Protein disulfide isomerase: A promising target for cancer therapy

Drug Discovery Today

Volumn 19, Issue 3, 2014, Pages 222-240

  Xu, Shili ^a   Sankar, Saranya ^b   Neamati, Nouri ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; 5,5' DITHIOBIS(2 NITROBENZOIC ACID); ACROLEIN; ANTIBIOTIC AGENT; ARSENOSOBENZENE; BACITRACIN; BACITRACIN B; BACITRACIN F; BACITRACIN H; BACOTRACIN A; CHAPERONE; CHLOROMERCURIBENZENESULFONIC ACID; CYSTAMINE; ENZYME INHIBITOR; ESTRADIOL; ESTROGEN; ESTRONE; IODOACETAMINDE; LIOTHYRONINE; N ETHYLMALEIMIDE; PROPYNOIC ACID CARBAMOYL METHYL AMIDE; PROTEIN DISULFIDE ISOMERASE; PROTEIN DISULFIDE ISOMERASE INHIBITOR; RIBOSTAMYCIN; RUTOSIDE; THIOL DERIVATIVE; THIOMUSCIMOL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

AMINO ACID SEQUENCE; CANCER SURVIVAL; CANCER THERAPY; CRYSTAL STRUCTURE; DISULFIDE BOND; DRUG SCREENING; DRUG TARGETING; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FLUOROMETRY; HIGH THROUGHPUT SCREENING; HUMAN; INSULIN DEGRADATION; ISOMERIZATION; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE COURSE; DRUG DESIGN; ENZYMOLOGY; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASMS; PROCEDURES;

ANIMALS; ANTINEOPLASTIC AGENTS; DISEASE PROGRESSION; DRUG DESIGN; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASMS; PROTEIN DISULFIDE-ISOMERASES; PROTEIN FOLDING;

EID: 84896394053     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2013.10.017     Document Type: Review

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