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Volumn 24, Issue 1, 2010, Pages 56-60

The in vitro genotoxicity of ethanol and acetaldehyde

Author keywords

Acetaldehyde; Alcohol; Aneuploidy; Cytokinesis Blocked Micronucleus assay; Ethanol; Genotoxic damage

Indexed keywords

ACETALDEHYDE; ALCOHOL; CLASTOGEN; DNA;

EID: 72049099843     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.09.003     Document Type: Article
Times cited : (36)

References (33)
  • 2
    • 0033945795 scopus 로고    scopus 로고
    • In vitro genotoxicity of ethanol and acetaldehyde in human lymphocytes and gastrointestinal tract mucosa cells
    • Balsiak J., Trzeciak A., Malecka-Panas E., Drewoski J., and Wojewodzka M. In vitro genotoxicity of ethanol and acetaldehyde in human lymphocytes and gastrointestinal tract mucosa cells. Toxicol. In vitro 14 (2000) 287-295
    • (2000) Toxicol. In vitro , vol.14 , pp. 287-295
    • Balsiak, J.1    Trzeciak, A.2    Malecka-Panas, E.3    Drewoski, J.4    Wojewodzka, M.5
  • 5
    • 23144448354 scopus 로고    scopus 로고
    • DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis
    • Brooks P.J., and Theruvathu J.A. DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis. Alcohol 35 (2005) 187-193
    • (2005) Alcohol , vol.35 , pp. 187-193
    • Brooks, P.J.1    Theruvathu, J.A.2
  • 6
    • 0026464966 scopus 로고
    • Clastogenic interactions between lobeline sulphate and ethyl alcohol
    • Brown N.M., Trizna Z., and Pathak S. Clastogenic interactions between lobeline sulphate and ethyl alcohol. Anticancer Res. 12 (1992) 1467-1469
    • (1992) Anticancer Res. , vol.12 , pp. 1467-1469
    • Brown, N.M.1    Trizna, Z.2    Pathak, S.3
  • 7
    • 35048828950 scopus 로고    scopus 로고
    • Aneuploidy and cancer
    • Chi Y.H., and Jeang K.T. Aneuploidy and cancer. J. Cell. Biochem. 102 3 (2007) 531-538
    • (2007) J. Cell. Biochem. , vol.102 , Issue.3 , pp. 531-538
    • Chi, Y.H.1    Jeang, K.T.2
  • 8
    • 0027217202 scopus 로고
    • Micronucleus assay using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal espoxide hydrolase
    • Crofton-Sleigh C., Doherty A., Ellard S., Parry E.M., and Venitt S. Micronucleus assay using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal espoxide hydrolase. Mutagenesis 8 4 (1993) 363-372
    • (1993) Mutagenesis , vol.8 , Issue.4 , pp. 363-372
    • Crofton-Sleigh, C.1    Doherty, A.2    Ellard, S.3    Parry, E.M.4    Venitt, S.5
  • 9
    • 33847702915 scopus 로고    scopus 로고
    • Aneugenic potential of the nitrogen mustard analogues melphalan, chlorambucil and p-N,N-bis(2-chloroethyl) aminophenylacetic acid in cell cultures in vitro
    • Efthimiou M., Andrianopoulos C., Stephanou G., Demopoulos NA., and Nikolaropoulos S.S. Aneugenic potential of the nitrogen mustard analogues melphalan, chlorambucil and p-N,N-bis(2-chloroethyl) aminophenylacetic acid in cell cultures in vitro. Mutat. Res. 617 1-2 (2007) 125-137
    • (2007) Mutat. Res. , vol.617 , Issue.1-2 , pp. 125-137
    • Efthimiou, M.1    Andrianopoulos, C.2    Stephanou, G.3    Demopoulos, NA.4    Nikolaropoulos, S.S.5
  • 10
    • 0026070376 scopus 로고
    • The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays
    • Ellard S., Mohammed Y., Dogra S., Wolfel C., Doehmer J., and Parry J.M. The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays. Mutagenesis 6 6 (1991) 461-470
    • (1991) Mutagenesis , vol.6 , Issue.6 , pp. 461-470
    • Ellard, S.1    Mohammed, Y.2    Dogra, S.3    Wolfel, C.4    Doehmer, J.5    Parry, J.M.6
  • 11
    • 0027262654 scopus 로고
    • Ethanol increases apoptotic cell death of thymocytes in vitro
    • Ewald S.J., and Shao H. Ethanol increases apoptotic cell death of thymocytes in vitro. Alcohol Clin. Exp. Res. 17 (1993) 359-365
    • (1993) Alcohol Clin. Exp. Res. , vol.17 , pp. 359-365
    • Ewald, S.J.1    Shao, H.2
  • 12
    • 0032728154 scopus 로고    scopus 로고
    • Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide
    • Fenech M., Crott J., Turner J., and Brown S. Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide. Mutagenesis 14 6 (1999) 605-612
    • (1999) Mutagenesis , vol.14 , Issue.6 , pp. 605-612
    • Fenech, M.1    Crott, J.2    Turner, J.3    Brown, S.4
  • 13
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech M. The in vitro micronucleus technique. Mutat. Res. 455 (2000) 81-95
    • (2000) Mutat. Res. , vol.455 , pp. 81-95
    • Fenech, M.1
  • 14
    • 17644367898 scopus 로고    scopus 로고
    • Carcinogenic and co-carcinogenic effects of metals and ethanol on human salivary gland tissue
    • Harréus U.A., Baumeister P., Wallner B.C., Berghaus A., and Kleinsasser N.H. Carcinogenic and co-carcinogenic effects of metals and ethanol on human salivary gland tissue. HNO 53 2 (2005) 155-162
    • (2005) HNO , vol.53 , Issue.2 , pp. 155-162
    • Harréus, U.A.1    Baumeister, P.2    Wallner, B.C.3    Berghaus, A.4    Kleinsasser, N.H.5
  • 15
    • 0022359190 scopus 로고
    • Induction and persistence of SCE-inducing damage in human lymphocytes exposed to vinyl acetate and acetaldehyde in vitro
    • He S.M., and Lambert B. Induction and persistence of SCE-inducing damage in human lymphocytes exposed to vinyl acetate and acetaldehyde in vitro. Mutat. Res. 158 (1985) 201-208
    • (1985) Mutat. Res. , vol.158 , pp. 201-208
    • He, S.M.1    Lambert, B.2
  • 16
    • 0025944745 scopus 로고
    • Increased frequency of acetaldehyde-induced sister-chromatid exchanges in human lymphocytes treated with an aldehyde dehydrogenase inhibitor
    • Helander A., and Lindahl-Kiessling K. Increased frequency of acetaldehyde-induced sister-chromatid exchanges in human lymphocytes treated with an aldehyde dehydrogenase inhibitor. Mutat. Res. 264 (1991) 103-107
    • (1991) Mutat. Res. , vol.264 , pp. 103-107
    • Helander, A.1    Lindahl-Kiessling, K.2
  • 17
    • 0023752312 scopus 로고
    • Effect of alcohol-drinking on mouse chromosomes I. Sister chromatid exchanges in the lymphocytes of mice administered ethanol
    • Hirai M., and Nakaya M. Effect of alcohol-drinking on mouse chromosomes I. Sister chromatid exchanges in the lymphocytes of mice administered ethanol. Arukoru Kenkyuto Yakubutsu Ison 23 (1988) 223-233
    • (1988) Arukoru Kenkyuto Yakubutsu Ison , vol.23 , pp. 223-233
    • Hirai, M.1    Nakaya, M.2
  • 18
    • 0023767772 scopus 로고
    • Effect of alcohol-drinking on mouse chromosomes II. Sister chromatid exchanges and chromosome disassociation in male germ cells of mice administered ethanol
    • Hirai M. Effect of alcohol-drinking on mouse chromosomes II. Sister chromatid exchanges and chromosome disassociation in male germ cells of mice administered ethanol. Arukoru Kenkyuto Yakubutsu Ison 23 (1988) 243-251
    • (1988) Arukoru Kenkyuto Yakubutsu Ison , vol.23 , pp. 243-251
    • Hirai, M.1
  • 19
    • 0025823957 scopus 로고
    • Ethyl alcohol as a carcinogen with special reference to the aerodigestive tract: a cytogenetic study
    • Hsu T.C., Furlong C., and Spitz M.R. Ethyl alcohol as a carcinogen with special reference to the aerodigestive tract: a cytogenetic study. Anticancer Res. 11 (1991) 1097-1101
    • (1991) Anticancer Res. , vol.11 , pp. 1097-1101
    • Hsu, T.C.1    Furlong, C.2    Spitz, M.R.3
  • 21
    • 33846007727 scopus 로고    scopus 로고
    • Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B ALDH2 gene polymorphisms
    • Ishikawa H., Ishikawa T., Yamamoto H., Fukao A., and Yokoyama K. Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B ALDH2 gene polymorphisms. Mutat. Res. 615 (2007) 134-142
    • (2007) Mutat. Res. , vol.615 , pp. 134-142
    • Ishikawa, H.1    Ishikawa, T.2    Yamamoto, H.3    Fukao, A.4    Yokoyama, K.5
  • 22
    • 31644442037 scopus 로고    scopus 로고
    • Gene-environment interactions between alcohol-drinking behaviour and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes
    • Ishikawa H., Miyatsu Y., Kurihara K., and Yokoyama K. Gene-environment interactions between alcohol-drinking behaviour and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes. Mutat. Res. 594 (2006) 1-9
    • (2006) Mutat. Res. , vol.594 , pp. 1-9
    • Ishikawa, H.1    Miyatsu, Y.2    Kurihara, K.3    Yokoyama, K.4
  • 23
    • 32144447643 scopus 로고    scopus 로고
    • Detection of in vivo DNA damage by ethanol in multiple organs of pregnant mice using the alkaline single cell gel electrophoresis (COMET) assay
    • Kido R., Sato I., and Tsuda S. Detection of in vivo DNA damage by ethanol in multiple organs of pregnant mice using the alkaline single cell gel electrophoresis (COMET) assay. J. Vet. Med. Sci 68 1 (2006) 41-47
    • (2006) J. Vet. Med. Sci , vol.68 , Issue.1 , pp. 41-47
    • Kido, R.1    Sato, I.2    Tsuda, S.3
  • 24
    • 0344393531 scopus 로고    scopus 로고
    • Acute exposure of cultured neurons to ethanol results in reversible DNA single strand breaks; whereas exposure causes loss of cell viability
    • Lamarche F., Gonthier B., Singnorini N., Eysseric H., and Barrret L. Acute exposure of cultured neurons to ethanol results in reversible DNA single strand breaks; whereas exposure causes loss of cell viability. Alcohol Alcoholism 38 6 (2003) 550-558
    • (2003) Alcohol Alcoholism , vol.38 , Issue.6 , pp. 550-558
    • Lamarche, F.1    Gonthier, B.2    Singnorini, N.3    Eysseric, H.4    Barrret, L.5
  • 25
    • 20044365114 scopus 로고    scopus 로고
    • Impact of ethanol and acetaldehyde on DNA and cell viability of cultured neurons
    • Lamarche F., Gonthier N., Signorini N., Eysseric H., and Barret L. Impact of ethanol and acetaldehyde on DNA and cell viability of cultured neurons. Cell Biol. Toxicol. 20 (2004) 361-374
    • (2004) Cell Biol. Toxicol. , vol.20 , pp. 361-374
    • Lamarche, F.1    Gonthier, N.2    Signorini, N.3    Eysseric, H.4    Barret, L.5
  • 26
    • 0023272762 scopus 로고
    • Metabolism and metabolic effects of ethanol, including interaction with drugs, carcinogens and nutrition
    • Lieber C.S., Baraona E., Leo M.A., and Garro A. Metabolism and metabolic effects of ethanol, including interaction with drugs, carcinogens and nutrition. Mutat. Res. 186 (1987) 201-233
    • (1987) Mutat. Res. , vol.186 , pp. 201-233
    • Lieber, C.S.1    Baraona, E.2    Leo, M.A.3    Garro, A.4
  • 27
    • 0030935567 scopus 로고    scopus 로고
    • Cytochrome P-4502E1: its physiological and pathological role
    • Lieber C.S. Cytochrome P-4502E1: its physiological and pathological role. Physiol. Rev. 77 (1997) 517-544
    • (1997) Physiol. Rev. , vol.77 , pp. 517-544
    • Lieber, C.S.1
  • 28
    • 0033645269 scopus 로고    scopus 로고
    • Increased cytogenetic damage detected by FISH analysis on micronuclei in peripheral lymphocytes from alcoholics
    • Maffei F., Fimognari C., Castelli E., Stefanini G.F., Forti G.C., and Hrelia P. Increased cytogenetic damage detected by FISH analysis on micronuclei in peripheral lymphocytes from alcoholics. Mutagenesis 15 6 (2000) 517-523
    • (2000) Mutagenesis , vol.15 , Issue.6 , pp. 517-523
    • Maffei, F.1    Fimognari, C.2    Castelli, E.3    Stefanini, G.F.4    Forti, G.C.5    Hrelia, P.6
  • 29
    • 0022357909 scopus 로고
    • Chromosome damage induced by vinyl acetate through in vitro formation of acetaldehyde in human lymphocytes and Chinese hamster ovary cells
    • Norppa H., Tursi F., Pfaffli P., Mäki-Paakkanen J., and Järventaus H. Chromosome damage induced by vinyl acetate through in vitro formation of acetaldehyde in human lymphocytes and Chinese hamster ovary cells. Cancer Res. 45 (1985) 4816-4821
    • (1985) Cancer Res. , vol.45 , pp. 4816-4821
    • Norppa, H.1    Tursi, F.2    Pfaffli, P.3    Mäki-Paakkanen, J.4    Järventaus, H.5
  • 31
    • 0035126756 scopus 로고    scopus 로고
    • Is ethanol genotoxic? A review of the published data
    • Phillips B.J., and Jenkinson P. Is ethanol genotoxic? A review of the published data. Mutagenesis 16 2 (2001) 91-101
    • (2001) Mutagenesis , vol.16 , Issue.2 , pp. 91-101
    • Phillips, B.J.1    Jenkinson, P.2
  • 32
    • 0035178711 scopus 로고    scopus 로고
    • Research advances in ethanol metabolism
    • Ramachandani V.A., Bosron W.F., and Li K.T. Research advances in ethanol metabolism. Pathol. Biol. 49 9 (2001) 676-682
    • (2001) Pathol. Biol. , vol.49 , Issue.9 , pp. 676-682
    • Ramachandani, V.A.1    Bosron, W.F.2    Li, K.T.3
  • 33
    • 0029043990 scopus 로고
    • Acetaldehyde: genotoxicity and cytotoxicity in human lymphocytes
    • Singh N.P., and Khan A. Acetaldehyde: genotoxicity and cytotoxicity in human lymphocytes. Mutat. Res. 337 (1995) 9-17
    • (1995) Mutat. Res. , vol.337 , pp. 9-17
    • Singh, N.P.1    Khan, A.2


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