Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry

Drug Metabolism Letters

Volumn 2, Issue 3, 2008, Pages 205-209

  Lahoz, Agustin ^a   Donato, Maria Teresa ^a,b   Picazo, Laura ^a   Castell, José V ^a,b   Gómez Lechón, Maria José ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

96 well plates; CYP cocktail; Drug induction; HPLC MS MS; Human hepatocytes

Indexed keywords

3 METHYLCHOLANTHRENE; BENZOXYRESORUFIN; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DICLOFENAC; MEPHENYTOIN; MIDAZOLAM; PHENACETIN; PHENOBARBITAL; RESORUFIN DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME INDUCTION; HEPATOCYTES; HUMANS; METHYLCHOLANTHRENE; PHARMACEUTICAL PREPARATIONS; PHENOBARBITAL; REPRODUCIBILITY OF RESULTS; RIFAMPIN; TANDEM MASS SPECTROMETRY;

EID: 53749100013     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208785425845     Document Type: Article

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