commission. 2010. Cosmetics directive. Council Directive 76/768/EEC. http://eur-lex.europa.eu/LexUriServ/LexUriServ. do?uri=CONSLEG: 1976L0768: 20100301: en:PDF.
    • (2010) Cosmetics Directive
  • 27
    • 0021230187 scopus 로고
    • Genetic mode of action of cocarcinogens and tumor promoters in yeast and mice
    • Fahrig, R. 1984. Genetic mode of action of cocarcinogens and tumor promoters in yeast and mice. Mol. Gen. Genet. 194: 7-14.
    • (1984) Mol. Gen. Genet. , vol.194 , pp. 7-14
    • Fahrig, R.1
  • 28
    • 0025916073 scopus 로고
    • Purpuric rash caused by dermal exposure to d-limonene
    • Falk, A., Fischer, T., and Hagberg, M. 1991.Purpuric rash caused by dermal exposure to d-limonene. Contact Dermatitis 25: 198-199.
    • (1991) Contact Dermatitis , vol.25 , pp. 198-199
    • Falk, A.1    Fischer, T.2    Hagberg, M.3
  • 29
    • 0027403346 scopus 로고
    • D-Limonene exposure to humans by inhalation: Uptake, distribution, elimination, and effects on the pulmonary function
    • Falk-Filipsson, A., Löf, A., Hagberg, M., Hjelm, E. W., and Wang, Z. 1993.d-Limonene exposure to humans by inhalation: Uptake, distribution, elimination, and effects on the pulmonary function. J. Toxicol. Environ. Health A 38: 77-88.
    • (1993) J. Toxicol. Environ. Health A , vol.38 , pp. 77-88
    • Falk-Filipsson, A.1    Löf, A.2    Hagberg, M.3    Hjelm, E.W.4    Wang, Z.5
  • 31
    • 0026011341 scopus 로고
    • The human relevance of the renal tumor-inducing potential of d-limonene in male rats: Implications for risk assessment
    • Flamm, W. G., and Lehman-McKeeman, L. D. 1991. The human relevance of the renal tumor-inducing potential of d-limonene in male rats: Implications for risk assessment. Regul. Toxicol. Pharmacol. 13: 70-86.
    • (1991) Regul. Toxicol. Pharmacol. , vol.13 , pp. 70-86
    • Flamm, W.G.1    Lehman-Mckeeman, L.D.2
  • 32
    • 0003626187 scopus 로고
    • Flavor and Extract Manufacturers Association Washington, DC: FEMA
    • Flavor and Extract Manufacturers Association. 1991. d-Limonene monograph. Washington, DC: FEMA.
    • (1991) D-Limonene Monograph
  • 33
    • 0018822306 scopus 로고
    • Screening of tobacco smoke constituents for mutagenicity using the Ames test
    • Florin, I., Rutberg, L., Curvall, M., and Enzell, C. R. 1980. Screening of tobacco smoke constituents for mutagenicity using the Ames test. Toxicology 15: 219-232.
    • (1980) Toxicology , vol.15 , pp. 219-232
    • Florin, I.1    Rutberg, L.2    Curvall, M.3    Enzell, C.R.4
  • 34
    • 34447099233 scopus 로고    scopus 로고
    • Assessment of sensi-tization potential of monoterpenes using the rat popliteal lymph node assay
    • Friedrich, K., Delgado, I. F., Santos, L. M., and Paumgartten, F. J. 2007. Assessment of sensi-tization potential of monoterpenes using the rat popliteal lymph node assay. Food Chem. Toxicol. 45: 1516-1522.
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1516-1522
    • Friedrich, K.1    Delgado, I.F.2    Santos, L.M.3    Paumgartten, F.J.4
  • 35
    • 0030867207 scopus 로고    scopus 로고
    • Cancer chemopreven-tion and therapy by monoterpenes
    • Gould, M. N. 1997. Cancer chemopreven-tion and therapy by monoterpenes. Environ. Health Perspect. 105: 977-979.
    • (1997) Environ. Health Perspect. , vol.105 , pp. 977-979
    • Gould, M.N.1
  • 36
    • 0002157794 scopus 로고
    • Cutaneous safety of fragrance material as measured by the maximization test
    • Greif, N. 1967.Cutaneous safety of fragrance material as measured by the maximization test. Am. Perfume Cosmet. 82: 54-57.
    • (1967) Am. Perfume Cosmet. , vol.82 , pp. 54-57
    • Greif, N.1
  • 37
    • 0028141872 scopus 로고
    • Risk assessment of d-limonene: An example of male rat-specific renal tumorigens
    • Hard, G. C., and Whysner, J. 1994. Risk assessment of d-limonene: An example of male rat-specific renal tumorigens. Crit. Rev. Toxicol. 24: 231-254.
    • (1994) Crit. Rev. Toxicol. , vol.24 , pp. 231-254
    • Hard, G.C.1    Whysner, J.2
  • 39
    • 84878184354 scopus 로고    scopus 로고
    • Health Canada accessed April 7, 2012
    • Health Canada. 2011. Cosmetic ingredient hotlist. http://www.hc-sc.gc.ca/ cps-spc/cosmet-person/indust/hot-list-critique/hotlist-liste-eng.php (accessed April 7, 2012).
    • (2011) Cosmetic Ingredient Hotlist
  • 40
    • 0026614355 scopus 로고
    • Organic chemicals in the air at Whitaker's Forest/Sierra Nevada Mountains, California
    • Helmig, D., and Arey, J. 1992. Organic chemicals in the air at Whitaker's Forest/Sierra Nevada Mountains, California. Sci. Total Environ. 112: 233-250.
    • (1992) Sci. Total Environ. , vol.112 , pp. 233-250
    • Helmig, D.1    Arey, J.2
  • 42
    • 0033290756 scopus 로고    scopus 로고
    • D-Limonene
    • IARC (International Agency for Research on Cancer)
    • IARC (International Agency for Research on Cancer). 1999. d-Limonene. IARC Monogr. Eval. Carcinogen. Risk Hum. 73: 307-327.
    • (1999) IARC Monogr. Eval. Carcinogen. Risk Hum. , vol.73 , pp. 307-327
  • 43
    • 84878199907 scopus 로고    scopus 로고
    • http://monographs.iarc.fr/ENG/Monographs/vol73/mono73-16.pdf
  • 44
    • 0015952750 scopus 로고
    • Studies on the metabolism of d-limonene (p-mentha-1, 8-diene): I. The absorption, distribution and excretion of d-limonene in rats
    • Igimi, H., Nishimura, M., Kodama, R., and Ide, H. 1974. Studies on the metabolism of d-limonene (p-mentha-1, 8-diene): I. The absorption, distribution and excretion of d-limonene in rats. Xenobiotica 4: 77-84.
    • (1974) Xenobiotica , vol.4 , pp. 77-84
    • Igimi, H.1    Nishimura, M.2    Kodama, R.3    Ide, H.4
  • 45
    • 0017193441 scopus 로고
    • The use of d-limonene preparation as a dissolving agent of gallstones
    • Igimi, H., Hisatsugu, T., and Nishimura, M. 1976.The use of d-limonene preparation as a dissolving agent of gallstones. Am. J. Dig. Dis. 21: 926-939.
    • (1976) Am. J. Dig. Dis. , vol.21 , pp. 926-939
    • Igimi, H.1    Hisatsugu, T.2    Nishimura, M.3
  • 48
    • 84878202160 scopus 로고    scopus 로고
    • International Programme on Chemical Safety accessed March 19, 2012
    • International Programme on Chemical Safety. 2005. d-Limonene. http://www.inchem.org/documents/icsc/icsc/eics0918.htm (accessed March 19, 2012).
    • (2005) D-Limonene
  • 49
    • 69449106665 scopus 로고    scopus 로고
    • Japan Ministry of Health, Labor, and Welfare Ministry of Health and Welfare Notification No. 331
    • Japan Ministry of Health, Labor, and Welfare. 2000. Standards for cosmetics. Ministry of Health and Welfare Notification No. 331. http://www.mhlw.go.jp/english/dl/cosmetics. pdf
    • (2000) Standards for Cosmetics
  • 50
    • 0023873480 scopus 로고
    • Quantitative analysis of monoterpenes and volatile organic pollution products (VOC) in forest air of the southern black forest
    • Jüttner, F. 1988. Quantitative analysis of monoterpenes and volatile organic pollution products (VOC) in forest air of the southern black forest. Chemosphere 17: 309-317.
    • (1988) Chemosphere , vol.17 , pp. 309-317
    • Jüttner, F.1
  • 51
    • 0023212168 scopus 로고
    • Comparison of short-term renal effects due to oral administration of decalin or d-limonene in young adult male Fischer-344 rats
    • Kanerva, R. L., Ridder, G. M., Lefever, F. R., and Alden, C. L. 1987.Comparison of short-term renal effects due to oral administration of decalin or d-limonene in young adult male Fischer-344 rats. Food Chem. Toxicol. 25: 345-353.
    • (1987) Food Chem. Toxicol. , vol.25 , pp. 345-353
    • Kanerva, R.L.1    Ridder, G.M.2    Lefever, F.R.3    Alden, C.L.4
  • 52
    • 0026203780 scopus 로고
    • Animal experiments on the allergenic-ity of d-limonene-The citrus solvent
    • Karlberg, A. T., Boman, A., and Melin, B. 1991.Animal experiments on the allergenic-ity of d-limonene-The citrus solvent. Ann. Occup. Hyg. 35: 419-426.
    • (1991) Ann. Occup. Hyg. , vol.35 , pp. 419-426
    • Karlberg, A.T.1    Boman, A.2    Melin, B.3
  • 53
    • 84862685333 scopus 로고    scopus 로고
    • Real refractive indices and formation yields of secondary organic aerosol generated from photooxidation of limonene and α-pinene: The effect of the HC/NO(x) ratio
    • Kim, H., Barkey, B., and Paulson, S. E. 2012. Real refractive indices and formation yields of secondary organic aerosol generated from photooxidation of limonene and α-pinene: The effect of the HC/NO(x) ratio. J. Phys. Chem. A 116: 6059-6067.
    • (2012) J. Phys. Chem. A , vol.116 , pp. 6059-6067
    • Kim, H.1    Barkey, B.2    Paulson, S.E.3
  • 54
    • 0017593623 scopus 로고
    • Screening of fragrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods
    • Klecak, G., Geleick, H., and Frey, J. 1977. Screening of fragrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods. J. Soc. Cosmet. Chem. 28: 53-64.
    • (1977) J. Soc. Cosmet. Chem. , vol.28 , pp. 53-64
    • Klecak, G.1    Geleick, H.2    Frey, J.3
  • 55
    • 0017063718 scopus 로고
    • Studies on the metabolism of d-limonene (p-mentha-1, 8-diene). IV. Isolation and characterization of new metabolites and species differences in metabolism
    • Kodama, R., Yano, T., Furukawa, K., Noda, K., and Ide, H. 1976. Studies on the metabolism of d-limonene (p-mentha-1, 8-diene). IV. Isolation and characterization of new metabolites and species differences in metabolism. Xenobiotica 6: 377-389.
    • (1976) Xenobiotica , vol.6 , pp. 377-389
    • Kodama, R.1    Yano, T.2    Furukawa, K.3    Noda, K.4    Ide, H.5
  • 56
    • 0017694348 scopus 로고
    • Studies on d-limonene as a gallstone solubilizer (VII): Effects on development of mouse fetuses and offspring
    • Kodama, R., Okubo, A., Araki, E., Noda, K., Ide, H., and Ikeda, T. 1977a. Studies on d-limonene as a gallstone solubilizer (VII): Effects on development of mouse fetuses and offspring. Oyo Yakuri 13: 863-873.
    • (1977) Oyo Yakuri , vol.13 , pp. 863-873
    • Kodama, R.1    Okubo, A.2    Araki, E.3    Noda, K.4    Ide, H.5    Ikeda, T.6
  • 57
    • 0017712869 scopus 로고
    • Studies on d-limonene as a gallstone solu-bilizer (IX).effects on development of rabbit fetuses and offspring
    • Kodama, R., Okubo, A., Sato, K., Araki, E., Noda, K., Ide, H., and Ikeda, T. 1977b. Studies on d-limonene as a gallstone solu-bilizer (IX).effects on development of rabbit fetuses and offspring. Oyo Yakuri 13: 885-898.
    • (1977) Oyo Yakuri , vol.13 , pp. 885-898
    • Kodama, R.1    Okubo, A.2    Sato, K.3    Araki, E.4    Noda, K.5    Ide, H.6    Ikeda, T.7
  • 58
    • 84878183846 scopus 로고    scopus 로고
    • Korea Food and Drug Administration KFDA notification no. 2010-99
    • Korea Food and Drug Administration. 2010. Provisions for designation of cosmetic ingredients. KFDA notification no. 2010-99. http://www.kfda.go.kr/ index. kfda?x=0&searchkey=title:contents&mid= 92&searchword= %C8%AD%C0%E5%C7%B 0&y=0&division=&pageNo=1&seq=3401& cmd=v
    • (2010) Provisions for Designation of Cosmetic Ingredients
  • 59
    • 84878200668 scopus 로고    scopus 로고
    • Kyoto Encyclopedia of Genes and Genome accessed July 26, 2012
    • Kyoto Encyclopedia of Genes and Genome. 2012. Limonene and pinene degradation. http://www.genome.jp/kegg-bin/show-path way?map00903 (accessed July 26, 2012).
    • (2012) Limonene and Pinene Degradation
  • 61
    • 0026528579 scopus 로고
    • Biochemical basis for mouse resistance to hyaline droplet nephropathy: Lack of relevance of the alpha 2u-globulin protein super-family in this male rat-specific syndrome
    • Lehman-McKeeman, L. D., and Caudill, D. 1992. Biochemical basis for mouse resistance to hyaline droplet nephropathy: Lack of relevance of the alpha 2u-globulin protein super-family in this male rat-specific syndrome. Toxicol. Appl. Pharmacol. 112: 214-221.
    • (1992) Toxicol. Appl. Pharmacol. , vol.112 , pp. 214-221
    • Lehman-Mckeeman, L.D.1    Caudill, D.2
  • 62
    • 0025232323 scopus 로고
    • Lysosomal degradation of alpha2μ -globulin and alpha2μ -globulin-xenobiotic conjugates
    • Lehman-McKeeman, L. D., Rodriguez, M. I., and Caudill, D. 1990. Lysosomal degradation of alpha2μ -globulin and alpha2μ -globulin-xenobiotic conjugates. Toxicol. Appl. Pharmacol. 103: 539-548.
    • (1990) Toxicol. Appl. Pharmacol. , vol.103 , pp. 539-548
    • Lehman-Mckeeman, L.D.1    Rodriguez, M.I.2    Caudill, D.3
  • 63
    • 0022479453 scopus 로고
    • Assessment of the ability of mice fed on vitamin A supplemented diet to respond to a variety of potential contact sensitizers
    • Maisey, J., and Miller, K. 1986. Assessment of the ability of mice fed on vitamin A supplemented diet to respond to a variety of potential contact sensitizers. Contact Dermatitis 15: 17-23.
    • (1986) Contact Dermatitis , vol.15 , pp. 17-23
    • Maisey, J.1    Miller, K.2
  • 64
    • 69949117551 scopus 로고    scopus 로고
    • Secondary organic aerosol formation from multiphase oxidation of limonene by ozone: Mechanistic constraints via two-dimensional heteronuclear NMR spectroscopy
    • Maksymiuk, C. S., Gayahtri, C., Gil, R. R., and Donahue, N. M. 2009. Secondary organic aerosol formation from multiphase oxidation of limonene by ozone: Mechanistic constraints via two-dimensional heteronuclear NMR spectroscopy. Phys. Chem. Chem. Phys. 11: 7810-7818.
    • (2009) Phys. Chem. Chem. Phys. , vol.11 , pp. 7810-7818
    • Maksymiuk, C.S.1    Gayahtri, C.2    Gil, R.R.3    Donahue, N.M.4
  • 68
    • 0021075311 scopus 로고
    • Toxic chemicals in an abandoned phenolic waste site
    • McCreary, J. J., Jackson, J. A. G., and Zoltek, J., Jr. 1983. Toxic chemicals in an abandoned phenolic waste site. Chemosphere 12: 1619-1632.
    • (1983) Chemosphere , vol.12 , pp. 1619-1632
    • McCreary, J.J.1    Jackson, J.A.G.2    Zoltek Jr., J.3
  • 69
    • 84878212790 scopus 로고
    • Occupational exposure limit value
    • National Board of Occupational Safety and Health
    • National Board of Occupational Safety and Health. 1993. Occupational exposure limit value. Ordinance AFS, Vol. 3.
    • (1993) Ordinance AFS , vol.3
  • 70
    • 84878202160 scopus 로고    scopus 로고
    • National Institute for Occupational Safety and Health accessed August 5, 2012
    • National Institute for Occupational Safety and Health. 2005. d-Limonene. http://www.cdc. gov/niosh/ipcsneng/neng0918.html (accessed August 5, 2012).
    • (2005) D-Limonene
  • 71
    • 84878183842 scopus 로고
    • 1 mice
    • National Toxicology Program
    • 1 mice. NTP TR 347, 1-165. http://ntp.niehs.nih.gov/ntp/htdocs/LT-rpts/tr347.pdf
    • (1990) NTP TR , vol.347 , pp. 1-165
  • 72
    • 0032989342 scopus 로고    scopus 로고
    • Are contact allergens stable in patch test preparations? Investigation of the degradation of d-limonene hydroperoxides in petrolatum
    • Nilsson, U., Magnusson, K., Karlberg, O., and Karlberg, A. T. 1999. Are contact allergens stable in patch test preparations? Investigation of the degradation of d-limonene hydroperoxides in petrolatum. Contact Dermatitis 40: 127-132.
    • (1999) Contact Dermatitis , vol.40 , pp. 127-132
    • Nilsson, U.1    Magnusson, K.2    Karlberg, O.3    Karlberg, A.T.4
  • 73
    • 14344252886 scopus 로고    scopus 로고
    • The effect on human eye blink frequency of exposure to limonene oxidation products and methacrolein
    • Nøjgaard, J. K., Christensen, K. B., and Wolkoff, P. 2005. The effect on human eye blink frequency of exposure to limonene oxidation products and methacrolein. Toxicol. Lett. 156: 241-251.
    • (2005) Toxicol. Lett. , vol.156 , pp. 241-251
    • Nøjgaard, J.K.1    Christensen, K.B.2    Wolkoff, P.3
  • 74
    • 0025102626 scopus 로고
    • Percutaneous absorption enhancing effect and skin irritation of mono-cyclic monoterpenes
    • Okabe, H., Obata, Y., Takayama, K., and Nagai, T. 1990. Percutaneous absorption enhancing effect and skin irritation of mono-cyclic monoterpenes. Drug Design Deliv. 6: 229-238.
    • (1990) Drug Design Deliv. , vol.6 , pp. 229-238
    • Okabe, H.1    Obata, Y.2    Takayama, K.3    Nagai, T.4
  • 75
    • 0025217788 scopus 로고
    • A comparison of male rat and human urinary proteins: Implications for human resistance to hyaline droplet nephropathy
    • Olson, M. J., Johnson, J. T., and Reidy, C. A. 1990. A comparison of male rat and human urinary proteins: Implications for human resistance to hyaline droplet nephropathy. Toxicol. Appl. Pharmacol. 102: 524-536.
    • (1990) Toxicol. Appl. Pharmacol. , vol.102 , pp. 524-536
    • Olson, M.J.1    Johnson, J.T.2    Reidy, C.A.3
  • 76
    • 0018565441 scopus 로고
    • Monographs on fragrance raw materials
    • Opdyke, D. L. 1979. Monographs on fragrance raw materials. Food Cosmet. Toxicol. 17: 241-275.
    • (1979) Food Cosmet. Toxicol. , vol.17 , pp. 241-275
    • Opdyke, D.L.1
  • 77
    • 0031965962 scopus 로고    scopus 로고
    • Exploration of the transformation potential of a unique male rat protein alpha2u-globulin using hamster embryonic cells
    • Oshiro, Y., Balwierz, P. S., Eurell, T. E., Morris, D. L., and Alden, C. L. 1998. Exploration of the transformation potential of a unique male rat protein alpha2u-globulin using hamster embryonic cells. Toxicol. Pathol. 26: 381-387.
    • (1998) Toxicol. Pathol. , vol.26 , pp. 381-387
    • Oshiro, Y.1    Balwierz, P.S.2    Eurell, T.E.3    Morris, D.L.4    Alden, C.L.5
  • 79
    • 0002486592 scopus 로고
    • Evaluation and relevance of the Syrian hamster embryo cell system
    • Pienta, R. 1980. Evaluation and relevance of the Syrian hamster embryo cell system. Appl. Met. Oncol. 3: 149-169.
    • (1980) Appl. Met. Oncol. , vol.3 , pp. 149-169
    • Pienta, R.1
  • 80
    • 0029868653 scopus 로고    scopus 로고
    • Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry
    • Poon, G., Vigushin, D., Griggs, L., Rowlands, M., Coombes, R., and Jarman, M. 1996. Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry. Drug Metab. Dispos 24: 565-571.
    • (1996) Drug Metab. Dispos , vol.24 , pp. 565-571
    • Poon, G.1    Vigushin, D.2    Griggs, L.3    Rowlands, M.4    Coombes, R.5    Jarman, M.6
  • 81
    • 67649484490 scopus 로고    scopus 로고
    • D-limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
    • Rabi, T., and Bishayee, A. 2009.d-limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis. J. Carcinogen. 8: 1-9.
    • (2009) J. Carcinogen. , vol.8 , pp. 1-9
    • Rabi, T.1    Bishayee, A.2
  • 83
    • 0037079931 scopus 로고    scopus 로고
    • Additive toxicity of limonene and 50% oxygen and the role of glutathione in detoxification in human lung cells
    • Rolseth, V., Djurhuus, R., and Svardal, A. M. 2002.Additive toxicity of limonene and 50% oxygen and the role of glutathione in detoxification in human lung cells. Toxicology 170: 75-88.
    • (2002) Toxicology , vol.170 , pp. 75-88
    • Rolseth, V.1    Djurhuus, R.2    Svardal, A.M.3
  • 84
    • 0019146648 scopus 로고
    • Allergic contact dermatitis from dipentene in honing oil
    • Rycroft, R. J. G. 1980. Allergic contact dermatitis from dipentene in honing oil. Contact Dermat. 6: 325-329.
    • (1980) Contact Dermat. , vol.6 , pp. 325-329
    • Rycroft, R.J.G.1
  • 85
    • 0019620622 scopus 로고
    • Volatile organic compounds in open ocean and coastal surface waters
    • Sauer, T. C. 1981. Volatile organic compounds in open ocean and coastal surface waters. Org. Geochem. 3: 91-101.
    • (1981) Org. Geochem. , vol.3 , pp. 91-101
    • Sauer, T.C.1
  • 86
    • 0020077796 scopus 로고
    • Die perkutaneresorptionverschiedener Terpene-Menthol, campher, limonen, isobornylacetat, α-Pinen-ausbadezusätzen
    • Schäfer, R., and Schäfer, W. 1982. Die perkutaneresorptionverschiedener Terpene-Menthol, campher, limonen, isobornylacetat, α-Pinen-ausbadezusätzen. Arzneim. Forsch. 32: 56-58.
    • (1982) Arzneim. Forsch. , vol.32 , pp. 56-58
    • Schäfer, R.1    Schäfer, W.2
  • 87
    • 0020783652 scopus 로고
    • Ambient concentrations of hydrocarbons from conifers in atmospheric gases and aerosol particles measured in soviet Georgia
    • Shaw, R. W., Crittenden, A. L., Stevens, R. K., Cronn, D. R., and Titov, V. S. 1983. Ambient concentrations of hydrocarbons from conifers in atmospheric gases and aerosol particles measured in soviet Georgia. Environ. Sci. Technol. 17: 389-395.
    • (1983) Environ. Sci. Technol. , vol.17 , pp. 389-395
    • Shaw, R.W.1    Crittenden, A.L.2    Stevens, R.K.3    Cronn, D.R.4    Titov, V.S.5
  • 89
    • 0025228499 scopus 로고
    • Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents
    • Steele, V. E., Kelloff, G. J., Wilkinson, B. P., and Arnold, J. T. 1990. Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents. Cancer Res. 50: 2068-2074.
    • (1990) Cancer Res. , vol.50 , pp. 2068-2074
    • Steele, V.E.1    Kelloff, G.J.2    Wilkinson, B.P.3    Arnold, J.T.4
  • 91
    • 35348929897 scopus 로고    scopus 로고
    • D-Limonene: Safety and clinical applications
    • Sun, J. 2007. d-Limonene: Safety and clinical applications. Altern. Med. Rev. 12: 259-264.
    • (2007) Altern. Med. Rev. , vol.12 , pp. 259-264
    • Sun, J.1
  • 93
    • 84878199115 scopus 로고
    • Studies on d-limonene, as gallstone sol-ubilizer (V): Effects on development of rat fetuses and offspring
    • Tsuji, M., Fujisaki, Y., Okubo, A., Arikawa, Y., Noda, K., Ide, H., and Ikeda, T. 1975a. Studies on d-limonene, as gallstone sol-ubilizer (V): Effects on development of rat fetuses and offspring. Oyo Yakuri 9: 179-186.
    • (1975) Oyo Yakuri , vol.9 , pp. 179-186
    • Tsuji, M.1    Fujisaki, Y.2    Okubo, A.3    Arikawa, Y.4    Noda, K.5    Ide, H.6    Ikeda, T.7
  • 95
    • 84878209386 scopus 로고
    • U.S. Environmental Protection Agency EPA-738-F-94-030, 1-5
    • U.S. Environmental Protection Agency. 1994. Limonene. EPA-738-F-94-030, 1-5. http://www.epa.gov/oppsrrd1/REDs/factsheets/3083fact.pdf
    • (1994) Limonene
  • 96
    • 84878213627 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency Arlington, VA: Office of Pesticide Programs
    • U.S. Environmental Protection Agency. 2004. Exposure and risk assessment on lower risk pesticide chemicals; d-Limonene. Arlington, VA: Office of Pesticide Programs. http://www.epa.gov/oppsrrd1/REDs/limonene-tred.pdf
    • (2004) Exposure and Risk Assessment on Lower Risk Pesticide Chemicals; D-Limonene
  • 97
    • 84878180813 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration 21 CFR §182.60
    • U.S. Food and Drug Administration. 2011. Synthetic flavoring substances and adjuvants. 21 CFR §182.60. http://www.accessdata. fda.gov/scripts/cdrh/ cfdocs/cfcfr/CFRSearch. cfm?fr=182.60
    • (2011) Synthetic Flavoring Substances and Adjuvants
  • 98
    • 84878190427 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration
    • U.S. Food and Drug Administration. 2012. General. 21 CFR §700. http://ecfr.gpoaccess. gov/cgi/t/text/text-idx?c=ecfr&sid=89cf1d1 eb4f13f6dd2564e0158a77d48&rgn=div5& view=text&node=21:7.0.1.2. 10&idno=21
    • (2012) General. 21 CFR §700
  • 99
    • 84878207164 scopus 로고
    • U.S. National Oceanic and Atmospheric Administration accessed March 19, 2012
    • U.S. National Oceanic and Atmospheric Administration. 1992. d-Limonene. http://cameochemicals.noaa.gov/chemical/20568 (accessed March 19, 2012).
    • (1992) D-Limonene
  • 100
  • 103
    • 34047222411 scopus 로고    scopus 로고
    • Photochemical aging of secondary organic aerosol particles generated from the oxidation of d-limonene
    • Walser, M. L., Park, J., Gomez, A. L., Russell, A. R., and Nizkorodov, S. A. 2007. Photochemical aging of secondary organic aerosol particles generated from the oxidation of d-limonene. J. Phys. Chem. A 111:1907-1913.
    • (2007) J. Phys. Chem. A , vol.111 , pp. 1907-1913
    • Walser, M.L.1    Park, J.2    Gomez, A.L.3    Russell, A.R.4    Nizkorodov, S.A.5
  • 104
    • 0019466150 scopus 로고
    • A comparative study on the metabolism of d-limonene and 4-vinylcyclohex-1-ene by hepatic microsomes
    • Watabe, T., Hiratsuka, A., Ozawa, N., and Isobe, M. 1981.A comparative study on the metabolism of d-limonene and 4-vinylcyclohex-1-ene by hepatic microsomes. Xenobiotica 11: 333-344.
    • (1981) Xenobiotica , vol.11 , pp. 333-344
    • Watabe, T.1    Hiratsuka, A.2    Ozawa, N.3    Isobe, M.4
  • 105
    • 0024817997 scopus 로고
    • Acute and subchronic nephrotoxicity of d-limonene in Fischer 344 rats
    • Webb, D., Ridder, G., and Alden, C. 1989. Acute and subchronic nephrotoxicity of d-limonene in Fischer 344 rats. Food. Chem. Toxicol. 27: 639-649.
    • (1989) Food. Chem. Toxicol. , vol.27 , pp. 639-649
    • Webb, D.1    Ridder, G.2    Alden, C.3
  • 107
    • 0029764924 scopus 로고    scopus 로고
    • D-limonene mechanistic data and risk assessment: Absolute species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion
    • Whysner, J., and Williams, G. M. 1996. d-limonene mechanistic data and risk assessment: Absolute species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion. Pharmacol Ther. 71: 127-136.
    • (1996) Pharmacol Ther. , vol.71 , pp. 127-136
    • Whysner, J.1    Williams, G.M.2
  • 108
    • 52349084057 scopus 로고    scopus 로고
    • Acute airway effects of ozone-initiated d-limonene chemistry: Importance of gaseous products
    • Wolkoff, P., Clausen, P. A., Larsen, K., Hammer, M., Larsen, S. T., and Nielsen, G. D. 2008. Acute airway effects of ozone-initiated d-limonene chemistry: importance of gaseous products. Toxicol Lett. 181: 171-176.
    • (2008) Toxicol Lett. , vol.181 , pp. 171-176
    • Wolkoff, P.1    Clausen, P.A.2    Larsen, K.3    Hammer, M.4    Larsen, S.T.5    Nielsen, G.D.6
  • 109
    • 0041634481 scopus 로고    scopus 로고
    • World Health Organization Limonene. Geneva, Switzerland: International Programme on Chemical Safety, WHO
    • World Health Organization. 1998. Concise international chemical assessment document 5. Limonene. Geneva, Switzerland: International Programme on Chemical Safety, WHO. http://whqlibdoc.who.int/publications/1998/9241530057.pdf
    • (1998) Concise International Chemical Assessment Document 5
  • 110
    • 77954379641 scopus 로고    scopus 로고
    • Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin e 2, and pro-inflammatory cytokines in RAW 264.7 macrophages
    • Yoon, W. J., Lee, N. H., and Hyun, C. G. 2010. Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E 2, and pro-inflammatory cytokines in RAW 264.7 macrophages. J. Oleo Sci. 59: 415-421.
    • (2010) J. Oleo Sci. , vol.59 , pp. 415-421
    • Yoon, W.J.1    Lee, N.H.2    Hyun, C.G.3
  • 111
    • 0029100534 scopus 로고
    • Skin irritation testing in man for hazard assessment-Evaluation of four patch systems
    • York, M., Basketter, D., Cuthbert, J., and Neilson, L. 1995. Skin irritation testing in man for hazard assessment-Evaluation of four patch systems. Hum. Exp. Toxicol. 14: 729-734.
    • (1995) Hum. Exp. Toxicol. , vol.14 , pp. 729-734
    • York, M.1    Basketter, D.2    Cuthbert, J.3    Neilson, L.4
  • 112
    • 71049152431 scopus 로고    scopus 로고
    • Sub-chronic effects of s-limonene on brain neurotransmitter levels and behavior of rats
    • Zhou, W., Yoshioka, M., and Yokogoshi, H. 2009. Sub-chronic effects of s-limonene on brain neurotransmitter levels and behavior of rats. J. Nutr. Sci. Vitaminol. (To k y o ) 55: 367-373.
    • (2009) J. Nutr. Sci. Vitaminol. (To K y O ) , vol.55 , pp. 367-373
    • Zhou, W.1    Yoshioka, M.2    Yokogoshi, H.3


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