1,3,5-triazine as a modular scaffold for covalent inhibitors with streamlined target identification

Journal of the American Chemical Society

Volumn 135, Issue 7, 2013, Pages 2497-2500

  Banerjee, Ranjan ^a   Pace, Nicholas J ^a   Brown, Douglas R ^a   Weerapana, Eranthie ^a  

^a BOSTON COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ,3 ,5-TRIAZINES; CELL-PERMEABLE; CHEMICAL GENETICS; CLICK CHEMISTRY; COVALENT MODIFICATIONS; DIVERSE PROTEINS; ELECTROPHILES; FUNCTIONAL ANNOTATION; IN-VITRO; IN-VIVO; PHARMACOLOGICAL AGENTS; PROTEIN ACTIVITY; PROTEIN DISULFIDE ISOMERASES; PROTEIN TARGETS; SMALL MOLECULES; SMALL-MOLECULE INHIBITORS; TARGET IDENTIFICATION; TARGET PROTEINS; THERAPEUTIC POTENTIALS; TUBULIN POLYMERIZATION;

ACETYLENE; AMINO ACIDS; MOLECULES; PROTEINS;

SCAFFOLDS (BIOLOGY);

ALKYNE; BETA TUBULIN; CYSTEINE; ELECTROPHILE; MOLECULAR SCAFFOLD; PROTEIN DISULFIDE ISOMERASE; PROTEOME; TRETAMINE; TRIAZINE DERIVATIVE;

ARTICLE; CELL MEMBRANE PERMEABILITY; IN VITRO STUDY; PROTEIN POLYMERIZATION;

CYSTEINE; DRUG DELIVERY SYSTEMS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HELA CELLS; HUMANS; PROTEINS; SMALL MOLECULE LIBRARIES; TRIAZINES;

EID: 84874024997     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja400427e     Document Type: Article

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