Use of HepG2 cell line for direct or indirect mutagens screening: Comparative investigation between comet and micronucleus assays

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 536, Issue 1-2, 2003, Pages 79-90

  Valentin Severin, Isabelle ^a   Le Hegarat, Ludovic ^b   Lhuguenot, Jean Claude ^a   Le Bon, Anne Marie ^a   Chagnon, Marie Christine ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

^b Healthy Pigs Production and Experimentation Section   (France)

Author keywords

Comet assay; HepG2 cell line; Micronucleus test; RNA synthesis inhibition assay

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; BENZO[A]PYRENE; DIMETHYLNITROSAMINE; DNA; MESYLIC ACID METHYL ESTER; MUTAGENIC AGENT; N (2 FLUORENYL)ACETAMIDE; RNA;

ACCURACY; ARTICLE; BIOTRANSFORMATION; CELL STRAIN HEPG2; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOTOXICITY; DNA DAMAGE; GENOTOXICITY; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; INTERMETHOD COMPARISON; LIVER CELL; MICRONUCLEUS TEST; MUTAGEN TESTING; PRIORITY JOURNAL; RNA SYNTHESIS; TOXICITY TESTING;

EID: 0346033363     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(03)00031-7     Document Type: Article

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