Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies

Drug Metabolism and Disposition

Volumn 36, Issue 6, 2008, Pages 1111-1118

  Jossé, Rozenn ^a   Aninat, Caroline ^a   Glaise, Denise ^b   Dumont, Julie ^a   Fessard, Valérie ^c   Morel, Fabrice ^a   Poul, Jean Michel ^c   Guguen Guillouzo, Christiane ^b   Guillouzo, André ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^c Healthy Pigs Production and Experimentation Section   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AFLATOXIN B1; ANDROGEN RECEPTOR; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; FRUCTOSE BISPHOSPHATE ALDOLASE; KETOCONAZOLE; ORGANIC CATION TRANSPORTER 1; PREGNANE X RECEPTOR;

ARTICLE; CELL DAMAGE; CELL DIFFERENTIATION; CELL FUNCTION; CHRONIC TOXICITY; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AFLATOXIN B1; CARCINOGENS; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; DNA DAMAGE; FEMALE; GENE EXPRESSION PROFILING; HEPATOCYTES; HUMANS; PHENACETIN; RNA, MESSENGER; TESTOSTERONE; TOXICITY TESTS; TUMOR CELLS, CULTURED;

EID: 44149105179     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.019901     Document Type: Article

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