In vivo genotoxic potential of microcystin-LR: A cyanobacterial toxin, investigated both by the unscheduled DNA synthesis (UDS) and the comet assays after intravenous administration

Environmental Toxicology

Volumn 24, Issue 2, 2009, Pages 200-209

  Gaudin, Julien ^a   Hegarat, Ludovic Le ^a   Nesslany, Fabrice ^b   Marzin, Daniel ^b   Fessard, Valérie ^a  

^a Healthy Pigs Production and Experimentation Section   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Comet assay; Genotoxicity; Microcystin LR; UDS assay

Indexed keywords

COMET ASSAY; CYANOBACTERIAL TOXINS; DAMAGED REGIONS; DNA DAMAGES; DNA SYNTHESIS; EXCISION REPAIRS; EXPOSURE-TIME; GENOTOXIC; GENOTOXICITY; HUMAN HEALTHS; IN-VIVO; INTRAPERITONEAL; INTRAVENOUS ADMINISTRATIONS; MECHANISM OF ACTIONS; MICROCYSTIN-LR; POTENTIAL THREATS; PROTEIN PHOSPHATASE; RAT HEPATOCYTES; RAT LIVERS; SENSITIVE TECHNIQUES; SPECIFIC INHIBITORS; UDS ASSAY;

BIOCHEMISTRY; DNA; ELECTRIC REACTORS; GENES; HEALTH RISKS; NUCLEIC ACIDS; SEMICONDUCTOR COUNTERS; TOXIC MATERIALS;

ASSAYS;

BACTERIAL TOXIN; DNA; MICROCYSTIN LR;

BIOASSAY; CARCINOGEN; CYANOBACTERIUM; GENOTOXICITY; RODENT; TOXIN; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARCINOGEN TESTING; CARCINOGENICITY; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA SYNTHESIS; EXCISION REPAIR; GENOTOXICITY; IN VIVO STUDY; INTRAVENOUS ADMINISTRATION; LIVER CARCINOGENESIS; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; UNSCHEDULED DNA SYNTHESIS;

ANIMALS; CARCINOGENS; CELL SURVIVAL; CELLS, CULTURED; COMET ASSAY; DNA DAMAGE; DNA REPAIR; HEPATOCYTES; MALE; MICROCYSTINS; MUTAGENS; RATS; RATS, INBRED F344;

CYANOBACTERIA; MUS; RATTUS;

EID: 65349175897     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20417     Document Type: Article

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