Protein disulfide isomerase in redox cell signaling and homeostasis

Free Radical Biology and Medicine

Volumn 52, Issue 9, 2012, Pages 1954-1969

  Laurindo, Francisco R M ^a   Pescatore, Luciana A ^a   De Castro Fernandes, Denise ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Endoplasmic reticulum stress; Free radicals; NADPH oxidase; Protein disulfide isomerase; Redox signaling; Thiols; Thioredoxin; Unfolded protein response

Indexed keywords

CHAPERONE; HUNTINGTIN; HYDROGEN PEROXIDE; ISOMERASE; OXIDOREDUCTASE; PEROXIREDOXIN 4; PROTEIN DISULFIDE ISOMERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2;

ALZHEIMER DISEASE; APOPTOSIS; ATTENTION DEFICIT DISORDER; BLOOD CLOTTING; BRAIN ISCHEMIA; BREAST CANCER; CATALYSIS; CELL ADHESION; CHRONIC LYMPHATIC LEUKEMIA; COLORECTAL CANCER; DISULFIDE BOND; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME SUBSTRATE; ESOPHAGUS CARCINOMA; HOMEOSTASIS; HUMAN; LIVER CELL CARCINOMA; LIVER TOXICITY; MACROPHAGE; MAJOR DEPRESSION; MEMBRANE PERMEABILITY; OBESITY; OLIGOMERIZATION; OUTER MEMBRANE; OXIDATION REDUCTION REACTION; PANCREAS CARCINOMA; PATHOPHYSIOLOGY; PERIODONTITIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROSTATE CANCER; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; STOMACH CANCER; STRUCTURE ACTIVITY RELATION; THROMBOSIS; VASCULAR SMOOTH MUSCLE;

ANIMALS; HOMEOSTASIS; HUMANS; OXIDATION-REDUCTION; PROTEIN DISULFIDE-ISOMERASES; SIGNAL TRANSDUCTION;

EID: 84859480323     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.02.037     Document Type: Review

References (271)

1. C.C. Winterbourn Reconciling the chemistry and biology of reactive oxygen species Nat. Chem. Biol. 4 2008 278 286
2. L.S. Terada Specificity in reactive oxidant signaling: think globally, act locally J. Cell Biol. 174 2006 615 623
3. D.P. Jones Redefining oxidative stress Antioxid. Redox Signal. 8 2006 1865 1879
4. F.Q. Schafer, and G.R. Buettner Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radic. Biol. Med. 30 2001 1191 1212
5. H.J. Forman, J.M. Fukuto, and M. Torres Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers Am. J. Physiol. Cell Physiol. 287 2004 C246 C256
6. Y.M. Janssen-Heininger, B.T. Mossman, N.H. Heintz, H.J. Forman, B. Kalyanaraman, T. Finkel, J.S. Stamler, S.G. Rhee, and A. van der Vliet Redox-based regulation of signal transduction: principles, pitfalls, and promises Free Radic. Biol. Med. 45 2008 1 17
7. A. Bindoli, J.M. Fukuto, and H.J. Forman Thiol chemistry in peroxidase catalysis and redox signaling Antioxid. Redox Signal. 10 2008 1549 1564
8. F.D. Oakley, D. Abbott, Q. Li, and J.F. Engelhardt Signaling components of redox active endosomes: the redoxosomes Antioxid. Redox Signal. 11 2009 1313 1333
9. U. Alon An Introduction to Systems Biology: Design Principles of Biological Circuits 2007 Chapman & Hall/CRC Press Boca Raton, FL
10. D.C. Fernandes, D. Bonatto, and F.R. Laurindo The envolving concept of oxidative stress H. Sauer, A.M. Shah, F.R. Laurindo, Studies in Cardiovascular Disorders 2010 Humana Press New York
11. C.C. Winterbourn, and M.B. Hampton Thiol chemistry and specificity in redox signaling Free Radic. Biol. Med. 45 2008 549 561
12. C.E. Bauer, S. Elsen, and T.H. Bird Mechanisms for redox control of gene expression Annu. Rev. Microbiol. 53 1999 495 523
13. H. Liu, H. Zhang, K.E. Iles, A. Rinna, G. Merrill, J. Yodoi, M. Torres, and H.J. Forman The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages Free Radic. Res. 40 2006 865 874
14. A. Hall, P.A. Karplus, and L.B. Poole Typical 2-Cys peroxiredoxins - structures, mechanisms and functions FEBS J. 276 2009 2469 2477
15. 2 accumulation for cell signaling Cell 140 2010 517 528
16. D. Bonatto A systems biology analysis of protein-protein interactions between yeast superoxide dismutases and DNA repair pathways Free Radic. Biol. Med. 43 2007 557 567
17. M.M. Harraz, J.J. Marden, W. Zhou, Y. Zhang, A. Williams, V.S. Sharov, K. Nelson, M. Luo, H. Paulson, C. Schoneich, and J.F. Engelhardt SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model J. Clin. Invest. 118 2008 659 670
18. F. Hatahet, and L.W. Ruddock Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formation Antioxid. Redox Signal. 11 2009 2807 2850
19. C. Appenzeller-Herzog, and L. Ellgaard The human PDI family: versatility packed into a single fold Biochim. Biophys. Acta 1783 2008 535 548
20. B. Wilkinson, and H.F. Gilbert Protein disulfide isomerase Biochim. Biophys. Acta 1699 2004 35 44
21. G. Kozlov, P. Maattanen, D.Y. Thomas, and K. Gehring A structural overview of the PDI family of proteins FEBS J. 277 2010 3924 3936
22. R.B. Freedman, P.J. Gane, H.C. Hawkins, R. Hlodan, S.H. McLaughlin, and J.W. Parry Experimental and theoretical analyses of the domain architecture of mammalian protein disulphide-isomerase Biol. Chem. 379 1998 321 328
23. H.R. Pelham The retention signal for soluble proteins of the endoplasmic reticulum Trends Biochem. Sci. 15 1990 483 486
24. G. Tian, S. Xiang, R. Noiva, W.J. Lennarz, and H. Schindelin The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites Cell 124 2006 61 73
25. G. Tian, F.X. Kober, U. Lewandrowski, A. Sickmann, W.J. Lennarz, and H. Schindelin The catalytic activity of protein-disulfide isomerase requires a conformationally flexible molecule J. Biol. Chem. 283 2008 33630 33640
26. C. Wang, S. Chen, X. Wang, L. Wang, A.K. Wallis, R.B. Freedman, and C.C. Wang Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance J. Biol. Chem. 285 2010 26788 26797
27. H. Cai, C.C. Wang, and C.L. Tsou Chaperone-like activity of protein disulfide isomerase in the refolding of a protein with no disulfide bonds J. Biol. Chem. 269 1994 24550 24552
28. A. Puig, and H.F. Gilbert Protein disulfide isomerase exhibits chaperone and anti-chaperone activity in the oxidative refolding of lysozyme J. Biol. Chem. 269 1994 7764 7771
29. H. Quan, G. Fan, and C.C. Wang Independence of the chaperone activity of protein disulfide isomerase from its thioredoxin-like active site J. Biol. Chem. 270 1995 17078 17080
30. S. Masui, S. Vavassori, C. Fagioli, R. Sitia, and K. Inaba Molecular bases of cyclic and specific disulfide interchange between human ERO1α protein and protein-disulfide isomerase (PDI) J. Biol. Chem. 286 2011 16261 16271
31. S. Imaoka Chemical stress on protein disulfide isomerases and inhibition of their functions Int. Rev. Cell Mol. Biol. 290 2011 121 166
32. V. Sideraki, and H.F. Gilbert Mechanism of the antichaperone activity of protein disulfide isomerase: facilitated assembly of large, insoluble aggregates of denatured lysozyme and PDI Biochemistry 39 2000 1180 1188
33. P. Moore, K.M. Bernardi, and B. Tsai The Ero1α-PDI redox cycle regulates retro-translocation of cholera toxin Mol. Biol. Cell 21 2010 1305 1313
34. A. Zapun, T.E. Creighton, P.J. Rowling, and R.B. Freedman Folding in vitro of bovine pancreatic trypsin inhibitor in the presence of proteins of the endoplasmic reticulum Proteins 14 1992 10 15
35. M.M. Lyles, and H.F. Gilbert Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer Biochemistry 30 1991 613 619
36. C. Hwang, A.J. Sinskey, and H.F. Lodish Oxidized redox state of glutathione in the endoplasmic reticulum Science 257 1992 1496 1502
37. M. Schwaller, B. Wilkinson, and H.F. Gilbert Reduction-reoxidation cycles contribute to catalysis of disulfide isomerization by protein-disulfide isomerase J. Biol. Chem. 278 2003 7154 7159
38. K.W. Walker, M.M. Lyles, and H.F. Gilbert Catalysis of oxidative protein folding by mutants of protein disulfide isomerase with a single active-site cysteine Biochemistry 35 1996 1972 1980
39. L.W. Ruddock, T.R. Hirst, and R.B. Freedman pH-dependence of the dithiol-oxidizing activity of DsbA (a periplasmic protein thiol:disulphide oxidoreductase) and protein disulphide-isomerase: studies with a novel simple peptide substrate Biochem. J. 315 1996 1001 1005
40. A.K. Lappi, M.F. Lensink, H.I. Alanen, K.E. Salo, M. Lobell, A.H. Juffer, and L.W. Ruddock A conserved arginine plays a role in the catalytic cycle of the protein disulphide isomerases J. Mol. Biol. 335 2004 283 295
41. C. Christis, N.H. Lubsen, and I. Braakman Protein folding includes oligomerization - examples from the endoplasmic reticulum and cytosol FEBS J. 275 2008 4700 4727
42. C. Appenzeller-Herzog, J. Riemer, E. Zito, K.T. Chin, D. Ron, M. Spiess, and L. Ellgaard Disulphide production by Ero1α-PDI relay is rapid and effectively regulated EMBO J. 29 2010 3318 3329
43. L. Meunier, Y.K. Usherwood, K.T. Chung, and L.M. Hendershot A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins Mol. Biol. Cell 13 2002 4456 4469
44. C.E. Jessop, R.H. Watkins, J.J. Simmons, M. Tasab, and N.J. Bulleid Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins J. Cell Sci. 122 2009 4287 4295
45. A.R. Frand, and C.A. Kaiser The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum Mol. Cell 1 1998 161 170
46. M.G. Pollard, K.J. Travers, and J.S. Weissman Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum Mol. Cell 1 1998 171 182
47. T.J. Tavender, and N.J. Bulleid Molecular mechanisms regulating oxidative activity of the Ero1 family in the endoplasmic reticulum Antioxid. Redox Signal. 13 2010 1177 1187
48. A.R. Frand, and C.A. Kaiser Two pairs of conserved cysteines are required for the oxidative activity of Ero1p in protein disulfide bond formation in the endoplasmic reticulum Mol. Biol. Cell 11 2000 2833 2843
49. L. Wang, S.J. Li, A. Sidhu, L. Zhu, Y. Liang, R.B. Freedman, and C.C. Wang Reconstitution of human Ero1-Lα/protein-disulfide isomerase oxidative folding pathway in vitro: position-dependent differences in role between the a and a′ domains of protein-disulfide isomerase J. Biol. Chem. 284 2009 199 206
50. K.M. Baker, S. Chakravarthi, K.P. Langton, A.M. Sheppard, H. Lu, and N.J. Bulleid Low reduction potential of Ero1α regulatory disulphides ensures tight control of substrate oxidation EMBO J. 27 2008 2988 2997
51. E. Gross, C.S. Sevier, N. Heldman, E. Vitu, M. Bentzur, C.A. Kaiser, C. Thorpe, and D. Fass Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p Proc. Natl. Acad. Sci. U.S.A. 103 2006 299 304
52. G.C. Brown, and V. Borutaite There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells Mitochondrion 12 2012 1 4
53. C. Appenzeller-Herzog Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum J. Cell Sci. 124 2011 847 855
54. 2 mediates endoplasmic reticulum signaling through local Ras activation Mol. Cell. Biol. 30 2010 3553 3568
55. J.D. Malhotra, H. Miao, K. Zhang, A. Wolfson, S. Pennathur, S.W. Pipe, and R.J. Kaufman Antioxidants reduce endoplasmic reticulum stress and improve protein secretion Proc. Natl. Acad. Sci. U.S.A. 105 2008 18525 18530
56. C.X. Santos, L.Y. Tanaka, J. Wosniak, and F.R. Laurindo Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase Antioxid. Redox Signal. 11 2009 2409 2427
57. A.R. Karala, A.K. Lappi, M.J. Saaranen, and L.W. Ruddock Efficient peroxide-mediated oxidative refolding of a protein at physiological pH and implications for oxidative folding in the endoplasmic reticulum Antioxid. Redox Signal. 11 2009 963 970
58. E. Zito, K.T. Chin, J. Blais, H.P. Harding, and D. Ron ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis J. Cell Biol. 188 2010 821 832
59. M.J. Saaranen, A.R. Karala, A.K. Lappi, and L.W. Ruddock The role of dehydroascorbate in disulfide bond formation Antioxid. Redox Signal. 12 2010 15 25
60. W. Li, S. Schulman, R.J. Dutton, D. Boyd, J. Beckwith, and T.A. Rapoport Structure of a bacterial homologue of vitamin K epoxide reductase Nature 463 2010 507 512
61. Z. Cao, T.J. Tavender, A.W. Roszak, R.J. Cogdell, and N.J. Bulleid Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle J. Biol. Chem. 286 2011 42257 42266
62. E. Zito, E.P. Melo, Y. Yang, A. Wahlander, T.A. Neubert, and D. Ron Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin Mol. Cell 40 2010 787 797
63. T.J. Tavender, J.J. Springate, and N.J. Bulleid Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum EMBO J. 29 2010 4185 4197
64. 2 produced during disulphide formation J. Cell Sci. 123 2010 2672 2679
65. F.R. Laurindo, D.C. Fernandes, A.M. Amanso, L.R. Lopes, and C.X. Santos Novel role of protein disulfide isomerase in the regulation of NADPH oxidase activity: pathophysiological implications in vascular diseases Antioxid. Redox Signal. 10 2008 1101 1113
66. B. Kornmann, E. Currie, S.R. Collins, M. Schuldiner, J. Nunnari, J.S. Weissman, and P. Walter An ER-mitochondria tethering complex revealed by a synthetic biology screen Science 325 2009 477 481
67. C. Kumsta, and U. Jakob Redox-regulated chaperones Biochemistry 48 2009 4666 4676
68. D.F. Trindade, G. Cerchiaro, and O. Augusto A role for peroxymonocarbonate in the stimulation of biothiol peroxidation by the bicarbonate/carbon dioxide pair Chem. Res. Toxicol. 19 2006 1475 1482
69. V.D. Nguyen, M.J. Saaranen, A.R. Karala, A.K. Lappi, L. Wang, I.B. Raykhel, H.I. Alanen, K.E. Salo, C.C. Wang, and L.W. Ruddock Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation J. Mol. Biol. 406 2011 503 515
70. S.N. Molteni, A. Fassio, M.R. Ciriolo, G. Filomeni, E. Pasqualetto, C. Fagioli, and R. Sitia Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum J. Biol. Chem. 279 2004 32667 32673
71. I. Tabas, and D. Ron Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress Nat. Cell Biol. 13 2011 184 190
72. D. Ron, and P. Walter Signal integration in the endoplasmic reticulum unfolded protein response Nat. Rev. Mol. Cell Biol. 8 2007 519 529
73. D.T. Rutkowski, and R.J. Kaufman That which does not kill me makes me stronger: adapting to chronic ER stress Trends Biochem. Sci. 32 2007 469 476
74. J. Lewerenz, and P. Maher Basal levels of eIF2α phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression J. Biol. Chem. 284 2009 1106 1115
75. L. Liu, D.R. Wise, J.A. Diehl, and M.C. Simon Hypoxic reactive oxygen species regulate the integrated stress response and cell survival J. Biol. Chem. 283 2008 31153 31162
76. G. Li, C. Scull, L. Ozcan, and I. Tabas NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis J. Cell Biol. 191 2010 1113 1125
77. E. Pedruzzi, C. Guichard, V. Ollivier, F. Driss, M. Fay, C. Prunet, J.C. Marie, C. Pouzet, M. Samadi, C. Elbim, Y. O'Dowd, M. Bens, A. Vandewalle, M.A. Gougerot-Pocidalo, G. Lizard, and E. Ogier-Denis NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells Mol. Cell. Biol. 24 2004 10703 10717
78. A. Diwan, S.J. Matkovich, Q. Yuan, W. Zhao, A. Yatani, J.H. Brown, J.D. Molkentin, E.G. Kranias, and G.W. Dorn III Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death J. Clin. Invest. 119 2009 203 212
79. J.M. Timmins, L. Ozcan, T.A. Seimon, G. Li, C. Malagelada, J. Backs, T. Backs, R. Bassel-Duby, E.N. Olson, M.E. Anderson, and I. Tabas Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways J. Clin. Invest. 119 2009 2925 2941
80. R.F. Wu, and L.S. Terada Focal oxidant and Ras signaling on the ER surface activates autophagy Autophagy 6 2010 828 829
81. S. Bernales, K.L. McDonald, and P. Walter Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response PLoS Biol. 4 2006 e423
82. M. Yokouchi, N. Hiramatsu, K. Hayakawa, M. Okamura, S. Du, A. Kasai, Y. Takano, A. Shitamura, T. Shimada, J. Yao, and M. Kitamura Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response J. Biol. Chem. 283 2008 4252 4260
83. X. Xue, J.H. Piao, A. Nakajima, S. Sakon-Komazawa, Y. Kojima, K. Mori, H. Yagita, K. Okumura, H. Harding, and H. Nakano Tumor necrosis factor α (TNFα) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFα J. Biol. Chem. 280 2005 33917 33925
84. A.H. Lee, N.N. Iwakoshi, K.C. Anderson, and L.H. Glimcher Proteasome inhibitors disrupt the unfolded protein response in myeloma cells Proc. Natl. Acad. Sci. U.S.A. 100 2003 9946 9951
85. A.M. Amanso, V. Debbas, and F.R. Laurindo Proteasome inhibition represses unfolded protein response and Nox4, sensitizing vascular cells to endoplasmic reticulum stress-induced death PLoS One 6 2011 e14591
86. K. Zhang, H.N. Wong, B. Song, C.N. Miller, D. Scheuner, and R.J. Kaufman The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis J. Clin. Invest. 115 2005 268 281
87. C.M. Haynes, and D. Ron The mitochondrial UPR - protecting organelle protein homeostasis J. Cell Sci. 123 2010 3849 3855
88. P.I. Merksamer, A. Trusina, and F.R. Papa Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions Cell 135 2008 933 947
89. 2: implications for oxidative stress during apoptosis J. Biol. Chem. 278 2003 29410 29419
90. O. Hori, F. Ichinoda, T. Tamatani, A. Yamaguchi, N. Sato, K. Ozawa, Y. Kitao, M. Miyazaki, H.P. Harding, D. Ron, M. Tohyama, and S. Ogawa Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease J. Cell Biol. 157 2002 1151 1160
91. C. Hetz, P. Bernasconi, J. Fisher, A.H. Lee, M.C. Bassik, B. Antonsson, G.S. Brandt, N.N. Iwakoshi, A. Schinzel, L.H. Glimcher, and S.J. Korsmeyer Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1α Science 312 2006 572 576
92. T. Simmen, E.M. Lynes, K. Gesson, and G. Thomas Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM) Biochim. Biophys. Acta 1798 2010 1465 1473
93. B.G. Hoffstrom, A. Kaplan, R. Letso, R.S. Schmid, G.J. Turmel, D.C. Lo, and B.R. Stockwell Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins Nat. Chem. Biol. 6 2010 900 906
94. K. Chen, M.T. Kirber, H. Xiao, Y. Yang, and J.F. Keaney Jr. Regulation of ROS signal transduction by NADPH oxidase 4 localization J. Cell Biol. 181 2008 1129 1139
95. I. Helmcke, S. Heumuller, R. Tikkanen, K. Schroder, and R.P. Brandes Identification of structural elements in Nox1 and Nox4 controlling localization and activity Antioxid. Redox Signal. 11 2009 1279 1287
96. L. Serrander, L. Cartier, K. Bedard, B. Banfi, B. Lardy, O. Plastre, A. Sienkiewicz, L. Forro, W. Schlegel, and K.H. Krause NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation Biochem. J. 406 2007 105 114
97. T.A. Seimon, M.J. Nadolski, X. Liao, J. Magallon, M. Nguyen, N.T. Feric, M.L. Koschinsky, R. Harkewicz, J.L. Witztum, S. Tsimikas, D. Golenbock, K.J. Moore, and I. Tabas Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress Cell Metab. 12 2010 467 482
98. P. Maattanen, G. Kozlov, K. Gehring, and D.Y. Thomas ERp57 and PDI: multifunctional protein disulfide isomerases with similar domain architectures but differing substrate-partner associations Biochem. Cell Biol. 84 2006 881 889
99. M.P. Rigobello, A. Donella-Deana, L. Cesaro, and A. Bindoli Distribution of protein disulphide isomerase in rat liver mitochondria Biochem. J. 356 2001 567 570
100. C. Turano, S. Coppari, F. Altieri, and A. Ferraro Proteins of the PDI family: unpredicted non-ER locations and functions J. Cell. Physiol. 193 2002 154 163
101. B. Henderson, and A.G. Pockley Molecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammation J. Leukoc. Biol. 88 2010 445 462
102. S. Lee, B. Park, K. Kang, and K. Ahn Redox-regulated export of the major histocompatibility complex class I-peptide complexes from the endoplasmic reticulum Mol. Biol. Cell 20 2009 3285 3294
103. R.J. Ellis Molecular chaperones: assisting assembly in addition to folding Trends Biochem. Sci. 31 2006 395 401
104. D.W. Essex Redox control of platelet function Antioxid. Redox Signal. 11 2009 1191 1225
105. N.I. Popescu, C. Lupu, and F. Lupu Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure Blood 116 2010 993 1001
106. C. Reinhardt, M.L. von Bruhl, D. Manukyan, L. Grahl, M. Lorenz, B. Altmann, S. Dlugai, S. Hess, I. Konrad, L. Orschiedt, N. Mackman, L. Ruddock, S. Massberg, and B. Engelmann Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation J. Clin. Invest. 118 2008 1110 1122
107. J. Cho, B.C. Furie, S.R. Coughlin, and B. Furie A critical role for extracellular protein disulfide isomerase during thrombus formation in mice J. Clin. Invest. 118 2008 1123 1131
108. K.A. Hotchkiss, L.J. Matthias, and P.J. Hogg Exposure of the cryptic Arg-Gly-Asp sequence in thrombospondin-1 by protein disulfide isomerase Biochim. Biophys. Acta 1388 1998 478 488
109. S. Bi, P.W. Hong, B. Lee, and L.G. Baum Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry Proc. Natl. Acad. Sci. U.S.A. 108 2011 10650 10655
110. S.H. Willems, C.J. Tape, P.L. Stanley, N.A. Taylor, I.G. Mills, D.E. Neal, J. McCafferty, and G. Murphy Thiol isomerases negatively regulate the cellular shedding activity of ADAM17 Biochem. J. 428 2010 439 450
111. T.A. Bennett, B.S. Edwards, L.A. Sklar, and S. Rogelj Sulfhydryl regulation of L-selectin shedding: phenylarsine oxide promotes activation-independent L-selectin shedding from leukocytes J. Immunol. 164 2000 4120 4129
112. C. Booth, and G.L. Koch Perturbation of cellular calcium induces secretion of luminal ER proteins Cell 59 1989 729 737
113. M. Swiatkowska, G. Padula, L. Michalec, M. Stasiak, S. Skurzynski, and C.S. Cierniewski Ero1α is expressed on blood platelets in association with protein-disulfide isomerase and contributes to redox-controlled remodeling of αIIbβ3 J. Biol. Chem. 285 2010 29874 29883
114. N. Donoghue, P.T. Yam, X.M. Jiang, and P.J. Hogg Presence of closely spaced protein thiols on the surface of mammalian cells Protein Sci. 9 2000 2436 2445
115. X.M. Jiang, M. Fitzgerald, C.M. Grant, and P.J. Hogg Redox control of exofacial protein thiols/disulfides by protein disulfide isomerase J. Biol. Chem. 274 1999 2416 2423
116. A. Zai, M.A. Rudd, A.W. Scribner, and J. Loscalzo Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide J. Clin. Invest. 103 1999 393 399
117. N. Ramachandran, P. Root, X.M. Jiang, P.J. Hogg, and B. Mutus Mechanism of transfer of NO from extracellular S-nitrosothiols into the cytosol by cell-surface protein disulfide isomerase Proc. Natl. Acad. Sci. U.S.A. 98 2001 9539 9544
118. T. Uehara, T. Nakamura, D. Yao, Z.Q. Shi, Z. Gu, Y. Ma, E. Masliah, Y. Nomura, and S.A. Lipton S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration Nature 441 2006 513 517
119. K. Terada, P. Manchikalapudi, R. Noiva, H.O. Jauregui, R.J. Stockert, and M.L. Schilsky Secretion, surface localization, turnover, and steady state expression of protein disulfide isomerase in rat hepatocytes J. Biol. Chem. 270 1995 20410 20416
120. M. Desjardins ER-mediated phagocytosis: a new membrane for new functions Nat. Rev. Immunol. 3 2003 280 291
121. N. Touret, P. Paroutis, M. Terebiznik, R.E. Harrison, S. Trombetta, M. Pypaert, A. Chow, A. Jiang, J. Shaw, C. Yip, H.P. Moore, N. van der Wel, D. Houben, P.J. Peters, C. de Chastellier, I. Mellman, and S. Grinstein Quantitative and dynamic assessment of the contribution of the ER to phagosome formation Cell 123 2005 157 170
122. C.X. Santos, B.S. Stolf, P.V. Takemoto, A.M. Amanso, L.R. Lopes, E.B. Souza, H. Goto, and F.R. Laurindo Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages J. Leukoc. Biol. 86 2009 989 998
123. S. Duclos, G. Clavarino, G. Rousserie, G. Goyette, J. Boulais, V. Camossetto, E. Gatti, S. LaBoissiere, P. Pierre, and M. Desjardins The endosomal proteome of macrophage and dendritic cells Proteomics 11 2011 854 864
124. A.M. de A. Paes, S. Verissimo-Filho, L.L. Guimaraes, A.C. Silva, J.T. Takiuti, C.X. Santos, M. Janiszewski, F.R. Laurindo, and L.R. Lopes Protein disulfide isomerase redox-dependent association with p47(phox): evidence for an organizer role in leukocyte NADPH oxidase activation J. Leukoc. Biol. 90 2011 799 810
125. J.D. Stockton, M.C. Merkert, and K.V. Kellaris A complex of chaperones and disulfide isomerases occludes the cytosolic face of the translocation protein Sec61p and affects translocation of the prion protein Biochemistry 42 2003 12821 12834
126. M. Keller, A. Ruegg, S. Werner, and H.D. Beer Active caspase-1 is a regulator of unconventional protein secretion Cell 132 2008 818 831
127. Y. Fujinaga, A.A. Wolf, C. Rodighiero, H. Wheeler, B. Tsai, L. Allen, M.G. Jobling, T. Rapoport, R.K. Holmes, and W.I. Lencer Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulum Mol. Biol. Cell 14 2003 4783 4793
128. R. Bartz, J.K. Zehmer, M. Zhu, Y. Chen, G. Serrero, Y. Zhao, and P. Liu Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation J. Proteome Res. 6 2007 3256 3265
129. A. Raturi, S. Miersch, J.W. Hudson, and B. Mutus Platelet microparticle-associated protein disulfide isomerase promotes platelet aggregation and inactivates insulin Biochim. Biophys. Acta 1778 2008 2790 2796
130. A.N. Kapustin, J.D. Davies, J.L. Reynolds, R. McNair, G.T. Jones, A. Sidibe, L.J. Schurgers, J.N. Skepper, D. Proudfoot, M. Mayr, and C.M. Shanahan Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization Circ. Res. 109 2011 e1 e12
131. H.H. Versteeg, and W. Ruf Thiol pathways in the regulation of tissue factor prothrombotic activity Curr. Opin. Hematol. 18 2011 343 348
132. J. van den Akker, A. van Weert, G. Afink, E.N. Bakker, E. van der Pol, A.N. Boing, R. Nieuwland, and E. Vanbavel Transglutaminase 2 is secreted from smooth muscle cells by transamidation-dependent microparticle formation Amino Acids 42 2012 961 973
133. M. Gonzalez-Gronow, M.A. Selim, J. Papalas, and S.V. Pizzo GRP78: a multifunctional receptor on the cell surface Antioxid. Redox Signal. 11 2009 2299 2306
134. Y. Zhang, R. Liu, M. Ni, P. Gill, and A.S. Lee Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP J. Biol. Chem. 285 2010 15065 15075
135. M. Janiszewski, L.R. Lopes, A.O. Carmo, M.A. Pedro, R.P. Brandes, C.X. Santos, and F.R. Laurindo Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells J. Biol. Chem. 280 2005 40813 40819
136. D.C. Fernandes, A.H. Manoel, J. Wosniak Jr., and F.R. Laurindo Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: effects of nitrosothiol exposure Arch. Biochem. Biophys. 484 2009 197 204
137. J. Wosniak Jr., C.X. Santos, A.J. Kowaltowski, and F.R. Laurindo Cross-talk between mitochondria and NADPH oxidase: effects of mild mitochondrial dysfunction on angiotensin II-mediated increase in Nox isoform expression and activity in vascular smooth muscle cells Antioxid. Redox Signal. 11 2009 1265 1278
138. M.H. Gambim, O. do Carmo Ade, L. Marti, S. Verissimo-Filho, L.R. Lopes, and M. Janiszewski Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction Crit. Care 11 2007 R107
139. W. Chen, W.H. Shang, Y. Adachi, K. Hirose, D.M. Ferrari, and T. Kamata A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72 Biochem. J. 416 2008 55 63
140. A.K. Walker, M.A. Farg, C.R. Bye, C.A. McLean, M.K. Horne, and J.D. Atkin Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis Brain 133 2010 105 116
141. J.D. Atkin, M.A. Farg, B.J. Turner, D. Tomas, J.A. Lysaght, J. Nunan, A. Rembach, P. Nagley, P.M. Beart, S.S. Cheema, and M.K. Horne Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1 J. Biol. Chem. 281 2006 30152 30165
142. Y.S. Yang, N.Y. Harel, and S.M. Strittmatter Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis J. Neurosci. 29 2009 13850 13859
143. M.L. Forster, K. Sivick, Y.N. Park, P. Arvan, W.I. Lencer, and B. Tsai Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation J. Cell Biol. 173 2006 853 859
144. K. Cho, S. Cho, S.O. Lee, C. Oh, K. Kang, J. Ryoo, S. Lee, S. Kang, and K. Ahn Redox-regulated peptide transfer from the transporter associated with antigen processing to major histocompatibility complex class I molecules by protein disulfide isomerase Antioxid. Redox Signal. 15 2011 621 633
145. G. Dong, P.A. Wearsch, D.R. Peaper, P. Cresswell, and K.M. Reinisch Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer Immunity 30 2009 21 32
146. K.C. Fae, D. Diefenbach da Silva, A.M. Bilate, A.C. Tanaka, P.M. Pomerantzeff, M.H. Kiss, C.A. Silva, E. Cunha-Neto, J. Kalil, and L. Guilherme PDIA3, HSPA5 and vimentin, proteins identified by 2-DE in the valvular tissue, are the target antigens of peripheral and heart infiltrating T cells from chronic rheumatic heart disease patients J. Autoimmun. 31 2008 136 141
147. S. Haefliger, C. Klebig, K. Schaubitzer, J. Schardt, N. Timchenko, B.U. Mueller, and T. Pabst Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML Blood 117 2011 5931 5940
148. F. Delom, B. Mallet, P. Carayon, and P.J. Lejeune Role of extracellular molecular chaperones in the folding of oxidized proteins: refolding of colloidal thyroglobulin by protein disulfide isomerase and immunoglobulin heavy chain-binding protein J. Biol. Chem. 276 2001 21337 21342
149. J.C. Watts, H. Huo, Y. Bai, S. Ehsani, A.H. Jeon, T. Shi, N. Daude, A. Lau, R. Young, L. Xu, G.A. Carlson, D. Williams, D. Westaway, and G. Schmitt-Ulms Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones PLoS Pathog. 5 2009 e1000608
150. S. Hashimoto, K. Shiomoto, K. Okada, and S. Imaoka The binding site of bisphenol A to protein disulfide isomerase J. Biochem. 151 2012 35 45
151. A.R. Karala, and L.W. Ruddock Bacitracin is not a specific inhibitor of protein disulfide isomerase FEBS J. 277 2010 2454 2462
152. R.R. Bach, and D. Monroe What is wrong with the allosteric disulfide bond hypothesis? Arterioscler. Thromb. Vasc. Biol. 29 2009 1997 1998
153. J.K. Burgess, K.A. Hotchkiss, C. Suter, N.P. Dudman, J. Szollosi, C.N. Chesterman, B.H. Chong, and P.J. Hogg Physical proximity and functional association of glycoprotein 1bα and protein-disulfide isomerase on the platelet plasma membrane J. Biol. Chem. 275 2000 9758 9766
154. M. Swiatkowska, J. Szymanski, G. Padula, and C.S. Cierniewski Interaction and functional association of protein disulfide isomerase with αVβ3 integrin on endothelial cells FEBS J. 275 2008 1813 1823
155. J. Lahav, E.M. Wijnen, O. Hess, S.W. Hamaia, D. Griffiths, M. Makris, C.G. Knight, D.W. Essex, and R.W. Farndale Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin α2β1 Blood 102 2003 2085 2092
156. B. Molins, E. Pena, T. Padro, L. Casani, C. Mendieta, and L. Badimon Glucose-regulated protein 78 and platelet deposition: effect of rosuvastatin Arterioscler. Thromb. Vasc. Biol. 30 2010 1246 1252
157. C. Banfi, M. Brioschi, R. Wait, S. Begum, E. Gianazza, A. Pirillo, L. Mussoni, and E. Tremoli Proteome of endothelial cell-derived procoagulant microparticles Proteomics 5 2005 4443 4455
158. M. Janiszewski, A.O. Do Carmo, M.A. Pedro, E. Silva, E. Knobel, and F.R. Laurindo Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: a novel vascular redox pathway Crit. Care Med. 32 2004 818 825
159. Y. Wang, A.H. Herrera, Y. Li, K.K. Belani, and B. Walcheck Regulation of mature ADAM17 by redox agents for L-selectin shedding J. Immunol. 182 2009 2449 2457
160. M. Vallon, P. Aubele, K.P. Janssen, and M. Essler Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase Biochem. J. 441 2012 937 944
161. B.K. Kaiser, D. Yim, I.T. Chow, S. Gonzalez, Z. Dai, H.H. Mann, R.K. Strong, V. Groh, and T. Spies Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands Nature 447 2007 482 486
162. J. Gilbert, W. Ou, J. Silver, and T. Benjamin Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus J. Virol. 80 2006 10868 10870
163. A. Gallina, T.M. Hanley, R. Mandel, M. Trahey, C.C. Broder, G.A. Viglianti, and H.J. Ryser Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry J. Biol. Chem. 277 2002 50579 50588
164. D.M. Townsend, Y. Manevich, L. He, Y. Xiong, R.R. Bowers Jr., S. Hutchens, and K.D. Tew Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response Cancer Res. 69 2009 7626 7634
165. E. Quemeneur, R. Guthapfel, and P. Gueguen A major phosphoprotein of the endoplasmic reticulum is protein disulfide isomerase J. Biol. Chem. 269 1994 5485 5488
166. R.G. Hu, C.S. Brower, H. Wang, I.V. Davydov, J. Sheng, J. Zhou, Y.T. Kwon, and A. Varshavsky Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms J. Biol. Chem. 281 2006 32559 32573
167. C.C. Wong, T. Xu, R. Rai, A.O. Bailey, J.R. Yates III, Y.I. Wolf, H. Zebroski, and A. Kashina Global analysis of posttranslational protein arginylation PLoS Biol. 5 2007 e258
168. K.S. Na, B.C. Park, M. Jang, S. Cho, H. Lee do, S. Kang, C.K. Lee, K.H. Bae, and S.G. Park Protein disulfide isomerase is cleaved by caspase-3 and -7 during apoptosis Mol. Cells 24 2007 261 267
169. N. Chignard, S. Shang, H. Wang, J. Marrero, C. Brechot, S. Hanash, and L. Beretta Cleavage of endoplasmic reticulum proteins in hepatocellular carcinoma: detection of generated fragments in patient sera Gastroenterology 130 2006 2010 2022
170. D.L. Carbone, J.A. Doorn, Z. Kiebler, and D.R. Petersen Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase Chem. Res. Toxicol. 18 2005 1324 1331
171. D.C. Love, and J.A. Hanover The hexosamine signaling pathway: deciphering the "O-GlcNAc code." Sci. STKE 2005 re13
172. D.R. Macer, and G.L. Koch Identification of a set of calcium-binding proteins in reticuloplasm, the luminal content of the endoplasmic reticulum J. Cell Sci. 91 1988 61 70
173. R. Noiva Protein disulfide isomerase: the multifunctional redox chaperone of the endoplasmic reticulum Semin. Cell Dev. Biol. 10 1999 481 493
174. S. Narindrasorasak, P. Yao, and B. Sarkar Protein disulfide isomerase, a multifunctional protein chaperone, shows copper-binding activity Biochem. Biophys. Res. Commun. 311 2003 405 414
175. A. Solovyov, and H.F. Gilbert Zinc-dependent dimerization of the folding catalyst, protein disulfide isomerase Protein Sci. 13 2004 1902 1907
176. A.A. Alaiya, M. Al-Mohanna, M. Aslam, Z. Shinwari, L. Al-Mansouri, M. Al-Rodayan, M. Al-Eid, I. Ahmad, K. Hanash, A. Tulbah, A. Bin Mahfooz, and C. Adra Proteomics-based signature for human benign prostate hyperplasia and prostate adenocarcinoma Int. J. Oncol. 38 2011 1047 1057
177. H. Bu, S. Bormann, G. Schafer, W. Horninger, P. Massoner, A. Neeb, V.K. Lakshmanan, D. Maddalo, A. Nestl, H. Sultmann, A.C. Cato, and H. Klocker The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection Prostate 71 2011 575 587
178. N.C. Pressinotti, H. Klocker, G. Schafer, V.D. Luu, M. Ruschhaupt, R. Kuner, E. Steiner, A. Poustka, G. Bartsch, and H. Sultmann Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer Mol. Cancer 8 2009 130
179. N.K. Agarwal, G.A. Mueller, C. Mueller, J.H. Streich, A.R. Asif, and H. Dihazi Expression proteomics of acute promyelocytic leukaemia cells treated with methotrexate Biochim. Biophys. Acta 1804 2010 918 928
180. T. Voss, H. Ahorn, P. Haberl, H. Dohner, and K. Wilgenbus Correlation of clinical data with proteomics profiles in 24 patients with B-cell chronic lymphocytic leukemia Int. J. Cancer 91 2001 180 186
181. P. Thongwatchara, W. Promwikorn, C. Srisomsap, D. Chokchaichamnankit, P. Boonyaphiphat, and P. Thongsuksai Differential protein expression in primary breast cancer and matched axillary node metastasis Oncol. Rep. 26 2011 185 191
182. P. Gromov, I. Gromova, J. Bunkenborg, T. Cabezon, J.M. Moreira, V. Timmermans-Wielenga, P. Roepstorff, F. Rank, and J.E. Celis Up-regulated proteins in the fluid bathing the tumour cell microenvironment as potential serological markers for early detection of cancer of the breast Mol. Oncol. 4 2010 65 89
183. K. Chahed, M. Kabbage, B. Hamrita, C.L. Guillier, M. Trimeche, S. Remadi, L. Ehret-Sabatier, and L. Chouchane Detection of protein alterations in male breast cancer using two dimensional gel electrophoresis and mass spectrometry: the involvement of several pathways in tumorigenesis Clin. Chim. Acta 388 2008 106 114
184. K. Chahed, M. Kabbage, L. Ehret-Sabatier, C. Lemaitre-Guillier, S. Remadi, J. Hoebeke, and L. Chouchane Expression of fibrinogen E-fragment and fibrin E-fragment is inhibited in the human infiltrating ductal carcinoma of the breast: the two-dimensional electrophoresis and MALDI-TOF-mass spectrometry analyses Int. J. Oncol. 27 2005 1425 1431
185. L. Bianchi, C. Canton, L. Bini, R. Orlandi, S. Menard, A. Armini, M. Cattaneo, V. Pallini, L.R. Bernardi, and I. Biunno Protein profile changes in the human breast cancer cell line MCF-7 in response to SEL1L gene induction Proteomics 5 2005 2433 2442
186. B.S. Sorensen, M.R. Horsman, H. Vorum, B. Honore, J. Overgaard, and J. Alsner Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics Radiother. Oncol. 92 2009 443 449
187. M.K. Kashyap, H.C. Harsha, S. Renuse, H. Pawar, N.A. Sahasrabuddhe, M.S. Kim, A. Marimuthu, S. Keerthikumar, B. Muthusamy, K. Kandasamy, Y. Subbannayya, T.S. Prasad, R. Mahmood, R. Chaerkady, S.J. Meltzer, R.V. Kumar, A.K. Rustgi, and A. Pandey SILAC-based quantitative proteomic approach to identify potential biomarkers from the esophageal squamous cell carcinoma secretome Cancer Biol. Ther. 10 2010 796 810
188. T.T. Huang, J.Y. Chen, C.E. Tseng, Y.C. Su, H.C. Ho, M.S. Lee, C.T. Chang, Y.K. Wong, and H.R. Chen Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan J. Formos. Med. Assoc. 109 2010 326 337
189. J.W. Ryu, H.J. Kim, Y.S. Lee, N.H. Myong, C.H. Hwang, G.S. Lee, and H.C. Yom The proteomics approach to find biomarkers in gastric cancer J. Korean Med. Sci. 18 2003 505 509
190. P. Zhang, L. Huang, Y.L. Ma, J.Y. Peng, T.Y. Shen, H.Q. Chen, Y.K. Zhou, M. Zhang, Z.X. Chu, and H.L. Qin HnRNP K and PDI marked response to chemotherapy to human colorectal cancer cells Electrophoresis 31 2010 1731 1738
191. Y. Wang, Y. Ma, B. Lu, E. Xu, Q. Huang, and M. Lai Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study Exp. Biol. Med. 232 2007 1152 1159
192. P.M. Tang, N.H. Bui-Xuan, C.K. Wong, W.P. Fong, and K.P. Fung Pheophorbide a-mediated photodynamic therapy triggers HLA class I-restricted antigen presentation in human hepatocellular carcinoma Transl. Oncol. 3 2010 114 122
193. N. Chen, W. Sun, X. Deng, Y. Hao, X. Chen, B. Xing, W. Jia, J. Ma, H. Wei, Y. Zhu, X. Qian, Y. Jiang, and F. He Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC Proteomics 8 2008 5108 5118
194. R. Teramoto, H. Minagawa, M. Honda, K. Miyazaki, Y. Tabuse, K. Kamijo, T. Ueda, and S. Kaneko Protein expression profile characteristic to hepatocellular carcinoma revealed by 2D-DIGE with supervised learning Biochim. Biophys. Acta 1784 2008 764 772
195. K. Mikuriya, Y. Kuramitsu, S. Ryozawa, M. Fujimoto, S. Mori, M. Oka, K. Hamano, K. Okita, I. Sakaida, and K. Nakamura Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry Int. J. Oncol. 30 2007 849 855
196. J. Shen, M.D. Person, J. Zhu, J.L. Abbruzzese, and D. Li Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry Cancer Res. 64 2004 9018 9026
197. D. Cecconi, H. Astner, M. Donadelli, M. Palmieri, E. Missiaglia, M. Hamdan, A. Scarpa, and P.G. Righetti Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2′-deoxycytidine Electrophoresis 24 2003 4291 4303
198. L. Gonzalez-Santiago, P. Alfonso, Y. Suarez, A. Nunez, L.F. Garcia-Fernandez, E. Alvarez, A. Munoz, and J.I. Casal Proteomic analysis of the resistance to aplidin in human cancer cells J. Proteome Res. 6 2007 1286 1294
199. P. Alfonso, I. Dolado, A. Swat, A. Nunez, A. Cuadrado, A.R. Nebreda, and J.I. Casal Proteomic analysis of p38α mitogen-activated protein kinase-regulated changes in membrane fractions of RAS-transformed fibroblasts Proteomics 6 Suppl. 1 2006 S262 S271
200. G. Lessner, O. Schmitt, S.J. Haas, S. Mikkat, M. Kreutzer, A. Wree, and M.O. Glocker Differential proteome of the striatum from hemiparkinsonian rats displays vivid structural remodeling processes J. Proteome Res. 9 2010 4671 4687
201. J.M. Dhahbi, P.L. Mote, J.B. Tillman, R.L. Walford, and S.R. Spindler Dietary energy tissue-specifically regulates endoplasmic reticulum chaperone gene expression in the liver of mice J. Nutr. 127 1997 1758 1764
202. J.H. Lee, S.M. Won, J. Suh, S.J. Son, G.J. Moon, U.J. Park, and B.J. Gwag Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice Exp. Mol. Med. 42 2010 386 394
203. T. Ahtoniemi, M. Jaronen, V. Keksa-Goldsteine, G. Goldsteins, and J. Koistinaho Mutant SOD1 from spinal cord of G93A rats is destabilized and binds to inner mitochondrial membrane Neurobiol. Dis. 32 2008 479 485
204. E.V. Ilieva, V. Ayala, M. Jove, E. Dalfo, D. Cacabelos, M. Povedano, M.J. Bellmunt, I. Ferrer, R. Pamplona, and M. Portero-Otin Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis Brain 130 2007 3111 3123
205. J.D. Atkin, M.A. Farg, B.J. Turner, D. Tomas, J.A. Lysaght, J. Nunan, A. Rembach, P. Nagley, P.M. Beart, S.S. Cheema, and M.K. Horne Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1 J. Biol. Chem. 281 2006 30152 30165
206. E. Kitzmueller, K. Krapfenbauer, H. Hoeger, R. Weitzdoerfer, G. Lubec, and B. Lubec Life-long effects of perinatal asphyxia on stress-induced proteins and dynamin 1 in rat brain Neurochem. Res. 29 2004 1767 1777
207. J.S. Truettner, K. Hu, C.L. Liu, W.D. Dietrich, and B. Hu Subcellular stress response and induction of molecular chaperones and folding proteins after transient global ischemia in rats Brain Res. 1249 2009 9 18
208. B.C. Yoo, K. Krapfenbauer, N. Cairns, G. Belay, M. Bajo, and G. Lubec Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease Neurosci. Lett. 334 2002 196 200
209. P.C. McHugh, G.R. Rogers, B. Loudon, D.M. Glubb, P.R. Joyce, and M.A. Kennedy Proteomic analysis of embryonic stem cell-derived neural cells exposed to the antidepressant paroxetine J. Neurosci. Res. 86 2008 306 316
210. K.Y. Kam, S.J. Yu, N. Jeong, J.H. Hong, A.M. Jalin, S. Lee, Y.W. Choi, C.K. Lee, and S.G. Kang p-Hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia Mol. Cells 31 2011 209 215
211. M. Hengstschlager, M. Rosner, M. Fountoulakis, J.E. Oh, and G. Lubec Protein levels of α1-tubulin, protein disulfide isomerase, tropomyosins and vimentin are regulated by the tuberous sclerosis gene products Cancer Lett. 210 2004 219 226
212. T.M. Chang, G.Y. Shi, H.L. Wu, C.H. Wu, Y.D. Su, H.L. Wang, H.Y. Wen, and H.C. Huang Effects of salvianolic acid B on protein expression in human umbilical vein endothelial cells Evid. Based Complement. Altern. Med. 2011 2011 213050
213. M.G. Barderas, J. Tunon, V.M. Darde, F. De la Cuesta, J.J. Jimenez-Nacher, N. Tarin, L. Lopez-Bescos, J. Egido, and F. Vivanco Atorvastatin modifies the protein profile of circulating human monocytes after an acute coronary syndrome Proteomics 9 2009 1982 1993
214. A. Severino, M. Campioni, S. Straino, F.N. Salloum, N. Schmidt, U. Herbrand, S. Frede, G. Toietta, G. Di Rocco, R. Bussani, F. Silvestri, M. Piro, G. Liuzzo, L.M. Biasucci, P. Mellone, F. Feroce, M. Capogrossi, F. Baldi, J. Fandrey, M. Ehrmann, F. Crea, A. Abbate, and A. Baldi Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy J. Am. Coll. Cardiol. 50 2007 1029 1037
215. A. Azfer, J. Niu, L.M. Rogers, F.M. Adamski, and P.E. Kolattukudy Activation of endoplasmic reticulum stress response during the development of ischemic heart disease Am. J. Physiol. Heart Circ. Physiol. 291 2006 H1411 H1420
216. B. Gharesi-Fard, J. Zolghadri, and E. Kamali-Sarvestani Proteome differences of placenta between pre-eclampsia and normal pregnancy Placenta 31 2010 121 125
217. L.Z. Sun, N.N. Yang, W. De, and Y.S. Xiao Proteomic analysis of proteins differentially expressed in preeclamptic trophoblasts Gynecol. Obstet. Invest. 64 2007 17 23
218. E. Shibata, K. Ejima, H. Nanri, N. Toki, C. Koyama, M. Ikeda, and M. Kashimura Enhanced protein levels of protein thiol/disulphide oxidoreductases in placentae from pre-eclamptic subjects Placenta 22 2001 566 572
219. L. Zhang, Y.H. Hou, K. Wu, J.S. Zhai, and N. Lin Proteomic analysis reveals molecular biological details in varioliform gastritis without Helicobacter pylori infection World J. Gastroenterol. 16 2010 3664 3673
220. C. Lopez-Pedrera, P. Ruiz-Limon, M.A. Aguirre, N. Barbarroja, C. Perez-Sanchez, P. Buendia, I.C. Rodriguez-Garcia, A. Rodriguez-Ariza, E. Collantes-Estevez, F. Velasco, M. Khasmahta, and M.J. Cuadrado Global effects of fluvastatin on the prothrombotic status of patients with antiphospholipid syndrome Ann. Rheum. Dis. 70 2011 675 682
221. J.H. Yu, J.Y. Seo, K.H. Kim, and H. Kim Differentially expressed proteins in cerulein-stimulated pancreatic acinar cells: implication for acute pancreatitis Int. J. Biochem. Cell Biol. 40 2008 503 516
222. H. Wang, P.K. Chan, S.Y. Pan, K.H. Kwon, Y. Ye, J.H. Chu, W.F. Fong, W.M. Tsui, and Z.L. Yu ERp57 is up-regulated in free fatty acids-induced steatotic L-02 cells and human nonalcoholic fatty livers J. Cell. Biochem. 110 2010 1447 1456
223. W. Zhang, S. Ambati, M.A. Della-Fera, Y.H. Choi, C.A. Baile, and T.M. Andacht Leptin modulated changes in adipose tissue protein expression in ob/ob mice Obesity 19 2011 255 261
224. G. Boden, and S. Merali Measurement of the increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals Methods Enzymol. 489 2011 67 82
225. L. Zhang, G. Perdomo, D.H. Kim, S. Qu, S. Ringquist, M. Trucco, and H.H. Dong Proteomic analysis of fructose-induced fatty liver in hamsters Metabolism 57 2008 1115 1124
226. G. Boden, X. Duan, C. Homko, E.J. Molina, W. Song, O. Perez, P. Cheung, and S. Merali Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals Diabetes 57 2008 2438 2444
227. G. Nardai, K. Stadler, E. Papp, T. Korcsmaros, J. Jakus, and P. Csermely Diabetic changes in the redox status of the microsomal protein folding machinery Biochem. Biophys. Res. Commun. 334 2005 787 795
228. M. Ahmed, and P. Bergsten Glucose-induced changes of multiple mouse islet proteins analysed by two-dimensional gel electrophoresis and mass spectrometry Diabetologia 48 2005 477 485
229. J.P. Morand, J. Macri, and K. Adeli Proteomic profiling of hepatic endoplasmic reticulum-associated proteins in an animal model of insulin resistance and metabolic dyslipidemia J. Biol. Chem. 280 2005 17626 17633
230. M. Baryshev, E. Sargsyan, G. Wallin, A. Lejnieks, S. Furudate, A. Hishinuma, and S. Mkrtchian Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism J. Mol. Endocrinol. 32 2004 903 920
231. L.L. Wong, S.T. Fan, K. Man, W.H. Sit, P.P. Jiang, I.W. Jor, C.Y. Lee, W.L. Ling, K.T. Tam, and J.M. Wan Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity Hum. Exp. Toxicol. 30 2011 1369 1381
232. Y. Ding, B. Lu, D. Chen, L. Meng, Y. Shen, and S. Chen Proteomic analysis of colonic mucosa in a rat model of irritable bowel syndrome Proteomics 10 2010 2620 2630
233. S.O. Cho, J.W. Lim, J.H. Jun, K.H. Kim, and H. Kim Helicobacter pylori in a Korean isolate expressed proteins differentially in human gastric epithelial cells Dig. Dis. Sci. 55 2010 1550 1564
234. K. Steiling, A.Y. Kadar, A. Bergerat, J. Flanigon, S. Sridhar, V. Shah, Q.R. Ahmad, J.S. Brody, M.E. Lenburg, M. Steffen, and A. Spira Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers PLoS One 4 2009 e5043
235. S.G. Kelsen, X. Duan, R. Ji, O. Perez, C. Liu, and S. Merali Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach Am. J. Respir. Cell Mol. Biol. 38 2008 541 550
236. J. Wu, F. Wang, Y. Gong, D. Li, J. Sha, X. Huang, and X. Han Proteomic analysis of changes induced by nonylphenol in Sprague-Dawley rat Sertoli cells Chem. Res. Toxicol. 22 2009 668 675
237. J.A. Saba, M.E. McComb, D.L. Potts, C.E. Costello, and S. Amar Proteomic mapping of stimulus-specific signaling pathways involved in THP-1 cells exposed to Porphyromonas gingivalis or its purified components J. Proteome Res. 6 2007 2211 2221
238. S.S. Gouraud, K. Heesom, S.T. Yao, J. Qiu, J.F. Paton, and D. Murphy Dehydration-induced proteome changes in the rat hypothalamo-neurohypophyseal system Endocrinology 148 2007 3041 3052
239. M. Li, Z.Q. Xiao, Z.C. Chen, J.L. Li, C. Li, P.F. Zhang, and M.Y. Li Proteomic analysis of the aging-related proteins in human normal colon epithelial tissue J. Biochem. Mol. Biol. 40 2007 72 81
240. F. Boraldi, L. Bini, S. Liberatori, A. Armini, V. Pallini, R. Tiozzo, I. Pasquali-Ronchetti, and D. Quaglino Proteome analysis of dermal fibroblasts cultured in vitro from human healthy subjects of different ages Proteomics 3 2003 917 929
241. S.G. Paule, L.M. Airey, Y. Li, A.N. Stephens, and G. Nie Proteomic approach identifies alterations in cytoskeletal remodelling proteins during decidualization of human endometrial stromal cells J. Proteome Res. 9 2010 5739 5747
242. V. Thongboonkerd, E. Gozal, L.R. Sachleben Jr., J.M. Arthur, W.M. Pierce, J. Cai, J. Chao, M. Bader, J.B. Pesquero, D. Gozal, and J.B. Klein Proteomic analysis reveals alterations in the renal kallikrein pathway during hypoxia-induced hypertension J. Biol. Chem. 277 2002 34708 34716
243. Z. Yi, C. Jingting, and Z. Yu Proteomics reveals protein profile changes in cyclooxygenase-2 inhibitor-treated endometrial cancer cells Int. J. Gynecol. Cancer 19 2009 326 333
244. M. Wu, X. Bai, G. Xu, J. Wei, T. Zhu, Y. Zhang, Q. Li, P. Liu, A. Song, L. Zhao, C. Gang, Z. Han, S. Wang, J. Zhou, Y. Lu, and D. Ma Proteome analysis of human androgen-independent prostate cancer cell lines: variable metastatic potentials correlated with vimentin expression Proteomics 7 2007 1973 1983
245. S. Park, J. Lee, and C.H. Yeom A proteomic approach to the identification of early molecular targets changed by L-ascorbic acid in NB4 human leukemia cells J. Cell. Biochem. 99 2006 1628 1641
246. D. Grebenova, P. Halada, J. Stulik, V. Havlicek, and Z. Hrkal Protein changes in HL60 leukemia cells associated with 5-aminolevulinic acid-based photodynamic therapy: early effects on endoplasmic reticulum chaperones Photochem. Photobiol. 72 2000 16 22
247. Y.J. Qi, Q.Y. He, Y.F. Ma, Y.W. Du, G.C. Liu, Y.J. Li, G.S. Tsao, S.M. Ngai, and J.F. Chiu Proteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma J. Cell. Biochem. 104 2008 1625 1635
248. C.M. Leys, S. Nomura, B.J. LaFleur, S. Ferrone, M. Kaminishi, E. Montgomery, and J.R. Goldenring Expression and prognostic significance of prothymosin-α and ERp57 in human gastric cancer Surgery 141 2007 41 50
249. M.J. Ahn, Y.D. Yoo, K.H. Lee, J.I. Ahn, D.H. Yu, H.S. Lee, H.S. Oh, J.H. Choi, and Y.S. Lee cDNA microarray analysis of differential gene expression in gastric cancer cells sensitive and resistant to 5-fluorouracil and cisplatin Cancer Res. Treat. 37 2005 54 62
250. H. Ren, N. Du, G. Liu, H.T. Hu, W. Tian, Z.P. Deng, and J.S. Shi Analysis of variabilities of serum proteomic spectra in patients with gastric cancer before and after operation World J. Gastroenterol. 12 2006 2789 2792
251. I. Gromova, P. Gromov, and J.E. Celis Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure Electrophoresis 20 1999 241 248
252. X.M. Fu, X. Dai, J. Ding, and B.T. Zhu Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions J. Mol. Histol. 40 2009 189 199
253. F. Odreman, M. Vindigni, M.L. Gonzales, B. Niccolini, G. Candiano, B. Zanotti, M. Skrap, S. Pizzolitto, G. Stanta, and A. Vindigni Proteomic studies on low- and high-grade human brain astrocytomas J. Proteome Res. 4 2005 698 708
254. R.T. Netea-Maier, S.W. Hunsucker, B.M. Hoevenaars, S.M. Helmke, P.J. Slootweg, A.R. Hermus, B.R. Haugen, and M.W. Duncan Discovery and validation of protein abundance differences between follicular thyroid neoplasms Cancer Res. 68 2008 1572 1580
255. D. Jiang, W. Ying, Y. Lu, J. Wan, Y. Zhai, W. Liu, Y. Zhu, Z. Qiu, X. Qian, and F. He Identification of metastasis-associated proteins by proteomic analysis and functional exploration of interleukin-18 in metastasis Proteomics 3 2003 724 737
256. X. Kuang, W. Hu, M. Yan, and P.K. Wong Phenylbutyric acid suppresses protein accumulation-mediated ER stress in retrovirus-infected astrocytes and delays onset of paralysis in infected mice Neurochem. Int. 57 2010 738 748
257. K. Takahashi, K. Saito, J. Masuda, S. Fujigaki, M. Takemura, H. Ito, and M. Seishima Changes in neuronal protein expression in LP-BM5-infected mice Neurosci. Lett. 422 2007 114 118
258. J.S. Truettner, B. Hu, O.F. Alonso, H.M. Bramlett, K. Kokame, and W.D. Dietrich Subcellular stress response after traumatic brain injury J. Neurotrauma 24 2007 599 612
259. J. Lee, J.H. Seo, J.W. Lim, and H. Kim Membrane proteome analysis of cerulein-stimulated pancreatic acinar cells: implication for early event of acute pancreatitis Gut Liver 4 2010 84 93
260. Y. Naito, T. Takagi, H. Okada, T. Omatsu, K. Mizushima, O. Handa, S. Kokura, H. Ichikawa, H. Fujiwake, and T. Yoshikawa Identification of inflammation-related proteins in a murine colitis model by 2D fluorescence difference gel electrophoresis and mass spectrometry J. Gastroenterol. Hepatol. 25 Suppl. 1 2010 S144 S148
261. S. Hino, S. Kondo, K. Yoshinaga, A. Saito, T. Murakami, S. Kanemoto, H. Sekiya, K. Chihara, Y. Aikawa, H. Hara, T. Kudo, T. Sekimoto, T. Funamoto, E. Chosa, and K. Imaizumi Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis J. Bone Miner. Metab. 28 2010 131 138
262. F.Y. Deng, Y.Z. Liu, L.M. Li, C. Jiang, S. Wu, Y. Chen, H. Jiang, F. Yang, J.X. Xiong, P. Xiao, S.M. Xiao, L.J. Tan, X. Sun, X.Z. Zhu, M.Y. Liu, S.F. Lei, X.D. Chen, J.Y. Xie, G.G. Xiao, S.P. Liang, and H.W. Deng Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density Proteomics 8 2008 4259 4272
263. C.R. Muhlenkamp, and S.S. Gill A glucose-regulated protein, GRP58, is down-regulated in C57B6 mouse liver after diethylhexyl phthalate exposure Toxicol. Appl. Pharmacol. 148 1998 101 108
264. S.R. Berglund, A.R. Santana, D. Li, R.H. Rice, D.M. Rocke, and Z. Goldberg Proteomic analysis of low dose arsenic and ionizing radiation exposure on keratinocytes Proteomics 9 2009 1925 1938
265. M. Fukasawa, K. Okamoto, M. Nakamura, K. Mikami, S. Shimada, Y. Tanaka, K. Nagai, M. Arito, M.S. Kurokawa, K. Masuko, N. Suematsu, I. Koizuka, and T. Kato Proteomic analysis of the rat cerebellar flocculus during vestibular compensation J. Vestib. Res. 19 2009 83 94
266. C. Lopez-Pedrera, M.J. Cuadrado, V. Herandez, P. Buendia, M.A. Aguirre, N. Barbarroja, L.A. Torres, J.M. Villalba, F. Velasco, and M. Khamashta Proteomic analysis in monocytes of antiphospholipid syndrome patients: deregulation of proteins related to the development of thrombosis Arthritis Rheum. 58 2008 2835 2844
267. T.H. Kim, Y.H. Lee, K.H. Kim, S.H. Lee, J.Y. Cha, E.K. Shin, S. Jung, A.S. Jang, S.W. Park, S.T. Uh, Y.H. Kim, J.S. Park, H.G. Sin, W. Youm, E.S. Koh, S.Y. Cho, Y.K. Paik, T.Y. Rhim, and C.S. Park Role of lung apolipoprotein A-I in idiopathic pulmonary fibrosis: antiinflammatory and antifibrotic effect on experimental lung injury and fibrosis Am. J. Respir. Crit. Care Med. 182 2010 633 642
268. J.Y. Noh, S.H. Oh, J.H. Lee, Y.S. Kwon, D.J. Ryu, and K.H. Lee Can blood components with age-related changes influence the ageing of endothelial cells? Exp. Dermatol. 19 2010 339 346
269. M. Paz Gavilan, J. Vela, A. Castano, B. Ramos, J.C. del Rio, J. Vitorica, and D. Ruano Cellular environment facilitates protein accumulation in aged rat hippocampus Neurobiol. Aging 27 2006 973 982
270. O. Serve, Y. Kamiya, A. Maeno, M. Nakano, C. Murakami, H. Sasakawa, Y. Yamaguchi, T. Harada, E. Kurimoto, M. Yagi-Utsumi, T. Iguchi, K. Inaba, J. Kikuchi, O. Asami, T. Kajino, T. Oka, M. Nakasako, and K. Kato Redox-dependent domain rearrangement of protein disulfide isomerase coupled with exposure of its substrate-binding hydrophobic surface J. Mol. Biol. 396 2010 361 374
271. V.K. Kodali, and C. Thorpe Oxidative protein folding and the quiescin-sulfhydryl oxidase family of flavoproteins Antioxid. Redox Signal. 13 2010 1217 1230